Recerca i immigració VII : migracions dels segles XX i XXI: una mirada candeliana

Aquest volum recull les aportacions d'estudiosos vinculats principalment al Centre d'Estudis Demogràfics (CED) de la Universitat Autònoma de Barcelona. De fet, es basa en les ponències presentades al Museu d'Història de Catalunya el 17 de desembre de 2014 dins la jornada «Migracions dels segles XX i XXI a Catalunya. Una mirada candeliana. Anàlisi sociodemogràfica», organitzada pel CED, la Fundació Paco Candel i la Direcció General per a la Immigració del Departament de Benestar Social i Família

Transient exposure to miR-203 expands the differentiation capacity of pluripotent stem cells

Full differentiation potential along with self‐renewal capacity is a major property of pluripotent stem cells (PSCs). However, the differentiation capacity frequently decreases during expansion of PSCs in vitro . We show here that transient exposure to a single microRNA, expressed at early stages during normal development, improves the differentiation capacity of already‐established murine and human PSCs. Short exposure to miR‐203 in PSCs (mi PSCs) induces a transient expression of 2C markers that later results in expanded differentiation potency to multiple lineages, as well as improved efficiency in tetraploid complementation and human–mouse interspecies chimerism assays. Mechanistically, these effects are at least partially mediated by direct repression of de novo DNA methyltransferases Dnmt3a and Dnmt3b, leading to transient and reversible erasure of DNA methylation. These data support the use of transient exposure to miR‐203 as a versatile method to reset the epigenetic memory in PSCs, and improve their effectiveness in regenerative medicine

New logics of Integration in European Security and Defence Policy: Change in Conflict-Resolution Mechanisms in the Intergovernmental Decision-Making Process.

The EU is undertaking important developments in the area of European security without asserting new fundamental goals. This paper proposes a conceptualisation of new logics of integration in the ESDP, by focusing on the transformation of conflict-resolution mechanisms in the adoption and implementation of policy provisions in the area. I argue that since 1998, pressing external events have led to an integrative policy change in the area of European security, manifest in an increasing use of expert incrementalist methods within the intergovernmental framework of the EU. The urgency of collective decisions adopted in substantive negotiations at a high political level combines with the incrementalist “filling-in” in the operational phase. While bargaining is highly determinant in the adoption of key compromises, the operational phase has become infused with administrative management and expert consultation, corresponding with the proliferation of newly created specialized agencies and think tanks, thus creating dynamics for the introduction of novel program specifications. Integrative outcomes are manifest in the progress in military operational capacity, the actual accomplishment of EU-based “Petersberg” operations, the focus on a more pragmatic understanding of the relationship with NATO and the proposals for coordination and flexibility envisaged in the draft of the Constitutional Treaty. The focus on conflict-resolution mechanisms provides theoretical determinants to explain integration logics in the ESDP, as a process of development of practical goals