A Boundary-Based Measure for Gerrymandering

This paper presents a new measure for quantifying legislative gerrymandering based intuitive observation that in a non-gerrymandered district a randomly placed observer should be able to walk in a straight line and only cross the boundary of the district once, when the district is exited. We make this notion precise in terms of the expected value of such crossings. The result is the Boundary Intersection Number, or BIN. Properties of the BIN score are proven and its computational properties discussed

Integrating Analysis Into a Warehouse Design Workflow

Supply chain analyses, including those related to material handling systems, are typically purpose-built to answer specific questions and therefore have many different implementations depending on the question, the instance data, and the solver. The purpose-built nature of these models makes it difficult to integrate them into an iterative design workflow. Despite the myriad analysis implementations, the fundamental structure of these systems and their problem domain remains unchanged, suggesting that perhaps analyses could be automatically generated on demand, given an appropriate specification of the particular system to be analyzed. We apply model-based systems engineering (MBSE) methodologies to explore this possibility in the context of functional warehouse design

Toward an Engineering Discipline of Warehouse Design

Warehouses today are complex dynamic engineered systems, incorporating automation, mechanization, equipment, fixtures, computers, networks, products and people, and they can support the flow of tens or hundreds of thousands of different items to enable fulfilling thousands or tens of thousands of orders daily. In that sense, they represent a design challenge that is not terribly different from the design of other complex dynamic engineered systems, such as a modern passenger airplane, an automobile, or a unique building. What is different is that the design of these other complex dynamic engineered systems typically follows some engineering design discipline. Here, we argue for the development of a corresponding engineering discipline of warehouse design

Beyond the Law of Attraction

Beyond reveals evidence of three of the most sought after universal and human mysteries - the origin of the universe, the location of God's spiritual dimension, and the origin of human consciousness. Beyond unveils a highly syntactic, pragmatic paradigm, a universal, interconnecting system that places access to all pre-existing potential knowledge in the possession of humanity. Dr. Sprock reveals these three discoveries as the Occam's razor (Scientific principle: All things being equal, the simplest explanation tends to be the correct one) of explanations of how the universe was created, the location of God's spiritual dimension, and the origin of human consciousness. This new knowledge takes humanity to its final destination. We can now tap into the universal vault of information that is coded into the universal frequencies within the fabric of the universe that have their origin in the infinite, spiritual dimension of God consciousness. How the systems of the universe function are brought to Earth level and are explained as to how they work in everyday living situations. The emotional burden carried by humans, due to lack of understanding, of why situations and circumstances occur are lifted, freeing you to focus on your life without emotional upheavals that distract you from your destiny's path. Beneficiaries are empowered to choose anew rather than continually recall and repeat undesired patterns of resistance-attraction and self-sabotage. This knowledge will bring greater joy and prosperity into your life. All the dots of modern science and ancient scripture have been connected. The code has been cracked and now will shift the perception human consciousness has of reality, forever. This is a huge game changer for the consciousness of humankind. Once this knowledge is introduced, accepted, and then applied to your daily routines, you will receive the boost needed to surge beyond your 10-12% brain usage at this point in your history. The Bose-Einstein Condensation is in direct concurrence with Dr. Sprock's location of God consciousness; the wave/frequency aspect of Nature yields the mental/consciousness; the particle/matter aspect of Nature yields the material. Dr. Sprock applies this phenomenon to the God consciousness/human consciousness connection. Dr. Sprock takes the Condensate a step further and explains the location of God consciousness existing in a spiritual, infinite dimension that spatially extended Spiritual DNA consciousness through frequency (Wave), which then vibrated to form density particles (Matter), creating the three dimensions of the physical universe and the origin of human consciousness. The frequencies carry the codes of God consciousness to human consciousness via the physical brain and the subconscious mind hologram

Characterization of neurophysiologic and neurocognitive biomarkers for use in genomic and clinical outcome studies of schizophrenia.

BackgroundEndophenotypes are quantitative, laboratory-based measures representing intermediate links in the pathways between genetic variation and the clinical expression of a disorder. Ideal endophenotypes exhibit deficits in patients, are stable over time and across shifts in psychopathology, and are suitable for repeat testing. Unfortunately, many leading candidate endophenotypes in schizophrenia have not been fully characterized simultaneously in large cohorts of patients and controls across these properties. The objectives of this study were to characterize the extent to which widely-used neurophysiological and neurocognitive endophenotypes are: 1) associated with schizophrenia, 2) stable over time, independent of state-related changes, and 3) free of potential practice/maturation or differential attrition effects in schizophrenia patients (SZ) and nonpsychiatric comparison subjects (NCS). Stability of clinical and functional measures was also assessed.MethodsParticipants (SZ n = 341; NCS n = 205) completed a battery of neurophysiological (MMN, P3a, P50 and N100 indices, PPI, startle habituation, antisaccade), neurocognitive (WRAT-3 Reading, LNS-forward, LNS-reorder, WCST-64, CVLT-II). In addition, patients were rated on clinical symptom severity as well as functional capacity and status measures (GAF, UPSA, SOF). 223 subjects (SZ n = 163; NCS n = 58) returned for retesting after 1 year.ResultsMost neurophysiological and neurocognitive measures exhibited medium-to-large deficits in schizophrenia, moderate-to-substantial stability across the retest interval, and were independent of fluctuations in clinical status. Clinical symptoms and functional measures also exhibited substantial stability. A Longitudinal Endophenotype Ranking System (LERS) was created to rank neurophysiological and neurocognitive biomarkers according to their effect sizes across endophenotype criteria.ConclusionsThe majority of neurophysiological and neurocognitive measures exhibited deficits in patients, stability over a 1-year interval and did not demonstrate practice or time effects supporting their use as endophenotypes in neural substrate and genomic studies. These measures hold promise for informing the "gene-to-phene gap" in schizophrenia research

Análise do uso de livros-texto digitais abertos no contexto da Educação Superior na América Latina

Entre as muitas barreiras para o acesso e permanência na Educação Superior nos países em desenvolvimento e subdesenvolvidos, como é o caso da totalidade dos países da América Latina, encontra-se o fator financeiro: ainda que não haja taxas de matrículas e mensalidades a serem pagas, há uma série de custos colaterais que nem sempre são considerados. Um destes custos é o dos materiais didáticos, em especial os livros-texto das disciplinas, de forma que iniciativas que possibilitem alternativas para os livros tradicionais devem ser consideradas. Neste sentido, o presente trabalho mostra os resultados da utilização de 25 livros-texto abertos gratuitos, criados de maneira colaborativa por autores de nove países Latino-americanas, disponibilizados de forma digital, no âmbito do Projeto LATIn. Um conjunto de 186 professores e 1.835 alunos espalhados em nove Universidades utilizou e avaliou as potencialidades e fragilidades deste modelo, e os resultados desta análise são apresentados neste artigo

Patrones de Multiculturalidad para el Diseño de Aplicaciones Web

The cultural diversity on the Web is the result of the growth of the Internet in the last years, making that the Web services and applications be every time more used for users in different cultures who, in many cases, are different to the initial users in which the design and development were based. This paper studies the differences in the cultural communication through the Web starting by the cultural dimensions proposed by Victor, Hofstede, Trompenaars and Hall. The Web design elements associated with the cultural dimensions and its behavior in representative Websites of Argentina, Colombia and Spain were identified to finally build a set of multiculturalism Patterns for Web Application Design with those elementsLa diversidad cultural en la Web surge como resultado del crecimiento de internet en los últimos años, logrando que los servicios y aplicaciones Web sean cada vez más utilizados por usuarios de diversas culturas, que en muchos casos terminan siendo diferentes a los usuarios iniciales en los que se basó su diseño y construcción. Este trabajo analiza las diferencias que se presentan en la comunicación multicultural a través de la Web, tomando como punto de partida las dimensiones culturales propuestas por Victor, Hofstede, Trompenaars y Hall. Se identificaron los elementos de diseño Web que están relacionados con las dimensiones culturales y su comportamiento en sitios Web representativos de Argentina, Colombia y España para finalmente construir un conjunto de Patrones de Multiculturalidad para el Diseño de Aplicaciones Web

Is There an Association between Advanced Paternal Age and Endophenotype Deficit Levels in Schizophrenia?

The children of older fathers have increased risks of developing schizophrenia spectrum disorders, and among those who develop these disorders, those with older fathers present with more severe clinical symptoms. However, the influence of advanced paternal age on other important domains related to schizophrenia, such as quantitative endophenotype deficit levels, remains unknown. This study investigated the associations between paternal age and level of endophenotypic impairment in a well-characterized family-based sample from the Consortium on the Genetics of Schizophrenia (COGS). All families included at least one affected subject and one unaffected sibling. Subjects met criteria for schizophrenia (probands; n = 293) or were unaffected first-degree siblings of those probands (n = 382). Paternal age at the time of subjects’ birth was documented. Subjects completed a comprehensive clinical assessment and a battery of tests that measured 16 endophenotypes. After controlling for covariates, potential paternal age–endophenotype associations were analyzed using one model that included probands alone and a second model that included both probands and unaffected siblings. Endophenotype deficits in the Identical Pairs version of the 4-digit Continuous Performance Test and in the Penn Computerized Neurocognitive Battery verbal memory test showed significant associations with paternal age. However, after correcting for multiple comparisons, no endophenotype was significantly associated with paternal age. These findings suggest that factors other than advanced paternal age at birth may account for endophenotypic deficit levels in schizophrenia

Deficient prepulse inhibition in schizophrenia detected by the multi-site COGS

BACKGROUND: Startle inhibition by weak prepulses (PPI) is studied to understand the biology of information processing in schizophrenia patients and healthy comparison subjects (HCS). The Consortium on the Genetics of Schizophrenia (COGS) identified associations between PPI and single nucleotide polymorphisms in schizophrenia probands and unaffected relatives, and linkage analyses extended evidence for the genetics of PPI deficits in schizophrenia in the COGS-1 family study. These findings are being extended in a 5-site “COGS-2” study of 1800 patients and 1200 unrelated HCS to facilitate genetic analyses. We describe a planned interim analysis of COGS-2 PPI data. METHODS: Eyeblink startle was measured in carefully screened HCS and schizophrenia patients (n=1402). Planned analyses of PPI (60 ms intervals) assessed effects of diagnosis, sex and test site, PPI-modifying effects of medications and smoking, and relationships between PPI and neurocognitive measures. RESULTS: 884 subjects met strict inclusion criteria. ANOVA of PPI revealed significant effects of diagnosis (p=0.0005) and sex (p<0.002), and a significant diagnosis × test site interaction. HCS > schizophrenia PPI differences were greatest among patients not taking 2(nd) generation antipsychotics, and were independent of smoking status. Modest but significant relationships were detected between PPI and performance in specific neurocognitive measures. DISCUSSION: The COGS-2 multi-site study detects schizophrenia-related PPI deficits reported in single-site studies, including patterns related to diagnosis, prepulse interval, sex, medication and other neurocognitive measures. Site differences were detected and explored. The target COGS-2 schizophrenia “endophenotype” of reduced PPI should prove valuable for identifying and confirming schizophrenia risk genes in future analyses