Community Regeneration and Complexity

Introduction Over a period of 5 years, a remarkable process of change took place on the Beacon and Old Hill estate in Falmouth, Cornwall. Overlooking the gleaming boats in the multi-million pound marina below, by 1995 the estates had come, , to be known to the other communities in Falmouth as ‘Beirut’. One of the most deprived areas in Britain, the estate was blighted by violent crime, drug dealing and intimidation. The process initiated within the community that we describe stands as one of the most extraordinary examples of neighbourhood regeneration in the whole of the UK. Perhaps most strikingly, it has led to a series of notable health outcomes. In this chapter we describe the regeneration of the Beacon and Old Hill estates and advance our initial hypotheses explaining how and why this process of regeneration occurred

A revised biosynthetic pathway for the cofactor F-420 in prokaryotes

Cofactor F420 plays critical roles in primary and secondary metabolism in a range of bacteria and archaea as a low-potential hydride transfer agent. It mediates a variety of important redox transformations involved in bacterial persistence, antibiotic biosynthesis, pro-drug activation and methanogenesis. However, the biosynthetic pathway for F420 has not been fully elucidated: neither the enzyme that generates the putative intermediate 2-phospho-L-lactate, nor the function of the FMN-binding C-terminal domain of the γ-glutamyl ligase (FbiB) in bacteria are known. Here we present the structure of the guanylyltransferase FbiD and show that, along with its archaeal homolog CofC, it accepts phosphoenolpyruvate, rather than 2-phospho-L-lactate, as the substrate, leading to the formation of the previously uncharacterized intermediate dehydro-F420-0. The C-terminal domain of FbiB then utilizes FMNH2 to reduce dehydro-F420-0, which produces mature F420 species when combined with the γ-glutamyl ligase activity of the N-terminal domain. These new insights have allowed the heterologous production of F420 from a recombinant F420 biosynthetic pathway in Escherichia coli

Why health visiting? Examining the potential public health benefits from health visiting practice within a universal service: A narrative review of the literature

INTRODUCTION: There is increasing international interest in universal, health promoting services for pregnancy and the first three years of life and the concept of proportionate universalism. Drawing on a narrative review of literature, this paper explores mechanisms by which such services might contribute to health improvement and reducing health inequalities. OBJECTIVES: Through a narrative review of empirical literature, to identify: DESIGN: The paper draws upon a scoping study and narrative review. REVIEW METHODS: We used three complementary approaches to search the widely dispersed literature: Our key inclusion criterion was information about health visiting practice. We included empirical papers from United Kingdom (UK) from 2004 to February 2012 and older seminal papers identified in search (3), identifying a total of 348 papers for inclusion. A thematic content analysis compared the older (up to 2003) with more recent research (2004 onwards). RESULTS: The analysis revealed health visiting practice as potentially characterized by a particular 'orientation to practice.' This embodied the values, skills and attitudes needed to deliver universal health visiting services through salutogenesis (health creation), person-centredness (human valuing) and viewing the person in situation (human ecology). Research about health visiting actions focuses on home visiting, needs assessment and parent-health visitor relationships. The detailed description of health visitors' skills, attitudes, values, and their application in practice, provides an explanation of how universal provision can potentially help to promote health and shift the social gradient of health inequalities. CONCLUSIONS: Identification of needs across an undifferentiated, universal caseload, combined with an outreach style that enhances uptake of needed services and appropriate health or parenting information, creates opportunities for parents who may otherwise have remained unaware of, or unwilling to engage with such provision. There is a lack of evaluative research about health visiting practice, service organization or universal health visiting as potential mechanisms for promoting health and reducing health inequalities. This paper offers a potential foundation for such research in future

Memorials of Twickenham: parochial and topographical.

"Appendix B. Table of the elections ... to Christ's hospital, made by the vestry of the parish of Twickenham": p. 407-412.Mode of access: Internet

A revised biosynthetic pathway for the cofactor F420 in prokaryotes

Cofactor F420 plays crucial roles in bacterial and archaeal metabolism, but its biosynthetic pathway is not fully understood. Here, the authors present the structure of one of the enzymes and provide experimental evidence for a substantial revision of the pathway, including the identification of a new intermediate

Poly-γ-glutamylation of biomolecules

Abstract Poly-γ-glutamate tails are a distinctive feature of archaeal, bacterial, and eukaryotic cofactors, including the folates and F420. Despite decades of research, key mechanistic questions remain as to how enzymes successively add glutamates to poly-γ-glutamate chains while maintaining cofactor specificity. Here, we show how poly-γ-glutamylation of folate and F420 by folylpolyglutamate synthases and γ-glutamyl ligases, non-homologous enzymes, occurs via processive addition of L-glutamate onto growing γ-glutamyl chain termini. We further reveal structural snapshots of the archaeal γ-glutamyl ligase (CofE) in action, crucially including a bulged-chain product that shows how the cofactor is retained while successive glutamates are added to the chain terminus. This bulging substrate model of processive poly-γ-glutamylation by terminal extension is arguably ubiquitous in such biopolymerisation reactions, including addition to folates, and demonstrates convergent evolution in diverse species from archaea to humans

Impact analysis of wind farms on telecommunication services

AbstractWind power is one of the fastest-growing technologies for renewable energy generation. Unfortunately, in the recent years some cases of degradation on certain telecommunication systems have arisen due to the presence of wind farms, and expensive and technically complex corrective measurements have been needed. This paper presents a comprehensive review on the impact of wind turbines on the telecommunication services. The paper describes the potential affections to several telecommunication services, the methodology to evaluate this impact, and mitigation measures to be taken in case of potential degradation, both preventive and corrective. The telecommunication services included in this review are those that have demonstrated to be more sensitive to nearby wind turbines: weather, air traffic control and marine radars, radio navigation systems, terrestrial television and fixed radio links. The methods described in the paper allow a thorough case-by-case analysis before the wind farm is installed, taking into account the particular features of each installation and the involved services. The prediction of the potential impact makes it possible to propose alternative solutions in order to assure the coexistence between the wind turbines and the telecommunication services