Virtualització dels serveis d'una empresa

La virtualització és una tecnologia que permet l'abstracció del programari respecte dels recursos del maquinari, tant d'aplicacions com del sistema operatiu. Aquesta tecnologia està constantment en evolució, i el que fa pocs anys era un entorn de treball exclusiu per test de laboratori i aplicacions molt especifiques, ara permet oferir aplicacions i serveis d'entorns empresarials, permetent aprofitar el màxim els recursos disponibles. Aquest projecte tracta de plantejar la virtualització com a solució per a maximitzar el rendiments dels equips informàtics de una empresa. Introduirem la tecnologia de virtualització, planificarem la conversió dels serveis de l'empresa en màquines virtuals, detallarem els aspectes tècnics de la implementació i mostrarem els resultats d'aquesta virtualització.La virtualizacion es una tecnología que permite la abstracción del software respecto a los recursos de hardware, tanto a nivel de aplicaciones como de sistema operativo. Esta tecnología está en constante evolución, y lo que hace pocos años era un entorno de trabajo exclusivo para pruebas de laboratorio y aplicaciones muy especificas, ahora permite ofrecer aplicaciones y servicios de entornos empresariales, permitiendo aprovechar al máximo los recursos disponibles. Este proyecto trata de plantear la virtualización como una solución para maximizar el rendimiento de los equipos informáticos de una empresa. Introduciremos la tecnología de virtualización, planificares la conversión de los servicios de la empresa en máquinas virtuales, detallaremos los aspectos técnicos de la implementación y mostraremos los resultados de esta virtualización.Virtualization is a technology that allows to abstract software from the hardware resources, both for application and operating system. This technology is constantly evolving, in constant evolution, and what a few years ago was an workbench for laboratory test and very specific applications, now can offer applications and services for business and would maximize the hardware resources available. This project seeks to raise virtualization as a solution to maximize the performance of the hardware equipment of a company. Will introduce virtualization technology, plan how to convert the company's services in virtual machines, detail the technical implementation and show the results of this virtualization

Human Papillomavirus, Chlamydia trachomatis and Herpes Simplex Virus

Introduction: Some sexually transmitted infections (STIs) are possible risk factors for oral cancer although their role as etiological agents of head and neck cancer is controversial and should be further studied. Among STI that can infect the oral mucosa stand out Human Papillomavirus (HPV), Herpes Simplex Virus (HSV) and Chlamydia trachomatis (C. trachomatis), an obligate intracellular bacterium that causes inflammation and dysplasia in the cervix. Objectives: To evaluate the presence of HPV, C. trachomatis and HSV in benign, potentially malignant and cancerous oral cavity lesions, in Córdoba, Argentina. Methods: We studied oral cytobrush of lesion from 318 patients (149 men and 169 female). Samples consisted of 137 benign lesions (BL), 96 potentially malignant lesions (PML) and 85 oral squamous cell carcinomas (OSCC). These were analyzed by Polymerase Chain Reaction method and Restriction Fragment Length Polymorphism (RFLP) was used to detect HPV genotype. Results: The prevalence of HPV was 34% (n=109). The HPV detection rate was increasing as the severity of the lesion increased (28% BL, 35% PML and 42% OSCC). The most frequent HPV genotypes were 6 and 16. There was no statistical significance between HPV, lesions, genotypes and gender. However, greater detection of high-risk HPV could be observed in OSCC and low risk HPV in BL. The prevalence of C. trachomatis was 16% (n=54) and HSV was 3% (n=10). We detected 4% (n=13) co infections HPV- C. trachomatis, mostly in BL and 0.3% (n=1) co infection HPV-HSV in BL too. Conclusions. Due the association of HPV and cervical cancer and morphological similarity of genital and oropharyngeal epithelia, these preliminary results allow us to infer that the evolution of the oral lesions could be influenced not only by the conventional risk factors, also the HPV genotype detected. These results show the importance of detecting these pathogens as well as HPV genotype in all kind of oral lesions. Such data are important to improve our knowledge of the epidemiology of oral HPV and co-infections. Indeed, C. trachomatis infection can alter the normal structure of epithelial cell junctions, increasing susceptibility to HPV or HSV infection, both in genital and oral mucosa.Fil: Mosmann, Jessica Paola. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Fil: Mosmann, Jessica Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Virología Dr. José María Vanella; ArgentinaFil: Talavera, Angel Daniel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Criscuolo, María Inés. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología B; Argentina.Fil: Venezuela, Raul Fernando. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Fil: Kiguen, Ana Ximena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Fil: Ferreyra de Prato, Ruth. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Anatomía Patológica A; Argentina.Fil: López de Blanc, Silvia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología B; Argentina.Fil: Ré, Viviana Elisabeth. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Fil: Ré, Viviana Elisabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Virología Dr. José María Vanella; ArgentinaFil: Cuffini, Cecilia Gabriela . Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Fil: Cuffini, Cecilia Gabriela . Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Virología Dr. José María Vanella; Argentina.Otras Ciencias de la Salu

Plan estratégico de la Alianza Pillsens – CVS

La presente investigación tiene como finalidad el desarrollo de un plan estratégico para la división de Estados Unidos de Pillsens, una empresa farmacéutica que produce analgésicos y antinflamatorios. El plan busca aumentar las ventas de la compañía en un mercado estancado debido a una guerra de precios. Para lograrlo se establecerá una alianza comercial con CVS, la principal farmacia minorista en dicho país, para desarrollar un nuevo producto en la categoría de nutrición deportiva, además de un plan de marketing para estimular el crecimiento de las ventas con los distribuidores actuales. Se elaboró un estudio de mercado que identificó una oportunidad para impulsar las ventas de Pillsens en Estados Unidos, ya que se proyecta un crecimiento promedio del 4% en las ventas de analgésicos y del 2.69% en las ventas de antioxidantes para el período 2024-2028. Además, se proyecta un crecimiento económico por encima del 5% del PBI. El plan estratégico se enfoca en capturar un mayor porcentaje de ventas a una tasa superior que el crecimiento del mercado de ambos productos. Para ello, se establecerá un plan de acción que incluye actividades agresivas de marketing como una mayor inversión en publicidad, incentivos comerciales y mejoramiento de la asistencia para los clientes B2B. También se propone una alianza estratégica con CVS para incrementar las ventas en un mercado altamente competitivo, alianza que permitiría a ambas empresas explotar sus capacidades y recursos para generar economías de escala en la manufactura

Mediterranean lifestyle index and 24-h systolic blood pressure and heart rate in community-dwelling older adults

Specifc foods, nutrients, dietary patterns, and physical activity are associated with lower blood pressure (BP) and heart rate (HR), but little is known about the joint efect of lifestyle factors captured in a multidimensional score. We assessed the association of a validated Mediterranean-lifestyle (MEDLIFE) index with 24-h-ambulatory BP and HR in everyday life among community-living older adults. Data were taken from 2,184 individuals (51% females, mean age: 71.4 years) from the SeniorsENRICA-2 cohort. The MEDLIFE index consisted of 29 items arranged in three blocks: 1) Food consumption; 2) Dietary habits; and 3) Physical activity, rest, and conviviality. A higher MEDLIFE score (0–29 points) represented a better Mediterranean lifestyle adherence. 24-h-ambulatory BP and HR were obtained with validated oscillometric devices. Analyses were performed with linear regression adjusted for the main confounders. The MEDLIFEhighest quintile (vs Q1) was associated with lower nighttime systolic BP (SBP) (-3.17 mmHg [95% CI: -5.25, -1.08]; p-trend=0.011), greater nocturnal-SBP fall (1.67% [0.51, 2.83]; p-trend=0.052), and lower HR (-2.04 bpm [daytime], -2.33 bpm [nighttime], and -1.93 bpm [24-h]; all p-trend<0.001). Results were similar for each of the three blocks of MEDLIFE and by hypertension status (yes/no). Among older adults, higher adherence to MEDLIFE was associated with lower nighttime SBP, greater nocturnal-SBP fall, and lower HR in their everyday life. These results suggest a synergistic BP-related protection from the components of the Mediterranean lifestyle. Future studies should determine whether these results replicate in older adults from other Mediterranean and non-Mediterranean countriesThis work was supported by FIS grants 19/319, 20/00896, and 22/1164 from the Carlos III Health Institute, the Secretary of R+D+I, and the European Regional Development Fund/European Social Fund; and by International; REACT EU Program. Comunidad de Madrid and European Regional Development Fund (ERDF), European Union: FACINGLCOVID-CM project, Comunidad de Madrid and European Regional Development Fund (ERDF), European Union. MSP holds a Ramón y Cajal contract (RYC2018–025069-I) from the Spanish Ministry of Science, Innovation and Universitie

Estudio del virus papiloma humano en lesiones potencialmente malignas de la cavidad oral

Al Virus Papiloma Humano (VPH) se lo conoce como el agente etiológico del cáncer cervical, no obstante su papel como agente etiológico del cáncer oral es controversial y debe ser estudiado con mayor profundidad. Es difícil comprender el rol del VPH en la carcinogénesis oral debido a las diferentes frecuencias de la infección en lesiones potencialmente malignas (LPM) y en cáncer oral. La leucoplasia verrugosa, líquen queratótico, queratoacantoma, candidiasis crónica y líquen atrófico se definen como LPM. En muchas ocasiones estas lesiones son clínicamente indistinguibles de un carcinoma. El objetivo del trabajo fue determinar la asociación de la presencia del VPH en LPM de la cavidad oral.Fil: Mosmann, Jessica Paola. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Fil: Mosmann, Jessica Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Virología Dr. José María Vanella; ArgentinaFil: Talavera, Angel Daniel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Frutos, María Celia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Fil: Frutos, María Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Virología Dr. José María Vanella; ArgentinaFil: Monetti, Marina Soledad. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Fil: Monetti, Marina Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Virología Dr. José María Vanella; ArgentinaFil: Kiguen, Ana Ximena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Fil: Venezuela, Raul Fernando. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Fil: Ferreyra de Prato, Ruth. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Anatomía Patológica A; Argentina.Fil: Cuffini, Cecilia Gabriela . Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Fil: Cuffini, Cecilia Gabriela . Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Virología Dr. José María Vanella; Argentina.Salud Pública y Medioambienta

The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control study

Background: Abdominal obesity (AO) is a common modifiable risk factor for certain non-communicable diseases associated with enhanced oxidative stress (OS). The objective of this work was to investigate whether the interaction between antioxidant vitamin intake and OS-related polymorphisms modulates gene-associated anthropometry in a Spanish population. Methods: A total of 246 subjects with AO, and 492 age and gender matched non-AO subjects were included in the study. Anthropometric, biochemical, and OS parameters, and antioxidant dietary intake data were assessed using validated procedures. DNA from white blood cells was isolated and the genotype of seven polymorphisms from genes involved in OS (pro-oxidant and antioxidant) were analyzed using the SNPlex system. The effects of the c.-793T > C polymorphism on promoter activity and thus thioredoxin (TXN) activity were examined using reporter assays. Results: The AO group had higher 8-Oxo-2′-deoxyguanosine levels and took in less vitamin A and vitamin E compared to the non-AO group. Logistic regression analysis revealed that the rs2301241 polymorphism in TXN and rs740603 in catechol-O-methyltransferase (COMT) were associated with waist circumference (WC) and AO. Moreover, these polymorphisms were more strongly associated with variations in WC in subjects with low vitamin E intakes. A promoter assay revealed that the T to C conversion at c.-793 (rs2301241) induced a more than two fold increase in reporter gene expression. Conclusions: WC is associated both with dietary vitamin E intake and genetic variants of TXN and COMT suggesting that existence of a complex nutrigenetic pathway that involves regulation of AO

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio