Body dissatisfaction in university women: new psychometric evidence from the 14-item Body Shape Questionnaire (BSQ-14)

In recent years, young university students have experienced a greater concern for the body aspect that is related to having a slim figure. In this sense, it is important to have tools to measure the dissatisfaction they may have with their body appearance. The objective of the study was to evaluate the psychometric properties of the Body Shape Questionnaire (BSQ-14). Specifically, to evaluate the internal structure of the BSQ-14, the internal consistency of the model, the evidence of discriminant validity based on the correlations of the average score of the BSQ-14 with a measure of mindfulness and the invariance of the BSQ-14 model, considering the variable of performance of physical activities. For hundred two young university students from Metropolitan Lima participated, with an average age of 20.05 years (SD = 18.18). A test battery including the BSQ-14 and Mindful Attention Awareness Scale (MASS-5) was administered. The results indicate that the one-dimensional structure of the BSQ-14 presented a good fit (x2 = 571,420; CFI = 0.962; SRMR = 0.051) and adequate reliability by the internal consistency method (ω = 0.962). Likewise, the BSQ-14 showed negative correlations with Mindfulness and body satisfaction. The BSQ-14 was shown to be invariant among university women who do or do not exercise. It is concluded that the study provides results that support the use of the BSQ-14 to measure body dissatisfaction with evidence of validity and reliability in a sample of young university students. of Metropolitan Lima

Ongrowing of Octopus vulgaris Cuvier, 1797 in floating cages fed with bogue Boops boops (L., 1758) from fish farm discards

The first two experiences of ongrowing the octopus Octopus vulgaris Cuvier, 1797, fed solely on fish of low commercial value, such as discarded bogue Boops boops (L., 1758) accidentally reared in seabream Sparus aurata L., 1758 culture cages, were carried out in the Canary Islands. The present study was made in a floating cage of galvanized mesh, divided vertically into two semi-cages. In a first experiment, individuals of two different initial average sizes were compared: 1.5 kg and 2.3 kg, both stocked at a density of 11 kg/m³. They were reared for 57 days, obtaining octopus of 2.643 kg from the 1.5 kg group, and of 3.812 kg from the 2.3 kg group. The survival rate was 91 % for the initially smaller group, and 82 % for the larger group. Density of individuals was increased in a second experience, in which the initial sizes were smaller, 1.0 kg and 0.8 kg, in each semi-cage. This second experience was carried out for 81 days, and the final weight of the octopus was 3.111 kg for the 1 kg group and 3.052 kg for the 0.8 kg group, with a survival rate of 44 % for the former and 50 % for the latter. The use of bogue as a single feed was found to be enough to sustain good growth in octopus cage rearing. Best results in terms of specific growth rate and average daily growth were obtained in the lowest size group, 0.8 kg of initial weight, with a SGR of 1.65 %, whereas the smallest rates of growth (SGR of 0.86 %) were in octopus of 2.337 kg of initial weight.Las dos primeras experiencias de engorde de pulpo Octopus vulgaris Cuvier, 1797 utilizando como único alimento peces de bajo valor comercial, como boga Boops boops (L., 1758), introducidos accidentalmente en las jaulas de engorde de dorada Sparus aurata L., 1758, se llevaron a cabo en las islas Canarias. El estudio se realizó en una jaula flotante de malla galvanizada, dividida verticalmente en dos mitades. En una primera experiencia se engordaron ejemplares con tamaños medios iniciales diferentes, 1,5 kg y 2,3 kg, en ambos casos a la densidad de 11 kg/m³. El engorde se realizó durante 57 días, obteniéndose al final individuos de 2,64 kg y 3,81 kg, respectivamente, con supervivencias del 91 % y el 82 %, también respectivamente. La densidad inicial fue incrementada en una segunda experiencia, donde se partió de tamaños inferiores a 1,0 kg y 0,8 kg en las semijaulas y que se prolongó durante 81 días; en ella, los pulpos alcanzaron un peso final de 3,11 kg y 3,05 kg, con una supervivencia del 44 y 50 %, respectivamente. La utilización de boga de descarte de acuicultura como único alimento en jaulas de engorde de pulpo parece proporcionar un buen crecimiento a este molusco. Los mejores resultados en términos de crecimiento específico (SGR) y crecimiento diario (IPD) fueron obtenidos en los ejemplares de menor tamaño inicial (0,8 kg), con un SGR de 1,65 %, mientras que las menores tasas de SGR (0,86 %) se registraron en ejemplares mayores de 2,34 kg de peso inicial.Instituto Español de Oceanografí

iCLIP Predicts the Dual Splicing Effects of TIA-RNA Interactions

Transcriptome-wide analysis of protein-RNA interactions predicts the dual splicing effects of TIA proteins, showing that their local enhancing function is associated with diverse distal splicing silencing effects

Multi-dimensionality and variability in folk classification of stingless bees (Apidae: Meliponini)

Background: Not long ago Eugene Hunn suggested using a combination of cognitive, linguistic, ecological and evolutionary theories in order to account for the dynamic character of ethnoecology in the study of folk classification systems. In this way he intended to question certain homogeneity in folk classifications models and deepen in the analysis and interpretation of variability in folk classifications. This paper studies how a rural culturally mixed population of the Atlantic Forest of Misiones (Argentina) classified honey-producing stingless bees according to the linguistic, cognitive and ecological dimensions of folk classification. We also analyze the socio-ecological meaning of binomialization in naming and the meaning of general local variability in the appointment of stingless bees. Methods: We used three different approaches: the classical approach developed by Brent Berlin which relies heavily on linguistic criteria, the approach developed by Eleonor Rosch which relies on psychological (cognitive) principles of categorization and finally we have captured the ecological dimension of folk classification in local narratives. For the second approximation, we developed ways of measuring the degree of prototypicality based on a total of 107 comparisons of the type "X is similar to Y" identified in personal narratives. Results: Various logical and grouping strategies coexist and were identified as: graded of lateral linkage, hierarchical and functional. Similarity judgments among folk taxa resulted in an implicit logic of classification graded according to taxa's prototypicality. While there is a high agreement on naming stingless bees with monomial names, a considerable number of underrepresented binomial names and lack of names were observed. Two possible explanations about reported local naming variability are presented. Conclusions: We support the multidimensionality of folk classification systems. This confirms the specificity of local classification systems but also reflects the use of grouping strategies and mechanisms commonly observed in other cultural groups, such as the use of similarity judgments between more or less prototypical organisms. Also we support the idea that alternative naming results from a process of fragmentation of knowledge or incomplete transmission of knowledge. These processes lean on the facts that culturally based knowledge, on the one hand, and biologic knowledge of nature on the other, can be acquired through different learning pathways.Fil: Zamudio, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Hilgert, Norma Ines. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Centro Cientifico Tecnologico Nordeste. Instituto de Biologia Subtropical. Instituto de Biologia Subtropical - Nodo Puerto Iguazu; Argentin

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement

# The Author(s) 2008. This article is published with open access at Springerlink.com Rationale One of the major complaints most people face during aging is an impairment in cognitive functioning. This has a negative impact on the quality of daily life and is even more prominent in patients suffering from neurodegenerative and psychiatric disorders including Alzheimer’s disease, schizophrenia, and depression. So far, the majority of cognition enhancers are generally targeting one particular neurotransmitter system. However, recently phosphodiesterases (PDEs) have gained increased attention as a potential new target for cognition enhancement. Inhibition of PDEs increases the intracellular availability of the second messengers cGMP and/or cAMP. Objective The aim of this review was to provide an overvie

Association of a single nucleotide polymorphism combination pattern of the Klotho gene with non-cardiovascular death in patients with chronic kidney disease

Chronic kidney disease (CKD) is associated with an elevated risk of all-cause mortality, with cardiovascular death being extensively investigated. However, non-cardiovascular mortality represents the biggest percentage, showing an evident increase in recent years. Klotho is a gene highly expressed in the kidney, with a clear influence on lifespan. Low levels of Klotho have been linked to CKD progression and adverse outcomes. Single nucleotide polymorphisms (SNPs) of the Klotho gene have been associated with several diseases, but studies investigating the association of Klotho SNPs with noncardiovascular death in CKD populations are lacking. The main aim of this study was to assess whether 11 Klotho SNPs were associated with non-cardiovascular death in a subpopulation of the National Observatory of Atherosclerosis in Nephrology (NEFRONA) study (n ¼ 2185 CKD patients). After 48 months of follow-up, 62 cardiovascular deaths and 108 non-cardiovascular deaths were recorded. We identified a high non-cardiovascular death risk combination of SNPs corresponding to individuals carrying the most frequent allele (G) at rs562020, the rare allele (C) at rs2283368 and homozygotes for the rare allele (G) at rs2320762 (rs562020 GG/AG þ rs2283368 CC/CT þ rs2320762 GG). Among the patients with the three SNPs genotyped (n ¼ 1016), 75 (7.4%) showed this combination. Furthermore, 95 (9.3%) patients showed a low-risk combination carrying all the opposite genotypes (rs562020 AA þ rs2283368 TT þ rs2320762 GT/TT). All the other combinations [n ¼ 846 (83.3%)] were considered as normal risk. Using competing risk regression analysis, we confirmed that the proposed combinations are independently associated with a higher fhazard ratio [HR] 3.28 [confidence interval (CI) 1.51-7.12]g and lower [HR 6 × 10- (95% CI 3.3 × 10--1.1 × 10-)] risk of suffering a non-cardiovascular death in the CKD population of the NEFRONA cohort compared with patients with the normal-risk combination. Determination of three SNPs of the Klotho gene could help in the prediction of non-cardiovascular death in CKD

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation.

OBJECTIVES: To provide an accurate, web-based tool for stratifying patients with atrial fibrillation to facilitate decisions on the potential benefits/risks of anticoagulation, based on mortality, stroke and bleeding risks. DESIGN: The new tool was developed, using stepwise regression, for all and then applied to lower risk patients. C-statistics were compared with CHA2DS2-VASc using 30-fold cross-validation to control for overfitting. External validation was undertaken in an independent dataset, Outcome Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). PARTICIPANTS: Data from 39 898 patients enrolled in the prospective GARFIELD-AF registry provided the basis for deriving and validating an integrated risk tool to predict stroke risk, mortality and bleeding risk. RESULTS: The discriminatory value of the GARFIELD-AF risk model was superior to CHA2DS2-VASc for patients with or without anticoagulation. C-statistics (95% CI) for all-cause mortality, ischaemic stroke/systemic embolism and haemorrhagic stroke/major bleeding (treated patients) were: 0.77 (0.76 to 0.78), 0.69 (0.67 to 0.71) and 0.66 (0.62 to 0.69), respectively, for the GARFIELD-AF risk models, and 0.66 (0.64-0.67), 0.64 (0.61-0.66) and 0.64 (0.61-0.68), respectively, for CHA2DS2-VASc (or HAS-BLED for bleeding). In very low to low risk patients (CHA2DS2-VASc 0 or 1 (men) and 1 or 2 (women)), the CHA2DS2-VASc and HAS-BLED (for bleeding) scores offered weak discriminatory value for mortality, stroke/systemic embolism and major bleeding. C-statistics for the GARFIELD-AF risk tool were 0.69 (0.64 to 0.75), 0.65 (0.56 to 0.73) and 0.60 (0.47 to 0.73) for each end point, respectively, versus 0.50 (0.45 to 0.55), 0.59 (0.50 to 0.67) and 0.55 (0.53 to 0.56) for CHA2DS2-VASc (or HAS-BLED for bleeding). Upon validation in the ORBIT-AF population, C-statistics showed that the GARFIELD-AF risk tool was effective for predicting 1-year all-cause mortality using the full and simplified model for all-cause mortality: C-statistics 0.75 (0.73 to 0.77) and 0.75 (0.73 to 0.77), respectively, and for predicting for any stroke or systemic embolism over 1 year, C-statistics 0.68 (0.62 to 0.74). CONCLUSIONS: Performance of the GARFIELD-AF risk tool was superior to CHA2DS2-VASc in predicting stroke and mortality and superior to HAS-BLED for bleeding, overall and in lower risk patients. The GARFIELD-AF tool has the potential for incorporation in routine electronic systems, and for the first time, permits simultaneous evaluation of ischaemic stroke, mortality and bleeding risks. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier for GARFIELD-AF (NCT01090362) and for ORBIT-AF (NCT01165710)