INTELLECTUAL ANALYTICAL GEOINFORMATION SYSTEM “EARTH SCIENCE DATA FOR THE TERRITORY OF RUSSIA”

The present study is aimed at the integration of data on geography, geology, geophysics, geoecology and other Earth sciences in the comprehensive problem-oriented geoinformation system (GIS) including the intellectual superstructure for geoinformation analysis. At the present time GIS provide only limited opportunities for general analysis of geodata handled. At the same time, among the scientific community, dealing with the Earth sciences data, the requirement of more profound and comprehensive data analyzing and processing is constantly growing. The theory and methods of artificial intellect (AI) must become not only an integral, but the main core of a modern GIS. The methods of fuzzy mathematics correlate with a fuzzy character of geophysical data. The AI methods, developed by the authors, and presently applied to volcanic activity monitoring, search and interpretation of anomalies in geophysical fields, solving environmental, geodynamic and other problems, turned out to be a success

Intellectual Geoinformation System for Earth Sciences

A new technology was elaborated, combining a geoinformation system (GIS) and GIS- oriented algorithmic methods of artificial intellect (AI). Numerous thematic layers for geosciences, obtained from Russian and international scientific sources, were imported into the GIS. Technology and software for integration of AI methods within the GIS in the form of the Centralized Catalogue of Geodata Processing Algorithms (CCGPA) was developed. A GIS visualization subsystem was created to provide interaction between the GIS and its users. It performs geodata layers visualization, map operations, geodata set management, execution of CCGPA-stored algorithms and representation of application results

Self-Government Bodies in Russia: Formation and Development Policies

The article aims at studying the legal nature and essence of local self-government bodies in the Russian Federation as exemplified by the theoretical and legal comprehension of the historical aspects of forming local self-government bodies. The article uses the methods of induction and systemic scientific analysis, as well as comparative-legal and historical methods. The authors of the article proved that the implementation of the principles of local self-government in the Russian state apparatus became effective since it is based on objective economic, political and social prerequisites and conditions. As a result, all cities and rural settlements became municipalities.Keywords: Local self-government; Constitution; Municipal authority; Municipal structure; Human rights. Badan Pemerintahan Lokal di Rusia: Kebijakan Pembentukan dan Pengembangan AbstrakArtikel ini bertujuan untuk mempelajari sifat hukum dan esensi dari badan-badan Pemerintahan Lokal di Federasi Rusia, sebagaimana yang dicontohkan oleh pemahaman teoretis dan hukum dari aspek-aspek sejarah pembentukan badan-badan pemerintahan lokal sendiri. Artikel ini menggunakan metode induksi dan analisis ilmiah sistemik, serta metode komparatif-hukum dan historis. Penulis artikel membuktikan bahwa penerapan prinsip-prinsip pemerintahan lokal sendiri di aparatur negara Rusia menjadi efektif karena didasarkan pada prasyarat dan kondisi ekonomi, politik dan sosial yang objektif. Akibatnya, semua kota dan pemukiman pedesaan menjadi kotamadya.Kata Kunci: Pemerintahan Daerah Lokal; Konstitusi; Otoritas Kota; Struktur Kota; Hak Asasi Manusia.Органы местного самоуправления в России: Политика формирования и развития АннотацияСтатья направлена на изучение правовой природы и сущности органов местного самоуправления в Российской Федерации на примере теоретико-правового осмысления исторических аспектов формирования органов местного самоуправления. В статье используются методы индукции и системного научного анализа, а также сравнительно-правовой и исторический методы. Автор статьи доказал, что реализация принципов местного самоуправления в российском государственном аппарате стала эффективной, поскольку основывается на объективных экономических, политических и социальных предпосылках и условиях. В результате все города и сельские поселения стали муниципалитетами.Ключевые слова: Местное самоуправление; Конституция; Муниципальная власть; Муниципальное устройство; Права человека

Liposomal quercetin potentiates maxi-K channel openings in smooth muscles and restores its activity after oxidative stress

© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. The effects of quercetin-loaded liposomes (PCL-Q) and their constituents, that is, free quercetin (Q) and ‘empty’ phosphatidylcholine vesicles (PCL), on maxi-K channel activity were studied in single mouse ileal myocytes before and after H 2 O 2 -induced oxidative stress. Macroscopic Maxi-K channel currents were recorded using whole-cell patch clamp techniques, while single BK Ca channel currents were recorded in the cell-attached configuration. Bath application of PCL-Q (100 μg/ml of lipid and 3 μg/ml of quercetin) increased single Maxi-K channel activity more than threefold, from 0.010 ± 0.003 to 0.034 ± 0.004 (n = 5; p \u3c 0.05), whereas single-channel conductance increased non-significantly from 138 to 146 pS. In the presence of PCL-Q multiple simultaneous channel openings were observed, with up to eight active channels in the membrane patch. Surprisingly, ‘empty’ PCL (100 μg/ml) also produced some channel activation, although it was less potent compared to PCL-Q, that is, these increased NPo from 0.010 ± 0.003 to 0.019 ± 0.003 (n = 5; p \u3c 0.05) and did not affect single-channel conductance (139 pS). Application of PCL-Q restored macroscopic Maxi-K currents suppressed by H 2 O 2 -induced oxidative stress in ileal smooth muscle cells. We conclude that PCL-Q can activate Maxi-K channels in ileal myocytes mainly by increasing channel open probability, as well as maintain Maxi-K-mediated whole-cell current under the conditions of oxidative stress. While fusion of the ‘pure’ liposomes with the plasma membrane may indirectly activate Maxi-K channels by altering channel’s phospholipids environment, the additional potentiating action of quercetin may be due to its better bioavailability

C\u3csub\u3e60\u3c/sub\u3e fullerenes selectively inhibit BK\u3csub\u3eCa\u3c/sub\u3e but not K\u3csub\u3ev\u3c/sub\u3e channels in pulmonary artery smooth muscle cells

© 2019 Elsevier Inc. Possessing unique physical and chemical properties, C60 fullerenes are arising as a potential nanotechnological tool that can strongly affect various biological processes. Recent molecular modeling studies have shown that C60 fullerenes can interact with ion channels, but there is lack of data about possible effects of C60 molecule on ion channels expressed in smooth muscle cells (SMC). Here we show both computationally and experimentally that water-soluble pristine C60 fullerene strongly inhibits the large conductance Ca2+-dependent K+ (BKCa), but not voltage-gated K+ (Kv) channels in pulmonary artery SMC. Both molecular docking simulations and analysis of single channel activity indicate that C60 fullerene blocks BKCa channel pore in its open state. In functional tests, C60 fullerene enhanced phenylephrine-induced contraction of pulmonary artery rings by about 25% and reduced endothelium-dependent acetylcholine-induced relaxation by up to 40%. These findings suggest a novel strategy for biomedical application of water-soluble pristine C60 fullerene in vascular dysfunction

Publisher Correction:Fuelling conditions at staging sites can mitigate Arctic warming effects in a migratory bird (Nature Communications, (2018), 9, 1, (4263), 10.1038/s41467-018-06673-5)

In the original HTML version of this Article, the order of authors within the author list was incorrect. The consortium VRS Castricum was incorrectly listed after Theunis Piersma and should have been listed after Cornelis J. Camphuysen. This error has been corrected in the HTML version of the Article; the PDF version was correct at the time of publication

Fuelling conditions at staging sites can mitigate Arctic warming effects in a migratory bird

Under climate warming, migratory birds should align reproduction dates with advancing plant and arthropod phenology. To arrive on the breeding grounds earlier, migrants may speed up spring migration by curtailing the time spent en route, possibly at the cost of decreased survival rates. Based on a decades-long series of observations along an entire flyway, we show that when refuelling time is limited, variation in food abundance in the spring staging area affects fitness. Bar-tailed godwits migrating from West Africa to the Siberian Arctic reduce refuelling time at their European staging site and thus maintain a close match between breeding and tundra phenology. Annual survival probability decreases with shorter refuelling times, but correlates positively with refuelling rate, which in turn is correlated with food abundance in the staging area. This chain of effects implies that conditions in the temperate zone determine the ability of godwits to cope with climate-related changes in the Arctic

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe