Surgical Management of Hidradenitis Suppurativa

Background: Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory disease of skin, characterized by recurrent draining sinuses and abscesses, predominantly in skin folds carrying terminal hairs and apocrine glands

Self Cannibalism of Fingers in an Alzheimer Patient

In society, the instinct to eat one's own tissues is rare. However it is generally limited to reported cases concerning soft tissue. A patient who was admitted to our department had eaten the distal and middle phalangeal soft tissue along with bone tissue

Repair of a Giant Congenital Melanocytic Nevus with an Abdominoplasty Flap: Case Report

WOS: 000290353100035Congenital melonocytic nevi contains nevus cell of cells of nevus and present at birth or within the first year of life. The nevi with a size of 20 cm are called "giant" nevi. These giant congenital nevi are usually excised due to malignant potential and cosmetic concerns, however resulting wide defects are not easy to repair. Thirty seven year-old-women with a giant congenital nevus of 26 x 29 cm on her back, was admitted to our clinic. The nevus was excised and the defective area was closed with abdominoplasty flaps raised from the abdomen, sagitally splitted and rotated to the back of the patient. Congenital melanocytic nevi rarely exceed giant sizes of more than 20 cm. Total excision is necessary due to malignant potential and cosmetic concerns. Wide defective area may be repaired with various surgical techniques, however, reconstruction with abdominoplasty flaps should also be considered in the patients with an excessive abdominal tissue

A Practical Dressing Method to be Used in Experimental Studies on the Extremities of Rabbits: Scientific Letter

Rabbits' higher sensitivity to infections, stronger muscles and vulnerability to emotional stress require careful and fastidious laboratory practices. We used Ilizarov distractors that were prepared to adjust the tibias of the rabbits. Then the leg was wrapped over the Ilizarov distractor by sterilized sponges. After this phase, problems began to occur as the rabbits began to remove the dressings rapidly during their natural movements or by gnawing them. To solve these problems, a cotton sack was sewed at the size of the lower extremity of the rabbit This method facilitated the daily distraction procedure considerably and following its use, no infections occurred among the rabbits

Surgical Management of Hidradenitis Suppurativa

Background: Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory disease of skin, characterized by recurrent draining sinuses and abscesses, predominantly in skin folds carrying terminal hairs and apocrine glands. Method: This study reviewed 54 sites in 27 patients with moderate to extensive chronic inflammatory skin lesions treated surgically in our hospital from 2004 through 2009, with a follow-up of at least 6 months. Result: A total number of 54 operative procedures were performed during the study period with 42% (23 sites) involving the axilla, 20% (11 sites) involving the gluteal area, %24 (13 sites) involving the perineal area and 12% (7 sites) involving the inguinal region. Conclusion: Conservative treatment methods have little or no effects especially on gluteal, perineal/perianal, axillary hidradenitis suppurativa. The morbidity associated with the established form of this disease is significant, and the only successful treatment is wide surgical excision.</p

Autologous rabbit adipose tissue-derived mesenchymal stromal cells for the treatment of bone injuries with distraction osteogenesis

Background aims. Adipose tissue-derived mesenchymal stromal cells (MSCs) have a higher capacity for proliferation and differentiation compared with other cell lineages. Although distraction osteogenesis is the most important therapy for treating bone defects, this treatment is restricted in many situations. The aim of this study was to examine the therapeutic potential of adipose tissue-derived MSCs and osteoblasts differentiated from adipose tissue-derived MSCs in the treatment of bone defects. Methods. Bone defects were produced in the tibias of New Zealand rabbits that had previously undergone adipose tissue extraction. Tibial osteotomy was performed, and a distractor was placed on the right leg of the rabbits. The rabbits were placed in control (group I), stem cell (group II) and osteoblast-differentiated stem cell (group III) treatment groups. The rabbits were sacrificed, and the defect area was evaluated by radiologic, biomechanical and histopathologic tests to examine the therapeutic effects of adipose tissue-derived MSCs. Results. Radiologic analyses revealed that callus density and the ossification rate increased in group III compared with group I and group II. In biomechanical tests, the highest ossification rate was observed in group III. Histopathologic studies showed that the quality of newly formed bone and the number of cells active in bone formation were significantly higher in group III rabbits compared with group I and group II rabbits. Conclusions. These data reveal that osteoblasts differentiated from adipose tissue-derived MSCs shorten the consolidation period of distraction osteogenesis. Stem cells could be used as an effective treatment for bone defects

Autologous rabbit adipose tissue-derived mesenchymal stromal cells for the treatment of bone injuries with distraction osteogenesis

Background aims. Adipose tissue-derived mesenchymal stromal cells (MSCs) have a higher capacity for proliferation and differentiation compared with other cell lineages. Although distraction osteogenesis is the most important therapy for treating bone defects, this treatment is restricted in many situations. The aim of this study was to examine the therapeutic potential of adipose tissue-derived MSCs and osteoblasts differentiated from adipose tissue-derived MSCs in the treatment of bone defects. Methods. Bone defects were produced in the tibias of New Zealand rabbits that had previously undergone adipose tissue extraction. Tibial osteotomy was performed, and a distractor was placed on the right leg of the rabbits. The rabbits were placed in control (group I), stem cell (group II) and osteoblast-differentiated stem cell (group III) treatment groups. The rabbits were sacrificed, and the defect area was evaluated by radiologic, biomechanical and histopathologic tests to examine the therapeutic effects of adipose tissue-derived MSCs. Results. Radiologic analyses revealed that callus density and the ossification rate increased in group III compared with group I and group II. In biomechanical tests, the highest ossification rate was observed in group III. Histopathologic studies showed that the quality of newly formed bone and the number of cells active in bone formation were significantly higher in group III rabbits compared with group I and group II rabbits. Conclusions. These data reveal that osteoblasts differentiated from adipose tissue-derived MSCs shorten the consolidation period of distraction osteogenesis. Stem cells could be used as an effective treatment for bone defects