2,098 research outputs found
Limited effects of the maternal rearing environment on the behaviour and fitness of an insect herbivore and its natural enemy
The maternal rearing environment can affect offspring fitness or phenotype indirectly via âmaternal effectsâ and can also influence a motherâs behaviour and fecundity directly. However, it remains uncertain how the effects of the maternal rearing environment cascade through multiple trophic levels, such as in plant-insect herbivore-natural enemy interactions. Pea aphids (Acyrthosiphon pisum) show differential fitness on host legume species, while generalist aphid parasitoids can show variable fitness on different host aphid species, suggesting that maternal effects could operate in a plant-aphid-parasitoid system. We tested whether the maternal rearing environment affected the behaviour and fitness of aphids by rearing aphids on two plant hosts that were either the same as or different from those experienced by the mothers. A similar approach was used to test the behaviour and fitness of parasitoid wasps in response to maternal rearing environment. Here, the host environment was manipulated at the plant or plant and aphid trophic levels for parasitoid wasps. We also quantified the quality of host plants for aphids and host aphids for parasitoid wasps. In choice tests, aphids and parasitoid wasps had no preference for the plant nor plant and aphid host environment on which they were reared. Aphid offspring experienced 50.8% higher intrinsic rates of population growth, 43.4% heavier offspring and lived 14.9% longer when feeding on bean plants compared to aphids feeding on pea plants, with little effect of the maternal rearing environment. Plant tissue nitrogen concentration varied by 21.3% in response to aphid mothersâ rearing environment, and these differences correlated with offspring fitness. Maternal effects in parasitoid wasps were only observed when both the plant and aphid host environment was changed: wasp offspring were heaviest by 10.9â73.5% when both they and their mothers developed in bean-reared pea aphids. Also, parasitoid wasp fecundity was highest by 38.4% when offspring were oviposited in the maternal rearing environment. These findings indicate that maternal effects have a relatively small contribution towards the outcome of plant-aphid-parasitoid interactions
Detection of skewed X-chromosome inactivation in Fragile X syndrome and X chromosome aneuploidy using quantitative melt analysis.
Methylation of the fragile X mental retardation 1 (FMR1) exon 1/intron 1 boundary positioned fragile X related epigenetic element 2 (FREE2), reveals skewed X-chromosome inactivation (XCI) in fragile X syndrome full mutation (FM: CGGÂ >Â 200) females. XCI skewing has been also linked to abnormal X-linked gene expression with the broader clinical impact for sex chromosome aneuploidies (SCAs). In this study, 10 FREE2 CpG sites were targeted using methylation specific quantitative melt analysis (MS-QMA), including 3 sites that could not be analysed with previously used EpiTYPER system. The method was applied for detection of skewed XCI in FM females and in different types of SCA. We tested venous blood and saliva DNA collected from 107 controls (CGGÂ <Â 40), and 148 FM and 90 SCA individuals. MS-QMA identified: (i) most SCAs if combined with a Y chromosome test; (ii) locus-specific XCI skewing towards the hypomethylated state in FM females; and (iii) skewed XCI towards the hypermethylated state in SCA with 3 or more X chromosomes, and in 5% of the 47,XXY individuals. MS-QMA output also showed significant correlation with the EpiTYPER reference method in FM males and females (PÂ <Â 0.0001) and SCAs (PÂ <Â 0.05). In conclusion, we demonstrate use of MS-QMA to quantify skewed XCI in two applications with diagnostic utility
The effect of virtual reality on visual vertigo symptoms in patients with peripheral vestibular dysfunction: a pilot study
Individuals with vestibular dysfunction may experience visual vertigo (VV), in which symptoms are provoked or exacerbated by excessive or disorientating visual stimuli (e.g. supermarkets). VV can significantly improve when customized vestibular rehabilitation exercises are combined with exposure to optokinetic stimuli. Virtual reality (VR), which immerses patients in realistic, visually challenging environments, has also been suggested as an adjunct to VR to improve VV symptoms. This pilot study compared the responses of sixteen patients with unilateral peripheral vestibular disorder randomly allocated to a VR regime incorporating exposure to a static (Group S) or dynamic (Group D) VR environment. Participants practiced vestibular exercises, twice weekly for four weeks, inside a static (Group S) or dynamic (Group D) virtual crowded square environment, presented in an immersive projection theatre (IPT), and received a vestibular exercise program to practice on days not attending clinic. A third Group D1 completed both the static and dynamic VR training. Treatment response was assessed with the Dynamic Gait Index and questionnaires concerning symptom triggers and psychological state. At final assessment, significant betweengroup differences were noted between Groups D (p = 0.001) and D1 (p = 0.03) compared to Group S for VV symptoms with the former two showing a significant 59.2% and 25.8% improvement respectively compared to 1.6% for the latter. Depression scores improved only for Group S (p = 0.01) while a trend towards significance was noted for Group D regarding anxiety scores (p = 0.07). Conclusion: Exposure to dynamic VR environments should be considered as a useful adjunct to vestibular rehabilitation programs for patients with peripheral vestibular disorders and VV symptoms
Duality for Finite Multiple Harmonic q-Series
We define two finite q-analogs of certain multiple harmonic series with an
arbitrary number of free parameters, and prove identities for these q-analogs,
expressing them in terms of multiply nested sums involving the Gaussian
binomial coefficients. Special cases of these identities--for example, with all
parameters equal to 1--have occurred in the literature. The special case with
only one parameter reduces to an identity for the divisor generating function,
which has received some attention in connection with problems in sorting
theory. The general case can be viewed as a duality result, reminiscent of the
duality relation for the ordinary multiple zeta function.Comment: 12 pages AMSLaTeX. Submitted for publication October 26, 2003;
revised September 14, 2004. New title reflects change in emphasis and new
section devoted to connections with inverse pairs and Hoffman duality.
References added and typos correcte
Price Discovery and the Accuracy of Consolidated Data Feeds in the U.S. Equity Markets
Both the scientific community and the popular press have paid much attention
to the speed of the Securities Information Processor, the data feed
consolidating all trades and quotes across the US stock market. Rather than the
speed of the Securities Information Processor, or SIP, we focus here on its
accuracy. Relying on Trade and Quote data, we provide various measures of SIP
latency relative to high-speed data feeds between exchanges, known as direct
feeds. We use first differences to highlight not only the divergence between
the direct feeds and the SIP, but also the fundamental inaccuracy of the SIP.
We find that as many as 60 percent or more of trades are reported out of
sequence for stocks with high trade volume, therefore skewing simple measures
such as returns. While not yet definitive, this analysis supports our
preliminary conclusion that the underlying infrastructure of the SIP is
currently unable to keep pace with the trading activity in today's stock
market.Comment: 18 pages, 20 figures, 2 table
Assessment and optimisation of STCA performance: Using the Pareto optimal receiver operating characteristic
EUROCONTROL Annual Safety R&D Seminar (2008), Southampton, UK, 22-24 October 2008Short Term Conflict Alert (STCA) systems are complex software programs, with many parameters that must be adjusted to achieve best performance. We describe a simple evolutionary algorithm for optimising the trade-off between wanted alerts and nuisance alerts. The procedure yields an estimate of the Pareto optimal Receiver Operating Characteristic for the STCA system and we discuss additional uses of this for characterising and comparing the performance of STCA systems and airspaces
An integrated carbon and oxygen isotope approach to reconstructing past environmental variability in the northeast Atlantic Ocean
The combined influence of temperature and the isotopic composition of the seawater (δ18Ow) often precludes the use of oxygen isotope (δ18O) records, derived from marine carbonates, to reconstruct absolute seawater temperatures, without the application of an independent δ18Ow proxy. Here we investigate the application of carbon isotope records (δ13Cshell), derived from the long-lived marine bivalve Glycymeris glycymeris, as a proxy for δ18Ow variability. Our analyses indicate G. glycymeris δ13Cshell data derived from growth increments >20âŻyears of age contain strong ontogenetic trends (â0.013â° yrâ1, RâŻ=âŻ0.98, PâŻ<âŻ0.001, NâŻ=âŻ51). These analyses demonstrate that, coupled with the ontogenetic trends, 54% of the variability in G. glycymeris δ13Cshell records can be explained by a combination of the marine Suess effect and physical (salinity and riverine input) and biological processes (primary production). The application of these δ13Cshell data in conjunction with co-registered δ18Oshell and growth increment width series, each of which have been shown to be sensitive to seawater temperature and primary productivity respectively, can therefore provide new insights into past environmental variability and help constrain uncertainties on reconstructions of past seawater temperature variability
On the Metric Dimension of Cartesian Products of Graphs
A set S of vertices in a graph G resolves G if every vertex is uniquely
determined by its vector of distances to the vertices in S. The metric
dimension of G is the minimum cardinality of a resolving set of G. This paper
studies the metric dimension of cartesian products G*H. We prove that the
metric dimension of G*G is tied in a strong sense to the minimum order of a
so-called doubly resolving set in G. Using bounds on the order of doubly
resolving sets, we establish bounds on G*H for many examples of G and H. One of
our main results is a family of graphs G with bounded metric dimension for
which the metric dimension of G*G is unbounded
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