Modeling arrival scattering due to surface roughness

Signal scattering due to surface roughness constitutes one of the most important modeling problems in underwater acoustics when dealing with signal processing at large frequencies (i.e. above 1 kHz). Such modeling requires, in particular, realistic predictions of the ocean surface, which is usually perturbed by the propagation of swells and wind driven surface waves. Most of experimental studies had been dealing with short-range propagation, although it still remains unclear the separated impact of periodic vs. stochastic surface roughness on the arrival structure of received signals. The main purpose of the discussion presented in this paper is to clarify such issues through the calculation of impulse responses at high frequencies, at short and large ranges, using a ray tracing acustic propagation model. The results of the simulations are expected to improve strategies of signal processing when scattering affects the received signal

Paraganglioma of Prostatic Origin

Introduction Paragangliomas are usually benign tumors arising from chromaffin cells located outside the adrenal gland. Prostatic paraganglioma is an unusual entity in adult patients, with only 10 cases reported in the medical literature. Case Report A 34-year-old male with a history of chronic prostatitis consulted for perineal pain. On digital rectal examination the prostate was enlarged and firm, without nodules. The PSA level was 0.8 ng/mL and the catecholamines in the urine were elevated. On ultrasound a retrovesical 9 cm mass of undetermined origin measuring was present. A PET-CT scan showed a pelvic lesion measuring 9 cm with moderate increase in glucidic metabolism localized in the area of the prostate. A biopsy of the prostate revealed a neuroendocrine tumor, possibly a prostatic paraganglioma. A body scintigraphy with MIBG I-123 ruled out the presence of metastases or multifocal tumor. A radical prostatectomy with excision of the pelvic mass was performed under adrenergic blockade. One year after surgery the patient is asymptomatic and disease free. Discussion/Conclusions Prostatic paraganglioma is a rare, usually benign tumor, which should be considered in the differential diagnosis of prostate tumors in young males. Its diagnosis is based on the determination of catecholamine in blood and 24-hour urine and in imaging studies principally scintigraphy with MIBG I-123. Diagnostic confirmation is by histopathological study. The treatment consists of radical resection under adrenergic blockade and volume expansion. Given the limited number of cases reported, it is difficult to establish prognostic factors. Malignancy is defined by clinical criteria, and requires life long follow-up

Seismic effects in archaeological sites: Archaeoseismological cataloguing and quantification

The analysis of the damage caused by seismic events in archaeological sites provides significant information about ancient and historic earthquakes that can improve seismic hazard analysis. In this paper a methodological analysis to quantify the deformation of structural damage recorded in archaeological sites is proposed. This methodology focuses on the establishment of the seismic/non-seismic origin of the observed damage and consists of three phases: (a) identification and inventory of damage; (b) quantification of deformation; and (c) incorporation of the results to seismic catalogues. The first phase is the inventory and mapping of the damage according with the classification of archaeological effects of earthquakes (EAEs). The second phase is to quantify the deformation of damage by setting different parameters such as the direction of maximum horizontal strain (ey). This analysis is performed at different levels: for each of the recorded EAEs, for all the records of a particular category of EAEs, and finally for the complete archaeological site including all the categories of EAEs. The homogeneity of the results (damage orientation) allows us to establish the seismic origin of deformations. This methodology has been developed in the Roman site of Baelo Claudia (Cádiz, Spain) and has been applied to different historical earthquakes in the Iberian Peninsula. To calibrate the method, analyses on oriented damage were carried out immediately after the recent instrumental earthquakes of Lorca 2011 (5.1 Mw, Spain) and Emilia Romagna 2012 (5.9 Mw; Italy).The analysis of the damage caused by seismic events in archaeological sites provides significant information about ancient and historic earthquakes that can improve seismic hazard analysis. In this paper a methodological analysis to quantify the deformation of structural damage recorded in archaeological sites is proposed. This methodology focuses on the establishment of the seismic / non-seismic origin of the observed damage and consists of three phases: (a) identification and inventory of damage; (b) quantification of deformation; and (c) incorporation of the results to seismic catalogues. The first phase is the inventory and mapping of the damage according with the classification of archaeological effects of earthquakes (EAEs). The second phase is to quantify the deformation of damage by setting different parameters such as the direction of maximum horizontal strain (ey). This analysis is performed at different levels: for each of the recorded EAEs, for all the records of a particular category of EAEs, and finally for the complete archaeological site including all the categories of EAEs. The homogeneity of the results (damage orientation) allows us to establish the seismic origin of deformations. This methodology has been developed in the Roman site of Baelo Claudia (Cádiz, Spain) and has been applied to different historical earthquakes in the Iberian Peninsula. To calibrate the method, analyses on oriented damage were carried out immediately after the recent instrumental earthquakes of Lorca 2011 (5.1 Mw, Spain) and Emilia Romagna 2012 (5.9 Mw; Italy).Este trabajo ha sido financiado por los proyectos CGL2015-67169-P (QTECTSPAIN, USAL) y CATESI-07 (IGME). Es una contribución al INQUA TERPRO Project 1299 y a los grupos de trabajo QTECT-AEQUA y GQMAEQU

Common Reactions of Furfural to scalable processes of Residual Biomass

Energy and the environment will always play key roles in society. The climate emergency cannot be ruled out to enable the transition for a clean energy future. Currently, non-renewable energy resources are declining, therefore is important to continuously explore renewable resources. Biomass is a renewable resource that can be applied to reduce climate changes and to accomplhish emission policies. Cellulose is the most abundant type of biomass worldwide, which can be transformed into biofuels and potential building block platform molecules (e.g furfural) throughout biological or chemical methods. Furfural can be synthetized from cellulose using hydrolysis and dehydration reactions. Furfural has a furan ring and carbonyl functional group which makes it an important intermediary to produce higher value-added molecules at  industrial level. These molecules include gasoline, diesel and jet fuel. However, furfural can also be transformed by hydrogenation, oxidation, decarboxylation and condensation reactions. The selective hydrogenation of furfural produces furfuryl alcohol, an important industrial compound, which is widely employed in the production of resins, fibers, and is considered an essential product for pharmaceutical applications. On the other hand, the oxidation of furfural produces furoic acid which is appliedin the agrochemical industry, where it is commonly transformed to furoyl chloride which is finally  used in the production of drugs and insecticides. The oxidation and reduction of furfural can carry out through heterogeneous and homogeneous catalysis, and biocatalysis.  Selectivity is an important issue in furfural hydrogenation and oxidation reactions since different products can be obtained by using monometallic or bimetallic catalysts and/or different catalyst supports. In biocatalysis approach, different enzymes, complete cells, tools of modern biotechnology, DNA sequencing, regulation of metabolic networks, overexpression of genes that encode enzymes of interest and optimization of the cellular properties of the microorganism are used. Herein, a review on the current status of furfuryl alcohol and furoic acid production from furfural by heterogeneous catalysis and biocatalysis has been studied. The stability, selectivity and activity of catalystsalong with the different furfural oxidation and reduction conditions have been pointed out. Additionally, the main enzymes, microorganisms and mechanism involved in the furfural degradation process have also been discussed.publishersversionpublishe

Differential lipid accumulation on HepG2 cells triggered by palmitic and linoleic fatty acids exposure

Lipid metabolism pathways such as β-oxidation, lipolysis and, lipogenesis, are mainly associated with normal liver function. However, steatosis is a growing pathology caused by the accumulation of lipids in hepatic cells due to increased lipogenesis, dysregulated lipid metabolism, and/or reduced lipolysis. Accordingly, this investigation hypothesizes a selective in vitro accumulation of palmitic and linoleic fatty acids on hepatocytes. After assessing the metabolic inhibition, apoptotic effect, and reactive oxygen species (ROS) generation by linoleic (LA) and palmitic (PA) fatty acids, HepG2 cells were exposed to different ratios of LA and PA to study the lipid accumulation using the lipophilic dye Oil Red O. Lipidomic studies were also carried out after lipid isolation. Results revealed that LA was highly accumulated and induced ROS production when compared to PA. Lipid profile modifications were observed after LA:PA 1:1 (v/v) exposure, which led to a four-fold increase in triglycerides (TGs) (mainly in linoleic acid-containing species), as well as a increase in cholesterol and polyunsaturated fatty acids (PUFA) content when compared to the control cells. The present work highlights the importance of balancing both PA and LA fatty acids concentrations in HepG2 cells to maintain normal levels of free fatty acids (FFAs), cholesterol, and TGs and to minimize some of the observed in vitro effects (i.e., apoptosis, ROS generation and lipid accumulation) caused by these fatty acids.info:eu-repo/semantics/publishedVersio

Oxoisoaporphines and aporphines: Versatile molecules with anticancer effects

Indexación: Scopus.Cancer is a disease that involves impaired genome stability with a high mortality index globally. Since its discovery, many have searched for effective treatment, assessing different molecules for their anticancer activity. One of the most studied sources for anticancer therapy is natural compounds and their derivates, like alkaloids, which are organic molecules containing nitrogen atoms in their structure. Among them, oxoisoaporphine and sampangine compounds are receiving increased attention due to their potential anticancer effects. Boldine has also been tested as an anticancer molecule. Boldine is the primary alkaloid extract from boldo, an endemic tree in Chile. These compounds and their derivatives have unique structural properties that potentially have an anticancer mechanism. Different studies showed that this molecule can target cancer cells through several mechanisms, including reactive oxygen species generation, DNA binding, and telomerase enzyme inhibition. In this review, we summarize the state-of-art research related to oxoisoaporphine, sampangine, and boldine, with emphasis on their structural characteristics and the relationship between structure, activity, methods of extraction or synthesis, and anticancer mechanism. With an effective cancer therapy still lacking, these three compounds are good candidates for new anticancer research.https://www.mdpi.com/1420-3049/25/1/10

Distribución geográfica y estado de conservación de los peces sierra Pristis spp (Pristiformes: Pristidae) en el Caribe sur

The former presence of sawfishes (Pristis spp) is confirmed for the southern Caribbean Sea from the coasts of Colombia and Venezuela, based on review of eleven rostral saws exhibited in businesses, museums and private collections, as well as bibliographic references, photographs and surveys to detect sightings or captures in both countries. We determined that Pristis pristis and Pristis pectinata were present in the southern Caribbean coasts of Colombia and Venezuela, but that they are now probably locally extinct.Se confirma la presencia en el pasado de las especies de pez sierra (Pristis spp) en el mar Caribe de Colombia y Venezuela, a partir de la revisión de once extensiones rostrales exhibidas en establecimientos, museos y colecciones de particulares, así como la consulta bibliográfica, encuestas y el examen de material fotográfico disponible sobre avistamientos o capturas realizadas en ambos países. Se determinó que las especies presentes en el Caribe de Colombia y Venezuela eran Pristis pristis y Pristis pectinata, las cuales en la actualidad se encuentran probablemente extintas localmente

Feasibility of Noninvasive Positive Pressure Ventilation in the Treatment of Oxygen-Dependent COVID-19 Patients in Peru

Intensive care is expensive, and availability is limited. Low- and middle-income countries in particular have struggled to cope with the large influx of critically ill patients during the COVID-19 pandemic. Noninvasive respiratory support devices delivering continuous positive airways pressure (CPAP) require less resource and staff expertise compared with invasive mechanical ventilators and can be routinely used outside of intensive care units. This study assessed the use of the UCL-Ventura Wayrachi CPAP device in hospitalized patients with COVID-19 in Peru. A secondary analysis of data collected for a feasibility study commissioned by the Peruvian Ministry of Health was conducted. Data were collected from three hospitals, including patient demographics, clinical data, and outcomes. Forty-five patients were enrolled from July 16 to September 1, 2020. Eight patients (18%) were intolerant of the CPAP mask. Of the remainder, 18 (48.7%) improved and were discharged from hospital after 6 days. Eight (21.6%) died while on CPAP and 11 (29.7%) were eventually intubated, of whom two died. In total, 27 (60%) survived to hospital discharge. Participating physicians noted the device was easy to use and provided patient benefit, though voiced concerns about the strain on hospital oxygen supplies. In conclusion, the UCL Ventura Wayrachi CPAP device proved feasible in COVID-19 patients in Peru, and offered a bridging therapy for patients who required a ventilator when none were available