Numerical study of halo concentrations in dark-energy cosmologies

We study the concentration parameters, their mass dependence and redshift evolution, of dark-matter halos in different dark-energy cosmologies with constant and time-variable equation of state, and compare them with "standard'' Lambda-CDM and OCDM models. We find that previously proposed algorithms for predicting halo concentrations can be well adapted to dark-energy models. When centred on the analytically expected values, halo concentrations show a log-normal distribution with a uniform standard deviation of ~0.2. The dependence of averaged halo concentrations on mass and redshift permits a simple fit of the form (1+z) c=c0 (M/M0)^a, with a~-0.1 throughout. We find that the cluster concentration depends on the dark energy equation of state at the cluster formation redshift z_{coll} through the linear growth factor D_+(z_{coll}). As a simple correction accounting for dark-energy cosmologies, we propose scaling c0 from Lambda-CDM with the ratio of linear growth factors, c0 -> c0 D_+(z_{coll})/D_{+,Lambda-CDM}(z_{coll}).Comment: 11 pages, submitted to Astronomy & Astrophysic

Diffuse inverse Compton and synchrotron emission from dark matter annihilations in galactic satellites

Annihilating dark matter particles produce roughly as much power in electrons and positrons as in gamma ray photons. The charged particles lose essentially all of their energy to inverse Compton and synchrotron processes in the galactic environment. We discuss the diffuse signature of dark matter annihilations in satellites of the Milky Way (which may be optically dark with few or no stars), providing a tail of emission trailing the satellite in its orbit. Inverse Compton processes provide X-rays and gamma rays, and synchrotron emission at radio wavelengths might be seen. We discuss the possibility of detecting these signals with current and future observations, in particular EGRET and GLAST for the gamma rays.Comment: 13 pages, 5 figure

The optical calcium frequency standards of PTB and NIST

We describe the current status of the Ca optical frequency standards with laser-cooled neutral atoms realized in two different laboratories for the purpose of developing a possible future optical atomic clock. Frequency measurements performed at the Physikalisch-Technische Bundesanstalt (PTB) and the National Institute of Standards and Technology (NIST) make the frequency of the clock transition of 40Ca one of the best known optical frequencies (relative uncertainty 1.2e-14) and the measurements of this frequency in both laboratories agree to well within their respective uncertainties. Prospects for improvement by orders of magnitude in the relative uncertainty of the standard look feasible.Comment: 13 pages, 11 figures, to appear in Comptes Rendus Physiqu

Indirect search for dark matter: prospects for GLAST

Possible indirect detection of neutralino, through its gamma-ray annihilation product, by the forthcoming GLAST satellite from our galactic halo, M31, M87 and the dwarf galaxies Draco and Sagittarius is studied. Gamma-ray fluxes are evaluated for the two representative energy thresholds, 0.1 GeV and 1.0 GeV, at which the spatial resolution of GLAST varies considerably. Apart from dwarfs which are described either by a modified Plummer profile or by a tidally-truncated King profiles, fluxes are compared for halos with central cusps and cores. It is demonstrated that substructures, irrespective of their profiles, enhance the gamma-ray emission only marginally. The expected gamma-ray intensity above 1 GeV at high galactic latitudes is consistent with the residual emission derived from EGRET data if the density profile has a central core and the neutralino mass is less than 50 GeV, whereas for a central cusp only a substantial enhancement would explain the observations. From M31, the flux can be detected above 0.1 GeV and 1.0 GeV by GLAST only if the neutralino mass is below 300 GeV and if the density profile has a central cusp, case in which a significant boost in the gamma-ray emission is produced by the central black hole. For Sagittarius, the flux above 0.1 GeV is detectable by GLAST provided the neutralino mass is below 50 GeV. From M87 and Draco the fluxes are always below the sensitivity limit of GLAST.Comment: 14 Pages, 7 Figures, 3 Tables, version to appear on Physical Review

ESO-Athena Synergy White Paper

The Advanced Telescope for High ENergy Astrophysics (Athena) is the X-ray observatory mission selected by ESA within its Cosmic Vision 2015-2025 programme to address the Hot and Energetic Universe scientific theme. The ESO-Athena Synergy Team (EAST) has been tasked to single out the potential scientific synergies between Athena and optical/near-infrared (NIR) and sub/mm ground based facilities, in particular those of ESO (i.e., the VLT and ELT, ALMA and APEX), by producing a White Paper to identify and develop the: 1. needs to access ESO ground-based facilities to achieve the formulated Athena science objectives; 2. needs to access Athena to achieve the formulated science objectives of ESO facilities contemporary to Athena; 3. science areas where the synergetic use of Athena and ESO facilities in the late 2020s will result in scientific added value. Community input to the process happened primarily via a dedicated ESO - Athena Synergy Workshop that took place on Sept. 14 - 16, 2016 at ESO, Garching. This White Paper presents the results of the EAST's work, sorted by synergy area, and deals with the following topics: 1. the Hot Universe: Early groups and clusters and their evolution, Physics of the Intracluster medium, Missing baryons in cosmic filaments; 2. the Energetic Universe: Supermassive black hole (SMBH) history, SMBH accretion disks, Active Galactic Nuclei feedback - Molecular outflows, Ultra-fast outflows, Accretion Physics, Transient Science; 3. Observatory Science: Star Formation, Stars. It then discusses the optical-NIR-sub-mm perspective by providing details on VLT/MOONS, the E-ELT instruments, in particular the MOS, VISTA/4MOST, the ESO and ALMA archives, future ALMA and ESO developments, and finally the (likely) ESO - Athena astronomical scene in the 2020s. (abridged)Comment: 70 pages, 16 figure

UKPMC: a full text article resource for the life sciences

UK PubMed Central (UKPMC) is a full-text article database that extends the functionality of the original PubMed Central (PMC) repository. The UKPMC project was launched as the first ‘mirror’ site to PMC, which in analogy to the International Nucleotide Sequence Database Collaboration, aims to provide international preservation of the open and free-access biomedical literature. UKPMC (http://ukpmc.ac.uk) has undergone considerable development since its inception in 2007 and now includes both a UKPMC and PubMed search, as well as access to other records such as Agricola, Patents and recent biomedical theses. UKPMC also differs from PubMed/PMC in that the full text and abstract information can be searched in an integrated manner from one input box. Furthermore, UKPMC contains ‘Cited By’ information as an alternative way to navigate the literature and has incorporated text-mining approaches to semantically enrich content and integrate it with related database resources. Finally, UKPMC also offers added-value services (UKPMC+) that enable grantees to deposit manuscripts, link papers to grants, publish online portfolios and view citation information on their papers. Here we describe UKPMC and clarify the relationship between PMC and UKPMC, providing historical context and future directions, 10 years on from when PMC was first launched

The Additional Representative Images for Legacy (ARI-L) project for the ALMA Science Archive

The Additional Representative Images for Legacy (ARI-L) project is a European Development project for ALMA Upgrade approved by the Joint ALMA Observatory (JAO) and the European Southern Observatory (ESO), started in June 2019. It aims to increase the legacy value of the ALMA Science Archive (ASA) by bringing the reduction level of ALMA data from Cycles 2-4 close to that of data from more recent Cycles processed for imaging with the ALMA Pipeline. As of mid-2021 more than 150000 images have been returned to the ASA for public use. At its completion in 2022, the project will have provided enhanced products for at least 70% of the observational data from Cycles 2-4 processable with the ALMA Pipeline. In this paper we present the project rationale, its implementation, and the new opportunities offered to ASA users by the ARI-L products. The ARI-L cubes and images complement the much limited number of archival image products generated during the data quality assurance stages (QA2), which cover only a small fraction of the available data for those Cycles. ARI-L imaging products are highly relevant for many science cases and significantly enhance the possibilities for exploiting archival data. Indeed, ARI-L products facilitate archive access and data usage for science purposes even for non-expert data miners, provide a homogeneous view of all data for better dataset comparisons and download selections, make the archive more accessible to visualization and analysis tools, and enable the generation of preview images and plots similar to those possible for subsequent Cycles.Comment: 15 pages. Accepted for publication in PAS

Simulation techniques for cosmological simulations

Modern cosmological observations allow us to study in great detail the evolution and history of the large scale structure hierarchy. The fundamental problem of accurate constraints on the cosmological parameters, within a given cosmological model, requires precise modelling of the observed structure. In this paper we briefly review the current most effective techniques of large scale structure simulations, emphasising both their advantages and shortcomings. Starting with basics of the direct N-body simulations appropriate to modelling cold dark matter evolution, we then discuss the direct-sum technique GRAPE, particle-mesh (PM) and hybrid methods, combining the PM and the tree algorithms. Simulations of baryonic matter in the Universe often use hydrodynamic codes based on both particle methods that discretise mass, and grid-based methods. We briefly describe Eulerian grid methods, and also some variants of Lagrangian smoothed particle hydrodynamics (SPH) methods.Comment: 42 pages, 16 figures, accepted for publication in Space Science Reviews, special issue "Clusters of galaxies: beyond the thermal view", Editor J.S. Kaastra, Chapter 12; work done by an international team at the International Space Science Institute (ISSI), Bern, organised by J.S. Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke

The association of health literacy with adherence in older 2 adults, and its role in interventions: a systematic meta-review

Background: Low health literacy is a common problem among older adults. It is often suggested to be associated with poor adherence. This suggested association implies a need for effective adherence interventions in low health literate people. However, previous reviews show mixed results on the association between low health literacy and poor adherence. A systematic meta-review of systematic reviews was conducted to study the association between health literacy and adherence in adults above the age of 50. Evidence for the effectiveness of adherence interventions among adults in this older age group with low health literacy was also explored. Methods: Eight electronic databases (MEDLINE, ERIC, EMBASE, PsycINFO, CINAHL, DARE, the Cochrane Library, and Web of Knowledge) were searched using a variety of keywords regarding health literacy and adherence. Additionally, references of identified articles were checked. Systematic reviews were included if they assessed the association between health literacy and adherence or evaluated the effectiveness of interventions to improve adherence in adults with low health literacy. The AMSTAR tool was used to assess the quality of the included reviews. The selection procedure, data-extraction, and quality assessment were performed by two independent reviewers. Seventeen reviews were selected for inclusion. Results: Reviews varied widely in quality. Both reviews of high and low quality found only weak or mixed associations between health literacy and adherence among older adults. Reviews report on seven studies that assess the effectiveness of adherence interventions among low health literate older adults. The results suggest that some adherence interventions are effective for this group. The interventions described in the reviews focused mainly on education and on lowering the health literacy demands of adherence instructions. No conclusions could be drawn about which type of intervention could be most beneficial for this population. Conclusions: Evidence on the association between health literacy and adherence in older adults is relatively weak. Adherence interventions are potentially effective for the vulnerable population of older adults with low levels of health literacy, but the evidence on this topic is limited. Further research is needed on the association between health literacy and general health behavior, and on the effectiveness of interventions

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types