Assessing Healthcare Leader Competency Proficiency Levels in Evaluating Graduate Healthcare Leadership Student Competency Proficiency Levels and Curriculum

Healthcare leaders must possess specific competencies to perform their job requirements by identifying what competencies may need development and take steps to further their education, knowledge, and proficiency. This exploratory research aims to utilize industry data when evaluating student competency proficiency and how that data might impact curriculum development. The research question that is addressed: At what competency proficiency level do working healthcare leaders rate themselves utilizing Benner’s Novice to Expert Theory (1982)? Graduate programs should evaluate current industry data to evaluate how students’ progress in their programs and determine if curriculum changes are needed. Graduate programs should also determine a competency proficiency level goal that students will achieve based off stakeholder input. Twenty-two healthcare leaders from a Midwest, non-profit healthcare organization were invited to participate in an online survey that utilized a 5-point Likert scale in which participants rated their level of proficiency across five domains: (a) leadership, (b) professionalism, (c) communication and relationship building, (d) knowledge of the healthcare environment, and (e) business skills. The corresponding competencies were adapted from the American College of Healthcare Executives (ACHE) Competencies Tool (2019) and the Healthcare Leadership Alliance (HLA) Competency Directory (2010). The majority of participants rated themselves between competent and intermediate/advanced on the competencies. Corresponding means and modes were rated highest with levels above three (intermediate) and four (between intermediate/advanced) related to the domains of leadership, professionalism, and communication and relationship building. The domains of knowledge of the healthcare environment and business skills had intermediate and intermediate/advanced ratings with lower means compared to the other three domains. The results of this study could help graduate programs define a program goal for student competency proficiency level and design a plan to utilize industry data to design, evaluate, and update graduate curriculum to help students meet the identified competency proficiency goal

Investigation of the Effect of PKC Activation on In vitro Prostate Cell Metabolism using 13C NMR

PKC isozymes have been implicated in regulating everything from transformation and proliferation of prostate cancer cells to apoptosis. Many recent studies have implicated PKC-e, a novel PKC, in supporting cell survival and proliferation in addition to having an anti-apoptotic effect through interactions with BAX. PKC-d is another novel PKC that has been shown to promote apoptosis in LNCaP cells, and thus antagonizing the antiapoptotic effect of PKC-e. 13C-NMR and 13C(3)-aspartate supplemented media were utilized to examine the metabolism of LNCaP, DU-145 and BPH cell lines with and without activation of PKC by phorbol 12-myristate 13-acetate (PMA). Equivalent amounts of 13C-lactate were produced by the BPH cell line irrespective of addition of PMA (0.50±0.0.06 mM without PMA and 0.50±0.04 mM with PMA). The LNCaP cells produced significantly less 13C-lactate on PMA treatment from 0.40±0.04 mM to 0.25±0.10 mM, while the DU-145 cells nearly doubled the production of 13C-lactate on PMA treatment from 0.27±0.09 mM to 0.53±0.09 mM. Real-time PCR experiments showed the dramatic effect of PMA on cell metabolism could not be directly explained by the relative expression level of PKC-e and PKC-d mRNA as there was no statistically significant difference in levels of PKC-e and PKC-d mRNA. These results suggest an alternative explanation, such as 2nd messenger expression levels, need to be explored

Proton-enhanced 13 C imaging/spectroscopy by polarization transfer

Carbon-13 magnetic resonance imaging/spectroscopy (CMRI/S) was performed using polarization transfer techniques where sensitivity of the carbon signal was enhanced by transferring the proton spin order to the carbon nuclei. The experimental feasibility of using polarization transfer techniques at 2.0 T was demonstrated with a phantom and an intact chicken egg. The potential clinical applications of CMRI/S with polarization transfer include the assessment of prostate cancer. Preliminary results using human prostate specimens are presented. © 1990 Academic Press, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/38483/1/1910150111_ftp.pd

Påvirkes vannkvalitet av rør

Rent drikkevann er en viktig ressurs for samfunnet. Derfor analyseres drikkevannet jevnlig for innholdet av ulike stoffer. I dette tilfellet ble vannkvaliteten i Kongsvinger sjekket for innhold av kobberioner. Vann ble samlet inn fra tre forskjellige steder i Kongsvinger. Disse ble tatt med på laben for å bestemme kobbernivået. Ut ifra dette og forskriftene om vann kunne vi trekke konklusjoner om hvordan vannkvaliteten er på de tre ulike stedene. Det viste seg at industriområdet hadde høye kobbernivåer, et tilfelle med over 1 mg/l, noe som er over lovlig standard. De to boligområdene hadde nivåer som var godt innenfor lovlige rammer.

Dynamics of viscous amphiphilic films supported by elastic solid substrates

The dynamics of amphiphilic films deposited on a solid surface is analyzed for the case when shear oscillations of the solid surface are excited. The two cases of surface- and bulk shear waves are studied with film exposed to gas or to a liquid. By solving the corresponding dispersion equation and the wave equation while maintaining the energy balance we are able to connect the surface density and the shear viscocity of a fluid amphiphilic overlayer with experimentally accessible damping coefficients, phase velocity, dissipation factor and resonant frequency shifts of shear waves.Comment: 19 pages, latex, 3 figures in eps-forma

Imaging and localized spectroscopy of 13C by polarization transfer

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/27907/1/0000328.pd

Bioagent detection using miniaturized NMR and nanoparticle amplification : final LDRD report.

This LDRD program was directed towards the development of a portable micro-nuclear magnetic resonance ({micro}-NMR) spectrometer for the detection of bioagents via induced amplification of solvent relaxation based on superparamagnetic nanoparticles. The first component of this research was the fabrication and testing of two different micro-coil ({micro}-coil) platforms: namely a planar spiral NMR {micro}-coil and a cylindrical solenoid NMR {micro}-coil. These fabrication techniques are described along with the testing of the NMR performance for the individual coils. The NMR relaxivity for a series of water soluble FeMn oxide nanoparticles was also determined to explore the influence of the nanoparticle size on the observed NMR relaxation properties. In addition, The use of commercially produced superparamagnetic iron oxide nanoparticles (SPIONs) for amplification via NMR based relaxation mechanisms was also demonstrated, with the lower detection limit in number of SPIONs per nanoliter (nL) being determined

The disruption of protein-protein interactions as a therapeutic strategy for prostate cancer

This is an accepted manuscript of an article published by Elsevier in Pharmacological Research on 16/08/2020, available online: https://doi.org/10.1016/j.phrs.2020.105145 The accepted version of the publication may differ from the final published version.Prostate cancer (PCa) is one of the most common male-specific cancers worldwide, with high morbidity and mortality rates associated with advanced disease stages. The current treatment options of PCa are prostatectomy, hormonal therapy, chemotherapy or radiotherapy, the selection of which is usually dependent upon the stage of the disease. The development of PCa to a castration-resistant phenotype (CRPC) is associated with a more severe prognosis requiring the development of a new and effective therapy. Protein-protein interactions (PPIs) have been recognised as an emerging drug modality and targeting PPIs is a promising therapeutic approach for several diseases, including cancer. The efficacy of several compounds in which target PPIs and consequently impair disease progression were validated in phase I/II clinical trials for different types of cancer. In PCa, various small molecules and peptides proved successful in inhibiting important PPIs, mainly associated with the androgen receptor (AR), Bcl-2 family proteins, and kinases/phosphatases, thus impairing the growth of PCa cells in vitro. Moreover, a majority of these compounds require further validation in vivo and, preferably, in clinical trials. In addition, several other PPIs associated with PCa progression have been identified and now require experimental validation as potential therapeutic loci. In conclusion, we consider the disruption of PPIs to be a promising though challenging therapeutic strategy for Pca. Agents which modulate PPIs might be employed as a monotherapy or as an adjunct to classical chemotherapeutics to overcome drug resistance and improve efficacy. The discovery of new PPIs with important roles in disease progression, and of novel optimized strategies to target them, are major challenges for the scientific and pharmacological communities.We thank the Portuguese Foundation for Science and Technology(FCT), European Union, QREN, FEDER and COMPETE for funding iBiMED (UIDB/04501/2020, POCI-01-0145-FEDER-23007628 and UID/BIM/04501/2019) and an individual scholarship from BM (SFRH/BD/146032/2019)