Information Security Management Curriculum Design: A Joint Industry and Academic Effort

In this paper the authors present a curriculum design for Information Security Management, which was synthesized using the inputs from both the industry and academia. The top down curriculum design process carried out in Korea starts with the analysis of the job of an Information Security Manager (ISM), identifies the knowledge elements needed for successfully fulfilling the main responsibilities of the job and finally synthesizes them into seven courses suitable for flexible implementation. Additionally, a lateral occupational analysis of ISM reveals the value-skills (soft-skills) that should be considered in the actual implementation of the curriculum

Integrating Soft Skills Assessment through University, College, and Programmatic Efforts at an AACSB Accredited Institution

The growing demand for verification that students are, indeed, learning what they need to learn is driving institutions and programs to develop tools for assessing the level of knowledge and skills of their graduating students. One such tool, the Information Systems Analyst (ISA) certification, is a recently developed instrument for measuring eight skill areas based upon the IS2002 Model Curriculum. While the exam strongly evaluates the technical skill set of Information Systems (IS) majors, in this paper, the authors suggest additional means of addressing and measuring requisite soft skills for Information Technology (IT), accounting, and other business students. In this article, the authors address the concerns voiced by the employers of college graduates regarding the apparent insufficient competency in soft skills and suggest an assurance of learning model for incorporating these skills into curricula. In addition, the authors share activities at the university, college, and program level to integrate the assessment of soft skills at educational institutions

Accommodating Information Security in Our Curricula

When the power of computing and communications technology was unleashed for the benefit of the society, only the good intentions were at heart and not enough attention was paid to the possible illegal and unethical activities in cyberspace. The intrinsic nature of Information Technology (IT) is such that, in today\u27s world, even what is thought to be a simple criminal behavior could cause colossal damage to the society. The need to pay attention to the security issues in IT has been recognized, as evidenced by a major emphasis on security in industry and education. While it may take considerable research and development effort to bring about infrastructures and applications that are fundamentally security-centric, there is need to cope with the prevailing information security problems. Educational institutions, for their part, have responded by initiating security related research and curricula

Rare and low-frequency coding variants alter human adult height

Height is a highly heritable, classic polygenic trait with ~700 common associated variants identified so far through genome - wide association studies . Here , we report 83 height - associated coding variants with lower minor allele frequenc ies ( range of 0.1 - 4.8% ) and effects of up to 2 16 cm /allele ( e.g. in IHH , STC2 , AR and CRISPLD2 ) , >10 times the average effect of common variants . In functional follow - up studies, rare height - increasing alleles of STC2 (+1 - 2 cm/allele) compromise d proteolytic inhibition of PAPP - A and increased cleavage of IGFBP - 4 in vitro , resulting in higher bioavailability of insulin - like growth factors . The se 83 height - associated variants overlap genes mutated in monogenic growth disorders and highlight new biological candidates ( e.g. ADAMTS3, IL11RA, NOX4 ) and pathways ( e.g . proteoglycan/ glycosaminoglycan synthesis ) involved in growth . Our results demonstrate that sufficiently large sample sizes can uncover rare and low - frequency variants of moderate to large effect associated with polygenic human phenotypes , and that these variants implicate relevant genes and pathways

The Polygenic and Monogenic Basis of Blood Traits and Diseases

Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant global health burden. Here we integrate data from UK Biobank and a large-scale international collaborative effort, including data for 563,085 European ancestry participants, and discover 5,106 new genetic variants independently associated with 29 blood cell phenotypes covering a range of variation impacting hematopoiesis. We holistically characterize the genetic architecture of hematopoiesis, assess the relevance of the omnigenic model to blood cell phenotypes, delineate relevant hematopoietic cell states influenced by regulatory genetic variants and gene networks, identify novel splice-altering variants mediating the associations, and assess the polygenic prediction potential for blood traits and clinical disorders at the interface of complex and Mendelian genetics. These results show the power of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide allelic spectrum of human variation.</p

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant associations at p &lt; 5 × 10−9, including 71 novel associations not found in EUR populations. We also identified 28 additional novel variants in ancestry-specific, non-EUR meta-analyses, including an IL7 missense variant in South Asians associated with lymphocyte count in vivo and IL-7 secretion levels in vitro. Fine-mapping prioritized variants annotated as functional and generated 95% credible sets that were 30% smaller when using the trans-ethnic as opposed to the EUR-only results. We explored the clinical significance and predictive value of trans-ethnic variants in multiple populations and compared genetic architecture and the effect of natural selection on these blood phenotypes between populations. Altogether, our results for hematological traits highlight the value of a more global representation of populations in genetic studies. Delineation of the genetic architecture of hematological traits in a multi-ethnic dataset allows identification of rare variants with strong effects specific to non-European populations and improved fine mapping of GWAS variants using the trans-ethnic approach