44 research outputs found
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The platelet-surface thiol isomerase enzyme ERp57 modulates platelet function
- Author
- Publication venue
- 'Wiley'
- Publication date
- 13/12/2011
- Field of study
Background: Thiol isomerases are a family of endoplasmic reticulum enzymes which orchestrate redox-based modifications of protein disulphide bonds. Previous studies have identified important roles for the thiol isomerases PDI and ERp5 in the regulation of normal platelet function. Objectives: Recently, we demonstrated the presence of a further five thiol isomerases at the platelet surface. In this report we aim to report the role of one of these enzymes - ERp57 in the regulation of platelet function. Methods/Results: Using enzyme activity function blocking antibodies, we demonstrate a role for ERp57 in platelet aggregation, dense granule secretion, fibrinogen binding, calcium mobilisation and thrombus formation under arterial conditions. In addition to the effects of ERp57 on isolated platelets, we observe the presence of ERp57 in the developing thrombus in vivo. Furthermore the inhibition of ERp57 function was found to reduce laser-injury induced arterial thrombus formation in a murine model of thrombosis. Conclusions: These data suggest that ERp57 is important for normal platelet function and opens up the possibility that the regulation of platelet function by a range of cell surface thiol isomerases may represent a broad paradigm for the regulation of haemostasis and thrombosis
Paneth cell metaplasia in newly diagnosed inflammatory bowel disease in children
- Author
- AB Thomson
- AB West
- Alan Phillips
- Alan WH Bates
- CL Bevins
- D Jenkins
- DA Symonds
- DE Jones
- Evi Karanika
- G Perminow
- G Schumacher
- H Kiyohara
- J Mitsuhashi
- J Paneth
- JC Paterson
- JN Glickman
- M Gersemann
- M Mathan
- M Tanaka
- M Zilbauer
- Mark Furman
- MP Kumarasinghe
- Naomi Simmonds
- NH Salzman
- P Kelly
- PJ Puiman
- S Behjati
- SA Dundas
- SL Erlandsen
- TE Adolph
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
- Author
- Ahmad Tariq
- Attwood Antony P.
- Bailey Rebecca
- Ball Stephen G.
- Balmforth Anthony J.
- Ban Maria
- Barbour Jamie
- Barrett Jeffrey C.
- Barrett Jeffrey C.
- Barrett Jennifer H.
- Barton Anne
- Bentley David
- Bishop D. Timothy
- Boorman James P.
- Bradbury Linda A.
- Braga Carolina A.
- Braund Peter S.
- Bredin Francesca
- Breen Gerome
- Brown Matthew A.
- Brown Matthew A.
- Brown Morris J.
- Bruce Ian N.
- Bryan Claire
- Bumpstead Suzannah J.
- Burke Beverley
- Burton Paul R.
- Burton Paul R.
- Burton Paul R.
- Burton Paul R.
- Caesar Sian
- Campbell R. Duncan
- Cant Barbara
- Cardin Niall J.
- Cardon Lon R.
- Cardon Lon R.
- Cardon Lon R.
- Cardon Lon R.
- Caulfield Mark
- Caulfield Mark
- Chaney Amy
- Clayton David G.
- Clayton David G.
- Clayton David G.
- Clayton David G.
- Clayton David G.
- Clayton David G.
- Clayton David G.
- Collier David A.
- Compston Alastair
- Compston Alistair
- Connell John
- Conway David
- Cooper Jason D.
- Craddock Nick
- Craddock Nick
- Craddock Nick
- Cummings Fraser R.
- Davison Dan
- Davison Dan
- Deloukas Panos
- Deloukas Panos
- Deloukas Panos
- Dixon Richard J.
- Dobson Richard
- Dominiczak Anna
- Donnelly Peter
- Donnelly Peter
- Donnelly Peter
- Donnelly Peter
- Donovan Hannah
- Downes Kate
- Drummond Hazel
- Duncanson Audrey
- Dunger David B.
- Easton Doug
- Easton Doug
- Elkin Amanda
- Elliott Kate S.
- Evans David
- Evans David
- Everson Ursula
- Eyre Steve
- Farmer Anne
- Farrall Martin
- Farrall Martin
- Farrar Claire
- Ferreira Teresa
- Field Sarah F.
- Fisher Sheila A.
- Forbes Alastair
- Franklyn Jayne A.
- Fraser Christine
- Frayling Timothy M.
- Freathy Rachel M.
- Ghori Jilur
- Gilbert Paul D.
- Gordon-Smith Katherine
- Goris An
- Gough Stephen C. L.
- Gough Stephen C. L.
- Green Elaine K.
- Groves Christopher J.
- Grozeva Detelina
- Gungadoo Johannie
- Gwilliam Rhian
- Hall Alistair S.
- Hall Alistair S.
- Hallgrimsdóttir Ingeleif B.
- Hamshere Marian L.
- Hardy Matthew
- Hattersley Andrew T.
- Hattersley Andrew T.
- Heward Joanne M.
- Hider Samantha L.
- Hill Adrian V. S.
- Hill Adrian V. S.
- Hinks Anne M.
- Hitman Graham A.
- Holmans Peter A.
- Howie Bryan N.
- Howson Joanna M. M.
- Hulme John
- Hunt Sarah E.
- Hussey Judith M.
- Iles Mark M.
- Inouye Michael
- Jallow Muminatou
- Jewell Derek P.
- John Sally L.
- Jolley Jennifer D.
- Jones Ian R.
- Jones Lisa
- Jones Richard W.
- Keniry Andrew
- Khalid Mohiuddin M.
- King Emma
- King Erna
- Kirov George
- Knight Alexandra S.
- Koch Kerstin
- Kwiatkowski Dominic P.
- Kwiatkowski Dominic P.
- Kwiatkowski Dominic P.
- Lango Hana
- Lathrop G. Mark
- Lee Kate L.
- Lees Charles W.
- Leung Hin-Tak
- Leung Hin-Tak
- Lewis Cathryn M.
- Lindgren Cecilia M.
- Lyons Emily
- Maier Lisa M.
- Mangino Massimo
- Mansfield John C.
- Maqbool Azhar
- Marchini Jonathan L.
- Marchini Jonathan L.
- Masters Jennifer
- Mathew Christopher G.
- Mathew Christopher G.
- McArdle Wendy L.
- McCarthy Mark I.
- McCarthy Mark I.
- McCarthy Mark I.
- McGinnis Ralph
- McGuffin Peter
- Meech Elizabeth
- Morris Andrew P.
- Morris Andrew P.
- Moskvina Valentina
- Munroe Patricia B.
- Nejentsev Sergey
- Newhouse Stephen J.
- Newport Melanie
- Newport Melanie
- Nicol Ferrier I.
- Nikolov Ivan
- Nimmo Elaine R.
- Nutland Sarah
- Nutland Sarah
- Nutland Sarah
- Onipinla Abiodun
- Onnie Clive M.
- Ouwehand Willem H.
- Ouwehand Willem H.
- Ouwehand Willem H.
- Owen Michael J.
- O’Donovan Michael C.
- Parkes Miles
- Parkes Miles
- Pembrey Marcus
- Pembrey Marcus
- Pereira-Gale Joanne
- Perry John R. B.
- Pointon Jennifer J.
- Potter Catherine
- Potter Simon
- Prescott Natalie J.
- Prowse Christopher V.
- Rahman Nazneen
- Rahman Nazneen
- Ravindrarajah Rathi
- Rayner Nigel W.
- Reynolds Pamela
- Ribas Gloria
- Ring Susan M.
- Rockett Kirk A.
- Samani Nilesh J.
- Samani Nilesh J.
- Samani Nilesh J.
- Samani Nilesh J.
- Sanderson Jeremy
- Satsangi Jack
- Sawcer Stephen J.
- Seal Sheila
- Shields Beverley M.
- Silman Alan J.
- Simmonds Matthew J.
- Sirugo Giorgio
- Sirugo Giorgio
- Smyth Deborah
- Spencer Chris C. A.
- Spencer Chris C. A.
- St Clair David
- Stevens Helen E.
- Stevens Helen E.
- Stevens Helen E.
- Stevens Helen E.
- Stevens Suzanne
- Strachan David P.
- Stratton Michael R.
- Stratton Michael R.
- Su Zhan
- Symmons Deborah P. M.
- Szeszko Jeffrey
- Taylor Niall C.
- Thompson John R.
- Thomson Wendy
- Timpson Nicholas J.
- Tobin Martin D.
- Tobin Martin D.
- Tobin Martin D.
- Todd John A.
- Todd John A.
- Todd John A.
- Todd John A.
- Todd John A.
- Todd John A.
- Todhunter Catherine E.
- Tremelling Mark
- Vannberg Fredrik
- Vukcevic Damjan
- Walker Mark
- Walker Neil M.
- Walker Neil M.
- Walker Neil M.
- Walker Neil M.
- Wallace Chris
- Walters Graham R.
- Watkins Nicholas A.
- Webster John
- Weedon Michael N.
- Whittaker Pamela
- Widmer Barry
- Williamson Richard
- Winzer Thilo
- Withers David
- Wordsworth Paul
- Worthington Jane
- Worthington Jane
- Xue Mingzhan
- Ying Teo Yik
- Young Allan H.
- Yuldasheva Nadira
- Zeggini Eleftheria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study
The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1-3), but these genes cannot completely explain the association between type 1 diabetes and the MHC region. Owing to the region's extreme gene density, the multiplicity of disease-associated alleles, strong associations between alleles, limited genotyping capability, and inadequate statistical approaches and sample sizes, which, and how many, loci within the MHC determine susceptibility remains unclear. Here, in several large type 1 diabetes data sets, we analyse a combined total of 1,729 polymorphisms, and apply statistical methods - recursive partitioning and regression - to pinpoint disease susceptibility to the MHC class I genes HLA-B and HLA-A (risk ratios >1.5; Pcombined = 2.01 × 10-19 and 2.35 × 10-13, respectively) in addition to the established associations of the MHC class II genes. Other loci with smaller and/or rarer effects might also be involved, but to find these, future searches must take into account both the HLA class II and class I genes and use even larger samples. Taken together with previous studies, we conclude that MHC-class-I-mediated events, principally involving HLA-B*39, contribute to the aetiology of type 1 diabetes. ©2007 Nature Publishing Group
Acute mountain sickness.
- Author
- Alan H. Beggs
- Alan P. Knutsen
- Albert C. Ludolph
- Albert H. Gennip
- Albert H. Gennip
- Alessandra Baumer
- Alessia Diana
- Alexander K. C. Leung
- Alexander K. C. Leung
- Alexander K. C. Leung
- Alexander K. C. Leung
- Alexander K. C. Leung
- Alexander K. C. Leung
- Alexander K. C. Leung
- Alexander Leaf
- Alfried Kohlschütter
- Amrik Sahota
- Andrea Cignarella
- Andromachi Scaradavou
- André B. P. Kuilenburg
- André B. P. Kuilenburg
- Andy Wessels
- Anna Sarkozy
- Arndt Hartmann
- Atilla Şenaylı
- Avi Fischer
- Birgit Haack
- Björn Stork
- Bruno Dallapiccola
- Bruno Marino
- Carl Borrebaeck
- Carsten A. Wagner
- Christian Zietz
- Christie P. Thomas
- Christie P. Thomas
- Christopher K. Zarins
- Christos C. Zouboulis
- Colin A. Johnson
- Cord Sunderkötter
- Cord Sunderkötter
- Damian C. Melles∗
- Dan Donoghue
- Daniel Batlle
- Daniel Batlle
- Daniel Batlle
- Daniela Eser
- Darryl C. Zeldin
- Davendra Mehta
- David A. Lomas
- Deepak Kamat
- Deirdre Ward
- Dorothée Nashan
- Du Toit Loots
- Ehteshamudin Syed
- Eleanor M. Summerhill
- Engin Sezer
- Essi Viding
- F. Dennis McCool
- Federico Fracassi
- Filip Vanhoenacker
- Friedhelm Beyersdorf
- Gema Ariceta
- Gema Ariceta
- Georg Kojda
- Georges Berghe
- Gerd Hasenfuss
- Gordon Dent
- Guido Adler
- H. Anne Simmonds
- Hans H. Goebel
- Haran Burri
- Helmut Hintner
- Henrik Larsson
- Herbert L. Bonkovsky
- Holger S. Willenberg
- Holger S. Willenberg
- Hubert Scharnagl
- Hugo Ten Cate
- Jaak Jaeken
- Jacob I. Sznajder
- James K. Stoller
- James M. Powers
- James M. Powers
- Jay A. Tischfield
- Jeno Sebes
- Jens J. Kaden
- Jens Mogensen
- Jens Seiler
- John-John B. Schnog
- Jonathan M. Kalman
- Jorge Frank
- Karel Frasch
- Karina Yazdanbakhsh
- Kirsty Kiezebrink
- Klaus-Peter Lesch
- Konrad Beyreuther
- Kumarasamy Thangaraj
- Kurt C. Roberts-Thomson
- Lee A. Denson
- Lucia K. Ma
- M. Cristina Digilio
- Malin Lindstedt
- Manish Suneja
- Manish Suneja
- Manish Thapar
- Marc Zimmermann
- Mark Berneburg
- Mark G. Buckley
- Markus Böhm
- Markus Böhm
- Markus Jäger
- Markus Pfister
- Martin Rotter
- Martina Bienova
- Matthias Siepe
- Matthias Wenning
- Mayumi Endo
- Meinhard Schiller
- Michael Emberger
- Michael L. H. Ma
- Michael L. H. Ma
- Michael L. H. Ma
- Michael L. H. Ma
- Michael M. Hoffmann
- Michael S. Hershfield
- Michael Stürzl
- Michala Bezdekova
- Michelle M. Estrella
- Mohamed G. Atta
- Moosa Mohammadi
- Murat Bas
- Mónica Guevara
- Nada Kanaan
- Nigel G. Laing
- Nilufar Mohebbi
- Norbert Frey
- Norbert Gattermann
- Omar A. Ibrahimi
- Patrick T. S. Ma
- Patrick T. S. Ma
- Patrick T. S. Ma
- Patrick T. S. Ma
- Patrick T. S. Ma
- Patrick T. S. Ma
- Pavel Fencl
- Pere Ginès
- Peter Klein
- Raffi Bekeredjian
- Rainer Rupprecht
- Ralf Paus
- Randolf Brehler
- Randolf Brehler
- Renata Kucerova
- Rita L. McGill
- Robert Dalla Pozza
- Roberto Manfredi
- Rodolfo Paoletti
- Ruth Danzeisen
- S. Marie
- Sebastian Wesselborg
- Sehsuvar Ertürk
- Sim Kutlay
- Singh Rajender
- Siobhan D. Ma
- Sishir Mathur
- Srijita Sen-Chowdhry
- Stefan Kins
- Stefan R. Bornstein
- Stefan R. Bornstein
- Stephen T. Holgate
- Steven Mumm
- Susanna Mac
- Susanne Kohl
- Sven Schinner
- Svetlana Brychtova
- Sylvia Stöckler-Ipsiroglu
- Thomas A. Luger
- Thomas A. Luger
- Thomas Bourgeron
- Thomas Frieling
- Thomas Hawranek
- Thomas Klockgether
- Thomas Klockgether
- Thomas Klockgether
- Thomas Schwarz
- Thomas Schwarz
- Tim McQuinn
- Tobias W. Fischer
- Tomas Brychta
- Victor E. A. Gerdes
- Volker Liebe
- William J. McKenna
- Wim Hul
- Winfried März
- Winfried März
- Wolfgang Dietmaier
- Wolfgang Schillinger
- Yun Zhao
- Zdenek Kolar
- Zhirong Yao
- Publication venue
- Publication date
- 01/05/2001
- Field of study
Acute mountain sickness (AMS) is a clinical syndrome occurring in otherwise healthy normal individuals who ascend rapidly to high altitude. Symptoms develop over a period ofa few hours or days. The usual symptoms include headache, anorexia, nausea, vomiting, lethargy, unsteadiness of gait, undue dyspnoea on moderate exertion and interrupted sleep. AMS is unrelated to physical fitness, sex or age except that young children over two years of age are unduly susceptible. One of the striking features ofAMS is the wide variation in individual susceptibility which is to some extent consistent. Some subjects never experience symptoms at any altitude while others have repeated attacks on ascending to quite modest altitudes. Rapid ascent to altitudes of 2500 to 3000m will produce symptoms in some subjects while after ascent over 23 days to 5000m most subjects will be affected, some to a marked degree. In general, the more rapid the ascent, the higher the altitude reached and the greater the physical exertion involved, the more severe AMS will be. Ifthe subjects stay at the altitude reached there is a tendency for acclimatization to occur and symptoms to remit over 1-7 days
Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis:a randomised, double-blind, placebo-controlled, phase 2b trial
- Author
- Alton Eric W F W
- Armstrong David K
- Ashby Deborah
- Bayfield Katie J
- Bilton Diana
- Bloomfield Emily V
- Boyd A Christopher
- Brand June
- Buchan Ruaridh
- Calcedo Roberto
- Carvelli Paula
- Chan Mario
- Cheng Seng H
- Collie D David S
- Cunningham Steve
- Davidson Heather E
- Davies Gwyneth
- Davies Jane C
- Davies Lee A
- Dewar Maria H
- Doherty Ann
- Donovan Jackie
- Dwyer Natalie S
- Elgmati Hala I
- Featherstone Rosanna F
- Gavino Jemyr
- Gea-sorli Sabrina
- Geddes Duncan M
- Gibson James S R
- Gill Deborah R
- Greening Andrew P
- Griesenbach Uta
- Hansell David M
- Harman Katharine
- Higgins Tracy E
- Hodges Samantha L
- Hyde Stephen C
- Hyndman Laura
- Innes J Alastair
- Jacob Joseph
- Jones Nancy
- Keogh Brian F
- Limberis Maria P
- Lloyd-evans Paul
- Maclean Alan W
- Manvell Michelle C
- McCormick Dominique
- McGovern Michael
- McLachlan Gerry
- Meng Cuixiang
- Milligan Hazel
- Montero M Angeles
- Moyce Laura J
- Murray Gordon D
- Nicholson Andrew G
- Osadolor Tina
- Parra-leiton Javier
- Porteous David J
- Pringle Ian A
- Punch Emma K
- Pytel Kamila M
- Quittner Alexandra L
- Rivellini Gina
- Saunders Clare J
- Scheule Ronald K
- Sheard Sarah
- Simmonds Nicholas J
- Smith Keith
- Smith Stephen N
- Soussi Najwa
- Soussi Samia
- Spearing Emma J
- Stevenson Barbara J
- Sumner-jones Stephanie G
- Turkkila Minna
- Ureta Rosa P
- Waller Michael D
- Wasowicz Marguerite Y
- Wilson James M
- Wolstenholme-hogg Paul
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Background: Lung delivery of plasmid DNA encoding the CFTR gene complexed with a cationic liposome is a potential treatment option for patients with cystic fibrosis. We aimed to assess the efficacy of non-viral CFTR gene therapy in patients with cystic fibrosis. Methods: We did this randomised, double-blind, placebo-controlled, phase 2b trial in two cystic fibrosis centres with patients recruited from 18 sites in the UK. Patients (aged ≥12 years) with a forced expiratory volume in 1 s (FEV1) of 50–90% predicted and any combination of CFTR mutations, were randomly assigned, via a computer-based randomisation system, to receive 5 mL of either nebulised pGM169/GL67A gene–liposome complex or 0·9% saline (placebo) every 28 days (plus or minus 5 days) for 1 year. Randomisation was stratified by % predicted FEV1 (<70 vs ≥70%), age (<18 vs ≥18 years), inclusion in the mechanistic substudy, and dosing site (London or Edinburgh). Participants and investigators were masked to treatment allocation. The primary endpoint was the relative change in % predicted FEV1. The primary analysis was per protocol. This trial is registered with ClinicalTrials.gov, number NCT01621867. Findings: Between June 12, 2012, and June 24, 2013, we randomly assigned 140 patients to receive placebo (n=62) or pGM169/GL67A (n=78), of whom 116 (83%) patients comprised the per-protocol population. We noted a significant, albeit modest, treatment effect in the pGM169/GL67A group versus placebo at 12 months' follow-up (3·7%, 95% CI 0·1–7·3; p=0·046). This outcome was associated with a stabilisation of lung function in the pGM169/GL67A group compared with a decline in the placebo group. We recorded no significant difference in treatment-attributable adverse events between groups. Interpretation: Monthly application of the pGM169/GL67A gene therapy formulation was associated with a significant, albeit modest, benefit in FEV1 compared with placebo at 1 year, indicating a stabilisation of lung function in the treatment group. Further improvements in efficacy and consistency of response to the current formulation are needed before gene therapy is suitable for clinical care; however, our findings should also encourage the rapid introduction of more potent gene transfer vectors into early phase trials
Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease
- Author
- A Bossowski
- A Franke
- A Kottgen
- A Kottgen
- A Muto
- Aarno Palotie
- Ad R. Hermus
- Alan James
- Albert de la Chapelle
- Albert Hofman
- Alec Ross
- Alessandro Delitala
- Alexander Hamilton
- Alexander Kluttig
- Alexander Teumer
- Alexandra P. Bremner
- Alice Arnold
- Allan Linneberg
- Andrew T. Hattersley
- André G. Uitterlinden
- Anne Cappola
- Antonella Mulas
- AP Weetman
- AP Weetman
- B Bakker
- B Biondi
- B Faam
- B Gencer
- Betina Thuesen
- Beverley M. Shields
- Bijay Vaidya
- Bruce M. Psaty
- C Gieger
- C Selmer
- CH Nielsen
- Chris Cotsapas
- Christa Meisinger
- Christian Gieger
- Christin Spielhagen
- Cinzia Sala
- CJ Willer
- Corrado Masciullo
- Daniel Tiller
- Daniela Toniolo
- David I. W. Philips
- David Schlessinger
- Diana Pietzner
- Dörte Radke
- E Porcu
- EA Stahl
- Ee M. Lim
- Eero Kajantie
- Eleonora Porcu
- Elisabeth Widen
- Emanuele Bosi
- EN Pearce
- Eric Wichmann
- Ernst E. Rietzschel
- Eva Reischl
- Fernando Rivadeneira
- Fred C. Sweep
- G Huber
- G Milani
- G Pilia
- Gabriela L. Surdulescu
- Georg Homuth
- Giorgio Pistis
- Goncalo Abecasis
- Greet L. Roef
- H Bikker
- H Houlden
- H Tandeter
- Hans Jörgen Grabe
- Henri Wallaschofski
- Henriette Meyer zu Schwabedissen
- Henry Völzke
- Holger Prokisch
- Huiling He
- I Gramaglia
- J Gudmundsson
- J Ruf
- J. Brent Richards
- Jari Lahti
- Jayne A. Franklyn
- JC Barrett
- JC Denny
- JD Cooper
- JD Davis
- Jean-Marc Kaufman
- Jennie Hui
- Jerome I. Rotter
- JG Hollowell
- JJ Magana
- JJ Nicholls
- Johan G. Eriksson
- Johannes W. A. Smit
- John P. Beilby
- John P. Walsh
- Jürgen Kratzsch
- K Poppe
- Katharina Schramm
- Katri Räikkönen
- L Ortiz
- Lambertus A. Kiemeney
- Layal Chaker
- Linda Broer
- Lise Lotte N. Husemoen
- LV Wain
- M Medici
- Marco Medici
- Margit Heier
- Maria Grazia Plia
- Martijn van de Bunt
- Martin den Heijer
- Massimiliano Cocca
- Matteo Vocale
- Matthew J. Simmonds
- Matthias Nauck
- MD Linnik
- Michela Traglia
- MJ Simmonds
- MJ Simmonds
- Monia Lobina
- MP Vanderpump
- MR Velaga
- N Eriksson
- N Rodondi
- Nicola Pirastu
- Nicole Soranzo
- O Kordonouri
- PC Dubois
- Peter C. O'Leary
- Peter Feddema
- Peter J. Leedman
- PS Hansen
- R Negro
- Rachel M. Freathy
- Rajesh Rawal
- Rebecca Nagy
- Richard A. Jensen
- Robin P. Peeters
- Romana T. Netea-Maier
- S Raychaudhuri
- S Raychaudhuri
- S Ruhla
- S Sawcer
- S Steer
- S Thangaratinam
- Sandra Lai
- Sandya Liyanarachchi
- SC Gough
- Scott G. Wilson
- Serena Sanna
- SF Nielsen
- SH Wang
- Silvia Naitza
- Sita H. Vermeulen
- Stefano Mariotti
- Stephen C. L. Gough
- Stephen J. Fletcher
- Suzanne J. Brown
- Tanguy Corre
- Tessel E. Galesloot
- TG Strieder
- TG Strieder
- TH Brix
- TH Brix
- TH Collet
- Theo J. Visser
- Theo S. Plantinga
- Till Ittermann
- Tim de Meyer
- Tim I. M. Korevaar
- Timothy D. Spector
- Timothy M. Frayling
- Tom Forsen
- Torben Jørgensen
- U Bonuccelli
- U Schweizer
- UG Knaus
- Uwe Völker
- V Orru
- V Plagnol
- W. Edward Visser
- Wei Li
- WM Tunbridge
- X Liu
- Y Jin
- Y Tomer
- Y Wu
- Youri E. Taes
- Yurii S. Aulchenko
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
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- LEE SUNGHO.
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- LIETO ALBERTO. DI.
- LIGO Collaboration
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- MASCIOLI ADRIANO. FRATTALE.
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- MORALES ESTER. RUIZ.
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- MOURS Benoit
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- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
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- Zanolin M.
- Zeeshan M.
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- Zendri J. -P.
- Zevin Michael
- Zhang Jue
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
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- Arif Shaikh Md
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- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
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- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
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- Zhong Haowen
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- Zhu Xingjiang
- Zhu Zong-Hong
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- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
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- Barayoga J. C.
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- Barker D.
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- Chalathadka Subrahmanya Shreevathsa
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- Chanial Pierre
- Chao Shiuh
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- Charlton E. L.
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- Chaty Sylvain
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- Chen A.
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- CHIOFALO MARIA. LUISA.
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- Corsi Alessandra
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- Cumming Alan
- Cuoco E.
- Cusinato Marco
- César Martins Julio
- D'Angelo Beatrice
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- De Bolle Jorden
- De Laurentis Martina
- De Lillo Federico
- de Lluc Planas Maria
- De Marco F.
- De Matteis Fabio
- De Pietri Roberto
- De Rosa Rosario
- de rossi camilla
- De Simone R.
- de Souza Melo S. Assis
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- Degallaix Jerome
- Del Pozzo Walter
- Delfavero Vera
- Dell'Aquila Daniele
- Deléglise Samuel
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- di giovanni Fabrizio
- Di Giovanni M.
- Di Girolamo Tristano
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- Di Renzo Francesco
- DI. PALMA Irene
- Diab R.
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- Emma Mattia
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- Errico L.
- error error
- error error
- error error
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- Estevez Dimitri
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- Evans Matthew J.
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- Fabrizi Federica
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- Fafone Viviana
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- Fenyvesi Edit
- Ferguson Deborah
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- Fishbach Maya
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- Forsyth P. W. F.
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- Frasca S.
- Frasconi Franco
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- Frey Raymond
- Frischhertz W.
- Frolov V. V.
- Fuentes-Garcia Melina
- Fujii S.
- Fujimori T.
- Fujimoto Hiroki
- Fujita Tomohiro
- Fukunaga I.
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- Fyffe M.
- Gabella William
- Gadre Bhooshan
- Gaetano Fronzé Gabriele
- Gair Jonathan
- Galaudage Shanika
- Gallardo S.
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- Gamba Rossella
- Gamboa Aldo
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- Toropov Nikita
- Torres Forne Alejandro
- Torrie C. I.
- Toscani Martina
- Tosta e Melo Iara
- Tournefier Edwige
- TRAPANANTI Angela
- Travasso Flavio
- Traylor G.
- Trenado Juan
- Trevor M.
- Tripathee Aashish
- Troiano L.
- Trovato Agata
- Trozzo L.
- Trudeau R. J.
- Tso R.
- Tsuchida Satoshi
- Tsukada L.
- Tsutsui Takuya
- Turbang Kevin
- Turconi Margherita
- Turski C.
- Ubach Helena
- Ubhi A. S.
- Uchiyama Takashi
- Udall Rhiannon
- Uehara Tomoyuki
- Ueno Koh
- Unnikrishnan C. S.
- Ushiba Takafumi
- Vacatello Michele
- Vahlbruch Henning
- Vaidya Nina
- Vajente Gabriele
- Vajpeyi A.
- Valdes Guillermo
- Valencia J.
- Valentini Michele
- Vallejo-Peña S. A.
- Vallero S.
- Valsan Vinaya
- Valérie Martinez
- van Bakel N.
- van Beuzekom Martin
- van Dael Mathyn
- Van de Walle A.
- van den Brand Johannes
- Van Den Broeck C.
- van der Sluys Marc
- van Dongen Jesse
- Van Haevermaet Hans
- van Heijningen Joris
- van Putten Maurice
- Van Ranst Zeb
- van Remortel Nick
- Vander-Hyde D. C.
- Vandra K.
- Vanosky J.
- Vardaro M.
- Vargas A. F.
- varma vijay
- Vasuth Matyas
- vecchio alberto
- Vedovato G.
- Veitch John
- Veitch Peter
- Venikoudis S.
- Venneberg Jasper
- Verdier Patrice
- Verkindt Didier
- Verma B.
- Verma P.
- Verma Yogesh
- Vermeulen Sander M.
- Veske Doğa
- Vetrano F.
- Veutro A.
- Vibhute Ajay
- Viceré Andrea
- Vidyant S.
- Viets Aaron
- Vijaykumar Aditya
- Vilkha A.
- Villa-Ortega Verónica
- Vincent Erin
- Vinet J. -Y.
- Viret S.
- Virgo Collaboration
- Virtuoso Andrea
- Vitale Salvatore
- Vocca H.
- Voigt Daniel
- von Reis E. R. G.
- von Wrangel J. S. A.
- Vyatchanin Sergey P.
- Wade L. E.
- Wade Madeline
- Wagner Katelyn
- Walet R. C.
- Walker M.
- Wallace G. S.
- Wallace L.
- Wang Haoyu
- Wang J. Z.
- Wang W. H.
- Wang Z.
- Waratkar Gaurav
- Ward R. L.
- Warner J.
- Was Michal
- Washimi Tatsuki
- Washington N. Y.
- Watarai D.
- Wayt K. E.
- Weaver B.
- Weaving C. R.
- Webster S. A.
- Weinert M.
- Weinstein Alan J.
- Weiss R.
- Weizmann Kiendrebeogo R.
- Weller C. M.
- Weller Robert
- Wellmann F.
- Wen L.
- Wette Karl
- Weßels P.
- Whelan John
- White D. D.
- Whiting Bernard F.
- Whittle Chris
- Wildberger J. B.
- Wilk O. S.
- Wilken Dennis
- Willetts K.
- Williams Daniel
- Williams Michael J.
- Williams N. S.
- Willis Joshua
- Willke Benno
- Wils Milan
- Wipf C. C.
- Woan Graham
- Woehler J.
- Wofford Jared
- Wolfe N. E.
- Won Lee Hyung
- Won Seo Jin
- Wong D.
- Wong Henry T.
- Wright J. L.
- Wright Mick
- Wu Chien-Ming
- Wu David S.
- Wu Hsun-Chung
- Wysocki Daniel
- Xiao Liting
- Xu Victoria
- Xu Yumeng
- Yaala M. Ben
- Yadav Nikesh
- Yakovlev Alexey
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto M.
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yan T.
- Yang F.
- Yang Fengwei
- Yang Kate Z.
- Yang L. -C.
- Yang Yi
- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Genomic investigations of unexplained acute hepatitis in children
- Author
- Abdulla Amina
- Aebi Christoph
- Agbeko Rachel
- Aggelos Pefanis
- Agranoff Dan
- Agwuh Ken
- Agyeman Philipp
- Alba-Alejandre Irene
- Ali Ladan
- Alkema Wynand
- Allen Karen
- Alrabiah Dimah K.
- Amatya Puja
- Anderson Glenn
- Anderson Suzanne
- Andrade Catarina
- Andreani Julien
- Anpananthar Amutha
- Ansari Imran
- Antinao Diaz Juan F.
- Arif Tasnim
- Armstrong Diane
- Armstrong Jane A.
- Armstrong Lawrence
- Asgarian Zeinab
- Atkinson Laura
- Avcin Tadej
- Avramoska Tanja
- Baas Bryan
- Bahovec Natalija
- Baillie Kenneth
- Balode Anda
- Bamford Alasdair
- Barendregt A. M.
- Barral-Arca Ruth
- Barzdina Arta
- Barzdina Elza
- Basmaci Romain
- Bath David
- Bauchinger Sebastian
- Baumard Lucas
- Baumgart Hinrich
- Baxter Frances
- Bayzid Nadua
- Beer Sally
- Bell Ashley
- Bell Claire
- Bell Kathryn
- Bellini Arianna
- Bello Xabier
- Bellos Evangelos
- Benesch Martin
- Benesch Martin
- Bennet Joshua
- Berger Christoph
- Bernhard-Stirnemann Sara
- Beudeker Coco R.
- Beveridge Laura
- Bibi Sagida
- Bidlingmaier Christoph
- Biesbroek Giske
- Bijukchhe Sanjeev Man
- Billing Kyle
- Binder Alexander
- Binder Vera
- Birt Mark
- Bogovic Petra
- Bohmova Kristyna
- Bojang Kalifa
- Bont Louis J.
- Borensztajn Dorine M.
- Bories Pauline
- Branch Nicole
- Brengel-Pesce Karen
- Breuer Judith
- Broderick Claire
- Brotherton Helen
- Brown Julianne R.
- Brown Rachel
- Buddle Sarah
- Burling Sara
- Buschbeck Judith
- Cabello Laura
- Calle Irene Rivero
- Calvo-Bado Leo
- Campos Luis
- Candlish Janie
- Capozzi Lisa
- Carnota Sandra
- Caro Ivan
- Carrol Enitan D.
- Carson Gail
- Carter Michael
- Carter Michael J.
- Castellano Sergi
- Castro Maria Barreiro
- Cebey-López Miriam
- Ceesay Samba
- Celma Cristina
- Ceolotto Astrid
- Chan Adora
- Chand Meera
- Channon-Wells Samuel
- Charalambos Gogos
- Chikowore Primrose
- Chiurchiù Sara
- Chukkambotla Srikanth
- Chériaux Laura
- Clark Richard
- Clohisey Sara
- Cocklin Elizabeth
- Cohen Jonathan
- Cohen Laure
- Collings Kalvin
- Collins Emma
- Connon Maggie
- Cooray Samantha
- Cotillon Marie
- Counsell John R.
- Coutts Audrey
- Cresswell Fiona
- Crulley Stephen
- Cunnington Aubrey
- Curras-Tuala María José
- Czap Agata
- D'alessandro Umberto
- D?Souza Giselle
- Dall Anna
- Danekova Nevena
- Danhauser Katharina
- Darboe Saffiatou
- Darnell Sarah
- Daubney Esther
- Davis Francesca
- Davoust Juraté
- Dawson Joy
- de Groc Thibault
- de Groot Ronald
- de Haan L.
- de Jonge Marien I.
- de Silva Thushan
- de Tugny Alice
- de Vries Gabriella
- De Surjo
- De Tisham
- Deep Akash
- Deheragoda Maesha
- Deksne D?rta
- Devine Kirsty
- Dewez Juan Emmanuel
- Dewez Manuel
- Diaba Cynthia
- Dickinson Holly
- Dik W.
- Donelly Lorna
- Donohue Chloe
- Dorward David
- Drysdale Simon B.
- Dudley Julia
- Dunning Jake
- DuRand Ingrid
- Eber Ernst
- Eisen Sarah
- Eleftheriou Irini
- Ellis Donna
- Elorrieta Leire Estramiana
- Emonts Marieke
- Ensom Ruth
- Epalza Cristina
- Estrada-Rivadeneyra Diego
- Evans Benjamin
- Fabian Daniel
- Farmer Sarah
- Farto Cristina Balo
- Faust Saul
- Fawkes Angie
- Ferguson Susie
- Fernández Sonia Serén
- Feuchtinger Tobias
- Fidler Katy
- Fink Colin
- Finlayson Lauren
- Fish Matthew
- Fitchett Elizabeth
- Fletcher Tom
- Floyd Sharon
- Fullerton Duncan
- Galassini Rachel
- Gallagher Eileen
- Gallistl Siegfried
- Gannon Louise
- García Mirian Ben
- Gardiner Emma
- Garg Sanjeev
- Geissler J.
- Georgiou Pantelis
- Gerrits G. P. J. M.
- Giannoni Eric
- Gijón Manuel
- Gilchrist Tammy
- Gissen Paul
- Giuseppe Martina Di
- Gloerich Jolein
- Goetschalckx Ines
- Gonzalez Suam
- González Fernando Álvez
- Gores Gunther
- Gormley Stuart
- Graham Clive
- Grammatikopoulos Tassos
- Gravele Dagne
- Griese Matthias
- Grope Ilze
- Gruppen Mariken
- Guerra-Assunção José Afonso
- Gunson Rory
- Gurung Meeru
- Gutiérrez Lourdes
- Gómez-Carballa Alberto
- Haas Nikolaus
- Habgood-Coote Dominic
- Hadzic Nedim
- Hafezi Katarzyna
- Hagedoorn Nienke N.
- Haidl Harald
- Hamilton Shea
- Hamzah Lisa
- Hanlon Killian S.
- Hanson Anita
- Hardwick Hayley
- Harper Rosemary
- Hartshorn Stuart
- Hatcher James
- Hauer Almuthe
- Heidema J.
- Heightman Melissa
- Heininger Ulrich
- Henderson Paul
- Henriet Stefanie
- Herberg Jethro
- Hernández Irene
- Hibberd Martin
- Hickey Naomy
- Ho Antonia Y. W.
- Hodgson Luke
- Hoffmann Florian
- Hoggart Clive
- Holden Jennifer
- Holden Matt
- Hope Susan
- Hopton Sarah
- Hoschler Katja
- Houlihan Catherine
- Hourmat Sara
- Howman Ruth
- Hude Christa
- Huijnen Martijn
- Hutchinson J. Ciaran
- Hösele Susanne
- Iglesias Marisol Vilas
- Iglesias Pilar Leboráns
- Ijaz Samreen
- Ioanna Stergiou
- Irving Clare
- Isaacs John
- Jackson Heather
- Jacques Thomas S.
- Jansen Machiel H.
- Jarman Heather
- Jennings Aislinn
- Jennings Paul
- Jennings Rebecca
- Johnston Joanne
- Jones Amaryl
- Jongerius Ilse
- Jorgensen Rikke
- Juranek Sabrina
- Kaforou Mysini
- Kahlert Christian
- Kandasamy Rama
- Kapper Andreas
- Kappler Matthias
- Karolina Akinosoglou
- Kaufer Benedikt B.
- Kavanagh James
- Keil Julia
- Keldorfer Markus
- Kelgeri Chayarani
- Kelly Dominic F.
- Kelly Sarah
- Kenny Julia
- Khalid Nosheen
- Khanijau Aakash
- Khoo Say
- Kim Eunjung
- King Sharon
- Kishore Shyla
- Kitanovski Lidija
- Kloosterhuis Lieke
- Kohlfürst Daniela S.
- Kohlmaier Benno
- Kolberg Laura
- Kolnik Mojca
- Koshy George
- Krenn Larissa
- Kuijpers Taco
- Kuijpers Taco
- Lachaume Noémie
- Laivacuma Sniedze
- Laivacuma Sniedze
- Law Andrew
- Le Sébastien
- Lee Jack C. D.
- Leigh Simon
- Leiner Tamas
- Leitch Karen
- Leitner Manuel
- Lenihan Rebecca
- Lennon Alexander
- Lett Lauren
- Leurent Baptiste
- Levin Michael
- Lewis-Burke Nadia
- Liebeschuetz Susan
- Lim Emma
- Limb James
- Lin Naomi
- Linforth Michelle
- Little Jeff
- Liu Ching-Chuan
- Logan Sheena
- Lubinda Tim
- Luca Maia De
- Lurz Eberhard
- Löffler Sabine
- MacFarlane Susan
- MacGillivray Louise
- Machín Fátima
- Mackerness Christine
- Maclean Alan
- Maconochie Ian
- Macpherson Hannah
- Madelane Monta
- Maier Esther
- Malcolm Ivone Lancoma
- Mallet François
- Mandal Sema
- Manzanares Ángela
- Manzano Jesus-Rodriguez
- Maritsi Despoina
- Marjaneh Mahdi Moradi
- Markos Maragos
- Marmarinos Antonios
- Marmarinos Antonis
- Martin Bernal Luz Marina
- Martin Alex
- Martin Darran
- Martin Joanne
- Martin Mike
- Martinón-Torres Federico
- Martinón-Torres Nazareth
- Matovu Elijah
- Matthews Peter
- McAlinden Paul
- McArdle Andrew
- McCafferty Sarah
- McDonald Sam
- McDonald Sarah E.
- McDonnell Anne
- McGenily Laura
- McGill Fiona
- McKay Sarah
- Meiere Anija
- Meierford Anne
- Menikou Stephanie
- Merson Laura
- Michalis Voulgarelis
- Miedema C. J.
- Millar Margaret
- Miller Caroline
- Miller Danielle
- Milligan Barry
- Mills Sarah
- Miners Alec
- Mistry Ravi
- Mita Andrew
- Moll Henriëtte A.
- Mommert Marine
- Mommert-Tripon Marine
- Mondo Diana
- Montgomery Kylie-Ann
- Moore Catherine
- Moots Robert
- Moradi Marjaneh Mahdi
- Morfopoulou Sofia
- Morrice John
- Morrice Kirstie
- Morris Craig
- Moser Nicolas
- Muench Georg
- Murdoch David R.
- Murphy Lee
- Mustafa Sobia
- Márquez Sonia
- Nagelkerke Sietse
- Nahtigal Mirijam
- Nasher Magda
- Natalucci Giancarlo
- Neeleman C.
- Neill Claire
- Neshat Samira
- Newal Karen
- Newall Karen
- Ng Joanne
- Nichols Samuel
- Niederer-Loher Anita
- Niedrist Tobias
- Nijman Ruud
- Nijman Ruud
- Nokalna Ieva
- Nordberg Gudrun
- Norris Lucy
- Noursadeghi Mahdad
- Nyirenda Maggie
- O'Connor Daniel
- O?Reilly Peter
- O?Riordan Sean
- Obihara C. C.
- Obosi Lauren
- Odam Miranda
- Oliver Zoe
- Ong Kim-Thanh
- Oosthoek Wilma
- Oosthuyzen Wilna
- Openshaw Peter J. M.
- Ora Miguel Sadiki
- Osterman Veronika
- Owen Dan
- Pachot Alexandre
- Pajkrt D.
- Pajkrt Dasja
- Palmarini Massimo
- Panagiota Lourida
- Papst Lea
- Pardo-Seco Jacobo
- Patel Harsita
- Pathan Nazima
- Paulus Stéphane
- Paulus Stéphane
- Paulus Stéphane C.
- Pavare Jana
- Paz Ivonne Pena
- Pennisi Ivana
- Persand Salina
- Peters Mark
- Pfleger Andreas
- Pfurtscheller Klaus
- Philipsen Ria
- Pickering Ailsa
- Pierce Benjamin
- Pilch Heidemarie
- Pischedda Sara
- Player Jasmine
- Pokhrel Bhishma
- Pokorn Marko
- Pokorn Marko
- Pollara Gabriele
- Pollard Andrew J.
- Pollock Louisa
- Posfay-Barbe Klara M.
- Powell Natassia
- Powell Oliver
- Price Ashley
- Price David
- Price Nicholas
- Prunk Petra
- Pucuka Zanda
- Pérez Belén Mosquera
- Pölz Lena
- Rajic Glorija
- Rampling Tommy
- Ramsay Maxine
- Rashid Aqeela
- Redondo-Collazo Lorenzo
- Reich Jana
- Reid Ruth
- Reiter Karl
- Relly Christa
- Reschreiter Henrik
- Reynolds Tim
- Rhodes Mathew
- Rial Jose Gómez
- Richmond Vivien
- Riddell Anna
- Riedel Thomas
- Robbins Ceri
- Rodríguez Lidia Piñeiro
- Rodríguez-Tenreiro Carmen
- Roff Amy
- Rojo Pablo
- Romaine Sam
- Romani Lorenza
- Roome Tara
- Rosenheim Joshua
- Rowlands Emily
- Roy Sunando
- Rubick Lucy
- Rudzate Aleksandra
- Rughnani Prita
- Russell Clark D.
- Rusu Alexandra
- Rödl Siegfried
- Sagmeister Manfred G.
- Saidykhan Momodou
- Salas Antonio
- Santilli Giorgia
- Sarr Anna RocaIsatou
- Schlapbach Luregn
- Schlapbach Luregn J.
- Schlüchter Stefanie
- Schmied Patricia
- Schoen Carola
- Scholefield Barnaby J.
- Schonenberg D.
- Schonenberg Dieneke
- Schranz Rachel
- Schroepf Sebastian
- Schweintzger Nina A.
- Schöbi Nina
- Seal Matthew
- Secka Fatou
- Segal Terry
- Selecka Katrina
- Semple Malcolm Gracie
- Shackley Fiona
- Shah Priyen
- Shaji Mariya
- Shankar-Hari
- Shaw Victoria
- Shen Ching-Fen
- Shenton Geoff
- Shepherd Samantha J.
- Shrestha Shrijana
- Siam Ala?a
- Sidorova Aleksandra
- Simagan Teresa
- Simmonds Peter
- Simmons Ruth
- Skrabl-Baumgartner Andrea
- Solomon Tom
- Spencer Collette
- Sperl Matthias
- Sprenkeler Evelien
- Spyridis Nikos
- Srovin Tina Plankar
- Srpcic Anja
- Stampfer Laura
- Steele Michael
- Stevens Jake
- Stevens Molly
- Stocker Martin
- Stoiser Bianca
- Stoldere Diana
- Storey Nathaniel
- Strempfl Martina
- Strenger Volker
- Strijbosch Annelieke M.
- Strle Franc
- Suárez Carlos Durán
- Svile Dace
- Swingler Rachel
- Syggelou Kelly
- Sánchez José María Martinón
- Sée Hélène
- Tait Sarah
- Talts Tiina
- Tambouratzi Maria
- Tan Chantal
- Tappouni Luke J.
- Tauchert Maike K.
- Tavliavini Emma
- Tayler Rachel
- Tedder Richard S.
- Tempel Dennie
- Templeton Kate
- Thalassinos Konstantinos
- Thomas Daisy
- Thomson Emma
- Thomson Evelyn
- Thorson Stephen
- Tibby Shane
- Till Holger
- Tissing Wim J. E.
- Tkhayat Raja Ben
- Torres Montaguth Oscar Enrique
- Tramper-Stranders G. A.
- Trasorras Cristina Serén
- Treloar Owen
- Trobisch Andreas
- Tsolia Maria
- Turtle Lance C. W.
- Tutill Helena
- Urbane Urzula Nora
- Ushiro-Lumb Ines
- Usman Mariama
- Usuf Effua
- Valentine Lucille
- van Aerde Koen
- van de Kuip Martijn
- van den Berg J. M.
- van den Berg Merlijn
- van den Broek Bryan
- van der Flier Michiel
- van der Flier Michiel
- van der Giessen Ilona
- van der Kuip M.
- van der Velden Fabian
- van der Velden Fabian J. S.
- van der Zee Carlijn
- van Furth A. M.
- van Furth Marceline
- van Gool Alain J.
- van Hensbroek Michael Boele
- van Keulen Danielle
- van Leur M.
- van Mierlo G.
- Vastert Sebastiaan J.
- Venturini Cristina
- Vergnault Nathalie
- Verkuil Floris
- Vermont Clementien L.
- Vicente Luisa García
- Vijlbrief Daniel C.
- Villaverde Serena
- Vincek Katarina
- Vito Ortensia
- Voice Marie
- von Both Ulrich
- Vázquez Sara Rey
- Waddington Simon N.
- Wallia Diane
- Wallner Elmar
- Wang Shih-Min
- Ward Bryony
- Ward Catriona
- Watson Conall
- Weber Kathrin
- Wedderburn Catherine
- Wellings Lucy
- Wellman Paul
- Wham Murray
- White Deborah
- White Marie
- Whittaker Elizabeth
- Whittaker Paul
- Whittaker Thomas E.
- Willems Esther
- Williams Charlotte A.
- Williams Rachel
- Wilson Barbara
- Wilson Clare
- Winmill Helen
- Wolfs Tom F. W.
- Womersley Rebecca
- Wood Amanda
- Woodsford Phil
- Wright Victoria
- Wrobel Nicola
- Wyss Verena
- Wösten-van Asperen Roelie M.
- Xagorari Marietta
- Yeung Shunmay
- Zachariasse Joany
- Zaman Syed M. A.
- Zambon Maria
- Zandstra Judith
- Zavadska Dace
- Zennezini Chiozzi Riccardo
- Zenz Werner
- Zimmermann Elisa
- Zurl Christoph
- Zwerenz Manuela
- Publication venue
- Nature Research
- Publication date
- 30/03/2023
- Field of study
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children