Impact of Rural-urban Labour Migration on Education of Children: A Case Study of Left behind and Accompanied Migrant Children in India

In developing countries, seasonal labour migration from rural to urban or from backward to developed region is a household livelihood strategy to cope with poverty. In this process, the children of those migrants are the worst affected whether they accompany their parents or are left behind in the villages. The present paper explores the impact of temporary labour migration of parent(s) on school attendance of the children between 6–14 years and their dropping out from the school through an analysis of the cases from both the ends of migration stream in India. Data was collected from thirteen construction sites of Varanasi Uttar Pradesh and nine villages of Bihar by applying both qualitative and quantitative techniques. It is evident from the study that the migrants through remittances improve school accessibility for the left behind children and bridge gender gap in primary school education. However, among the accompanying migrant children of construction workers, many remain out of school and many are forced to drop out and some of them become vulnerable to work as child labour due to seasonal mobility of their parents. Thus, mainstreaming these children in development process is a big challenge in attaining the goal of universal primary education and inclusive growth in the country like India

Identification of Retinal Transformation Hot Spots in Developing Drosophila Epithelia

Background: The retinal determination (RD) network is an evolutionarily conserved regulatory circuit that governs early events in the development of eyes throughout the animal kingdom. Ectopic expression of many members of this network leads to the transformation of non-retinal epithelia into eye tissue. An often-overlooked observation is that only particular cell-populations within a handful of tissues are capable of having their primary developmental instructions superseded and overruled. Methodology/Preliminary Findings: Here we confirm that indeed, only a discrete number of cell populations within the imaginal discs that give rise to the head, antenna, legs, wings and halteres have the cellular plasticity to have their developmental fates altered. In contrast to previous reports, we find that all transformable cell populations do not lie within the TGFb or Hedgehog signaling domains. Additionally neither signaling cascade alone is sufficient for non-retinal cell types to be converted into retinal tissue. The transformation ‘‘hot spots’ ’ that we have identified appear to coincide with several previously defined transdetermination ‘‘weak spots’’, suggesting that ectopic eye formation is less the result of one network overriding the orders of another, as previously thought, but rather is the physical manifestation of redirecting cell populations of enormous cellular plasticity. We also demonstrate that the initiation of eye formation in non-retinal tissues occurs asynchronously compared to that of the normal eye suggesting that retinal development is not under the control o

Yki/YAP, Sd/TEAD and Hth/MEIS Control Tissue Specification in the Drosophila Eye Disc Epithelium

During animal development, accurate control of tissue specification and growth are critical to generate organisms of reproducible shape and size. The eye-antennal disc epithelium of Drosophila is a powerful model system to identify the signaling pathway and transcription factors that mediate and coordinate these processes. We show here that the Yorkie (Yki) pathway plays a major role in tissue specification within the developing fly eye disc epithelium at a time when organ primordia and regional identity domains are specified. RNAi-mediated inactivation of Yki, or its partner Scalloped (Sd), or increased activity of the upstream negative regulators of Yki cause a dramatic reorganization of the eye disc fate map leading to specification of the entire disc epithelium into retina. On the contrary, constitutive expression of Yki suppresses eye formation in a Sd-dependent fashion. We also show that knockdown of the transcription factor Homothorax (Hth), known to partner Yki in some developmental contexts, also induces an ectopic retina domain, that Yki and Scalloped regulate Hth expression, and that the gain-of-function activity of Yki is partially dependent on Hth. Our results support a critical role for Yki- and its partners Sd and Hth - in shaping the fate map of the eye epithelium independently of its universal role as a regulator of proliferation and survival

Yki/YAP, Sd/TEAD and Hth/MEIS Control Tissue Specification in the Drosophila Eye Disc Epithelium

During animal development, accurate control of tissue specification and growth are critical to generate organisms of reproducible shape and size. The eye-antennal disc epithelium of Drosophila is a powerful model system to identify the signaling pathway and transcription factors that mediate and coordinate these processes. We show here that the Yorkie (Yki) pathway plays a major role in tissue specification within the developing fly eye disc epithelium at a time when organ primordia and regional identity domains are specified. RNAi-mediated inactivation of Yki, or its partner Scalloped (Sd), or increased activity of the upstream negative regulators of Yki cause a dramatic reorganization of the eye disc fate map leading to specification of the entire disc epithelium into retina. On the contrary, constitutive expression of Yki suppresses eye formation in a Sd-dependent fashion. We also show that knockdown of the transcription factor Homothorax (Hth), known to partner Yki in some developmental contexts, also induces an ectopic retina domain, that Yki and Scalloped regulate Hth expression, and that the gain-of-function activity of Yki is partially dependent on Hth. Our results support a critical role for Yki- and its partners Sd and Hth - in shaping the fate map of the eye epithelium independently of its universal role as a regulator of proliferation and survival

Catalytic upgrading of bio-oils by esterification

Biomass is the term given to naturally-produced organic matter resulting from photosynthesis, and represents the most abundant organic polymers on Earth. Consequently, there has been great interest in the potential exploitation of lignocellulosic biomass as a renewable feedstock for energy, materials and chemicals production. The energy sector has largely focused on the direct thermochemical processing of lignocellulose via pyrolysis/gasification for heat generation, and the co-production of bio-oils and bio-gas which may be upgraded to produce drop-in transportation fuels. This mini-review describes recent advances in the design and application of solid acid catalysts for the energy efficient upgrading of pyrolysis biofuels

Properties of eco-friendly cement mortar contained recycled materials from different sources

Building materials such as sand, cement, bricks, and steel are usually the main components of the construction sector. All these materials are produced from existing natural resources and they will cause substantial damage to the environment as a result of their continuous depletion. Moreover, during the manufacture of various building materials, especially cement, a high concentration of carbon dioxide is constantly emitted into the atmosphere. Therefore, to reduce this environmental damage as well as to save natural resources, this study was performed to recycle the wastes of some of building materials such as marble, granite and porcelain tiles and clay brick through using them as cement and aggregate replacement materials in cement mortar. Sixteen mixtures were cast for this study. In addition to the control, the mortar mixes were divided into five groups, three mixes in each group. In four of the five groups, cement was replaced in three proportions (5%, 10%, 15% by weight) with each of marble, granite, porcelain and clay brick waste powders (passing through 150-μm sieve). The fifth group included 100% replacing (by weight) of the natural sand with the marble, granite and porcelain tiles wastes (with a comparable gradation). The influence of these wastes on flow rate, compressive strength, flexural strength, bulk density, ultrasonic pulse velocity (UPV) and water absorption tests were observed. Results showed that it is possible to produce an eco-friendly mortar made with 100% recycled marble or porcelain aggregate with a significant improvement in the mechanical and durability properties in comparison with natural aggregate mortar

Mechanisms of T cell organotropism

F.M.M.-B. is supported by the British Heart Foundation, the Medical Research Council of the UK and the Gates Foundation