495 research outputs found
The role of IL-6 in skin fibrosis and cutaneous wound healing
The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-β feedback loop is discussed in the context of fibrogenesis, while IL-6 expression and responses in advanced age, diabetes, and obesity is outlined regarding the development of chronic wounds. Current research on therapies that modulate IL-6 is explored. Here, we consider IL-6′s diverse impact on cutaneous wound healing
Variational Field Theoretic Approach to Relativistic Scattering
Nonperturbative polaron variational methods are applied, within the so-called
particle or worldline representation of relativistic field theory, to study
scattering in the context of the scalar Wick - Cutkosky model. Important
features of the variational calculation are that it is a controlled
approximation scheme valid for arbitrary coupling strengths, the Green
functions have all the cuts and poles expected for the exact result at any
order in perturbation theory and that the variational parameters are
simultaneously sensitive to the infrared as well as the ultraviolet behaviour
of the theory. We generalize the previously used quadratic trial action by
allowing more freedom for off-shell propagation without a change in the
on-shell variational equations and evaluate the scattering amplitude at first
order in the variational scheme. Particular attention is paid to the
-channel scattering near threshold because here non-perturbative effects can
be large. We check the unitarity of a our numerical calculation and find it
greatly improved compared to perturbation theory and to the zeroth order
variational results.Comment: 26 pages, Latex, 5 postscript figures embedded with epsf, submitted
to Nucl. Phys.
First Order Variational Calculation of Form Factor in a Scalar Nucleon--Meson Theory
We investigate a relativistic quantum field theory in the particle
representation using a non-perturbative variational technique. The theory is
that of two massive scalar particles, `nucleons' and `mesons', interacting via
a Yukawa coupling. We calculate the general Euclidean Green function involving
two external nucleons and an arbitrary number of external mesons in the
quenched approximation for the nucleons. The non-perturbative renormalization
and truncation is done in a consistent manner and results in the same
variational functional independent of the number of external mesons. We check
that the calculation agrees with one-loop perturbation theory for small
couplings. As an illustration the special case of meson absorption on the
nucleon is considered in detail. We derive the radius of the dressed particle
and numerically investigate the vertex function after analytic continuation to
Minkowski space.Comment: 28 pages standard LaTeX, 13 uuencoded postscript figures embedded
with psfig.st
How do we get people into contact? Predictors of intergroup contact and drivers of contact seeking
Compared to the impressive amount of research on consequences of intergroup contact, relatively little work has been devoted to predictors of intergroup contact. Although opportunities for intergroup contact are constantly growing in modern diverse societies, these contact opportunities are not necessarily exploited. In the present review article, we describe current research on predictors of intergroup contact and drivers of contact seeking on a micro‐, meso‐, and macro‐level. We provide an overview of predictors, while focusing on recent research that is especially relevant for designing interventions and planning social policies aiming at increasing contact between different groups in varied societies. On the micro‐level, we discuss relational self‐expansion motives and confidence in contact as predictors of intergroup contact. On the meso‐level, we focus on the role of intragroup processes and historical intergroup conflicts in facilitating contact. On the macro‐level, we reflect on changing societal norms as a potential tool to increase the frequency intergroup contact. By focusing on the applied value of research findings, discussing diverse predictors, and applying a multilevel approach, we also address recent criticisms of the intergroup contact literature and demonstrate the generative nature of contemporary research in this area
Protein for Life: Review of Optimal Protein Intake, Sustainable Dietary Sources and the Effect on Appetite in Ageing Adults
With an ageing population, dietary approaches to promote health and independence later in life are needed. In part, this can be achieved by maintaining muscle mass and strength as people age. New evidence suggests that current dietary recommendations for protein intake may be insufficient to achieve this goal and that individuals might benefit by increasing their intake and frequency of consumption of high-quality protein. However, the environmental effects of increasing animal-protein production are a concern, and alternative, more sustainable protein sources should be considered. Protein is known to be more satiating than other macronutrients, and it is unclear whether diets high in plant proteins affect the appetite of older adults as they should be recommended for individuals at risk of malnutrition. The review considers the protein needs of an ageing population (>40 years old), sustainable protein sources, appetite-related implications of diets high in plant proteins, and related areas for future research
International Consortium for Health Outcomes Measurement (ICHOM): Standardized Patient-Centered Outcomes Measurement Set for Heart Failure Patients
Whereas multiple national, international, and trial registries for heart failure have been created, international standards for clinical assessment and outcome measurement do not currently exist. The working group's objective was to facilitate international comparison in heart failure care, using standardized parameters and meaningful patient-centered outcomes for research and quality of care assessments. The International Consortium for Health Outcomes Measurement recruited an international working group of clinical heart failure experts, researchers, and patient representatives to define a standard set of outcomes and risk-adjustment variables. This was designed to document, compare, and ultimately improve patient care outcomes in the heart failure population, with a focus on global feasibility and relevance. The working group employed a Delphi process, patient focus groups, online patient surveys, and multiple systematic publications searches. The process occurred over 10 months, employing 7 international teleconferences. A 17-item set has been established, addressing selected functional, psychosocial, burden of care, and survival outcome domains. These measures were designed to include all patients with heart failure, whether entered at first presentation or subsequent decompensation, excluding cardiogenic shock. Sources include clinician report, administrative data, and validated patient-reported outcome measurement tools: the Kansas City Cardiomyopathy Questionnaire; the Patient Health Questionnaire-2; and the Patient-Reported Outcomes Measurement Information System. Recommended data included those to support risk adjustment and benchmarking across providers and regions. The International Consortium for Health Outcomes Measurement developed a dataset designed to capture, compare, and improve care for heart failure, with feasibility and relevance for patients and clinicians worldwide
Search for composite and exotic fermions at LEP 2
A search for unstable heavy fermions with the DELPHI detector at LEP is
reported. Sequential and non-canonical leptons, as well as excited leptons and
quarks, are considered. The data analysed correspond to an integrated
luminosity of about 48 pb^{-1} at an e^+e^- centre-of-mass energy of 183 GeV
and about 20 pb^{-1} equally shared between the centre-of-mass energies of 172
GeV and 161 GeV. The search for pair-produced new leptons establishes 95%
confidence level mass limits in the region between 70 GeV/c^2 and 90 GeV/c^2,
depending on the channel. The search for singly produced excited leptons and
quarks establishes upper limits on the ratio of the coupling of the excited
fermio
Search for charginos in e+e- interactions at sqrt(s) = 189 GeV
An update of the searches for charginos and gravitinos is presented, based on
a data sample corresponding to the 158 pb^{-1} recorded by the DELPHI detector
in 1998, at a centre-of-mass energy of 189 GeV. No evidence for a signal was
found. The lower mass limits are 4-5 GeV/c^2 higher than those obtained at a
centre-of-mass energy of 183 GeV. The (\mu,M_2) MSSM domain excluded by
combining the chargino searches with neutralino searches at the Z resonance
implies a limit on the mass of the lightest neutralino which, for a heavy
sneutrino, is constrained to be above 31.0 GeV/c^2 for tan(beta) \geq 1.Comment: 22 pages, 8 figure
Search for lightest neutralino and stau pair production in light gravitino scenarios with stau NLSP
Promptly decaying lightest neutralinos and long-lived staus are searched for
in the context of light gravitino scenarios. It is assumed that the stau is the
next to lightest supersymmetric particle (NLSP) and that the lightest
neutralino is the next to NLSP (NNLSP). Data collected with the Delphi detector
at centre-of-mass energies from 161 to 183 \GeV are analysed. No evidence of
the production of these particles is found. Hence, lower mass limits for both
kinds of particles are set at 95% C.L.. The mass of gaugino-like neutralinos is
found to be greater than 71.5 GeV/c^2. In the search for long-lived stau,
masses less than 70.0 to 77.5 \GeVcc are excluded for gravitino masses from 10
to 150 \eVcc . Combining this search with the searches for stable heavy leptons
and Minimal Supersymmetric Standard Model staus a lower limit of 68.5 \GeVcc
may be set for the stau mas
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