Simulation and modelling of the performance of radial turbochargers under unsteady flow

[ES] Está fuera de toda duda que la industria del automóvil está viviendo una profunda transformación que, durante los últimos años, ha progresado a un ritmo acelerado. Debido a la crecientemente estricta regulación sobre emisiones contaminantes y la necesidad de satisfacer la siempre creciente demanda de movilidad sostenible, es necesario que los motores de combustión modernos reduzcan su consumo y emisiones manteniendo el rendimiento del motor. Para enfrentarse a este desafío, los ingenieros de investigación y desarrollo han redoblado sus esfuerzos a la hora de diseñar y mejorar los modelos unidimensionales, hasta el punto en el que el desarrollo de modelos 1D así como la simulación juegan un papel fundamental en los primeras etapas de diseño de nuevos motores y tecnologías. Al mismo tiempo, la tecnología de turbosobrealimentación se ha consolidado como una de las más efectivas a la hora de construir motores de alta eficiencia, lo que ha hecho evidente la importancia de comprender y modelar correctamente los efectos asociados a los turbogrupos. Particularmente, los fenómenos que ocurren en la turbina en condiciones de flujo fuertemente pulsante han demostrado ser complicadas de modelar y sin embargo decisivas, ya que los códigos de simulación son especialmente útiles cuando son diseñados para trabajar en condiciones realistas. Este trabajo se centra en mejorar los modelos unidimensionales actuales así como en desarrollar nuevas soluciones con el objetivo de contribuir a una mejor predicción del comportamiento de la turbina sometida a condiciones de flujo pulsante. Tanto los esfuerzos realizados en los trabajos experimentales como en los de modelado se han producido para poder proporcionar métodos que sean fáciles de adaptar a las diferentes configuraciones de turbogrupo usadas en la industria, por ello, pueden ser aplicados por ejemplo en turbinas de entrada simple y también en las cada vez más usadas turbinas de entrada doble. En cuanto al trabajo de modelado en la parte de turbina de entrada simple, el foco se ha puesto en presentar una versión mejorada de un código quasi-2D. La validación del modelo se basa en los datos experimentales que están disponibles de trabajos enteriores de la literatura, proporcionando una comparación completa entre los modelos quasi-2D y el clásico modelo 1D. La presión a la entrada y salida de la turbina se ha descompuesto en ondas que viajan hacia delante y hacia atrás por medio de la descomposición de presiones, empleando la componente reflejada y transmitida para verificar la bondad del modelo. El trabajo experimental de esta tesis se centra en desarrollar un nuevo método para ensayar cualquier turbina de doble entrada sometida a condiciones de flujo fuertemente pulsante. La configuración del banco de gas se ha diseñado para ser suficientemente flexible como para realizar pulsos en las dos ramas de entrada por separado, así como para usar condiciones de flujo caliente o condiciones ambiente con mínimos cambios en la instalación. La campaña experimental se usa para validar un modelo integrado unidimensional de turbina tipo twin scroll con especial foco en las componentes reflejada y transmitida para analizar el desempeño del modelo su capacidad de predicción de la acústica no lineal. Finalmente, después de desarrollar el trabajo experimental y de modelado, se presenta un procedimiento para caracterizar el sonido y ruido de la turbina por medio de matrices de transferencia acústica que es comparado con el código unidimensional completo. En este sentido, el método proporciona una herramienta útil y fácil de implementar para simulaciones en tiempo real que aplica de una manera práctica el trabajo de modelado expuesto a lo largo de esta tesis.[CA] Està fora de tot dubte que la indústria de l'automòbil està vivint una profunda transformació que, durant els últims anys, ha progressat a un ritme accelerat. A causa de la creixentment estricta regulació sobre emissions contaminants i la necessitat de satisfer la sempre creixent demanda de mobilitat sostenible, és necessari que els motors de combustió moderns reduïsquen el seu consum i emissions mantenint el rendiment del motor. Per a enfrontar-se a aquest desafiament, els enginyers de recerca i desenvolupament han redoblat els seus esforços a l'hora de dissenyar i millorar els models unidimensionals, fins al punt en el qual el desenvolupament de models 1D així com la simulació juguen un paper fonamental en les primeres etapes de disseny de nous motors i tecnologies. Al mateix temps, la tecnologia de turbosobrealimentación s'ha consolidat com una de les més efectives a l'hora de construir motors d'alta eficiència, la qual cosa ha fet evident la importància de comprendre i modelar correctament els efectes associats als turbogrupos. Particularment, els fenòmens que ocorren en la turbina en condicions de flux fortament polsant han demostrat ser complicades de modelar i no obstant això decisives, ja que els codis de simulació són especialment útils quan són dissenyats per a treballar en condicions realistes. Aquest treball se centra en millorar els models unidimensionals actuals així com a desenvolupar noves solucions amb l'objectiu de contribuir a una millor predicció del comportament de la turbina sotmesa a condicions de flux polsant. Tant els esforços realitzats en els treballs experimentals com en els de modelatge s'han produït per a poder proporcionar mètodes que siguen fàcils d'adaptar a les diferents configuracions de turbogrupo usades en l'indústria, per això, poden ser aplicats per exemple en turbines d'entrada simple i també en les cada vegada més usades turbines d'entrada doble. Pel que fa al treball de modelatge en la part de turbina d'entrada simple, el focus s'ha posat a presentar una versió millorada d'un codi quasi-2D. La validació del model es basa en les dades experimentals que estan disponibles de treballs anteriors de la literatura, proporcionant una comparació completa entre els models quasi-2D i el clàssic model 1D. La pressió a l'entrada i eixida de la turbina s'ha descompost en ones que viatgen cap avant i cap enrere per mitjà de la descomposició de pressions, emprant la component reflectida i transmesa per a verificar la bondat del model. El treball experimental d'aquesta tesi se centra en desenvolupar un nou mètode per a assajar qualsevol turbina de doble entrada sotmesa a condicions de flux fortament pulsante. La configuració del banc de gas s'ha dissenyat per a ser prou flexible com per a realitzar polsos en les dues branques d'entrada per separat, així com per a usar condicions de flux calent o condicions ambient amb mínims canvis en la instal·lació. La campanya experimental s'usa per a validar un model integrat unidimensional de turbina tipus twin-scroll amb especial focus en les components reflectida i transmesa per a analitzar l'acompliment del model la seua capacitat de predicció de l'acústica no lineal. Finalment, després de desenvolupar el treball experimental i de modelatge, es presenta un procediment per a caracteritzar el so i soroll de la turbina per mitjà de matrius de transferència acústica que és comparat amb el codi unidimensional complet. En aquest sentit, el mètode proporciona una eina útil i fàcil d'implementar per a simulacions en temps real que aplica d'una manera pràctica el treball de modelatge exposat al llarg d'aquesta tesi.[EN] It is beyond all doubt that the automotive industry is living a deep transformation that, during the last years, has progressed at an ever accelerating rate. Due to the increasingly stringent pollutant emission regulations and the necessity to fulfil an ever growing demand for sustainable mobility, the modern internal combustion engines are required to strongly reduce the fuel consumption and emissions, while keeping the engine performance. In order to confront this challenge, engine research and development engineers have redoubled their efforts in designing and improving one-dimensional codes, to the point that the development of 1D models and simulation campaigns play a major role in the early steps of designing new engines or technologies. At the same time as the turbocharging technology has arisen as one of the most effective and extended solutions for building high efficient engines, the importance of understanding and modelling correctly the turbocharger effects has become evident. In particular, the phenomena that occurs in the turbine under highly pulsating conditions have proven to be challenging to model and yet decisive, as simulation codes are especially useful when they are designed to work under realistic conditions. This work focusses on the improvement of current one-dimensional models as well as in the development of new solutions with the aim of contributing to a better prediction of the turbine performance under pulsating conditions. Both experimental and modelling efforts have been made in order to provide methods that are easily adaptable to different turbocharger configurations used in the industry, so they can be applied for example in single turbines and also in the increasingly used two-scroll turbine technology. Regarding the modelling work of the single entry turbine part, the work has been focused in presenting an improved version of a quasi-2D code. The validation of the model is based on the experimental data available from previous works of the literature, providing a complete comparison between the quasi-2D and a classic 1D model. By means of a pressure decomposition, the pressure at the turbine inlet and outlet has been split into forward and backward travelling waves, employing the reflected and transmitted components to verify the goodness of the model. The experimental work of the thesis is centred in developing a new method in order to test any two-scroll turbine under highly pulsating flow conditions. The gas stand setup has been designed to be flexible enough to perform pulses in both inlet branches separately as well as to use hot or ambient conditions with minimal changes in the installation. The experimental campaign is used to fully validate an integrated 1D twin-scroll turbine model with special focus in the reflected and transmitted components for analysing the performance of the model and its non-linear acoustics prediction capabilities. Finally, after the experiment and modelling work is developed, a procedure to characterise the turbine sound and noise by means of acoustic transfer matrices is presented and tested against the fully one-dimensional code. In this sense, this method provides a useful and easily-implementable tool for fast and real time simulations that applies in a practical way the modelling work exposed along this thesis.Soler Blanco, P. (2020). Simulation and modelling of the performance of radial turbochargers under unsteady flow [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/141609TESI

Experimental validation of a quasi-two-dimensional radial turbine model

[EN] This article presents the experimental validation of a quasi-two-dimensional radial turbine model able to be used in turbocharged reciprocating internal combustion engine simulations. A passenger car variable-geometry turbine has been tested under steady and pulsating flow conditions, instrumented with multiple pressure probes, temperature sensors and mass flow sensors. Using the data obtained, a pressure decomposition has been performed. The pressure at the turbine inlet and outlet has been split into forward and backward travelling waves, employing the reflected and transmitted waves to verify the goodness of the model. The experimental results have been used to compare the quasi-two-dimensional radial turbine model as well as a classic one-dimensional model. The quasi-two-dimensional code presents a good degree of correlation with the experimental results, providing better results than the one-dimensional approach, especially when studying the high-frequency spectrum.Pablo Soler is partially supported through contract FPI-2017-S2-1428 of Programa de Apoyo para la Investigación y Desarrollo (PAID) of Universitat Politècnica de València. The authors of this paper wish to thank M.A. Ortiz and V. Ucedo for their invaluable work during the experimental setup and the campaign.Galindo, J.; Arnau Martínez, FJ.; García-Cuevas González, LM.; Soler-Blanco, P. (2018). Experimental validation of a quasi-two-dimensional radial turbine model. International Journal of Engine Research. https://doi.org/10.1177/1468087418788502SKesgin, U. (2005). Effect of turbocharging system on the performance of a natural gas engine. Energy Conversion and Management, 46(1), 11-32. doi:10.1016/j.enconman.2004.02.006Tang, H., Pennycott, A., Akehurst, S., & Brace, C. J. (2014). A review of the application of variable geometry turbines to the downsized gasoline engine. International Journal of Engine Research, 16(6), 810-825. doi:10.1177/1468087414552289Pesiridis, A. (2012). The application of active control for turbocharger turbines. International Journal of Engine Research, 13(4), 385-398. doi:10.1177/1468087411435205Romagnoli, A., & Martinez-Botas, R. (2011). Performance prediction of a nozzled and nozzleless mixed-flow turbine in steady conditions. International Journal of Mechanical Sciences, 53(8), 557-574. doi:10.1016/j.ijmecsci.2011.05.003Payri, F., Serrano, J. R., Fajardo, P., Reyes-Belmonte, M. A., & Gozalbo-Belles, R. (2012). A physically based methodology to extrapolate performance maps of radial turbines. Energy Conversion and Management, 55, 149-163. doi:10.1016/j.enconman.2011.11.003Costall, A. W., McDavid, R. M., Martinez-Botas, R. F., & Baines, N. C. (2010). Pulse Performance Modeling of a Twin Entry Turbocharger Turbine Under Full and Unequal Admission. Journal of Turbomachinery, 133(2). doi:10.1115/1.4000566De Bellis, V., & Marelli, S. (2015). One-dimensional simulations and experimental analysis of a wastegated turbine for automotive engines under unsteady flow conditions. Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering, 229(13), 1801-1816. doi:10.1177/0954407015571672Serrano, J. R., Olmeda, P., Páez, A., & Vidal, F. (2010). An experimental procedure to determine heat transfer properties of turbochargers. Measurement Science and Technology, 21(3), 035109. doi:10.1088/0957-0233/21/3/035109Burke, R. D., Copeland, C. D., Duda, T., & Rayes-Belmote, M. A. (2016). Lumped Capacitance and Three-Dimensional Computational Fluid Dynamics Conjugate Heat Transfer Modeling of an Automotive Turbocharger. Journal of Engineering for Gas Turbines and Power, 138(9). doi:10.1115/1.4032663Olmeda, P., Dolz, V., Arnau, F. J., & Reyes-Belmonte, M. A. (2013). Determination of heat flows inside turbochargers by means of a one dimensional lumped model. Mathematical and Computer Modelling, 57(7-8), 1847-1852. doi:10.1016/j.mcm.2011.11.078Serrano, J., Olmeda, P., Arnau, F., Reyes-Belmonte, M., & Lefebvre, A. (2013). Importance of Heat Transfer Phenomena in Small Turbochargers for Passenger Car Applications. SAE International Journal of Engines, 6(2), 716-728. doi:10.4271/2013-01-0576Aghaali, H., Ångström, H.-E., & Serrano, J. R. (2014). Evaluation of different heat transfer conditions on an automotive turbocharger. International Journal of Engine Research, 16(2), 137-151. doi:10.1177/1468087414524755Serrano, J. R., Olmeda, P., Tiseira, A., García-Cuevas, L. M., & Lefebvre, A. (2013). Theoretical and experimental study of mechanical losses in automotive turbochargers. Energy, 55, 888-898. doi:10.1016/j.energy.2013.04.042Serrano, J. R., Olmeda, P., Tiseira, A., García-Cuevas, L. M., & Lefebvre, A. (2013). Importance of Mechanical Losses Modeling in the Performance Prediction of Radial Turbochargers under Pulsating Flow Conditions. SAE International Journal of Engines, 6(2), 729-738. doi:10.4271/2013-01-0577Galindo, J., Fajardo, P., Navarro, R., & García-Cuevas, L. M. (2013). Characterization of a radial turbocharger turbine in pulsating flow by means of CFD and its application to engine modeling. Applied Energy, 103, 116-127. doi:10.1016/j.apenergy.2012.09.013Hakeem, I., Su, C.-C., Costall, A., & Martinez-Botas, R. F. (2007). Effect of volute geometry on the steady and unsteady performance of mixed-flow turbines. Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy, 221(4), 535-549. doi:10.1243/09576509jpe314Hu X. An advanced turbocharger model for the internal combustion engine. PhD Thesis, Purdue University, West Lafayette, IN, 2000.King A. A turbocharger unsteady performance model for the GT-power internal combustion engine simulation. PhD Thesis, Purdue University, West Lafayette, IN, 2000.Rajoo, S., & Martinez-Botas, R. (2008). Variable Geometry Mixed Flow Turbine for Turbochargers: An Experimental Study. International Journal of Fluid Machinery and Systems, 1(1), 155-168. doi:10.5293/ijfms.2008.1.1.155Serrano, J. R., Tiseira, A., García-Cuevas, L. M., Inhestern, L. B., & Tartoussi, H. (2017). Radial turbine performance measurement under extreme off-design conditions. Energy, 125, 72-84. doi:10.1016/j.energy.2017.02.118Torregrosa, A. J., Broatch, A., Navarro, R., & García-Tíscar, J. (2014). Acoustic characterization of automotive turbocompressors. International Journal of Engine Research, 16(1), 31-37. doi:10.1177/1468087414562866Leufvén, O., & Eriksson, L. (2014). Measurement, analysis and modeling of centrifugal compressor flow for low pressure ratios. 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Same-day SARS-CoV-2 antigen test screening in an indoor mass-gathering live music event: a randomised controlled trial

Background The banning of mass-gathering indoor events to prevent SARS-CoV-2 spread has had an important effect on local economies. Despite growing evidence on the suitability of antigen-detecting rapid diagnostic tests (Ag-RDT) for mass screening at the event entry, this strategy has not been assessed under controlled conditions. We aimed to assess the effectiveness of a prevention strategy during a live indoor concert. Methods We designed a randomised controlled open-label trial to assess the effectiveness of a comprehensive preventive intervention for a mass-gathering indoor event (a live concert) based on systematic same-day screening of attendees with Ag-RDTs, use of facial masks, and adequate air ventilation. The event took place in the Sala Apolo, Barcelona, Spain. Adults aged 18–59 years with a negative result in an Ag-RDT from a nasopharyngeal swab collected immediately before entering the event were randomised 1:1 (block randomisation stratified by age and gender) to either attend the indoor event for 5 hours or go home. Nasopharyngeal specimens used for Ag-RDT screening were analysed by real-time reverse-transcriptase PCR (RT-PCR) and cell culture (Vero E6 cells). 8 days after the event, a nasopharyngeal swab was collected and analysed by Ag-RDT, RT-PCR, and a transcription-mediated amplification test (TMA). The primary outcome was the difference in incidence of RT-PCR-confirmed SARS-CoV-2 infection at 8 days between the control and the intervention groups, assessed in all participants who were randomly assigned, attended the event, and had a valid result for the SARS-CoV-2 test done at follow-up. The trial is registered at ClinicalTrials.gov, NCT04668625. Findings Participant enrollment took place during the morning of the day of the concert, Dec 12, 2020. Of the 1140 people who responded to the call and were deemed eligible, 1047 were randomly assigned to either enter the music event (experimental group) or continue with normal life (control group). Of the 523 randomly assigned to the experimental group, 465 were included in the analysis of the primary outcome (51 did not enter the event and eight did not take part in the follow-up assessment), and of the 524 randomly assigned to the control group, 495 were included in the final analysis (29 did not take part in the follow-up). At baseline, 15 (3%) of 495 individuals in the control group and 13 (3%) of 465 in the experimental group tested positive on TMA despite a negative Ag-RDT result. The RT-PCR test was positive in one case in each group and cell viral culture was negative in all cases. 8 days after the event, two (<1%) individuals in the control arm had a positive Ag-RDT and PCR result, whereas no Ag-RDT nor RT-PCR positive results were found in the intervention arm. The Bayesian estimate for the incidence between the experimental and control groups was –0·15% (95% CI –0·72 to 0·44). Interpretation Our study provides preliminary evidence on the safety of indoor mass-gathering events during a COVID-19 outbreak under a comprehensive preventive intervention. The data could help restart cultural activities halted during COVID-19, which might have important sociocultural and economic implications.Primavera Sound Group and the #YoMeCorono InitiativePeer ReviewedPostprint (author's final draft

Tuning branching in ceria nanocrystals

Branched nanocrystals (NCs) enable high atomic surface exposure within a crystalline network that provides avenues for charge transport. This combination of properties makes branched NCs particularly suitable for a range of applications where both interaction with the media and charge transport are involved. Herein we report on the colloidal synthesis of branched ceria NCs by means of a ligand-mediated overgrowth mechanism. In particular, the differential coverage of oleic acid as an X-type ligand at ceria facets with different atomic density, atomic coordination deficiency, and oxygen vacancy density resulted in a preferential growth in the [111] direction and thus in the formation of ceria octapods. Alcohols, through an esterification alcoholysis reaction, promoted faster growth rates that translated into nanostructures with higher geometrical complexity, increasing the branch aspect ratio and triggering the formation of side branches. On the other hand, the presence of water resulted in a significant reduction of the growth rate, decreasing the reaction yield and eliminating side branching, which we associate to a blocking of the surface reaction sites or a displacement of the alcoholysis reaction. Overall, adjusting the amounts of each chemical, well-defined branched ceria NCs with tuned number, thickness, and length of branches and with overall size ranging from 5 to 45 nm could be produced. We further demonstrate that such branched ceria NCs are able to provide higher surface areas and related oxygen storage capacities (OSC) than quasi-spherical NCs

Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when = 50 years and symptomatic for <= 7days were included. The intervention consisted of 200-300mL of CP with a predefined minimum level of antibodies. Primary endpoints were a 5-point disease severity scale and a composite of hospitalization or death by 28 days. Amongst the 797 patients included, 390 received CP and 392 placebo; they had a median age of 58 years, 1 comorbidity, 5 days symptoms and 93% had negative IgG antibody-test. Seventy-four patients were hospitalized, 6 required mechanical ventilation and 3 died. The odds ratio (OR) of CP for improved disease severity scale was 0.936 (credible interval (CI) 0.667-1.311); OR for hospitalization or death was 0.919 (CI 0.592-1.416). CP effect on hospital admission or death was largest in patients with <= 5 days of symptoms (OR 0.658, 95%CI 0.394-1.085). CP did not decrease the time to full symptom resolution

Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

publishersversionPeer reviewe

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe