25 research outputs found
Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature
Can Aortic Elastic Parameters be Used for the Diagnosis of Volume Overload in Patients with End Stage Renal Disease
Band-edge modifications due to photogenerated carriers in single p-type delta-doped GaAs layers
The photogenerated carrier-induced band-edge modifications of beryllium single delta-doped GaAs layers com comprising a two-dimensional hole gas (2DHG) were investigated by means of photoluminescence, selective photoluminescence, and photoluminescence excitation spectroscopies. The results show direct evidence for a photoinduced electron confinement effect, which strongly enhances the radiative-recombination probability between electrons and holes of the 2DHG at low temperatures,5974634463
Impact of antibiotic resistance on outcomes of neutropenic cancer patients with Pseudomonas aeruginosa bacteraemia (IRONIC study) : Study protocol of a retrospective multicentre international study
Introduction Pseudomonas aeruginosa (PA) has historically been one of the major causes of severe sepsis and death among neutropenic cancer patients. There has been a recent increase of multidrug-resistant PA (MDRPA) isolates that may determine a worse prognosis, particularly in immunosuppressed patients. The aim of this study is to establish the impact of antibiotic resistance on the outcome of neutropenic onco-haematological patients with PA bacteraemia, and to identify the risk factors for MDRPA bacteraemia and mortality. Methods and analysis This is a retrospective, observational, multicentre, international study. All episodes of PA bacteraemia occurring in neutropenic onco-haematological patients followed up at the participating centres from 1 January 2006 to 31 May 2018 will be retrospectively reviewed. The primary end point will be overall case-fatality rate within 30 days of onset of PA bacteraemia. The secondary end points will be to describe the following: the incidence and risk factors for multidrug-resistant and extremely drug-resistant PA bacteraemia (by comparing the episodes due to susceptible PA with those produced by MDRPA), the efficacy of ceftolozane/tazobactam, the rates of persistent bacteraemia and bacteraemia relapse and the risk factors for very early (48 hours), early (7 days) and overall (30 days) case-fatality rates. Ethics and dissemination The Clinical Research Ethics Committee of Bellvitge University Hospital approved the protocol of the study at the primary site. To protect personal privacy, identifying information of each patient in the electronic database will be encrypted. The processing of the patients' personal data collected in the study will comply with the Spanish Data Protection Act of 1998 and with the European Directive on the privacy of data. All data collected, stored and processed will be anonymised. Results will be reported at conferences and in peer-reviewed publications
Is the severity of glomerular igg staining in patient with iga nephropathy useful for predicting poor renal prognosis? The data from tsn-gold working group
in Turkey: the data from TSN-GOLD Working Group
Purpose Hematuria is one of the most common laboratory findings in nephrology practice. To date, there is no enough data regarding the clinical and histopathologic characteristics of primary glomerular disease (PGD) patients with hematuria in our country. Methods Data were obtained from national multicenter (47 centers) data entered into the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) database between May 2009 and June 2019. The data of all PGD patients over the age of 16 years who were diagnosed with renal biopsy and had hematuria data were included in the study. Demographic characteristics, laboratory and biopsy findings were also recorded. Results Data of 3394 PGD patients were included in the study. While 1699 (50.1%) patients had hematuria, 1695 (49.9%) patients did not have hematuria. Patients with hematuria had statistically higher systolic blood pressure, serum blood urea nitrogen, creatinine, albumin, levels and urine pyuria. However, these patients had statistically lower age, body mass index, presence of hypertension and diabetes, eGFR, 24-h proteinuria, serum total, HDL and LDL cholesterol, and C3 levels when compared with patients without hematuria. Hematuria was present 609 of 1733 patients (35.8%) among the patients presenting with nephrotic syndrome, while it was presented in 1090 of 1661 (64.2%) patients in non-nephrotics (p < 0.001). Conclusion This is the first multicenter national report regarding the demographic and histopathologic data of PGD patients with or without hematuria. Hematuria, a feature of nephritic syndrome, was found at a higher than expected in the PGDs presenting with nephrotic syndrome in our national database.C1 [Sumnu, Abdullah] Medipol Univ, Med Fac, Dept Nephrol, Medipol Mega Hastanesi, Goztepe Mahallesi Metin Sk 4, Istanbul, Turkey.[Turkmen, Kultigin] Necmettin Erbakan Univ, Meram Med Fac, Nephrol, Konya, Turkey.[Cebeci, Egemen; Uzun, Sami; Ozturk, Savas] Haseki Training & Res Hosp, Nephrol, Istanbul, Turkey.[Turkmen, Aydin] Istanbul Univ, Istanbul Med Fac, Nephrol, Istanbul, Turkey.[Eren, Necmi; Ergul, Metin] Kocaeli Univ, Nephrol Med Fac, Kocaeli, Turkey.[Seyahi, Nurhan; Dincer, Mevlut Tamer] Istanbul Univ, Cerrahpasa Med Fac, Nephrol, Istanbul, Turkey.[Oruc, Aysegul; Gullulu, Mustafa] Uludag Univ, Med Fac, Nephrol, Bursa, Turkey.[Dede, Fatih; Piskinpasa, Serhan] Ankara Numune Training & Res Hosp, Nephrol, Ankara, Turkey.[Derici, Ulver; Akcay, Omer Faruk] Gazi Univ, Med Fac, Nephrol, Ankara, Turkey.[Basturk, Taner; Unsal, Abdulkadir] Hamidiye Sisli Etfal Training & Res Hosp, Nephrol, Istanbul, Turkey.[Sahin, Garip] Eskisehir Osmangazi Univ, Med Fac, Nephrol, Eskisehir, Turkey.[Sipahioglu, Murat; Koyuncu, Sumeyra] Erciyes Univ, Med Fac, Nephrol, Kayseri, Turkey.[Sahin, Gulizar Manga; Gok, Mahmut] Sultan Abdulhamit Han Res & Training Hosp, Nephrol, Istanbul, Turkey.[Tatar, Erhan] Bozyaka Training & Res Hosp, Nephrol, Izmir, Turkey.[Dursun, Belda] Pamukkale Univ, Med Fac, Nephrol, Denizli, Turkey.[Sipahi, Savas] Sakarya Univ, Med Fac, Nephrol, Sakarya, Turkey.[Yilmaz, Murvet] Bakirkoy Sadi Konuk Training & Res Hosp, Nephrol, Istanbul, Turkey.[Suleymanlar, Gultekin] Akdeniz Univ, Med Fac, Nephrol, Antalya, Turkey.[Ulu, Sena] Afyon Kocatepe Univ, Med Fac, Nephrol, Afyon, Turkey.[Gungor, Ozkan] Sutcu Imam Univ, Med Fac, Nephrol, Kahramanmaras, Turkey.[Kutlay, Sim] Ankara Univ, Ibni Sina Hosp, Med Fac, Nephrol, Ankara, Turkey.[Bahcebasi, Zerrin Bicik] Dr Lutfi Kirdar Kartal Training & Res Hosp, Nephrol, Istanbul, Turkey.[Sahin, Idris] Inonu Univ, Med Fac, Nephrol, Malatya, Turkey.[Kurultak, Ilhan] Trakya Univ, Med Fac, Nephrol, Edirne, Turkey.[Sevinc, Can] Ataturk Univ, Med Fac, Nephrol, Erzurum, Turkey.[Yilmaz, Zulfikar] Dicle Univ, Diyarbakir, Turkey.[Kazancioglu, Rumeyza Turan] Bezmialem Vakif Univ, Med Fac, Nephrol, Istanbul, Turkey.[Cavdar, Caner] Dokuz Eylul Univ, Med Fac, Nephrol, Izmir, Turkey.[Candan, Ferhan] Cumhuriyet Univ, Med Fac, Nephrol, Sivas, Turkey.[Aydin, Zeki] Darica Farabi Training & Res Hosp, Nephrol, Kocaeli, Turkey.[Oygar, Deren] Burhan Nalbantoglu State Hosp, Nephrol, Nicosia, Cyprus.[Gul, Bulent] Bursa Yuksek Ihtisas Training & Res Hosp, Nephrol, Bursa, Turkey.[Altun, Bulent] Hacettepe Univ, Med Fac, Nephrol, Ankara, Turkey.[Paydas, Saime] Cukurova Univ, Med Fac, Nephrol, Adana, Turkey.[Istemihan, Zulal] Istanbul Univ, Istanbul Med Fac, Internal Med, Istanbul, Turkey
LID - 10.1007/s11255-020-02690-w [doi]
PURPOSE: Hematuria is one of the most common laboratory findings in nephrology practice. To date, there is no enough data regarding the clinical and histopathologic characteristics of primary glomerular disease (PGD) patients with hematuria in our country. METHODS: Data were obtained from national multicenter (47 centers) data entered into the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) database between May 2009 and June 2019. The data of all PGD patients over the age of 16 years who were diagnosed with renal biopsy and had hematuria data were included in the study. Demographic characteristics, laboratory and biopsy findings were also recorded. RESULTS: Data of 3394 PGD patients were included in the study. While 1699 (50.1%) patients had hematuria, 1695 (49.9%) patients did not have hematuria. Patients with hematuria had statistically higher systolic blood pressure, serum blood urea nitrogen, creatinine, albumin, levels and urine pyuria. However, these patients had statistically lower age, body mass index, presence of hypertension and diabetes, eGFR, 24-h proteinuria, serum total, HDL and LDL cholesterol, and C3 levels when compared with patients without hematuria. Hematuria was present 609 of 1733 patients (35.8%) among the patients presenting with nephrotic syndrome, while it was presented in 1090 of 1661 (64.2%) patients in non-nephrotics (p < 0.001). CONCLUSION: This is the first multicenter national report regarding the demographic and histopathologic data of PGD patients with or without hematuria. Hematuria, a feature of nephritic syndrome, was found at a higher than expected in the PGDs presenting with nephrotic syndrome in our national database