Contribution to the study of flocculation of digestate

The paper deals with the intensification of separating the solid phase of digestate using flocculants only. The separated solid phase should subsequently be used in agriculture for fertilising. Flocculants (polyacrylamides) are difficult to biodegrade. In this respect, they should not deteriorate the properties of the solid phase and the flocculant dose must be as low as possible. The research aimed to identify the optimal cationic flocculant and its application procedure which would enable a dosage that would be both economically and ecologically acceptable. We tested 21 cationic flocculants of different charge density and molecular weight and 1 mixture of two selected flocculants (Sokoflok 53 and Sokoflok 54) with the aim to discover the lowest possible dose of flocculating agent to achieve the effective aggregation of digestate particles. The lowest flocculant doses were obtained using the mixture of flocculants labelled Sokoflok 53 and Sokoflok 54 in 4:1 proportion, both of a low charge density and medium molecular weight, namely 14.54 g/kg of total solids for a digestate from the biogas plant Stonava and namely 11.80 g/kg of total solids for a digestate from the biogas plant Vrahovice. The findings also reveal that flocculation is most effective during two-stage flocculant dosing at different mixing time and intensity

Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin

Background. The Ouabain and Adducin for Specific Intervention on Sodium in Hypertension (OASIS-HT) Trial was a phase 2 dose-finding study of rostafuroxin, a digitoxygenin deivative, which selectively antagonizes the effects of endogenous ouabain (EO) on Na+,K+-ATPase and mutated adducin. Rostafuroxin lowered blood pressure (BP) in some animal models and in humans. Methods. OASIS-HT consisted of 5 concurrently running double-blind cross-over studies. After 4 weeks without treatment, 435 patients with uncomplicated systolic hypertension (140-169 mm Hg) were randomized to rostafuroxin (0.05, 0.15, 0.5, 1.5 or 5.0 mg/d) or matching placebo, each treatment period lasting 5 weeks. The primary endpoint was the reduction in systolic office BP. Among the secondary endpoints were diastolic office BP, 24 h ambulatory BP, plasma EO concentration and renin activity, 24-h urinary sodium and aldosterone excretion, and safety. ANOVA considered treatment sequence (fixed effect), subjects nested within sequence (random), period (fixed), and treatment (fixed). Results. Among 410 analyzable patients (40.5% women; mean age, 48.4 years), the differences in the primary endpoint (rostafuroxin minus placebo) ranged from -0.18 mm Hg (P=0.90) on 0.15 mg/d rostafuroxin to 2.72 mm Hg (P=0.04) on 0.05 mg/d. In the 5 dosage arms combined, the treatment effects averaged 1.30 mm Hg (P=0.03) for systolic office BP; 0.70 mm Hg (P=0.08) for diastolic office BP; 0.36 mm Hg (P=0.49) for 24-h systolic BP; and 0.05 mm Hg (P=0.88) for 24-h diastolic BP. In the 2 treatment groups combined, systolic (-1.36 mm Hg) and diastolic (-0.97 mm Hg) office BPs decreased from week 5 to 10 (P for period effect ≤=0.028), but carry-over effects were not significant (P≥=0.11). All other endpoints were not different on rostafuroxin and placebo. Minor side-effects occurred with similarly low frequency on rostafuroxin and placebo. Conclusions. In 5 concurrently running double-blind cross-over studies rostafuroxin did not reduce BP at any dose. Trial Registration: NCT00415038 http://www.clinicaltrials.gov)

Tools for Email Phishing Detection

Import 26/06/2013Cílem této bakalářské práce bylo vysvětlit problematiku a druhy počítačové kriminality, popsat forenzní analýzy dat při odhalování trestné činnosti a zajišťování důkazních prostředků. Analýza popisovaného problému proběhla na základě teoretických informací získaných z uvedených zdrojů. Návrh a implementace nástroje byly provedeny v jazyce C#. Vytvořený nástroj byl nasazen do zkušebního provozu na několika emailových účtech. Tento provoz ukázal, že nástroj lze úspěšně použít pro odhalení potencionální hrozby phishingu v elektronické poště z oblasti bankovnictví a odkazujících stránek.The aim of this bachelor thesis was to explain the problematic and types of cybercrime; also describe forensic data analysis in identification of crime and ensuring of evidence. Analysis of the problem was performed on the acquired theoretical information, design and implementation of a tool was performed in language C#. Created tool was deployed into trial operation on few email accounts. This operation showed that the instrument can be successfully used for detecting potential threats of phishing e-mails from banking area and referring pages.460 - Katedra informatikyvýborn

Modern Computer Attack Strategies and its Defence

Import 04/11/2015Cílem této diplomové práce bylo popsat moderní metody počítačových útoků, detekčních systémů a metod, které se používají pro obranu proti malwaru . Na základě získaných informací byla provedena analýza a návrh metody vhodné k detekci. Implementace nástroje byla provedena v jazyce C#. Navržený nástroj byl nasazen do zkušebního provozu. Pro účely testování byly nasazeny také škodlivé kódy simulující virové útoky. Kódy byly provedeny v jazyce C. Zkušební provoz tohoto nástroje ukázal, že metoda, která byla pro detekci použita je úspěšná při odhalování napadených spustitelných souborů, nebo dynamických knihoven.The aim of this thesis was to describe the modern methods of cyber attacks, detection systems and methods that are used for defense against malware. Based on information gathered was analyzed and draft methods suitable for detection. Instrument implementation was done in C # language. The proposed instrument was put into trial operation. For testing purposes, we were also deployed malicious codes simulating virus attacks. Codes were conducted in C. The trial operation of the instrument showed that the method was used for detection is successful in detecting infected executable files or dynamic-link libraries.460 - Katedra informatikydobř

Contribution To The Study Of Flocculation Of Digestate

The paper deals with the intensification of separating the solid phase of digestate using flocculants only. The separated solid phase should subsequently be used in agriculture for fertilising. Flocculants (polyacrylamides) are difficult to biodegrade. In this respect, they should not deteriorate the properties of the solid phase and the flocculant dose must be as low as possible. The research aimed to identify the optimal cationic flocculant and its application procedure which would enable a dosage that would be both economically and ecologically acceptable. We tested 21 cationic flocculants of different charge density and molecular weight and 1 mixture of two selected flocculants (Sokoflok 53 and Sokoflok 54) with the aim to discover the lowest possible dose of flocculating agent to achieve the effective aggregation of digestate particles. The lowest flocculant doses were obtained using the mixture of flocculants labelled Sokoflok 53 and Sokoflok 54 in 4:1 proportion, both of a low charge density and medium molecular weight, namely 14.54 g/kg of total solids for a digestate from the biogas plant Stonava and namely 11.80 g/kg of total solids for a digestate from the biogas plant Vrahovice. The findings also reveal that flocculation is most effective during two-stage flocculant dosing at different mixing time and intensity

Scenarios and their application in strategic planning

The article deals with the concept of scenario planning. Scenarios, as opposed to usual prediction methods, are focused on the identification of discontinuities in the development and help the organization cope with sudden changes and noticeably contribute to its survival. Contemporary methods of scenarios construction work on need to ensure flexibility of the strategic plan and get the firm ready for a quick reaction when set trigger points specifying the corresponding scenario come to pass. Processing of business environment information, known as Business Intelligence, becomes necessity. Based on the methodological platform, it describes in detail the stepwise process of scenario construction. The very process of scenario elaboration goes through six basic steps, Identification of risk factors and determination of their importance; Selection of key risks which, according to the company’s opinion, fundamentally influence fulfilment of strategic goals; Formulation of basic scenarios and testing their consistency; Determination of probability of scenarios occurrence and Performing a “gap analysis” for the sake of determining the extent of strategic goals fulfilment. There are various types of scenarios which might be respected due to the development of entrepreneurial environment introduced and discussed. Respecting the indicated risk factors and their influence on key risks of the financial plan, the spread of scenarios is being drafted. It is typical of business practice to work with 3–4 scenarios. Besides determining the impact of a risk on the firm’s performance (the rate of fulfilling set strategic goals), the probability assessment of each scenario is also necessary. Outputs from constructed scenarios are to be worked up into a particular strategic option, which may be used as a qualified base for the strategic decision- making process.The practical application shows how the methodology used raises flexibility in strategic planning of the firm

Long-term relationship between unattended automated blood pressure and auscultatory BP measurements in hypertensive patients

Aims: Unattended automated office blood pressure (uAutoOBP) has attracted more attention since SPRINT trial had been published. However, its long-term relationship to attended office blood pressure (AuscOBP) is not known. Material and methods: Stable treated hypertensive subjects were examined in four Czech academic hypertension centers. All subjects attended four clinical visits three months apart. uAutoOBP was measured with the BP Tru device; AuscOBP was measured three times with auscultatory method by the physician. 24-hour ambulatory blood pressure monitoring (ABPM) was performed within one week from the second clinical visit. Results: Data on 112 subjects aged 65.6 ± 10.8 years with mean AuscOBP 128.2 ± 12.2/78.5 ± 10.3 mm Hg are reported. Across the four clinical visits, the uAutoOBP was by 10.1/3.7 mm Hg lower than AuscOBP and the mean difference was similar during all four visits (P≥.061). Both uAutoOBP and AuscOBP had similar intra-individual variability during study follow-up as demonstrated by similar intraclass correlation coefficients (ICC, for systolic ICC = 0.50, for diastolic ICC = 0.72). However, the intra-individual variability of the systolic AuscOBP and uAutoOBP difference was high as demonstrated by low ICCs for absolute (ICC = 0.17 [95%CI, 0.09 – 0.25]) and low κ coefficients for categorized differences (κ ≤ 0.16). The main determinant of AuscOBP-uAutoOBP difference was AuscOBP level. The AuscOBP-uAutoOBP difference was poor tool to identify hypertension control categories defined on the basis of AuscOBP and ABPM. Conclusions: Although mean AuscOBP-uAutoOBP differences were relatively similar across the four clinical visits, intra-individual variability of this difference was high. The AuscOBP-uAutoOBP difference was poor tool to identify hypertension control categories defined on the basis of AuscOBP and ABPM. Therefore, uAutoOBP cannot be used as a replacement for ABPM