Numerical study and geometrical investigation of an onshore overtopping device wave energy converter with a seabed coupled structure

Studies regarding renewable energy sources have gained attention over recent years. One example is wave energy converters, which harvest energy from sea waves using different operational principles such as oscillating water columns, oscillating bodies, and overtopping devices. In the present paper, a numerical study is carried out, and a geometrical investigation of a fullscale overtopping device with a coupled structure mounted on the seabed is performed using the Constructal Design method. The main purpose is to investigate the influence of the design over the available power of the device. The areas of the overtopping ramp (Ar) and the trapezoidal seabed structure (At) are the problem constraints. Two degrees of freedom are studied, the ratio between the height and length of the ramp (H3/L3) and the ratio between the upper and lower basis of the trapezoidal obstacle (L1/L2). The device submersion is kept constant (H1 = 3.5 m). The equations of continuity, momentum, and the transport of volume fraction are solved with the Finite Volume Method, while the water–air mixture is treated with the multiphase model Volume of Fluid. Results showed that the ratio H3/L3 presented a higher sensibility than the ratio L1/L2 over the accumulated water in the reservoir. Despite that, the association of a structure coupled to the ramp of an overtopping device improved the performance of the converter by 30% compared to a conventional condition without the structure

Numerical analysis of an overtopping wave energy converter subjected to the incidence of irregular and regular waves from realistic sea states

The present study aims to evaluate the difference in the fluid-dynamic behavior of an overtopping wave energy converter under the incidence of irregular waves based on a realistic sea state when compared to the incidence of regular waves, representative of this sea state. Thus, the sea data of three regions from the Rio Grande do Sul coast, Brazil, were considered. Fluent software was employed for the computational modeling, which is based on the finite volume method (FVM). The numerical generation of waves occurred through the imposition of the velocity boundary conditions using transient discrete values through the WaveMIMO methodology. The volume of fluid (VOF) multiphase model was applied to treat the water–air interaction. The results for the water amount accumulated in the device reservoir showed that the fluid-dynamic behavior of the overtopping converter has significant differences when comparing the two proposed approaches. Differences up to 240% were found for the water mass accumulated in the overtopping device reservoir, showing evidence that the results can be overestimated when the overtopping device is analyzed under the incidence of the representative regular waves. Furthermore, for all studied cases, it was possible to approximate the water volume accumulated over time in the overtopping reservoir through a first-degree polynomial function

Looking at Data Science through the Lens of Scheduling and Load Balancing

The growth in data generated by private and public organizations leads to several opportunities to obtain valuable knowledge. In this scenario, data science becomes pertinent to define a structured methodology to extract valuable knowledge from raw data. It encompasses a heterogeneous group of techniques that challenge the implementation of a single platform capable of incorporating all the available resources. Thus, it is necessary to formulate a data science workflow based on different tools to extract knowledge from massive datasets. In this context, high-performance computing (HPC) provides the infrastructure required to optimize the processing time of data science workflows, which become a collection of tasks that must be efficiently scheduled to provide results in acceptable time intervals. While few studies explore the use of HPC for data science tasks, in the best of our knowledge, none conducts an in-depth analysis of scheduling and load balancing on such workflows. In this context, this chapter proposes an analysis of scheduling and load balancing from the perspective of data science scenarios. It presents concepts, environments, and tools to summarize the theoretical background required to define, assign, and execute data science workflows. Furthermore, we are also presenting new trends concerning the intersection of data science, scheduling, and load balance

Convalescent plasma for COVID-19 in hospitalised patients : an open-label, randomised clinical trial

Background: The effects of convalescent plasma (CP) therapy in hospitalised patients with coronavirus disease 2019 (COVID-19) remain uncertain. This study investigates the effect of CP on clinical improvement in these patients. Methods: This is an investigator-initiated, randomised, parallel arm, open-label, superiority clinical trial. Patients were randomly (1:1) assigned to two infusions of CP plus standard of care (SOC) or SOC alone. The primary outcome was the proportion of patients with clinical improvement 28 days after enrolment. Results: A total of 160 (80 in each arm) patients (66.3% critically ill, 33.7% severely ill) completed the trial. The median (interquartile range (IQR)) age was 60.5 (48–68) years; 58.1% were male and the median (IQR) time from symptom onset to randomisation was 10 (8–12) days. Neutralising antibody titres >1:80 were present in 133 (83.1%) patients at baseline. The proportion of patients with clinical improvement on day 28 was 61.3% in the CP+SOC group and 65.0% in the SOC group (difference −3.7%, 95% CI −18.8–11.3%). The results were similar in the severe and critically ill subgroups. There was no significant difference between CP+SOC and SOC groups in pre-specified secondary outcomes, including 28-day mortality, days alive and free of respiratory support and duration of invasive ventilatory support. Inflammatory and other laboratory marker values on days 3, 7 and 14 were similar between groups. Conclusions: CP+SOC did not result in a higher proportion of clinical improvement on day 28 in hospitalised patients with COVID-19 compared to SOC alone

Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences

The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; Nemésio 2009a–b; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on 18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based researchers who signed it in the short time span from 20 September to 6 October 2016

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation