Sophocles the Honeybee: Dramatic Context and Interaction

There have been very few large-scale studies of Sophocles\u27 poetic interactions with the other playwrights of the fifth century B.C. This project seeks to fill that gap by putting Sophocles in contact with both tragic and comic poets and offering new readings of his work from that angle. By examining Sophocles as an exploiter of other poets\u27 dramatic ideas and strategies, I hope to demonstrate his versatility and creativity; by viewing him as a source of inspiration for other dramatists, I aim to show his relevance and significance within his own time. The ancient Life of Sophocles claims that he was nicknamed melitta (\u22honeybee\u22) for his ability to glean the best elements from the work of other poets and integrate them effectively into his own plays. Taking this idea as my starting point, I explore the \u22immediate dramatic context\u22 of each of Sophocles\u27 late tragedies (Electra, Philoctetes, and Oedipus at Colonus) to show how they draw extensively on specific plays of Aeschylus and Euripides. I also aim to complicate common views of dramatic intertextuality, which, in light of the competitions at the festivals, is often understood in terms of simple imitation or rejection; in particular, the relationship between Sophocles and Euripides has frequently been reduced to one of polemics and polarity. My interest is rather in a type of engagement that was basically collaborative and constructive, and I argue that Sophocles and Euripides, as a result of working closely with each other\u27s material over the course of several decades, were actually much more similar in terms of style and interest than is usually recognized. Finally, drawing on recent work on comic intertextuality, I argue that all fifth-century playwrights were essentially honeybees in their own right, eager to experiment with recent innovations and developments in the theater. Sophocles thus becomes the basis for a more general model of dramatic inspiration and composition in the late fifth century: in contrast to the view that tragedy was becoming exhausted or even dying out, the poets continued to find new ways to exploit, expand, and build on each other\u27s material

Teaching Wikipedia: A Model for Critical Engagement with Open Information

In this chapter, the authors describe the learning experience and goals of a class assignment to write content for Wikipedia about women in science and technology fields. The authors, a university professor and two librarians, collaboratively developed this assignment to allow students to engage in rigorous research and contribute to the visibility of women scientists by writing content for the web. The authors chose the Wikipedia platform as the means to make the students work openly available because of its ubiquity and the potential for student work to make an important impact. The assignment, used in two iterations of the course, was designed to provide students not only with a hands-on experience on working on the open web, but also with tools to assess critically the uses and abuses of open access platforms

Review: RefME

RefME is a citation management tool released in 2014 as a mobile app and subsequently as a web-based platform. It is available for free and also with an individual or institutional subscription. It shares some similar features to both free and subscription competitors, including Zotero, Mendeley, Endnote, and RefWorks. The RefME mobile app stands out as a unique asset, as most competitors do not offer a mobile app that can be used to capture and annotate citations. The simplicity of design, ease of use, availability of a free version, and its overall functionality position RefME to become a good solution for institutions looking for a citation manager that is more intuitive than most

Bringing Creative Psychotherapies to Primary NHS Mental Health Services in the UK:A Feasibility Study on Patient and Staff Experiences of Arts for the Blues Workshops Delivered at Improving Access to Psychological Therapies (IAPT) services

There have been several arguments for the need to generate evidence-based creative forms of psychological interventions in Improving Access to Psychological Services (IAPT), the main primary mental health provider in hospitals in England, UK. In this feasibility study, we sought to identify helpful and unhelpful factors of a new creative group psychotherapy, titled Arts for the Blues. We also wanted to find out whether the research tools used were acceptable and sensitive. We therefore engaged a group of seven patients attending an IAPT service in the North West of England, and a group of six staff working in the same service, to attend one creative workshop each, followed by a focus group. The two focus groups were transcribed and analysed using thematic analysis. We also collected pre- and post-measures of depression (PHQ-9) and anxiety (GAD-7), measures commonly used in IAPT services, plus measures of well-being (WHO-5), the PANAS, and goal-setting, which were considered for acceptability and sensitivity. We received largely positive responses from service users and staff in the use of creative methods in psychotherapy. Although the measures used had limitations due to the short duration of one-off creative workshops, we found that they were sensitive enough, easy to complete and, thus, were acceptable. We concluded that Arts for the Blues is a promising intervention in IAPT, especially since it is shaped by service users and staff working in these services. Further work is needed to establish the effectiveness of this new intervention

Alternatively activated macrophages promotes necrosis resolution following acute liver injury

Background & Aim Following acetaminophen (APAP) overdose, acute liver injury (ALI) can occur in patients that present too late for N-acetylcysteine treatment, potentially leading to acute liver failure, systemic inflammation, and death. Macrophages influence the progression and resolution of ALI due to their innate immunological function and paracrine activity. Syngeneic primary bone marrow-derived macrophages (BMDMs) were tested as a cell-based therapy in a mouse model of APAP-induced ALI (APAP-ALI). Methods Several phenotypically distinct BMDM populations were delivered intravenously to APAP-ALI mice when hepatic necrosis was established, and then evaluated based on their effects on injury, inflammation, immunity, and regeneration. In vivo phagocytosis assays were used to interrogate the phenotype and function of alternatively activated BMDMs (AAMs) post-injection. Finally, primary human AAMs sourced from healthy volunteers were evaluated in immunocompetent APAP-ALI mice. Results BMDMs rapidly localised to the liver and spleen within 4 h of administration. Injection of AAMs specifically reduced hepatocellular necrosis, HMGB1 translocation, and infiltrating neutrophils following APAP-ALI. AAM delivery also stimulated proliferation in hepatocytes and endothelium, and reduced levels of several circulating proinflammatory cytokines within 24 h. AAMs displayed a high phagocytic activity both in vitro and in injured liver tissue post-injection. Crosstalk with the host innate immune system was demonstrated by reduced infiltrating host Ly6Chi macrophages in AAM-treated mice. Importantly, therapeutic efficacy was partially recapitulated using clinical-grade primary human AAMs in immunocompetent APAP-ALI mice, underscoring the translational potential of these findings. Conclusion We identify that AAMs have value as a cell-based therapy in an experimental model of APAP-ALI. Human AAMs warrant further evaluation as a potential cell-based therapy for APAP overdose patients with established liver injury. Lay summary After an overdose of acetaminophen (paracetamol), some patients present to hospital too late for the current antidote (N-acetylcysteine) to be effective. We tested whether macrophages, an injury-responsive leukocyte that can scavenge dead/dying cells, could serve as a cell-based therapy in an experimental model of acetaminophen overdose. Injection of alternatively activated macrophages rapidly reduced liver injury and reduced several mediators of inflammation. Macrophages show promise to serve as a potential cell-based therapy for acute liver injury

Identification of a Thymic Epithelial Cell Subset Sharing Expression of the Class Ib HLA-G Molecule with Fetal Trophoblasts

HLA-G is the only class I determinant of the major histocompatibility complex (MHC) expressed by the trophoblasts, the fetal cells invading the maternal decidua during pregnancy. A unique feature of this nonclassical HLA molecule is its low polymorphism, a property that has been postulated to play an important role in preventing local activation of maternal alloreactive T and natural killer cells against the fetus. Yet, the mechanisms by which fetal HLA-G can be recognized as a self-MHC molecule by the maternal immune system remain unclear. Here we report the novel observation that HLA-G is expressed in the human thymus. Expression is targeted to the cell surface of thymic medullary and subcapsular epithelium. Thymic epithelial cell lines were generated and shown to express three alternatively spliced HLA-G transcripts, previously identified in human trophoblasts. Sequencing of HLA-G1 transcripts revealed a few nucleotide changes resulting in amino acid substitutions, all clustered within exon 3 of HLA-G, encoding for the α2 domain of the molecule. Our findings raise the possibility that maternal unresponsiveness to HLA-G–expressing fetal tissues may be shaped in the thymus by a previously unrecognized central presentation of this MHC molecule on the medullary epithelium

The Sloan Digital Sky Survey Reverberation Mapping Project: Initial C IV lag results from four years of data

K.H. acknowledges support from STFC grant ST/M001296/1.We present reverberation-mapping (RM) lags and black hole mass measurements using the C iv λ1549 broad emission line from a sample of 348 quasars monitored as a part of the Sloan Digital Sky Survey RM Project. Our data span four years of spectroscopic and photometric monitoring for a total baseline of 1300 days, allowing us to measure lags up to ~750 days in the observed frame (this corresponds to a rest-frame lag of ~300 days in a quasar at z = 1.5 and ~190 days at z = 3). We report significant time delays between the continuum and the C iv λ1549 emission line in 48 quasars, with an estimated false-positive detection rate of 10%. Our analysis of marginal lag measurements indicates that there are on the order of ~100 additional lags that should be recoverable by adding more years of data from the program. We use our measurements to calculate black hole masses and fit an updated C iv radius–luminosity relationship. Our results significantly increase the sample of quasars with C iv RM results, with the quasars spanning two orders of magnitude in luminosity toward the high-luminosity end of the C iv radius–luminosity relation. In addition, these quasars are located at some of the highest redshifts (z ≈ 1.4–2.8) of quasars with black hole masses measured with RM. This work constitutes the first large sample of C iv RM measurements in more than a dozen quasars, demonstrating the utility of multiobject RM campaigns.Publisher PDFPeer reviewe

The Sloan Digital Sky Survey Reverberation Mapping Project : accretion disk sizes from continuum lags

K.H. acknowledges support from STFC grant ST/R000824/1We present accretion disk structure measurements from continuum lags in the Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project. Lags are measured using the JAVELIN software from the first-year SDSS-RM g and i photometry, resulting in well-defined lags for 95 quasars, 33 of which have lag S/N > 2σ. We also estimate lags using the ICCF software and find consistent results, though with larger uncertainties. Accretion disk structure is fit using a Markov chain Monte Carlo approach, parameterizing the measured continuum lags as a function of disk size normalization, wavelength, black hole mass, and luminosity. In contrast with previous observations, our best-fit disk sizes and color profiles are consistent (within 1.5σ) with the Shakura & Sunyaev analytic solution. We also find that more massive quasars have larger accretion disks, similarly consistent with the analytic accretion disk model. The data are inconclusive on a correlation between disk size and continuum luminosity, with results that are consistent with both no correlation and the Shakura & Sunyaev expectation. The continuum lag fits have a large excess dispersion, indicating that our measured lag errors are underestimated and/or our best-fit model may be missing the effects of orientation, spin, and/or radiative efficiency. We demonstrate that fitting disk parameters using only the highest-S/N lag measurements biases best-fit disk sizes to be larger than the disk sizes recovered using a Bayesian approach on the full sample of well-defined lags.Publisher PDFPeer reviewe

The Sloan Digital Sky Survey Reverberation Mapping Project: Hα and Hβ reverberation measurements from first-year spectroscopy and photometry

Funding: UK Sciences and Technology Facilities Council STFC grant ST/M001296/1 (KH).We present reverberation mapping results from the first year of combined spectroscopic and photometric observations of the Sloan Digital Sky Survey Reverberation Mapping Project. We successfully recover reverberation time delays between the g+i band emission and the broad Hβ emission line for a total of 44 quasars, and for the broad Hα emission line in 18 quasars. Time delays are computed using the JAVELIN and CREAM software and the traditional interpolated cross-correlation function (ICCF): using well-defined criteria, we report measurements of 32 Hβ and 13 Hα lags with JAVELIN, 42 Hβ and 17 Hα lags with CREAM, and 16 Hβ and eight Hα lags with the ICCF. Lag values are generally consistent among the three methods, though we typically measure smaller uncertainties with JAVELIN and CREAM than with the ICCF, given the more physically motivated light curve interpolation and more robust statistical modeling of the former two methods. The median redshift of our Hβ-detected sample of quasars is 0.53, significantly higher than that of the previous reverberation mapping sample. We find that in most objects, the time delay of the Hα emission is consistent with or slightly longer than that of Hβ. We measure black hole masses using our measured time delays and line widths for these quasars. These black hole mass measurements are mostly consistent with expectations based on the local – relationship, and are also consistent with single-epoch black hole mass measurements. This work increases the current sample size of reverberation-mapped active galaxies by about two-thirds and represents the first large sample of reverberation mapping observations beyond the local universe (z < 0.3).PostprintPeer reviewe