433 research outputs found

    Beneficial effects of exercise: shifting the focus from body weight to other markers of health

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    Background: Exercise is widely promoted as a method of weight management, while the other health benefits are often ignored. The purpose of this study was to examine whether exercise-induced improvements in health are influenced by changes in body weight. Methods: Fifty-eight sedentary overweight/obese men and women (BMI 31.8 (SD 4.5) kg/m2) participated in a 12-week supervised aerobic exercise intervention (70% heart rate max, five times a week, 500 kcal per session). Body composition, anthropometric parameters, aerobic capacity, blood pressure and acute psychological response to exercise were measured at weeks 0 and 12. Results: The mean reduction in body weight was −3.3 (3.63) kg (p<0.01). However, 26 of the 58 participants failed to attain the predicted weight loss estimated from individuals’ exercise-induced energy expenditure. Their mean weight loss was only −0.9 (1.8) kg (p<0.01). Despite attaining a lower-than-predicted weight reduction, these individuals experienced significant increases in aerobic capacity (6.3 (6.0) ml/kg/min; p<0.01), and a decreased systolic (−6.00 (11.5) mm Hg; p<0.05) and diastolic blood pressure (−3.9 (5.8) mm Hg; p<0.01), waist circumference (−3.7 (2.7) cm; p<0.01) and resting heart rate (−4.8 (8.9) bpm, p<0.001). In addition, these individuals experienced an acute exercise-induced increase in positive mood. Conclusions: These data demonstrate that significant and meaningful health benefits can be achieved even in the presence of lower-than-expected exercise-induced weight loss. A less successful reduction in body weight does not undermine the beneficial effects of aerobic exercise. From a public health perspective, exercise should be encouraged and the emphasis on weight loss reduced

    Changes in physical activity behavior and risk of falls over 8 years follow-up: English longitudinal study of ageing

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    Changes in physical activity behavior and risk of falls over 8 years follow-up: English longitudinal study of agein

    A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of β-N-acetylglucosaminidases

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    The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of β-N-acetylglucosaminidases are described. The compound is a good inhibitor of both human O-GlcNAcase and human β-hexosaminidase, as well as two bacterial β-N-acetylglucosaminidases. A 3-D structure of the complex of Bacteroides thetaiotaomicron BtGH84 with the inhibitor shows the unsaturated ring is surprisingly distorted away from its favoured solution phase conformation and reveals potential for improved inhibitor potency

    Lightcurves of Type Ia Supernovae from Near the Time of Explosion

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    We present a set of 11 type Ia supernova (SN Ia) lightcurves with dense, pre-maximum sampling. These supernovae (SNe), in galaxies behind the Large Magellanic Cloud (LMC), were discovered by the SuperMACHO survey. The SNe span a redshift range of z = 0.11 - 0.35. Our lightcurves contain some of the earliest pre-maximum observations of SNe Ia to date. We also give a functional model that describes the SN Ia lightcurve shape (in our VR-band). Our function uses the "expanding fireball" model of Goldhaber et al. (1998) to describe the rising lightcurve immediately after explosion but constrains it to smoothly join the remainder of the lightcurve. We fit this model to a composite observed VR-band lightcurve of three SNe between redshifts of 0.135 to 0.165. These SNe have not been K-corrected or adjusted to account for reddening. In this redshift range, the observed VR-band most closely matches the rest frame V-band. Using the best fit to our functional description of the lightcurve, we find the time between explosion and observed VR-band maximum to be 17.6+-1.3(stat)+-0.07(sys) rest-frame days for a SN Ia with a VR-band Delta m_{-10} of 0.52mag. For the redshifts sampled, the observed VR-band time-of-maximum brightness should be the same as the rest-frame V-band maximum to within 1.1 rest-frame days.Comment: 35 pages, 18 figures, 15 tables; Higher quality PDF available at http://ctiokw.ctio.noao.edu/~sm/sm/SNrise/index.html; AJ accepte

    Archosauromorph extinction selectivity during the Triassic–Jurassic mass extinction

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    Many traits have been linked to extinction risk among modern vertebrates, including mode of life and body size. However, previous work has indicated there is little evidence that body size, or any other trait, was selective during past mass extinctions. Here, we investigate the impact of the Triassic–Jurassic mass extinction on early Archosauromorpha (basal dinosaurs, crocodylomorphs and their relatives) by focusing on body size and other life history traits. We built several new archosauromorph maximum-likelihood supertrees, incorporating uncertainty in phylogenetic relationships. These supertrees were then employed as a framework to test whether extinction had a phylogenetic signal during the Triassic–Jurassic mass extinction, and whether species with certain traits were more or less likely to go extinct. We find evidence for phylogenetic signal in extinction, in that taxa were more likely to become extinct if a close relative also did. However, there is no correlation between extinction and body size, or any other tested trait. These conclusions add to previous findings that body size, and other traits, were not subject to selection during mass extinctions in closely-related clades, although the phylogenetic signal in extinction indicates that selection may have acted on traits not investigated here.ISSN:0031-0239ISSN:1475-498

    Velocity Segregation and Systematic Biases In Velocity Dispersion Estimates With the SPT-GMOS Spectroscopic Survey

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    The velocity distribution of galaxies in clusters is not universal; rather, galaxies are segregated according to their spectral type and relative luminosity. We examine the velocity distributions of different populations of galaxies within 89 Sunyaev Zel'dovich (SZ) selected galaxy clusters spanning 0.28<z<1.08 0.28 < z < 1.08. Our sample is primarily draw from the SPT-GMOS spectroscopic survey, supplemented by additional published spectroscopy, resulting in a final spectroscopic sample of 4148 galaxy spectra---2868 cluster members. The velocity dispersion of star-forming cluster galaxies is 17±417\pm4% greater than that of passive cluster galaxies, and the velocity dispersion of bright (m<m∗−0.5m < m^{*}-0.5) cluster galaxies is 11±411\pm4% lower than the velocity dispersion of our total member population. We find good agreement with simulations regarding the shape of the relationship between the measured velocity dispersion and the fraction of passive vs. star-forming galaxies used to measure it, but we find a small offset between this relationship as measured in data and simulations in which suggests that our dispersions are systematically low by as much as 3\% relative to simulations. We argue that this offset could be interpreted as a measurement of the effective velocity bias that describes the ratio of our observed velocity dispersions and the intrinsic velocity dispersion of dark matter particles in a published simulation result. Measuring velocity bias in this way suggests that large spectroscopic surveys can improve dispersion-based mass-observable scaling relations for cosmology even in the face of velocity biases, by quantifying and ultimately calibrating them out.Comment: Accepted to ApJ; 21 pages, 11 figures, 5 table

    Recalibrating the White Cube as a hub for social action

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    A new form of practice is developing in which cultural organisations are transformed from white cubes to hubs for social action and learning. Focus extends from the showing of art to its creation, and the empowerment and agency of communities through enactive learning. In this model the arts organisation acts as a catalyst for collaborative action and enquiry involving academia and a wider ecosystem of communities and stakeholders including the public, artists, digital creative industry, maker spaces and local government. The new model entails embedding of research, innovation and arts practice within the arts organisation itself. We illustrate the approach with examples of projects spanning mental health, physical disability, young people, veterans, children and parents, which have had a real impact on health and well-being of our communities
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