Riesgo cardiovascular en practicantes de clases grupales de fin de semana de la Villa Olímpica (Aerobistas novatos) del proyecto "La Villa" de la Secretaria Municipal de Deporte y Recreación Pereira 2009

El Centro para el control y prevención de enfermedades de Atlanta (CDC), el Colegio Americano de Medicina del Deporte (ACSM) y la Asociación Americana de Salud recomiendan que las personas participen por los menos durante 30 minutos o más en actividades físicas de moderada intensidad, por lo menos cinco días a la semana; sin embargo el ejercicio físico puede ser un arma de doble filo. Cerca de 1.5 millones de infartos al miocardio ocurren anualmente en los Estados Unidos, 75.000 de ellos producen muerte, dentro del cual 25.000 puede ocurrir después de practicar ejercicio físico; es decir, las personas con enfermedad cardiaca tienen aproximadamente 10 veces más probabilidad de sufrir muerte por enfermedad cardiaca si se compara con personas saludables, además el ejercicio puede ser un poderoso disparador de infarto al miocardio ya que aproximadamente 4 al 20% de infartos al miocardio ocurren durante o después del ejercicio físico. Es por esto que el trabajo presenta los niveles de riesgo cardiovascular en 70 entre 18 y 64 años de edad, que practicaban aeróbicos nivel del programa La Villa de La Secretaria Municipal de Deporte y Recreación. Resultados: porcentaje de actividad física a partir de los criterios suministrados según los criterios de el CDC de Atlanta, 53% eran regularmente activos mientras que el 47% eran irregularmente activos; dentro del grupo de los irregularmente activos el 18% se encontró en bajo riesgo, 46% se encontró en moderado riesgo y el 36% en alto riego, y del grupo de los regularmente activos se encontró en bajo riego el 60%, moderado riesgo 30% y en alto riesgo el 10%; en el porcentaje de personas encuestadas se encontró que el 77% eran mujeres y el 23% eran hombres, dentro de las limitaciones para realizar actividad física se encontró que el 31% falta de tiempo y el 10% falta de interés, y dentro de las motivaciones 12% le gusta y el 47% por salud. Discusión: 47% de la población encuestada es irregularmente activa, es un valor alto, si se tiene en cuenta, el contexto donde se desarrollo la investigación; al compararlo con un 41% en empleados de la UTP, de la población irregularmente activa un 36% estaba en alto riesgo cardiovascular, lo que aumenta el riesgo de morbimortalidad , en comparación con personas sin ningún factor de riesgo, según el ACSM desconocer los niveles de PA y colesterol se relacionan con enfermedades cardiovasculares, en este estudio un alto porcentaje desconoce sus niveles de PA y colesterol. Conclusión: Del 100% de la población, el 47% fue irregularmente activa, no cumple con las recomendaciones dadas por el ACSM El 37% de la población irregularmente activa estaba en alto riesgo de enfermedad cardiovascular De la población regularmente activa, solo un 10% se clasificó en alto riesgo. Recomendaciones: Establecer estrategias para fortalecer el proyecto Pasaporte a la Salud, Implementar los cuestionarios de detección de riesgo cardiovascular en todos los participantes del proyecto La Villa.The Centers for Disease Control and Prevention (CDC), the American College of Sports Medicine (ACSM) and American Health Association recommends that people involved at least 30 minutes or more in physical activity of moderate intensity at least five days a week, but exercise can be a double edged sword. About 1.5 million heart attacks occur annually in the United States, 75,000 of them produce death, in which 25,000 may occur after physical exercise, that is to say, people with heart disease are about 10 times more likely to suffer death from heart disease compared with healthy people, exercise can also be a powerful trigger of myocardial infarction with approximately 4 to 20% of myocardial infarctions occur during or after exercise. Is for this that the work presents the levels of cardiovascular risk in 70 between 18 and 64 years old, who practiced aerobics program at “La Villa” of The Secretaria Municipal de Deporte y Recreación. Results: The percentage of physical activity based on the criteria supplied by the criteria of the CDC in Atlanta, 53% were regularly active while 47% were irregularly active, within the group of irregularly active to 18% were at low risk , 46% were at moderate risk and 36% higher risk, and regularly active group was found in 60% irrigated, 30% moderate risk and high risk is 10%, in the percentage of respondents found that 77% were women and 23% were men, within the limitations for physical activity found that 31% lack of time and 10% lack of interest and motivation within likes and 12%, 47% for health. Discussion: 47% of the surveyed population is irregularly active, is a high value, taking into account the context in which development research, as compared to 41% by employees of the UTP, irregularly active population by 36 % were at high cardiovascular risk, which increases the risk of mortality compared with people without any risk factors, according to the ACSM ignore the PA and cholesterol levels are associated with cardiovascular disease in this study a high percentage levels unknown PA and cholesterol. Conclusion: Of 100% of the population, 47% were irregularly active, does not comply with the recommendations by the ACSM, 37% irregularly active population was at high risk of cardiovascular disease in the population regularly active, only 10% was classified as high risk. Recommendations: Establish strategies to strengthen the Health Passport Project, implement the questionnaires to detect cardiovascular risk in all project participants Villa

Uso de herramientas sociales como apoyo docente

El presente trabajo muestra una metodología de uso y aplicaciones de diversas herramientas de la Web 2.0 integradas en el proceso de enseñanza-aprendizaje, constituidas como un recurso contemporáneo de apoyo alternativo para docentes. En ese sentido se combina y maneja varios instrumentos de la web social, con el propósito que los estudiantes se vinculen con los contenidos de las asignaturas, interactúen con sus pares y también con sus maestros fuera del aula, así como también, en su tiempo libre con actividades curriculares que permitirán mejorar, pero sin dejar de lado el rigor. El uso de las herramientas sociales de la web tiene como propósito generar conocimiento propio o significativo a través de un aprendizaje apoyado en las Tecnologías de la Información y Comunicación (TIC). El enfoque utilizado dentro de la metodología utilizada es mixto ya que se analizó una realidad educativa, así como también, se recopiló información de campo a través de encuestas aplicadas a seis docentes voluntarios y 110 estudiantes usuarios de la Facultad de Contabilidad y Auditoría de la Universidad Técnica de Ambato, ubicada en la provincia de Tungurahua - Ecuador.This job presents a methodology where the integration of various Web 2.0 tools in the teaching-learning process are used and applied, constituting as a contemporary means of alternative support for teachers. This means, combines and manages various social web tools, allowing students to get involved with the subject content, interacting with their peers, and with their teachers outside the classroom, especially in their free time in any rigid curricular activity. The usage of these tools in the social web has the purpose to elicit self-knowledge through a meaningful learning supported by the Information Technology and Communication (ITC or TIC). The approach used in the methodology was qualitative and quantitative system which was analyzed in the educational system reality, as well as, a field data that was collected through surveys applied to six volunteer teachers and 110 enrolled students in the Accounting and Auditing Faculty of the Técnica de Ambato University, located in the province of Tungurahua – Ecuador

Importancia de la atención odontológica pre-tratamiento antineoplásico para reducir manifestaciones orales en pacientes pediátricos oncológicos. Revisión de la literatura

El cáncer en pacientes pediátricos y su tratamiento afectan directa o indirectamente la salud bucal de los niños, quienes van a requerir de tratamientos dentales para mantener estable la salud de su cavidad oral. En la presente revisión, se da a conocer la importancia de realizar procedimientos preventivos y rehabilitadores sobre las manifestaciones orales que presentan los pacientes que reciben terapia contra el cáncer, con el fin de ampliar y actualizar nuestro conocimiento sobre el protocolo de atención odontológico se puede realizar con mayor eficacia antes del tratamiento anti-neoplásicoo, y complementarlo con la rehabilitación durante y postratamiento, con el objetivo de reducir las complicaciones orales ya presentes, evitar o reducir la aparición de nuevas condiciones patológicas a nivel de la cavidad oral, y de esta forma mejorar en lo posible la calidad de vida del paciente pediátrico oncológico, quien se ve afectado de forma significativa.Cancer in pediatric patients and treatment affect directly or indirectly oral health in children, who will require dental treatments to maintain the health of their oral cavity stable. In this review, the importance of performing preventive and rehabilitative procedures on the oral manifestations presented by patients receiving cancer therapy is disclosed, to expand and update our knowledge about The dental care protocol can be performed more effectively before anti-neoplastic treatment or, and complemented with rehabilitation during and after treatment, with the aim of reducing existing oral complications, avoiding or reducing the appearance of new pathological conditions at the level of the oral cavity, and thus improve as much as possible the quality of life of pediatric cancer patients, who are significantly affected.OdontólogoCuenc

Expedición Naútica-científica : Fray Francisco Morillo. Río Bermejo, Argentina. 29/09-10/10/1984

Fil: López, Hugo Luis. División Zoología Vertebrados; Facultad de Ciencias Naturales y Museo; Universidad Nacional de La PlataFil: Piloni Tamayo, Gabriel. División Zoología Vertebrados; Facultad de Ciencias Naturales y Museo; Universidad Nacional de La PlataFil: Ponte Gómez, Justina. División Zoología Vertebrados; Facultad de Ciencias Naturales y Museo; Universidad Nacional de La Plat

Armed conflict, Peace and Economics

RESUMEN: En este artículo se basa en el interés de los autores por investigar los determinantes económicos subyacentes en el mantenimiento de la paz en el posconflicto. Para lograr el objetivo se seleccionó una muestra de países que después de atravesar por conflictos armados internos han logrado alcanzar la paz. La extensa cantidad de variables socioeconómicas disponibles en las bases de datos analizadas hace necesario utilizar una metodología de análisis de componentes principales para elegir aquellas con mayor poder explicativo. En adición, se construye un modelo probabilístico para determinar cuáles variables tienen una mayor probabilidad de sostener la paz. La evidencia sugiere que entre los factores más relevantes que incrementan la probabilidad de una paz duradera son: la ayuda internacional, el capital físico, la infraestructura, la tecnología, las condiciones macroeconómicas y el valor agregado de la producción nacional.ABSTRACT: In this paper we are interested in investigating the economic determinants for sustainable peace in post-conflict. To achieve the goal we selected a sample of countries, which after passing through internal armed conflicts, have managed to achieve peace. The large number of socioeconomic variables available in the databases analyzed involves using a methodology of principal components to choose those with the greatest explanatory power. In addition, a probabilistic model is constructed to determine which variables increase the probability of a sustaining peace. Our evidence suggests that the most important factors to get a lasting peace are: international aid, physical capital, infrastructure, technology, macroeconomic conditions and the added value of domestic production

¿Favorece el uso de la Informática el desarrollo de las habilidades de cálculo en los escolares primarios?

En este artículo se expresa el resultado de la aplicación de un experimento pedagógico realizado por el autor principal como parte de su tesis doctoral, en el que se aplica una metodología para el desarrollo de las habilidades de cálculo utilizando la Informática. Se describe la forma utilizada para medir las habilidades de cálculo, los resultados obtenidos y el análisis estadístico realizado con el objetivo de verificar si el uso de la Informática en el proceso de enseñanza-aprendizaje de la Matemática influye en el desarrollo de las habilidades de cálculo en los escolares del primer ciclo de la Educación Primaria

Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD

Non-alcoholic fatty liver disease (NAFLD) is characterised by an excess of hepatic fat that can progress to steatohepatitis, fibrosis, cirrhosis and hepatocarcinoma. The imbalance between lipid uptake/lipogenesis and lipid oxidation/secretion in the liver is a major feature of NAFLD. Given the lack of a non-invasive and reliable methods for the diagnosis of non-alcoholic steatohepatitis (NASH), it is important to find serum markers that are capable of discriminating or defining patients with this stage of NASH. Blood samples were obtained from 152 Caucasian subjects with biopsy-proven NAFLD due to persistently elevated liver enzyme levels. Metabolites representative of oxidative stress were assessed. The findings derived from this work revealed that NAFLD patients with a NASH score of ≥ 4 showed significantly higher levels of lipid peroxidation (LPO). Indeed, LPO levels above the optimal operating point (OOP) of 315.39 μM are an independent risk factor for presenting a NASH score of ≥ 4 (OR: 4.71; 95% CI: 1.68–13.19; p = 0.003). The area under the curve (AUC = 0.81, 95% CI = 0.73–0.89, p < 0.001) shows a good discrimination ability of the model. Therefore, understanding the molecular mechanisms underlying the basal inflammation present in these patients is postulated as a possible source of biomarkers and therapeutic targets in NASH.This research was funded by Consejería de Educación de Castilla y León (VA256P20), Instituto de Salud Carlos III (Grant CB21/13/0005, PI21/00917 and COV20/00491), Junta de Castilla y León (18IGOF), Gerencia Regional de Salud de Castilla y León (GRS2398/A/21), Fundación Ramón Areces (CIVP19A5953) and 7th Call for Gilead Biomedical Research Grants in HIV, Liver Diseases and Haemato-oncology

Gene Expression Patterns Distinguish Mortality Risk in Patients with Postsurgical Shock

Producción CientíficaNowadays, mortality rates in intensive care units are the highest of all hospital units. However, there is not a reliable prognostic system to predict the likelihood of death in patients with postsurgical shock. Thus, the aim of the present work is to obtain a gene expression signature to distinguish the low and high risk of death in postsurgical shock patients. In this sense, mRNA levels were evaluated by microarray on a discovery cohort to select the most differentially expressed genes between surviving and non-surviving groups 30 days after the operation. Selected genes were evaluated by quantitative real-time polymerase chain reaction (qPCR) in a validation cohort to validate the reliability of data. A receiver-operating characteristic analysis with the area under the curve was performed to quantify the sensitivity and specificity for gene expression levels, which were compared with predictions by established risk scales, such as acute physiology and chronic health evaluation (APACHE) and sequential organ failure assessment (SOFA). IL1R2, CD177, RETN, and OLFM4 genes were upregulated in the non-surviving group of the discovery cohort, and their predictive power was confirmed in the validation cohort. This work offers new biomarkers based on transcriptional patterns to classify the postsurgical shock patients according to low and high risk of death. The results present more accuracy than other mortality risk scores.Instituto de Salud Carlos III (grant PI15/01451)Junta de Castilla y León (grant 1255/A/16)Universidad de Valladolid - Fondo Europeo de Desarrollo Regional (grant VA321P18

Predictive modeling of poor outcome in severe COVID-19: A single-center observational study based on clinical, cytokine and laboratory profiles

Producción CientíficaPneumonia is the main cause of hospital admission in COVID-19 patients. We aimed to perform an extensive characterization of clinical, laboratory, and cytokine profiles in order to identify poor outcomes in COVID-19 patients. Methods: A prospective and consecutive study involving 108 COVID-19 patients was conducted between March and April 2020 at Hospital Clínico Universitario de Valladolid (Spain). Plasma samples from each patient were collected after emergency room admission. Forty-five serum cytokines were measured in duplicate, and clinical data were analyzed using SPPS version 25.0. Results: A multivariate predictive model showed high hepatocyte growth factor (HGF) plasma levels as the only cytokine related to intubation or death risk at hospital admission (OR = 7.38, 95%CI—(1.28–42.4), p = 0.025). There were no comorbidities included in the model except for the ABO blood group, in which the O blood group was associated with a 14-fold lower risk of a poor outcome. Other clinical variables were also included in the predictive model. The predictive model was internally validated by the receiver operating characteristic (ROC) curve with an area under the curve (AUC) of 0.94, a sensitivity of 91.7% and a specificity of 95%. The use of a bootstrapping method confirmed these results. Conclusions: A simple, robust, and quick predictive model, based on the ABO blood group, four common laboratory values, and one specific cytokine (HGF), could be used in order to predict poor outcomes in COVID-19 patients.Instituto de Salud Carlos III - ( Proyecto COV20/00491)Consejeria de Educación de Castilla y León - (Proyecto VA256P20)Junta de Castilla y León y Fondo Europeo de Desarrollo Regional (FEDER) - (Proyecto EDU/1100/2017

HGF, IL-1α, and IL-27 are robust biomarkers in early severity stratification of COVID-19 patients

© 2021 by the authors.Pneumonia is the leading cause of hospital admission and mortality in coronavirus disease 2019 (COVID-19). We aimed to identify the cytokines responsible for lung damage and mortality. We prospectively recruited 108 COVID-19 patients between March and April 2020 and divided them into four groups according to the severity of respiratory symptoms. Twenty-eight healthy volunteers were used for normalization of the results. Multiple cytokines showed statistically significant differences between mild and critical patients. High HGF levels were associated with the critical group (OR = 3.51; p < 0.001; 95%CI = 1.95–6.33). Moreover, high IL-1α (OR = 1.36; p = 0.01; 95%CI = 1.07–1.73) and low IL-27 (OR = 0.58; p < 0.005; 95%CI = 0.39–0.85) greatly increased the risk of ending up in the severe group. This model was especially sensitive in order to predict critical status (AUC = 0.794; specificity = 69.74%; sensitivity = 81.25%). Furthermore, high levels of HGF and IL-1α showed significant results in the survival analysis (p = 0.033 and p = 0.011, respectively). HGF, IL-1α, and IL 27 at hospital admission were strongly associated with severe/critical COVID-19 patients and therefore are excellent predictors of bad prognosis. HGF and IL-1α were also mortality biomarkers.This work was supported by the Carlos III Health Institute (Grant COV20/00491)