El concurso del Colegio Mayor 'Nuestra Señora de Luján' de 1964. Política, viajes y encuentros, dibujos

En septiembre de 1963 el Ministerio de Cultura y Educación de la República Argentina, con el patrocinio de la Sociedad Central de Arquitectos convocaba un concurso de anteproyectos para la construcción en la Ciudad Universitaria de Madrid de un Colegio Mayor para alojar a becarios e investigadores argentinos. El texto desvela las motivaciones políticas que existieron en el trasfondo de la convocatoria y traza los viajes, encuentros y dibujos que el matrimonio de arquitectos ganadores, Horacio Baliero y Carmen Córdova, hicieron por España y cómo estos viajes, reflejados en los dibujos de Baliero, propiciaron modificaciones del proyecto original

Comportamento clínico-epidemiológico das periontopatias no municipio Baracoa

A cross-sectional descriptive study was carried out in "Ramón Guevara Montano" Stomatology Clinic from September 2015 to May 2016 with the objective of characterizing the epidemiological behavior of periodontal diseases in the population. The periodontal status of the individuals according to sex was evaluated and the Russell Periodontal Index was used. The universe consisted of 400 patients from which a probabilistic sample was selected by simple random sampling (MAS) of 80 patients. The female sex predominated, the most significant age group was of 40-49 years, with established periodontitis manifesting, it was this type of periodontal disease that most afflicted patients.Se realizó estudio descriptivo transversal en la Clínica Estomatológica “Ramón Guevara Montano” en el período comprendido de septiembre 2015 a mayo 2016 con el objetivo de caracterizar el comportamiento epidemiológico de las periodontopatías en la población atendida. Se evaluó el estado periodontal de los individuos según sexo y se utilizó el índice periodontal de Russell. El universo estuvo conformado por 400 pacientes de la cual se seleccionó una muestra probabilística mediante un muestreo aleatorio simple (MAS) de 80 pacientes. Se analizaron las variables: grupos de edades, sexo, frecuencia y severidad de las periodontopatías e higiene bucal. Predominó el sexo femenino, el grupo etario más significativo fue el de 40-49 años, manifestándose la periodontitis establecida, fue este tipo de periodontopatías que más aquejó a los pacientes.Realizou-se estudo descritivo transversal na Clínica Odontologica “Ramón Guevara Montano” no período compreendido de setembro 2015 a maio 2016 com o objetivo de caracterizar o comportamento epidemiológico das periodontopatías na população atendida. Avaliou-se o estado periodontal dos indivíduos segundo sexo e utilizou-se o índice periodontal de Russell. O universo esteve conformado por 400 pacientes da qual se selecionou uma amostra probabilística mediante uma amostragem aleatória simples (MAS) de 80 pacientes. Analisaram-se as variáveis: grupos de idades, sexo, frequência e severidad das periodontopatías e higiene bucal. Predominou o sexo feminino, o grupo etario mais significativo foi o de 40-49 anos, manifestando-se a periodontitis estabelecida, foi este tipo de periodontopatías que mais aquejó aos pacientes

On Tubular vs. Swung surfaces

We determine necessary and sufficient conditions for a tubular surface to be swung, and viceversa. From these characterizations, we derive two symbolic algorithms. The first one decides whether a given implicit equation, of a tubular surface, admits a swung parametrization and, in the affirmative case, it outputs such a parametrization. The second one decides whether a given swung surface parametrization is a tubular surface and, in the affirmative case, it outputs the implicit equation

Factoring analytic multivariate polynomials and non-standard Cauchy–Riemann conditions

Motivated by previous work on the simplification of parametrizations of curves, in this paper we generalize the well-known notion of analytic polynomial (a bivariate polynomial P (x , y ), with complex coefficients, which arises by substituting z → x + iy on a univariate polynomial View the MathML source, i.e. p (z ) → p (x + iy ) = P (x , y )) to other finite field extensions, beyond the classical case of View the MathML source. In this general setting we obtain different properties on the factorization, gcd's and resultants of analytic polynomials, which seem to be new even in the context of Complex Analysis. Moreover, we extend the well-known Cauchy–Riemann conditions (for harmonic conjugates) to this algebraic framework, proving that the new conditions also characterize the components of generalized analytic polynomials

Supraorbital transciliary keyhole approach for removal of tuberculum sellae meningioma: 3D surgical video

Background: Tuberculum sellae meningiomas have an incidence from 5 to 10% of all intracranial meningiomas[2] and tend to be surgically difficult and challenging tumors given their proximity to important structures such as the internal carotid artery (ICA), anterior cerebral artery (ACA), and optic nerves.[3] Typically, their growth is posteriorly and superiorly oriented, thereby displacing the optic nerves and causing visual dysfunction, which is the primary indication for surgical treatment.[1] The main goals of the treatment are the preservation or restoration of visual abilities and a complete tumor resection.[1] Conventionally, surgical approaches to tuberculum meningiomas involve largely invasive extended bifrontal, interhemispheric, orbitozygomatic, pterional, and subfrontal eyebrow approaches. The supraorbital craniotomy, however, is a minimally invasive transcranial approach that offers a similar surgical corridor to conventional transcranial approaches, using a limited craniotomy and minimal brain retraction that can be used for tumoral and vascular pathologies,[4,5] offering added cosmetic outcomes.[1] We present the case of a patient undergoing a supraorbital transciliary craniotomy with a tuberculum sellae meningioma causing bitemporal hemianopsia. Case description: A 70-year-old female with chronic headaches and progressive vision loss and visual field deficit for about 1 year. On ophthalmological evaluation, she was able to fixate and follow objects with each eye, light perception was only present in the right eye, and the vision in the left eye was 0.2 decimal units. Her visual fields demonstrated severe campimetric deficits. Her extraocular movements were intact and bilateral pupils were equal, round, and reactive to light. MRI of the brain demonstrated tuberculum sellae meningioma with bilateral optic canal invasion, displacing the chiasm, and extending ≥180° around the medial ICA wall and anterior ACA wall. The patient underwent supraorbital transciliary keyhole approach for total resection of the tumor. Postoperatively, visual acuity and visual field were significantly improved. Conclusion: Performing a supraorbital transciliary keyhole craniotomy for tuberculum sellae meningiomas requires an adequate and meticulous preoperative planning to determine the optimal surgical corridor to the lesion. The use of supraorbital craniotomy is safe with good cosmetic results and potentially lower morbidity allowing for adequate exposure, resection, and release of neurovascular structures

Reparametrizing Swung Surfaces over the Reals

Let K⊆R be a computable subfield of the real numbers (for instance, Q). We present an algorithm to decide whether a given parametrization of a rational swung surface, with coefficients in K(i), can be reparametrized over a real (i.e., embedded in R) finite field extension of K. Swung surfaces include, in particular, surfaces of revolution

Comparison of ex vivo expansion culture conditions of mesenchymal stem cells for human cell therapy

Mesenchymal stem cells (MSCs) are multipotent stem cells. Based on their properties, several clinical trials have been designed to explore their potential therapeutic effect. Fetal calf serum (FCS, commonly used for in vitro expansion) is an undesirable source of xenogeneic antigens and bears the risk of transmitting contaminations. As an alternative for FCS, platelet lysate (PL) and both autologous and allogeneic human serum have been proposed. The aim of this study is to compare the culture of bone marrow (BM)- derived MSCs in the presence of different serum supplements to determine the effect on cell growth, differentiation potential, and immunologic function

Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial

Development of semi-automated devices that can reduce the hands-on time and standardize the production of clinical-grade CAR T-cells, such as CliniMACS Prodigy from Miltenyi, is key to facilitate the development of CAR T-cell therapies, especially in academic institutions. However, the feasibility of manufacturing CAR T-cell products from heavily pre-treated patients with this system has not been demonstrated yet. Here we report and characterize the production of 28 CAR T-cell products in the context of a phase I clinical trial for CD19+ B-cell malignancies (NCT03144583). The system includes CD4-CD8 cell selection, lentiviral transduction and T-cell expansion using IL-7/IL-15. Twenty-seven out of 28 CAR T-cell products manufactured met the full list of specifications and were considered valid products. Ex vivo cell expansion lasted an average of 8.5 days and had a mean transduction rate of 30.6 ± 13.44%. All products obtained presented cytotoxic activity against CD19+ cells and were proficient in the secretion of pro-inflammatory cytokines. Expansion kinetics was slower in patient's cells compared to healthy donor's cells. However, product potency was comparable. CAR T-cell subset phenotype was highly variable among patients and largely determined by the initial product. TCM and TEM were the predominant T-cell phenotypes obtained. 38.7% of CAR T-cells obtained presented a TN or TCM phenotype, in average, which are the subsets capable of establishing a long-lasting T-cell memory in patients. An in-depth analysis to identify individual factors contributing to the optimal T-cell phenotype revealed that ex vivo cell expansion leads to reduced numbers of TN, TSCM, and TEFF cells, while TCM cells increase, both due to cell expansion and CAR-expression. Overall, our results show for the first time that clinical-grade production of CAR T-cells for heavily pre-treated patients using CliniMACS Prodigy system is feasible, and that the obtained products meet the current quality standards of the field. Reduced ex vivo expansion may yield CAR T-cell products with increased persistence in vivo