38 research outputs found
Identification of a PA-Binding Peptide with Inhibitory Activity against Influenza A and B Virus Replication
- Author
- A Dias
- A Ghanem
- A Moscona
- A Moscona
- Anne-Sophie Holler
- Arnold Martin
- B Crescenzo-Chaigne
- B Perales
- BD Pilger
- Benjamin Mänz
- Charlene Ranadheera
- CR Parrish
- D Guilligay
- Daniel Mayer
- DR Perez
- DR Perez
- E De Clercq
- E Fodor
- E Jambrina
- E Obayashi
- E Torreira
- G Neumann
- Geoffrey Chase
- GG Brownlee
- GP Norton
- HW Kim
- J Munch
- JA Wells
- K Chokephaibulkit
- K Iwatsuki-Horimoto
- K Sugiyama
- Kerstin Wunderlich
- LT Vassilev
- LV Gubareva
- M Schmidtke
- M Schwemmle
- Martin Schwemmle
- Maxim Antopolsky
- ML Li
- N Sugaya
- NJ Dharan
- P Fechter
- P Yuan
- PF Wright
- PS Clark
- PW White
- R Chen
- RC Edgar
- Ro Coloma
- Ronald Frank
- S Hatakeyama
- S Kosugi
- S Pleschka
- T Berg
- T Berg
- TF Nolan Jr.
- TM Tumpey
- U Schneider
- Ulrich Kessler
- WB Baine
- Werner Tegge
- WL Davies
- WR Dostmann
- X He
- Y Ambroise
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
There is an urgent need for new drugs against influenza type A and B viruses due to incomplete protection by vaccines and the emergence of resistance to current antivirals. The influenza virus polymerase complex, consisting of the PB1, PB2 and PA subunits, represents a promising target for the development of new drugs. We have previously demonstrated the feasibility of targeting the protein-protein interaction domain between the PB1 and PA subunits of the polymerase complex of influenza A virus using a small peptide derived from the PA-binding domain of PB1. However, this influenza A virus-derived peptide did not affect influenza B virus polymerase activity. Here we report that the PA-binding domain of the polymerase subunit PB1 of influenza A and B viruses is highly conserved and that mutual amino acid exchange shows that they cannot be functionally exchanged with each other. Based on phylogenetic analysis and a novel biochemical ELISA-based screening approach, we were able to identify an influenza A-derived peptide with a single influenza B-specific amino acid substitution which efficiently binds to PA of both virus types. This dual-binding peptide blocked the viral polymerase activity and growth of both virus types. Our findings provide proof of principle that protein-protein interaction inhibitors can be generated against influenza A and B viruses. Furthermore, this dual-binding peptide, combined with our novel screening method, is a promising platform to identify new antiviral lead compounds
Polymer nanofilms with enhanced microporosity by interfacial polymerization
- Author
- AJ Brown
- Andrew G. Livingston
- AP Côté
- BD Freeman
- BS Ghanem
- CM Stafford
- D Fritsch
- DL Gin
- H Li
- H Qian
- H Sun
- HB Park
- HM El-Kaderi
- HW Kim
- I Ichinose
- J Weber
- JTA Jones
- JY Chung
- KE Hart
- Kim E. Jelfs
- L Abbott
- L Abbott
- L Dobrzańska
- LJ Abbott
- LJ Abbott
- LM Robeson
- M Carta
- M Carta
- M Pinheiro
- Maria F. Jimenez-Solomon
- Marta Munoz-Ibanez
- MD Guiver
- MF Jimenez Solomon
- MJ Frisch
- N Du
- N Du
- NB McKeown
- NB McKeown
- NB McKeown
- OM Yaghi
- P Gorgojo
- P Marchetti
- PM Budd
- PM Budd
- Q Song
- Q Song
- Q Song
- Q Song
- Qilei Song
- R Ameloot
- RR Nair
- S Karan
- S Karan
- S Karan
- S Kitagawa
- S Plimpton
- S Tsarkov
- T Rodenas
- T Tozawa
- TF Willems
- TM Murphy
- Y Peng
- YH See Toh
- YH See Toh
- YS Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 05/04/2016
- Field of study
Highly permeable and selective membranes are desirable for energy-efficient gas and liquid separations. Microporous organic polymers have attracted significant attention in this respect owing to their high porosity, permeability, and molecular selectivity. However, it remains challenging to fabricate selective polymer membranes with controlled microporosity which are stable in solvents. Here we report a new approach to designing crosslinked, rigid polymer nanofilms with enhanced microporosity by manipulating the molecular structure. Ultra-thin polyarylate nanofilms with thickness down to 20 nm were formed in-situ by interfacial polymerisation. Enhanced microporosity and higher interconnectivity of intermolecular network voids, as rationalised by molecular simulations, are achieved by utilising contorted monomers for the interfacial polymerisation. Composite membranes comprising polyarylate nanofilms with enhanced microporosity fabricated in-situ on crosslinked polyimide ultrafiltration membranes show outstanding separation performance in organic solvents, with up to two orders of magnitude higher solvent permeance than membranes fabricated with nanofilms made from noncontorted planar monomers
Diagnosis and Management of Infected Total Knee Arthroplasty§
- Author
- Bauer TW
- Bengston S
- Blom AW
- Booth RE
- Brause BD
- Buchholz HW
- Burnett RS
- Calton TF
- Cohen JC
- Costerton JW
- Cuckler JM
- Cui Q
- Deirmengian C
- Deirmengian C
- Di Cesare PE
- Durbhakula SM
- Emerson RH
- Falahee MH
- Fehring TK
- Ghanem E
- Greidanus NV
- Ha CW
- Haddad FS
- Haddad FS
- Hall-Stoodley L
- Hanssen AD
- Hanssen AD
- Hofmann AA
- Hofmann AA
- Insall JN
- Jacobs C
- Jamsen E
- Jasvinder A Singh
- Leone JM
- Levine BR
- Lombardi AV
- Lonner JH
- Love C
- Mabry TM
- Masri BA
- McDowell A
- Meek RM
- Mirra JM
- Mont MA
- Mont MA
- Morgan PM
- Nickel JC
- Niraj V Kalore
- Panousis K
- Pitto RP
- Pring DJ
- Rand JA
- Reinartz P
- Schoifet SD
- Segawa H
- Selan L
- Silva M
- Springer BD
- Stevens CM
- Stewart PS
- Stumpe KD
- Stumpe KD
- Tehranzadeh J
- Terence J Gioe
- Trampuz A
- Trampuz A
- Tsukayama DT
- Wahlig H
- Wilde AH
- Zhuang H
- Publication venue
- Bentham Open
- Publication date
- Field of study
Infection following total knee arthroplasty can be difficult to diagnose and treat. Diagnosis is multifactorial and relies on the clinical picture, radiographs, bone scans, serologic tests, synovial fluid examination, intra-operative culture and histology. Newer techniques including ultrasonication and molecular diagnostic studies are playing an expanded role. Two-stage exchange arthroplasty with antibiotic cement and 4-6 weeks of intravenous antibiotic treatment remains the most successful intervention for infection eradication. There is no consensus on the optimum type of interval antibiotic cement spacer. There is a limited role for irrigation and debridement, direct one-stage exchange, chronic antibiotic suppression and salvage procedures like arthrodesis and amputation. We examine the literature on each of the diagnostic modalities and treatment options in brief and explain their current significance
Autocrine PDGF stimulation in malignancies
- Author
- Afrakhte M
- Andrae J
- Arai H
- Armistead PM
- Bejcek BE
- Betsholtz C
- Betsholtz C
- Bigner SH
- Brennan C
- Carl-Henrik Heldin
- Clarke ID
- Cools J
- Deuel TF
- Dolloff NG
- Ehnman M
- Erlandsson A
- Ferletta M
- Fleming TP
- Fredriksson L
- Ghanem M
- Gotzmann J
- Guha A
- Hannink M
- Heldin C-H
- Heldin C-H
- Heldin C-H
- Hermanson M
- Hermanson M
- Huang SS
- Jechlinger M
- Jechlinger M
- Johansson FK
- Johnsson A
- Johnsson A
- Kawai T
- Keating MT
- Kilic T
- Kong D
- Kumabe T
- Lau CK
- Lindberg N
- Lindblom P
- Lokker NA
- Magnusson MK
- Magnusson MK
- Maxwell M
- McDermott U
- Nistér M
- Nistér M
- O'Brien KP
- Pardanani A
- Pietras K
- Puputti M
- Raines EW
- Robson MC
- Rodt SÅ
- Russell MR
- Russell MR
- Shimizu A
- Simon M-P
- Sjöblom T
- Smith JS
- Smits A
- Stürzl M
- Swartling FJ
- Taniguchi E
- Tchougounova E
- Tchougounova E
- Temin HM
- Thiery JP
- Todo T
- Toffalini F
- Uhrbom L
- Uhrbom L
- Ustach CV
- Ustach CV
- Valgeirsdóttir S
- Vassbotn FS
- Wang J
- Waterfield MD
- Westermark B
- Wolf RM
- Publication venue
- Informa Healthcare
- Publication date
- Field of study
Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are often over-expressed and contribute to the growth of both normal and malignant cells. This review focuses on tumors expressing PDGF isoforms together with their tyrosine kinase receptors, thus resulting in autocrine stimulation of growth and survival. Patients with such tumors could benefit from treatment with inhibitors of either PDGF or PDGF receptors
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elrasoul Y
- Abdallah E
- Abdel-Wahab NYE
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelkader M
- Abdelkareem A
- Abdelraheim M
- Abdelshafy M
- Abdulgawad M
- Abdullah AAN
- Abdullah NAN
- Abebe NS
- Abebe NS
- Aber A
- Abington E
- Aboarab A
- Aboraya M
- Aboraya M
- Abouelnasr A
- Abouzahra A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abudeeb H
- Abuseif M
- Acharya P
- Adams R
- Adebanjo A
- Adekoya A
- Adel A
- Adel A
- Ademuyiwa A
- Ademuyiwa AO
- Adeniran J
- Adeniyi A
- Adesanya O
- Adesina A
- Adesuyi A
- Adeyeye A
- Adham W
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agarwal A
- Agius M
- Aguilar-Jimenez J
- Aguilera M
- Aguilera O
- Ahlqvist S
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed SM
- Aigrain Y
- Ajao AE
- Akeel N
- Akhtar M
- Al Awwad S
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Faifi JJ
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-Mallah A
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-shammari A
- Alahmady O
- Alakaloko F
- Alamoudi U
- Albeladi B
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alfarsi MA
- Alghamdi B
- Alghamdi M
- Algohary O
- Alhabli I
- Alhendy M
- Ali A
- Ali A
- Ali H
- Ali SS
- Alimi Q
- Aljiffry M
- Aljohani E
- Aljohani S
- Alkammash A
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnawam E
- Alnuqaydan SA
- Alomar IN
- Alqahtani E
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Altaf A
- Altamimi A
- Althwainy A
- Altoe F
- Altwigry AM
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alwafai MG
- Aly AK
- Alyami R
- AlYoussef I
- Alzahrani M
- Alzayat T
- Amandito R
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin J
- Ammar M
- Ammar MS
- Amreia M
- Anandkumar D
- Anderson D
- Anderson R
- Anderson-Knight H
- Andersson L
- Andres Garcia-Marin J
- Ansaloni L
- Antar S
- Anthoulakis C
- Anwar AW
- Anwer W
- Anyanwu L-J
- Aql S
- Arachchi PP
- Arachchige LAJJ
- Aranzabal Durand SY
- Araujo R
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arulampalam T
- Asal M
- Asele FA
- Ashraf SF
- Ashton A
- Assouto PA
- Ata AAA
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia AM
- Aung KP
- Austraite A
- Awuku-Asabre J
- Ayad S
- Ayandipo OO
- Ayyar S
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Badr A
- Badwi NM
- Badwy A
- Baheeg M
- Bailey K
- Baillie K
- Baird A
- Bakhaidar M
- Baldacchino M
- Balila RMH
- Balkan AZA
- Balmaceda R
- Bamicha A
- Barakat SAE
- Barker T
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basson S
- Batista Lemaire S
- Batt J
- Beasley W
- Beaton C
- Behar N
- Beisa V
- Benevento A
- Benger M
- Benons N
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhattacharya S
- Bhopal KF
- Bin Mahamood A
- Birring A
- Bjorklund I
- Blencowe N
- Blower E
- Blundell R
- Boakye-Yiadom K
- Boal M
- Boddy A
- Bode C
- Boereboom C
- Boijsen M
- Bokhari S
- Bonavina L
- Bondurri A
- Bonnard A
- Borda Luque G
- Borg E
- Borin E
- Bortolasi L
- Boshnaq M
- Botes S
- Botto N
- Bouali O
- Bowe R
- Bowley D
- Bowman C
- Boyce T
- Bradulskis S
- Bratu R-M
- Braungart S
- Bray LD
- Breitenstein S
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
- Browning DRL
- Bugaev N
- Bugeja R
- Bukari M
- Burns H
- Cabala Chiong JA
- Cacurri A
- Cadogan DD
- Cahill R
- Camacho R
- Cameron B
- Camilleri-Brennan J
- Camilleri-Brennan JF
- Capleton P
- Careta MC
- Carlucci M
- Carreira J-A
- Carreiro De Freitas AV
- Castro Mollo M
- Cengiz Y
- Cengiz Y
- Ceriani C
- Chachulski W
- Chambers A
- Chan E
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Chen CY
- Chen JHC
- Chenn R
- Chew LS
- Chhabra S
- Chidambaram S
- Chiu S
- Chiu SMY
- Choi J
- Chong BFHK
- Chong CL
- Chong HY
- Chowdhury A
- Chun A
- Chun T
- Chung S
- Cirocchi R
- Clark DJ
- Clark T
- Clement KD
- Clements JM
- Clifford C
- Cloro LM
- Coasaca Huaraya R
- Coccolini F
- Cocker DM
- Collaborative G
- Colombani J-F
- Connor K
- Contreras Merida SM
- Contreras Urquizu M
- Contreras Vergara AL
- Coomber R
- Corro-Diaz Gonzalez S
- Costa-Maia J
- Court E
- Cragg J
- Cross K
- Cruz H
- Cucumazzo S
- Currow C
- D'aguzan N
- D'amours SK
- D'cruz R
- D'Souza R
- Da Silva LA
- Dabessa D
- Dablouk M
- Dablouk MO
- Dal Canto M
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daqeeq A
- Dar M
- Darweesh M
- Das A
- Das K
- Das S
- Davenport R
- Davies J
- Dawnay G
- Dawoud H
- De Bono P
- De Sousa AV
- Dean R
- Deckelbaum DL
- Decker E
- Deichsel F
- Dempster E
- Deputy M
- Dervenis C
- Despotidis V
- Desta S
- Devadasar GH
- Dharamshi HA
- Di Franco F
- Di Saverio S
- Diab A
- Diaconescu I-B
- Dias S
- Diaz-Zorrilla C
- Dickfos M
- Dickson L
- Dindyal S
- Domini E
- Donoghue D
- dos Santos DV
- Doughan S
- Doughty J
- Drake TM
- Driscoll A
- Du Plessis D
- Dubois A
- Duffy L
- Dwydar A
- Ebdewi H
- Ebrahim OS
- Eduard P
- Edwards J
- Edye M
- Eisner L
- El Ashal G
- El Deen KN
- El Gendy A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Hamouly AS
- El-Kashef H
- El-Ma'doul AS
- El-Rabaa S
- El-Shahat NS
- El-Sheemy H
- Elabdin HZ
- Elashmawy M
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbatahgy A
- Elbermawy M
- Eldamaty L
- Elebute O
- Elena G
- Elfeki H
- Elfil M
- Elfouly N
- Elfouly Y
- Elgebaly A
- Elgendy FI
- Elhendawy AOA
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkhadrawi M
- Elkholy A
- Elkolaly SS
- Elkorashy AM
- Elmelegy R
- Elnemr AE
- Elsawahly DME
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elshaer K
- Elshaer M
- Elshafay AE
- Elshanwany S
- Elsheikh S
- Elsherbiny AS
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Escobar EG
- Estupinian S
- Etchill E
- Etman M
- Eysa A
- Eyssartier E
- Faccincani R
- Fadel A
- Fahiem A
- Fahmy MAB
- Fahy C
- Fairfield C
- Fairfield C
- Fakher R
- Farah A
- Faraz A
- Farhad M
- Farinella E
- Farooq T
- Farquharson A
- Fattah AA
- Faturoti O
- Faure A
- Fautz T
- Fawzy A
- Felipe CO
- Fergusson S
- Fergusson SJ
- Fermani C
- Fernandez-Bueno F
- Fievet L
- Findlay-Cooper K
- Firdouse M
- Fitzgerald JEF
- Forno W
- Fouad A
- Fouad D
- Fowler AJ
- Fozard T
- Frade F
- Fraga GP
- Francois-Coridon H
- Freitas AV
- Frisk B
- Fujii F
- Furqan MM
- Gadhvi V
- Gaignard E
- Galloway S
- Gamaly E
- Garaycochea O
- Garcia Florez LJ
- Garcia Torres CP
- Garland A
- Gash K
- Gasteratos K
- Gemeah M
- Gemenetzis G
- George R
- Germanos S
- Gerosa A
- Ghandora N
- Ghanem E
- Ghanem S
- Gharib A
- Ghazy AA
- Gheith A
- Ghetia M
- Ghonaim MA
- Ghoneem M
- Giacci L
- Gilbert R
- Gilbert RW
- Giles J
- Gillespie M
- Gimzewska M
- Giuliani S
- Giuriato TF
- Glasbey JC
- Glover TE
- Gobin N
- Goh CC
- Gohar ME-SAM
- Gokani S
- Golding D
- Gomaa A
- Gomah M
- Gonzales Stuva JP
- Goodstein M
- Gosling S
- Gosling SG
- Gouda A
- Gould L
- Gouldthorpe C
- Gouvas N
- Graffeille V
- Graffieille V
- Grandinetti PP
- Grant A
- Grasset E
- Grassi V
- Gratton R
- Gravante G
- Green N
- Griffiths E
- Griffiths M
- Grossart C
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Gumar M
- Gunnarsson U
- Guo W
- Gustafsson U
- Gyanchandani N
- Habeeb MA
- Habeebullah A
- Hache-Marliere M
- Hafez AT
- Hafez M
- Hafiz S
- Hagar A
- Haines S
- Hakim H
- Hall N
- Hall NJ
- Hall TF
- Hallam S
- Hamad MGM
- Hamasaki J
- Hammad A
- Hammad AM
- Hampton M
- Hanafy M
- Hand C
- Hanks A
- Hanley I
- Hanrahan M
- Hantour U
- Harbord P
- Haroun A
- Harper E
- Harrison EM
- Harrison N
- Harrison P
- Harrison R
- Hasan A
- Hasheminia A
- Hashish A
- Hashish M
- Hassan A
- Hassan A
- Hassan A
- Hassan M
- Hassan S
- Hassan Z
- Hassanain M
- Havemann I
- Hawkins W
- Heath J
- Heffernan D
- Hegazy Y
- Hemeda D
- Hemingway D
- Hemmila M
- Henderson L
- Herrera Puma CM
- Herrera N
- Herrera-Matta J
- Hervieux E
- Hettiarachchi TS
- Hewage K
- Heywood EG
- Highcock S
- Hinojosa C
- Hjertberg M
- Ho CW
- Ho W
- Ho WC
- Hogea M
- Holton P
- Hoogakker E
- Horobjowsky A
- Hosein S-P
- Hosh M
- Hossaini S
- Houlden C
- Howells L
- Howie EE
- Huaman E
- Humm G
- Hussain M
- Hussein A
- Hussein S
- Husseini M
- Hutch W
- Huwait A
- Ibraheem HI
- Ibrahem AA
- Ibrahim I
- Ibrahim MH
- Ibrahim Y
- Idris SAI
- Iftikhar Z
- Ingabire JDLCA
- Iordache F-M
- Iqbal FM
- Irtan S
- Irwin G
- Isabel Villegas M
- Ismail L
- Ismail M
- Iyer D
- Jabbar A
- Jackson P
- Jacobe M
- Jaffry Z
- Jain P
- Jara Quezada JH
- Jarmin M
- Javed O
- Jawaid M
- Jenner E
- Jennings L
- Jennings V
- Jenvey C
- Jeyakumar J
- Jha M
- Jimenez J
- Johnson K
- Jokubauskas M
- Jokubonis K
- Jones C
- Jones E
- Jones TF
- Jordan H
- Jotautas V
- Jovine E
- Juciute S
- Jurdell E
- Kaafarani H
- Kabba J
- Kamil R
- Kang MK
- Karabacak U
- Karakahya M
- Karandikar S
- Karim A
- Karkeet M
- Karlo R
- Karousos D
- Karumnas P
- Kaselis N
- Kasem E
- Kazanavicius D
- Kefalidi E
- Kenibar A
- Kennedy ED
- Kennedy M
- Kennedy R
- Kerley R
- Kesinger M
- Khairy H
- Khajanchi M
- Khaled H
- Khalili M
- Khalique A
- Khan A
- Khan K
- Khan S
- Khan T
- Kharsa S
- Khatri C
- Khattab K
- Khedr AE-RH
- Khoja A
- Khouri Ferreira SA
- Khyrallh A
- Kiasat A
- Kielty P
- Kim MY-H
- Kim S-H
- Kim SB
- Kimaro M
- King R
- King S
- Kinnera SV
- Kirishnan A
- Kirupagaran A
- Kjellin A
- Koh C
- Koh H
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- Kolosov A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
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- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
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- Abdel-Kader SM
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- Asele FA
- Ashour A
- Ashour A
- Ashour K
- Ashraf SF
- Ashtari M
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- Asi F
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- Assal A
- Assouto PA
- Asturia S
- Asumah H
- Ata A
- Ata AAA
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- Atiyeh A
- Atkins ET
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- Attard M
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- Austraite A
- Aviles S
- Avoka A
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- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
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- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Badr A
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- Balkan AZA
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- Balmaceda R
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- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
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- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basilico S
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- Bassit KA
- Basso SMM
- Basson S
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- Beasley W
- Beaton C
- Bedada AG
- Bediako-Bowan A
- Behar N
- Beisa V
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- Bekhet AH
- Bekhet NM
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- Belkouchi A
- Belli A
- Bello B
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- Benevento A
- Benevento A
- Benger M
- Bennai RM
- Benons N
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- Bertuello I
- Beuran M
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- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
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- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
- Birring A
- Bisset C
- Bjorklund I
- Bjorklund I
- Blacker S
- Blackwell J
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- Blencowe N
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- Bliksoen M
- Blower E
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- Borg E
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- Bottini C
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- Breslin R
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- Burns H
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- Cabala Chiong JA
- Cacurri A
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- Camilleri-Brennan J
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- Camilo Correa J
- Campagnaro T
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- Cengiz Y
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- Chachulski W
- Chai C-A
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- Chan XW
- Chan Z
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- Chang K
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- Chapman A
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- Charles A
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- Chen CY
- Chen KY
- Chen T-L
- Chenn R
- Cheong YJ
- Chetta N
- Cheung YHE
- Chew LS
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
- Chilton G
- Chin PX
- Chin YR
- Chiu S
- Chiu S
- Chiu SMY
- Choi J
- Choi P
- Chong BFHK
- Chong CL
- Chong CL
- Chong CL
- Chong CS
- Chong H-Y
- Chong HY
- Choudhry A
- Chow CYN
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung KJ
- Chung S
- Ciccioli E
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- Ciubotaru C
- Claire R
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- Clark T
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- Clegg-Lamptey J-N
- Clement KD
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- Clerico G
- Clifford C
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- Dar M
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- Darweesh M
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- De Luca E
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- Dedey F
- Deichsel F
- Del Basso C
- del Pilar Paucar A
- Delforge X
- Dell A
- Dempster E
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- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar GH
- Dharamshi HA
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu I-B
- Dias S
- Diaz Vico T
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
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- Dione Parreno-Sacdalan M
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani RMNR
- Dorisme A
- dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake TM
- Drake TM
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- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
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- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Dwydar A
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- Ebrahim OS
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- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahmy MAB
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- Falco N
- Falzon M
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- Farag S
- Farah A
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- Faraz A
- Fares M
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- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fermani C
- Fermani CG
- Fernandes C
- Fernandez C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
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- Firwana A
- Fitsum A
- Fitzgerald JE
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- Florez Farfan ES
- Foco M
- Fok CYJ
- Fontana T
- Foo CC
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler AJ
- Fozard T
- Fozard T
- Frade F
- Fraga GP
- Francisco Roxas M
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas AV
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan MM
- Gaafar S
- Gaarder T
- Gad A
- Gad MO
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaignard E
- Gaignard E
- Gaizauskas V
- Gala T
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- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez CP
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan YY
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- Garaycochea O
- Garcia Bernardo C
- Garcia Florez LJ
- Garcia Septiem J
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- Gemenetzis G
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- Germanos S
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- Gerosa A
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- Geuoshy A
- Ghaben A
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- Gkiokas G
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- Glover TE
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- Glynn M
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- Goh W
- Gohar ME-SAM
- Gokani S
- Goldin E
- Golding D
- Gomaa A
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- Gonzales Stuva JP
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- Gray D
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- Grella MG
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- Griffiths E
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- Griffiths M
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- Grisin E
- Grizhja B
- Grobler DC
- Grosos C
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- Guevara Torres S
- Guevara R
- Guglielmo V
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- Gulcicek OB
- Gulielmi A
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- Gunawan R
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- Habeebullah A
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- Haddad N
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- Hafiz S
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- Haines M
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- Hajeh H
- Hakim H
- Halhouli O
- Halhouli O
- Halicioglu I
- Hall E
- Hall N
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- Hamarshi A
- Hamasaki Hamaguchi JL
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- Hanley I
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- Hany E
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- Harper E
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- Harvey N
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- Hasanah A
- Hasanain D
- Hascoet J
- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
- Hashish M
- Haslegrave A
- Hassaan A
- Hassaan A
- Hassan A
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- Hassan ATA
- Hassan I
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- Hassan OMM
- Hassan S
- Hassan Z
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- Hassanein AB
- Havemann I
- Hawkins W
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- Hegazy EM
- Hegazy Y
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- Helguero-Santin LM
- Hemeda D
- Hemingway D
- Hemmila M
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- Henderson L
- Henderson L
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- Henric N
- Henry F
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- Herebat A
- Herikstad R
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- Herrera Puma CM
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- Huwait A
- Iacono C
- Iannone I
- Ibraheem AAF
- Ibraheem HI
- Ibrahem AA
- Ibrahem AA
- Ibrahim A
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- Ibrahim A
- Ibrahim AM
- Ibrahim E
- Ibrahim EM
- Ibrahim I
- Ibrahim K
- Ibrahim M
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- Ibrahim Y
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- Idris SAI
- Iftekhar F
- Iftikhar Z
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- Ignatavicius P
- Ihediwa G
- Imoro O
- Ingabire JCA
- Ingabire JCA
- Ingabire JCA
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- Ioannidis O
- Iordache F-M
- Iqbal FM
- Iqbal MR
- Ireland P
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- Irwin G
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- Ishak N
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- Montrimaite M
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- Zerihun AB
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Acetaminophen attenuates lipopolysaccharide-induced cognitive impairment through antioxidant activity
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- A Benraiss
- A Rimessi
- A Semmler
- C Infante-Duarte
- C Landolfi
- C Zhang
- CA Grimes
- CI Ghanem
- CJ Locke
- CV Vorhees
- CW Wu
- D Casper
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- DJ Silva da
- DM Hockenbery
- DM Norden
- Dong-Xin Wang
- DS Maharaj
- DT Skelly
- ER Blough
- F Hua
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- G Leal
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- L Hritcu
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- M Naziroglu
- MA Lawson
- MH Kang
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- R Brandeis
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- Wei-Xing Zhao
- Xiao-Ying Zhang
- XY Zhang
- Y He
- Y Wang
- Yong-Yi Zhang
- You-Zhi Zhang
- Z Dong
- Z Guan
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- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Arulampalam T
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- Asare-Bediako K
- Asele Fa
- Ashour A
- Ashour A
- Ashour K
- Ashraf Sf
- Ashtari M
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- Asi F
- Asilah Smd
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- Ata Aaa
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- Atobatele K
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- Attard M
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- Attia Am
- Augestad Km
- Aung Kp
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad Sa
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo Oo
- Aydin Mc
- Ayyar S
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- Aziz Mra
- Aziz Na
- Azizeldine Mg
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- Azzis O
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- Badawy M
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- Baird A
- Bakhaidar M
- Baki Be
- Bakr A
- Bakry Hm
- Baky Fahmy MA
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- Baldacchino M
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- Ballouhey Q
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- Balmaceda R
- Balmaceda R
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- Bamford R
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- Bamicha A
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- Bandoh D
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- Baraka H
- Barakat Sae
- Barendegere V
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- Barmayehvar B
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- Barnacle J
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- Barrantes Ams
- Barreda Lma
- Barrientos Lam
- Barrios E
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- Barrios E
- Barry J
- Basilicò
- Basir Erm
- Bassem M
- Bassit Ka
- Basso Sm
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- Batt J
- Bautista Acm
- Bautista Acm
- Bayram S
- Beamon M
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- Bedada Ag
- Bediako-Bowan A
- Behar N
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- Beisa V
- Bekhet Ah
- Bekhet Nm
- Beleñ
- Belkouchi A
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- Benammi S
- Benevento A
- Benevento A
- Benger M
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- Benyaiche C
- Bermú
- Bernardo Cg
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- Bertuello I
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- Beuran M
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- Bezzina M
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- Bhat S
- Bhatnagar A
- Bhattacharya S
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- Bhopal Kf
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- Birring A
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- Bjö
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- Blacker S
- Blackwell J
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- Blanco-Colino R
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- Blencowe N
- Bliksø
- Blower E
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- Blundell R
- Boakye-Yiadom K
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- Boddy A
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- Bode C
- Bodur S
- Boereboom C
- Boggon A
- Boijsen M
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- Bonavia K
- Bonavina L
- Bonavina L
- Bond-Smith G
- Bondin J
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- Bondurri A
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- Borg E
- Borg E
- Borin E
- Bortolasi L
- Bortolasi L
- Boshnaq M
- Botero Jam
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- Botto N
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- Bré
- Bradulskis S
- Bradulskis S
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- Breistrand M
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- Bukari M
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- Bustangi N
- Butt Mt
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- Cardozo Ram
- Careta Mc
- Carlucci M
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- Carpio J
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- Castillo Vdp
- Castro Mr
- Catani M
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- Chai Fy
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- Chan Z
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- Chang Ky
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- Cheah Aez
- Chen Cy
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- Chen Ky
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- Chin Yr
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- Chiong Jac
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- Chun T
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- Chung S
- Ciccioli E
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- Clegg-Lampety Jn
- Clegg-Lamptey Jn
- Clement Kd
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- Corbellini C
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- Costa-Maia J
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- Court E
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- Coyoy-Gaitan O
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- D&apos
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- Da Silva LA
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- Dambrauskas Z
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- Daniyan M
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- Das K
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- Dashnyam E
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- Davenport R
- Davies J
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- Dawnay G
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- Dayie M
- De Boni D
- De Bono P
- De Bono P
- De Castro Segundo LCB
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- De La Medina AR
- de Leó
- De Leon MZP
- De Leon MZP
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- Delgado Msftl
- Dell A
- Dempster E
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- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
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- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
- Dhillon D
- Di Franco F
- Di Martino N
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- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu Ib
- Dias S
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
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- Dindyal S
- Dissanayake T
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- Domini E
- Domini E
- Donnelly P
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- Dorani Rmnr
- Dorismé
- Dos Santos DV
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- Drake Tm
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- Dueñ
- Duffy L
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- Durand Sya
- Dwydar A
- Ebdewi H
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- Eduard P
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- El Salam YA
- El Sayed GS
- El Sayed IM
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- El-Dien Ks
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- El-Gizawy E
- El-Hamouly As
- El-Kashef H
- El-Latif Nka
- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
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- El-Sawy A
- El-Sehily A
- El-Shahat Ns
- El-Sheemy H
- El-Taher E
- Elabdin Hz
- Elashmawy M
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- Elazayem Aa
- Elazoul M
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- Elbanby Es
- Elbatahgy A
- Elbe P
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- Eldafrawy M
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- Eldeen Ea
- Eldin Mab
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- Elebute O
- Elena G
- Elfarargy A
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- Elfeki H
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- Elgendy Fi
- Elgheriany M
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- Elkholy A
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- Elkolaly Ss
- Elkorashy Am
- Ellison Q
- Elmashala A
- Elmasry M
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- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
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- Elsawahly Dme
- Elsawy A
- Elsayed M
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- Elsayed Zm
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- Elsehimy M
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- Elshaar M
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- Elshaer M
- Elshaer M
- Elshafay Ae
- Elshami M
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- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
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- Espinoza Kt
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- Essam A
- Essam Aa
- Essam M
- Essoun S
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- Estee Mm
- Estupinian S
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- Etchill E
- Etienne S
- Etman M
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- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
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- Fahiem A
- Fahim M
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- Fairfield C
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- Fairfield C
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- Farah A
- Farahat Mm
- Faraz A
- Fares M
- Farfan Esf
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- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
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- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
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- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
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- Ferousis C
- Ferreira Sak
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
- Forlin L
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- Fouad D
- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
- Frade F
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- Francois-Coridon H
- Francone E
- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
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- Gü
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- Gaarder T
- Gad A
- Gad Mo
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- Gaiž
- Gaignard E
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- Galiqi G
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- Gallo G
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- Galvez Cp
- Gamal D
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- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan Yy
- Gani Ma
- Garaycochea O
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- Garcia-Marin Ja
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- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
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- Ghanem E
- Ghanem S
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- Ghannam M
- Gharib A
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- Ghazy Aa
- Gheith A
- Ghetia M
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- Giardino Fr
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- Giuriato Tf
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- Goldin E
- Golding D
- Gomaa A
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- Gudal A
- Gudal A
- Gudal A
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- Guevara R
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- Gui D
- Gulbinas A
- Gulcicek Ob
- Gulielmi A
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- Gustafsson U
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- Gyedu A
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- Haddad N
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- Hafiz S
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- Hagar A
- Haines M
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- Hakim H
- Halhouli O
- Halhouli O
- Halicioglu I
- Hall E
- Hall N
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- Haloho A
- Hamad Mgm
- Hamaguchi Jlh
- Hamarshi A
- Hamasaki J
- Hamdan A
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- Hammad A
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- Hanley I
- Hanoun S
- Hanrahan M
- Hanrahan M
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- Hantour U
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- Hany E
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- Har Pa
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- Haroun A
- Harper E
- Harrison Em
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- Hartford L
- Harvey N
- Hasan A
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- Hasanah A
- Hasanain D
- Hascoet J
- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
- Hashish M
- Haslegrave A
- Hasnan Mb
- Hassaan A
- Hassaan A
- Hassan A
- Hassan A
- Hassan A
- Hassan Ata
- Hassan I
- Hassan M
- Hassan Omm
- Hassan S
- Hassan Z
- Hassanain M
- Hassanain M
- Hassanein Ab
- Havemann I
- Hawkins W
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- Helguero-Santin Lm
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- Hemmila M
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- Herebat A
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- Hossameldin A
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- Hutch W
- Huwait A
- Iş
- Iacono C
- Iannone I
- Ibraheem Aa
- Ibraheem Hi
- Ibrahem Aa
- Ibrahem Aa
- Ibrahim A
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- Ibrahim A
- Ibrahim Am
- Ibrahim E
- Ibrahim Em
- Ibrahim I
- Ibrahim K
- Ibrahim M
- Ibrahim Mh
- Ibrahim Y
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- Idris F
- Idris Sai
- Iftekhar F
- Iftikhar Z
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- Ihediwa G
- Imoro O
- Ingabire Jca
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- Ioannidis O
- Iordache Fm
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- Ivros N
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- Kasputyte S
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- King R
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- Klappenbach R
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- Komolafe O
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- Kong C
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- Kose E
- Koskenvuo L
- Kostov E
- Kotb Ahe
- Kotecha D
- Koto Mz
- Kotobi H
- Koumpa F
- Kouraklis G
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- Kretzmann H
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- Kwizera S
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- Kyziridis D
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- La Brocca A
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- Labib P
- Ladukas A
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- Latif A
- Laufer Lav
- Laugzemys E
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- Laurie K
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- Law Jh
- Lawal A
- Lawal Ao
- Lawal T
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- Lawani I
- Lawther R
- Lazzari G
- Lazzari V
- Leal A
- Leal M
- Lecompte Jf
- Lee C
- Lee Ex
- Lee F
- Lee K
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- Lee Tsb
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- Leone N
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- Leung Kw
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- Leusink A
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- Licari L
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- Lo Conte A
- Loaloa Mr
- Lockey J
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- Loizides S
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- Longstaff L
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- Lossius Wj
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- Lytras D
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- Mabrouk M
- Macchiavello R
- Macchitella Y
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- Macdonald A
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- Macfarlane A
- Machaca M
- Maciejec L
- Madiba T
- Madkor Mh
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
- Magdy E
- Magdy H
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- Magee C
- Maghrabi A
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- Mahmoud M
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- Mapasse D
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- Marey A
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- Margaritis M
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret Jb
- Marshall Dc
- Martian Bv
- Martin A
- Mas R
- Mason C
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- Matheu A
- Mathew Sw
- Matos-Puig R
- Matta Jjh
- Mattar O
- Matter Sm
- Mauro L
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- Mentula P
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- Miranda C
- Mircea H
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- Mironescu A
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- Mirza A
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- Mistry A
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- Mitroudi M
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- Modolo Mm
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- Moe Tt
- Mogan Yp
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- Mohamed A
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- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
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- Mohammad A
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- Mohammed S
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- Molina G
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- Monaghan E
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- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
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- Montes I
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- Montrimaite M
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- Moodley Y
- Moore R
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- Moreira G
- Moreno Sc
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- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe Am
- Mshelbwala P
- Msiska N
- Msosa V
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- Muddebihal U
- Mukin Adf
- Muktar U
- Mukuzunga C
- Muller C
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- Munera A
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- Munipalle Pc
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- Mykoniatis I
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- Nada F
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- Nanthakumaran S
- Napolitano L
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- Naqvi Sa
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- Naranjo Aristizã
- Narayanan R
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- Nazir M
- Ndajiwo A
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- Ndegwa W
- Ndlovu Sr
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- Ne&apos
- Negida A
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- Nel D
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- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
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- Nesaratnam A
- Nessa A
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- Nevieraite V
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- Ng S
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- Njokanma I
- Nnajiuba H
- Nocito A
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- Nofal E
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- Nouh T
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- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana Vjp
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- Ntirenganya F
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- Nwabuoku E
- Nwinee V
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- Obute Rd
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- Odeyemi B
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- Odutola O
- Ogunsua O
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- Olaolorun A
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- Steccanella F
- Stefanopoulos A
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- Tanase A
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- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata Md
- Tatagiba Ls
- Tawfik Ba
- Tawfik G
- Tawfik G
- Taylor F
- Teasdale E
- Teasdale E
- Teasdale E
- Teasdale E
- Tedeschi U
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- Temoche E
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- Toeema Ag
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- Ukwenya Y
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- Upchurch E
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- Valioulis I
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- Yeung Mha
- Yifieyeh A
- Yildirim R
- Yip C
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- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
Anin vitro model for chick embryonic notochords
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study