610 research outputs found
Indexing Information for Data Forensics
We introduce novel techniques for organizing the indexing structures of how data is stored so that alterations from an original version can be detected and the changed values specifically identified. We give forensic constructions for several fundamental data structures, including arrays, linked lists, binary search trees, skip lists, and hash tables. Some of our constructions are based on a new reduced-randomness construction for nonadaptive combinatorial group testing
Alcohol policy enforcement and changes in student drinking rates in a statewide public college system: a follow-up study
<p>Abstract</p> <p>Background</p> <p>Heavy alcohol use among U.S. college students is a major contributor to young adult morbidity and mortality. The aim of this study was to examine whether college alcohol policy enforcement levels predict changes in student drinking and related behaviors in a state system of public colleges and universities, following a system-wide change to a stricter policy.</p> <p>Methods</p> <p>Students and administrators at 11 Massachusetts public colleges/universities completed surveys in 1999 (N of students = 1252), one year after the policy change, and again in 2001 (N = 1074). We calculated policy enforcement scores for each school based on the reports of deans of students, campus security chiefs, and students, and examined the correlations between perceived enforcement levels and the change in student drinking rates over the subsequent two year period, after weighting the 2001 data to adjust for demographic changes in the student body.</p> <p>Results</p> <p>Overall rates of any past-30-days drinking, heavy episodic drinking, and usual heavy drinking among past-30-days drinkers were all lower in 2001 compared to 1999. School-level analyses (N = 11) found deans' baseline reports of stricter enforcement were strongly correlated with subsequent declines in heavy episodic drinking (Pearson's r = -0.73, p = 0.011). Moreover, consistently high enforcement levels across time, as reported by deans, were associated with greater declines in heavy episodic drinking. Such relationships were not found for students' and security chiefs' reports of enforcement. Marijuana use did not rise during this period of decline in heavy drinking.</p> <p>Conclusions</p> <p>Study findings suggest that stronger enforcement of a stricter alcohol policy may be associated with reductions in student heavy drinking rates over time. An aggressive enforcement stance by deans may be an important element of an effective college alcohol policy.</p
The Evolution of Compact Binary Star Systems
We review the formation and evolution of compact binary stars consisting of
white dwarfs (WDs), neutron stars (NSs), and black holes (BHs). Binary NSs and
BHs are thought to be the primary astrophysical sources of gravitational waves
(GWs) within the frequency band of ground-based detectors, while compact
binaries of WDs are important sources of GWs at lower frequencies to be covered
by space interferometers (LISA). Major uncertainties in the current
understanding of properties of NSs and BHs most relevant to the GW studies are
discussed, including the treatment of the natal kicks which compact stellar
remnants acquire during the core collapse of massive stars and the common
envelope phase of binary evolution. We discuss the coalescence rates of binary
NSs and BHs and prospects for their detections, the formation and evolution of
binary WDs and their observational manifestations. Special attention is given
to AM CVn-stars -- compact binaries in which the Roche lobe is filled by
another WD or a low-mass partially degenerate helium-star, as these stars are
thought to be the best LISA verification binary GW sources.Comment: 105 pages, 18 figure
Inflows, Outflows, and a Giant Donor in the Remarkable Recurrent Nova M31N 2008-12a? - Hubble Space Telescope Photometry of the 2015 Eruption
The recurrent nova M31N 2008-12a experiences annual eruptions, contains a near-Chandrasekhar mass white dwarf, and has the largest mass accretion rate in any nova system. In this paper, we present Hubble Space Telescope (HST) WFC3/UVIS photometry of the late decline of the 2015 eruption. We couple these new data with archival HST observations of the quiescent system and Keck spectroscopy of the 2014 eruption. The late-time photometry reveals a rapid decline to a minimum luminosity state, before a possible recovery / re-brightening in the run-up to the next eruption. Comparison with accretion disk models supports the survival of the accretion disk during the eruptions, and uncovers a quiescent disk mass accretion rate of the order of , which may rise beyond during the super-soft source phase - both of which could be problematic for a number of well-established nova eruption models. Such large accretion rates, close to the Eddington limit, might be expected to be accompanied by additional mass loss from the disk through a wind and even collimated outflows. The archival HST observations, combined with the disk modeling, provide the first constraints on the mass donor; , , and K, which may be consistent with an irradiated M31 red-clump star. Such a donor would require a system orbital period days. Our updated analysis predicts that the M31N 2008-12a WD could reach the Chandrasekhar mass in < 20 kyr
Activation of JNK Triggers Release of Brd4 from Mitotic Chromosomes and Mediates Protection from Drug-Induced Mitotic Stress
Some anti-cancer drugs, including those that alter microtubule dynamics target mitotic cells and induce apoptosis in some cell types. However, such drugs elicit protective responses in other cell types allowing cells to escape from drug-induced mitotic inhibition. Cells with a faulty protective mechanism undergo defective mitosis, leading to genome instability. Brd4 is a double bromodomain protein that remains on chromosomes during mitosis. However, Brd4 is released from mitotic chromosomes when cells are exposed to anti-mitotic drugs including nocodazole. Neither the mechanisms, nor the biological significance of drug-induced Brd4 release has been fully understood. We found that deletion of the internal C-terminal region abolished nocodazole induced Brd4 release from mouse P19 cells. Furthermore, cells expressing truncated Brd4, unable to dissociate from chromosomes were blocked from mitotic progression and failed to complete cell division. We also found that pharmacological and peptide inhibitors of the c-jun-N-terminal kinases (JNK) pathway, but not inhibitors of other MAP kinases, prevented release of Brd4 from chromosomes. The JNK inhibitor that blocked Brd4 release also blocked mitotic progression. Further supporting the role of JNK in Brd4 release, JNK2–/– embryonic fibroblasts were defective in Brd4 release and sustained greater inhibition of cell growth after nocodazole treatment. In sum, activation of JNK pathway triggers release of Brd4 from chromosomes upon nocodazole treatment, which mediates a protective response designed to minimize drug-induced mitotic stress
M31N 2008-12a - the remarkable recurrent nova in M31: Pan-chromatic observations of the 2015 eruption
The Andromeda Galaxy recurrent nova M31N 2008-12a had been observed in eruption ten times, including yearly eruptions from 2008-2014. With a measured recurrence period of days (we believe the true value to be half of this) and a white dwarf very close to the Chandrasekhar limit, M31N 2008-12a has become the leading pre-explosion supernova type Ia progenitor candidate. Following multi-wavelength follow-up observations of the 2013 and 2014 eruptions, we initiated a campaign to ensure early detection of the predicted 2015 eruption, which triggered ambitious ground and space-based follow-up programs. In this paper we present the 2015 detection; visible to near-infrared photometry and visible spectroscopy; and ultraviolet and X-ray observations from the Swift observatory. The LCOGT 2m (Hawaii) discovered the 2015 eruption, estimated to have commenced at Aug. UT. The 2013-2015 eruptions are remarkably similar at all wavelengths. New early spectroscopic observations reveal short-lived emission from material with velocities km s, possibly collimated outflows. Photometric and spectroscopic observations of the eruption provide strong evidence supporting a red giant donor. An apparently stochastic variability during the early super-soft X-ray phase was comparable in amplitude and duration to past eruptions, but the 2013 and 2015 eruptions show evidence of a brief flux dip during this phase. The multi-eruption Swift/XRT spectra show tentative evidence of high-ionization emission lines above a high-temperature continuum. Following Henze et al. (2015a), the updated recurrence period based on all known eruptions is d, and we expect the next eruption of M31N 2008-12a to occur around mid-Sep. 2016
3D Gasdynamic Modelling of the Changes in the Flow Structure During Transition From Quiescent to Active State in Symbiotic Stars
The results of 3D modelling of the flow structure in the classical symbiotic
system Z~Andromedae are presented. Outbursts in systems of this type occur when
the accretion rate exceeds the upper limit of the steady burning range.
Therefore, in order to realize the transition from a quiescent to an active
state it is necessary to find a mechanism able to sufficiently increase the
accretion rate on a time scale typical to the duration of outburst development.
Our calculations have confirmed the transition mechanism from quiescence to
outburst in classic symbiotic systems suggested earlier on the basis of 2D
calculations (Bisikalo et al, 2002). The analysis of our results have shown
that for wind velocity of 20 km/s an accretion disc forms in the system. The
accretion rate for the solution with the disc is ~22.5-25% of the mass loss
rate of the donor, that is, ~4.5-5*10^(-8)Msun/yr for Z And. This value is in
agreement with the steady burning range for white dwarf masses typically
accepted for this system. When the wind velocity increases from 20 to 30 km/s
the accretion disc is destroyed and the matter of the disc falls onto the
accretor's surface. This process is followed by an approximately twofold
accretion rate jump. The resulting accretion rate growth is sufficient for
passing the upper limit of the steady burning range, thereby bringing the
system into an active state. The time during which the accretion rate is above
the steady burning value is in a very good agreement with observations.
The analysis of the results presented here allows us to conclude that small
variations in the donor's wind velocity can lead to the transition from the
disc accretion to the wind accretion and, as a consequence, to the transition
from quiescent to active state in classic symbiotic stars.Comment: 21 pages, 7 figure
DS-KCF: a real-time tracker for RGB-D data
© 2016 The Author(s) We propose an RGB-D single-object tracker, built upon the extremely fast RGB-only KCF tracker that is able to exploit depth information to handle scale changes, occlusions, and shape changes. Despite the computational demands of the extra functionalities, we still achieve real-time performance rates of 35–43 fps in MATLAB and 187 fps in our C++ implementation. Our proposed method includes fast depth-based target object segmentation that enables, (1) efficient scale change handling within the KCF core functionality in the Fourier domain, (2) the detection of occlusions by temporal analysis of the target’s depth distribution, and (3) the estimation of a target’s change of shape through the temporal evolution of its segmented silhouette allows. Finally, we provide an in-depth analysis of the factors affecting the throughput and precision of our proposed tracker and perform extensive comparative analysis. Both the MATLAB and C++ versions of our software are available in the public domain
c-Jun N-terminal kinase activation has a prognostic implication and is negatively associated with FOXO1 activation in gastric cancer
M31N 2008-12a - The REMARKABLE RECURRENT NOVA in M31: PANCHROMATIC OBSERVATIONS of the 2015 ERUPTION
© 2016. The American Astronomical Society. All rights reserved.The Andromeda Galaxy recurrent nova M31N 2008-12a had been observed in eruption 10 times, including yearly eruptions from 2008 to 2014. With a measured recurrence period of Prec = 351 ± 13 days (we believe the true value to be half of this) and a white dwarf very close to the Chandrasekhar limit, M31N 2008-12a has become the leading pre-explosion supernova type Ia progenitor candidate. Following multi-wavelength follow-up observations of the 2013 and 2014 eruptions, we initiated a campaign to ensure early detection of the predicted 2015 eruption, which triggered ambitious ground- and space-based follow-up programs. In this paper we present the 2015 detection, visible to near-infrared photometry and visible spectroscopy, and ultraviolet and X-ray observations from the Swift observatory. The LCOGT 2 m (Hawaii) discovered the 2015 eruption, estimated to have commenced at August 28.28 ± 0.12 UT. The 2013-2015 eruptions are remarkably similar at all wavelengths. New early spectroscopic observations reveal short-lived emission from material with velocities ∼13,000 km s-1, possibly collimated outflows. Photometric and spectroscopic observations of the eruption provide strong evidence supporting a red giant donor. An apparently stochastic variability during the early supersoft X-ray phase was comparable in amplitude and duration to past eruptions, but the 2013 and 2015 eruptions show evidence of a brief flux dip during this phase. The multi-eruption Swift/XRT spectra show tentative evidence of high-ionization emission lines above a high-temperature continuum. Following Henze et al. (2015a), the updated recurrence period based on all known eruptions is Prec = 174 ± 10 days, and we expect the next eruption of M31N 2008-12a to occur around 2016 mid-September
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