Social environmental impacts on survey cooperation

Social environmental influences on survey cooperation are explored using data from six national household surveys in the United States matched to 1990 decennial census data. Consistent with the past literature on prosocial behavior, cooperation rates in these six surveys are found to be lower in urban, densely populated, high crime rate areas. Measures of social cohesion show no evidence of influencing cooperation. The influence of the environmental variables is then observed after introducing statistical controls for household structure, race, age of household members, presence of children, and socioeconomic attributes of households. Over half of the measured influence of the environmental variables is explained by these household-level attributes. These findings have practical import for survey administrators and are informative for the construction of a theory of survey participation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43559/1/11135_2004_Article_BF00153986.pd

The structure of PGC Morale Scale in American and Japanese aged: A further note

This study involves a further replication of cross-cultural comparison of the structure of the Philadelphia Geriatric Center Morale Scale (PGCMS). Using Japanese and American data sets, the present research replicates and extends the findings reported by Liang et al. (1987). In particular, the earlier findings that four PGCMS items behave differently in two cultures are replicated. The present study yields two additional observations. First, the invariance in the PGCMS can now be extended beyond the urban elderly residents studied by Liang et al. (1987) to the entire aged population in the U.S. and Japan. Second, this comparability is robust despite the elimination of correlated measurement errors from the earlier specifications and when several exogenous variables are controlled. Further, the impact of selected demographic variables on the PGCMS was evaluated. In addition, qualitative data from in-depth interviews provide further insights concerning the cultural differences in the expression of well-being.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42991/1/10823_2004_Article_BF00116576.pd

Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contribute substantially to unexplained genetic variance. To test this, we analyzed exome-array data from up to 33,231 non-diabetic individuals of European ancestry. We found exome-wide significant (P<5×10-7) evidence for two loci not previously highlighted by common variant GWAS: GLP1R (p.Ala316Thr, minor allele frequency (MAF)=1.5%) influencing FG levels, and URB2 (p.Glu594Val, MAF = 0.1%) influencing FI levels. Coding variant associations can highlight potential effector genes at (non-coding) GWAS signals. At the G6PC2/ABCB11 locus, we identified multiple coding variants in G6PC2 (p.Val219Leu, p.His177Tyr, and p.Tyr207Ser) influencing FG levels, conditionally independent of each other and the non-coding GWAS signal. In vitro assays demonstrate that these associated coding alleles result in reduced protein abundance via proteasomal degradation, establishing G6PC2 as an effector gene at this locus. Reconciliation of single-variant associations and functional effects was only possible when haplotype phase was considered. In contrast to earlier reports suggesting that, paradoxically, glucose-raising alleles at this locus are protective against type 2 diabetes (T2D), the p.Val219Leu G6PC2 variant displayed a modest but directionally consistent association with T2D risk. Coding variant associations for glycemic traits in GWAS signals highlight PCSK1, RREB1, and ZHX3 as likely effector transcripts. These coding variant association signals do not have a major impact on the trait variance explained, but they do provide valuable biological insights

Meta-analysis of type 2 Diabetes in African Americans Consortium

Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 × 10(-94)<P<5 × 10(-8), odds ratio (OR)  = 1.09 to 1.36). Fine-mapping revealed that 88 of 158 previously identified T2D or glucose homeostasis loci demonstrated nominal to highly significant association (2.2 × 10(-23) < locus-wide P<0.05). These novel and previously identified loci yielded a sibling relative risk of 1.19, explaining 17.5% of the phenotypic variance of T2D on the liability scale in African Americans. Overall, this study identified two novel susceptibility loci for T2D in African Americans. A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies.Peer reviewe

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits : A Multi-Ethnic Meta-Analysis of 45,891 Individuals

J. Kaprio, S. Ripatti ja M.-L. Lokki työryhmien jäseniä.Peer reviewe

Use of noise to augment training data: A neural network method of mineral–potential mapping in regions of limited known deposit examples

One of the main factors that affects the performance of MLP neural networks trained using the backpropagation algorithm in mineral-potential mapping isthe paucity of deposit relative to barren training patterns. To overcome this problem, random noise is added to the original training patterns in order to create additional synthetic deposit training data. Experiments on the effect of the number of deposits available for training in the Kalgoorlie Terrane orogenic gold province show that both the classification performance of a trained network and the quality of the resultant prospectivity map increasesignificantly with increased numbers of deposit patterns. Experiments are conducted to determine the optimum amount of noise using both uniform and normally distributed random noise. Through the addition of noise to the original deposit training data, the number of deposit training patterns is increased from approximately 50 to 1000. The percentage of correct classifications significantly improves for the independent test set as well as for deposit patterns in the test set. For example, using ±40% uniform random noise, the test-set classification performance increases from 67.9% and 68.0% to 72.8% and 77.1% (for test-set overall and test-set deposit patterns, respectively). Indices for the quality of the resultant prospectivity map, (i.e. D/A, D × (D/A), where D is the percentage of deposits and A is the percentage of the total area for the highest prospectivity map-class, and area under an ROC curve) also increase from 8.2, 105, 0.79 to 17.9, 226, 0.87, respectively. Increasing the size of the training-stop data set results in a further increase in classification performance to 73.5%, 77.4%, 14.7, 296, 0.87 for test-set overall and test-set deposit patterns, D/A, D × (D/A), and area under the ROC curve, respectively

Artificial neural networks: A new method for mineral prospectivity mapping

A multilayer feed‐forward neural network, trained with a gradient descent, back‐propagation algorithm, is used to estimate the favourability for gold deposits using a raster GIS database for the Tenterfield 1:100 000 sheet area, New South Wales. The database consists of solid geology, regional faults, airborne magnetic and gamma‐ray survey data (U, Th, K and total count channels), and 63 deposit and occurrence locations. Input to the neural network consists of feature vectors formed by combining the values from co‐registered grid cells in each GIS thematic layer. The network was trained using binary target values to indicate the presence or absence of deposits. Although the neural network was trained as a binary classifier, output values for the trained network are in the range [0.1, 0.9] and are interpreted to indicate the degree of similarity of each input vector to a composite of all the deposit vectors used in training. These values are rescaled to produce a multiclass prospectivity map. To validate and assess the effectiveness of the neural‐network method, mineral‐prospectivity maps are also prepared using the empirical weights of evidence and the conceptual fuzzy‐logic methods. The neural‐network method produces a geologically plausible mineral‐prospectivity map similar, but superior, to the fuzzy logic and weights of evidence maps. The results of this study indicate that the use of neural networks for the integration of large multisource datasets used in regional mineral exploration, and for prediction of mineral prospectivity, offers several advantages over existing methods. These include the ability of neural networks to: (i) respond to critical combinations of parameters rather than increase the estimated prospectivity in response to each individual favourable parameter; (ii) combine datasets without the loss of information inherent in existing methods; and (iii) produce results that are relatively unaffected by redundant data, spurious data and data containing multiple populations. Statistical measures of map quality indicate that the neural‐network method performs as well as, or better than, existing methods while using approximately one‐third less data than the weights of evidence method

Regression-based response probing for assessing the validity of survey questions

We describe a procedure for assessing the validity of survey questions. Response probes are administered which ask respondents to say in their own words what came to mind when answering the question. The verbatim responses are coded to a frame which captures the conceptual content of the responses and are then included as predictors in a regression model, where the question that was used to elicit the verbatim responses is specified as the outcome. Controls are included so that the estimated coefficients of the model can be used to interpret whether and to what extent the different cognitive frames identified in the verbatim data align with responses to the question. The technique can be extended to include split-ballot designs, where variants of the target question are randomised across groups. We illustrate the procedure using two example questions: interpersonal trust and fear of crime