Organocatalytic enantioselective Friedel-Crafts alkylation of 1-naphthol derivatives and activated phenols with ethyl trifluoropyruvate

An organocatalytic enantioselective Friedel-Crafts alkylation of a series of substituted 1‐naphthol derivatives and activated phenols with ethyl trifluoropyruvate, catalyzed by a quinine‐derived squaramide, is presented. Good yields and high to excellent enantioselectivities of the Friedel-Crafts alkylation products were obtained

Refoldable Foldamers:Global Conformational Switching by Deletion or Insertion of a Single Hydrogen Bond

Small changes in the structure of a foldamer may lead to gross changes in conformational preference. We show that the simple insertion or deletion of a single hydrogen bond by changes in pH or by photochemical deprotection is sufficient to refold a helical oligomer, interconverting M and P screw‐sense preference. As a consequence of the switch, information may be transmitted to a remote catalytic site, selectively directing the formation of either of two enantiomeric products by a reaction involving 1,22‐remote intermolecular asymmetric induction

ドッキョウ イカ ダイガク コシガヤ ビョウイン キョウショクイン ニオケル ケンコウ シンダン ノ ゲンジョウ ト コンゴ ノ カダイ : ヘイセイ 18 ネンド データ カイセキ ニ ツイテ

獨協医科大学越谷病院に勤務する教職員を対象に,平成18年度健康診断受診率および健康診断結果を全国平均と比較し,現状と今後の課題について検討した.胸部レントゲン検査,血圧,尿検査,心電図検査,聴力検査では要精検率が全国平均を下回ったが,男性では血中脂質,女性では貧血の項目で全国平均を上回る者が多くみられた.その要因としては,運動不足や食生活などの生活習慣の問題があると考えられ,それらの改善が必要であると推測された.To clarify actual and near future health concerns, a study was performed on the faculty and staff of Dokkyo Medical University, Koshigaya Hospital, Japan, in 2006. Chest x-ray, blood pressure, proteinuria and urine sugar, ECG (electrocardiogram), and aural test results indicated a lower percentage of abnormality when compared with the general population of Japan. A high level of hyperlipidemia in males and anemia in females was recognized in the data, especially for those past the age of fifty. It can be speculated that a change in life style is necessary, for example improvement of our dietary habits and making up for the lack of proper exercise, in order to maintain good health