Some Adventures in the Search for a Modified Gravity Explanation for Cosmic Acceleration

The discovery of cosmic acceleration has raised the intriguing possibility that we are witnessing the first breakdown of General Relativity on cosmological scales. In this article I will briefly review current attempts to construct a theoretically consistent and observationally viable modification of gravity that is capable of describing the accelerating universe. I will discuss f(R) models, and their obvious extensions, and the DGP model as an example of extra-dimensional implementations. I will then briefly describe the Galileon models and their very recent multifield and curved space extensions - a class of four-dimensional effective field theories encoding extra dimensional modifications to gravity. This article is dedicated to the career of my friend and former colleague, Joshua Goldberg, and is written to appear in his festschrift.Comment: 17 pages, to appear in a festschrift for Joshua Goldber

The Big Trip and Wheeler-DeWitt equation

Of all the possible ways to describe the behavior of the universe that has undergone a big trip the Wheeler-DeWitt equation should be the most accurate -- provided, of course, that we employ the correct formulation. In this article we start by discussing the standard formulation introduced by Gonz\'alez-D\'iaz and Jimenez-Madrid, and show that it allows for a simple yet efficient method of the solution's generation, which is based on the Moutard transformation. Next, by shedding the unnecessary restrictions, imposed on aforementioned standard formulation we introduce a more general form of the Wheeler-DeWitt equation. One immediate prediction of this new formula is that for the universe the probability to emerge right after the big trip in a state with $w=w_0$ will be maximal if and only if $w_0=-1/3$.Comment: accepted in Astrophysics and Space Scienc

Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques

The Zika virus (ZIKV) epidemic is associated with fetal brain lesions and other serious birth defects classified as congenital ZIKV syndrome. Postnatal ZIKV infection in infants and children has been reported; however, data on brain anatomy, function, and behavioral outcomes following infection are absent. We show that postnatal ZIKV infection of infant rhesus macaques (RMs) results in persistent structural and functional alterations of the central nervous system compared to age-matched controls. We demonstrate ZIKV lymphoid tropism and neurotropism in infant RMs and histopathologic abnormalities in the peripheral and central nervous systems including inflammatory infiltrates, astrogliosis, and Wallerian degeneration. Structural and resting-state functional magnetic resonance imaging (MRI/rs-fMRI) show persistent enlargement of lateral ventricles, maturational changes in specific brain regions, and altered functional connectivity (FC) between brain areas involved in emotional behavior and arousal functions, including weakened amygdala-hippocampal connectivity in two of two ZIKV-infected infant RMs several months after clearance of ZIKV RNA from peripheral blood. ZIKV infection also results in distinct alterations in the species-typical emotional reactivity to acute stress, which were predicted by the weak amygdala-hippocampal FC. We demonstrate that postnatal ZIKV infection of infants in this model affects neurodevelopment, suggesting that long-term clinical monitoring of pediatric cases is warranted

On the selection of AGN neutrino source candidates for a source stacking analysis with neutrino telescopes

The sensitivity of a search for sources of TeV neutrinos can be improved by grouping potential sources together into generic classes in a procedure that is known as source stacking. In this paper, we define catalogs of Active Galactic Nuclei (AGN) and use them to perform a source stacking analysis. The grouping of AGN into classes is done in two steps: first, AGN classes are defined, then, sources to be stacked are selected assuming that a potential neutrino flux is linearly correlated with the photon luminosity in a certain energy band (radio, IR, optical, keV, GeV, TeV). Lacking any secure detailed knowledge on neutrino production in AGN, this correlation is motivated by hadronic AGN models, as briefly reviewed in this paper. The source stacking search for neutrinos from generic AGN classes is illustrated using the data collected by the AMANDA-II high energy neutrino detector during the year 2000. No significant excess for any of the suggested groups was found.Comment: 43 pages, 12 figures, accepted by Astroparticle Physic

All-particle cosmic ray energy spectrum measured with 26 IceTop stations

We report on a measurement of the cosmic ray energy spectrum with the IceTop air shower array, the surface component of the IceCube Neutrino Observatory at the South Pole. The data used in this analysis were taken between June and October, 2007, with 26 surface stations operational at that time, corresponding to about one third of the final array. The fiducial area used in this analysis was 0.122 km^2. The analysis investigated the energy spectrum from 1 to 100 PeV measured for three different zenith angle ranges between 0{\deg} and 46{\deg}. Because of the isotropy of cosmic rays in this energy range the spectra from all zenith angle intervals have to agree. The cosmic-ray energy spectrum was determined under different assumptions on the primary mass composition. Good agreement of spectra in the three zenith angle ranges was found for the assumption of pure proton and a simple two-component model. For zenith angles {\theta} < 30{\deg}, where the mass dependence is smallest, the knee in the cosmic ray energy spectrum was observed between 3.5 and 4.32 PeV, depending on composition assumption. Spectral indices above the knee range from -3.08 to -3.11 depending on primary mass composition assumption. Moreover, an indication of a flattening of the spectrum above 22 PeV were observed.Comment: 38 pages, 17 figure

Population of neutron-rich nuclei around 48ca with deep inelastic collisions

The deep inelastic reaction 48Ca+64Ni at 6 MeV/A has been studied using the CLARA–PRISMA setup. Angular distributions for pure elastic scattering and total cross-sections of the most relevant transfer channels have been measured. The experimental results are compared with predictions from a semiclassical model, showing good agreement for the presently analyzed few neutrons transfer channels. The decay of the most intense reaction products has also been studied, giving indications of the population of states with very short lifetimes.Gadea Raga, Andrés, [email protected]

Reaction dynamics and nuclear structure studies via deep inelastic collisions with heavy-ions: spin and parity assignment in (49)Ca

The population and gamma decay of neutron rich nuclei around 48Ca has been measured at Legnaro National Laboratory with the PRISMA-CLARA setup, using deep-inelastic collisions (DIC) on 64Ni, at an energy approximately twice the Coulomb barrier. The reaction properties of the main products are investigated, focusing on total cross sections and angular distributions both integrated in energy and associated to the population of specific excited states. Gamma spectroscopy studies are also performed, giving evidence, for the first time in transfer reactions with heavy ions, of a large spin alignment ( 3c70%), perpendicular to the reaction plane. This makes possible the use of angular distributions and polarization measurements to firmly establish the spin and parity of excited states populated in nucleon transfer channels, as in the case of 49Ca, where candidates for particle-core coupling are investigated. Both reaction and gamma spectroscopy studies demonstrate the relevance of DIC with heavy ions for a detailed investigation of moderately neutron rich systems

Role of the repeat expansion size in predicting age of onset and severity in RFC1 disease

RFC1 disease, caused by biallelic repeat expansion in RFC1, is clinically heterogeneous in terms of age of onset, disease progression and phenotype. We investigated the role of the repeat size in influencing clinical variables in RFC1 disease. We also assessed the presence and role of meiotic and somatic instability of the repeat. In this study, we identified 553 patients carrying biallelic RFC1 expansions and measured the repeat expansion size in 392 cases. Pearson’s coefficient was calculated to assess the correlation between the repeat size and age at disease onset. A Cox model with robust cluster standard errors was adopted to describe the effect of repeat size on age at disease onset, on age at onset of each individual symptoms, and on disease progression. A quasi-Poisson regression model was used to analyse the relationship between phenotype and repeat size. We performed multivariate linear regression to assess the association of the repeat size with the degree of cerebellar atrophy. Meiotic stability was assessed by Southern blotting on first-degree relatives of 27 probands. Finally, somatic instability was investigated by optical genome mapping on cerebellar and frontal cortex and unaffected peripheral tissue from four post-mortem cases. A larger repeat size of both smaller and larger allele was associated with an earlier age at neurological onset [smaller allele hazard ratio (HR) = 2.06, P < 0.001; larger allele HR = 1.53, P < 0.001] and with a higher hazard of developing disabling symptoms, such as dysarthria or dysphagia (smaller allele HR = 3.40, P < 0.001; larger allele HR = 1.71, P = 0.002) or loss of independent walking (smaller allele HR = 2.78, P < 0.001; larger allele HR = 1.60; P < 0.001) earlier in disease course. Patients with more complex phenotypes carried larger expansions [smaller allele: complex neuropathy rate ratio (RR) = 1.30, P = 0.003; cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS) RR = 1.34, P < 0.001; larger allele: complex neuropathy RR = 1.33, P = 0.008; CANVAS RR = 1.31, P = 0.009]. Furthermore, larger repeat expansions in the smaller allele were associated with more pronounced cerebellar vermis atrophy (lobules I–V β = −1.06, P < 0.001; lobules VI–VII β = −0.34, P = 0.005). The repeat did not show significant instability during vertical transmission and across different tissues and brain regions. RFC1 repeat size, particularly of the smaller allele, is one of the determinants of variability in RFC1 disease and represents a key prognostic factor to predict disease onset, phenotype and severity. Assessing the repeat size is warranted as part of the diagnostic test for RFC1 expansion