Self-assembly of Clicked Star-Shaped Triazines into Functional Nanostructures

Two non-amphiphilic star-shaped 2, 4, 6-tris(1, 2, 3-triazol-4-yl)-1, 3, 5-triazines showing different behavior in terms of self-assembly and luminescent properties are described. They aggregate in the liquid phase to form low-dimensional nanostructures with a variety of morphologies, such as spherical particles, one-hole hollow spheres, toroids, twisted fibers or helical nanotubes, just by varying the conditions of a straightforward reprecipitation method. Aggregation has an opposite effect concerning the fluorescent properties of the proposed compounds, either causing the enhancement or the quenching of the emission after the self-assembly. Quantum chemical calculations have been also performed to assist in the structural and electronic characterization of the two star-shaped compounds

Deployment and evaluation of an Industry 4.0 use case over 5G

The arrival of 5G paves the way for the deployment of the so-called Industry 4.0, which is a new paradigm devoted to the digital transformation of manufacturing and factory production. Because of the resources required to perform this transformation, the importance of field trials and experimentation cannot be overstated, both to support the design of novel methodologies and to validate these designs. In this article, we leverage the 5G EVE end-to-end open platform to design and validate a novel operation approach for automated guided vehicles (AGVs). This use case consists of the placement of the intelligence that controls the AGV in a remote entity. This movement could improve and simplify the operation of industrial processes. The customizability of the 5G validation platform proves fundamental to evaluate the solution under different deployment architectures and to assess its performance under hazardous radio conditions. Our results demonstrate the ability of 5G to handle latency-constrained use cases with superior performance compared to the current state-of-the-art mobile technology.This work was partly funded by the European Commission under the European Union's Horizon 2020 program, grant agreement number 815074 (5G EVE project). The article solely reflects the views of the authors. The Commission is not responsible for the contents of this article or any use made thereof. The authors would like to thank Ignacio Berberana and Neftali Gonzalez from the 5TONIC Laboratory for their support in setting up the Spanish site

Identification of Vibration Modes in Floating Offshore Wind Turbines

Compared to onshore turbines, floating offshore wind turbines (FOWTs) take advantage of the increased availability of offshore wind while causing less environmental impact. However, the strong winds, waves, and currents to which they are subjected trigger oscillations that can cause significant damage to the entire structural system and reduce its useful life. To reduce these loads, active tower damping techniques such as filter banks can be used. These filters must be carefully tuned to block specific vibration frequencies. Therefore, it is essential to analyze the nature of the oscillations in the FOWT and to understand how the frequencies vary in time. This topic is usually approached from a point of view very focused on a specific turbine. What is proposed here is a general method, which can be applied to any type of wind turbine, to automatically study the relationship between vibration frequencies and the degrees of freedom (DOF) of the turbine, which facilitates the design of structural control. Each frequency is associated with the DOF of the FOWT that produces it. This methodology has been successfully validated in simulation experiments with the NREL 5 MW ITI Barge FOWT. Under the wind conditions of the experiments, the main frequency found is 0.605 Hz. This frequency coincides with the 3P theoretical frequency of the FOWT. This proposal may help to design structural control systems able to damp these vibration frequencies with accuracy and efficiency

A novel strategy based on genomics and specific PCR reveals how a multidrug resistant Mycobacterium tuberculosis strain became prevalent in Equatorial Guinea 15 years after its emergence.

OBJECTIVE: Molecular epidemiology techniques in tuberculosis (TB) can identify high-risk strains that are actively transmitted. We aimed to implement a novel strategy to optimize the identification and control of multidrug-resistant (MDR) TB in a specific population. METHODS: We developed a strain-specific PCR tailored from whole genome sequencing (WGS) data to track a specific MDR prevalent strain in Equatorial Guinea (EG-MDR). RESULTS: The PCR was applied prospectively on remnants of GeneXpert reaction mixtures owing to the lack of culture facilities in Equatorial Guinea. In 147 (93%) of 158 cases, we were able to differentiate between infection by the EG-MDR strain or by any other strain and found that 44% of all rifampicin-resistant TB cases were infected by EG-MDR. We also analysed 93 isolates obtained from Equatorial Guinea 15 years ago, before MDR-TB had become the problem it is today. We found that two of the scarce historical MDR cases were infected by EG-MDR. WGS revealed low variability-six single nucleotide polymorphisms acquired by this strain over 15 years-likely because of the lack in the country of a specific program to treat MDR-TB. CONCLUSIONS: Our novel strategy, which integrated WGS analysis and strain-specific PCRs, represents a low-cost, rapid and transferable strategy that allowed a prospective efficient survey and fast historical analysis of MDR-TB in a population

Ageism and nursing students, past or reality?: a systematic review

Objective: This systematic review aimed to summarise and update existing knowledge about ageism among nursing students through the following research question: what is the perception and attitudes of ageism among student nurses? Design: A systematic review of longitudinal and cross-sectional studies of ageism in nursing students was carried out. Data sources: The literature search was conducted in the scientific databases Pubmed and Scopus in February 2021. Review methods: After the screening process, 22 studies meeting the selection criteria were selected; 8 more were identified after manually searching the selected paper' reference lists. A total of 30 studies were included in the review. The JBI Critical Appraisal Checklists for Analytical Cross-Sectional studies and for Cohort Studies were used to appraise the articles' quality. Results: There was large variability in the manifestation of ageism among student nurses, as well as in the instruments used for assessment. Most of the articles analysed attitudes towards old age, the majority of which were positive. Being a female student, being on the final year of study and having regular contact or cohabitation with an older adult were three of the main determinants in the expression of positive attitudes towards the elderly. Conclusions: Our findings suggest that student nurses generally have positive attitudes towards old age, although ageist beliefs and discriminatory behaviours were identified and should be studied in greater depth. Training programs for future care professionals have a responsibility to educate from a non-stereotypical perspective based on current societal needs

Estudio sobre la integración en aula específica, de un IES, de alumnado diagnosticado como negativista desafiante y su posible inclusión en aula ordinaria

It is known that, nowadays, with the arrival of the inclusive school, in our classrooms we find a greater functional diversity in the students than in the past, diversity that is not always known and accepted within normality. The present investigation, based on the real experience, has as objective the integration in an IES of specific classroom of students affected by serious behavior disorders, such as the defiant negativist disorder, for its later inclusion in the ordinary classroom, in principle, under supervision. The sample consists of 5 subjects whose ages range between 13 and 15 years, who, due to serious alterations in their behavior, can not have full-time schooling in the ordinary classroom. Three of these students are enrolled in 1st of Compulsory Secondary Education (ESO) and 2 of them in 2nd. The serious behavioral problems led to the application of a behavior modification program and a cognitive restructuring and a self-control training.Es sabido que, en la actualidad, con la llegada de la escuela inclusiva, en nuestras aulas nosencontramos con una mayor diversidad funcional en el alumnado que en tiempos pasados, diversidad que no siempre es conocida y aceptada dentro de la normalidad. La presente investigación, basada en la experiencia real, tiene como objetivo la integración en un IES de un aula específica de alumnado afectado de trastornos graves de conducta, como es el trastorno negativista desafiante, para su posterior inclusión en el aula ordinaria, en principio, bajo supervisión. La muestra consta de 5 sujetos cuyas edades oscilan entre los 13 y 15 años, que por presentar graves alteraciones en su conducta no pueden tener una escolarización a tiempo completo en el aula ordinaria. Tres de estos alumnos, estan matriculados en 1º de la Educación Secundaria Obligatoria (ESO) y 2 de ellos en 2º. Los graves problemas de conducta llevaron a la aplicación de un programa de modificación de conducta cognitivo conductual, a una reestructuración cognitiva y a un entrenamiento en autocontrol

A global phylogenomic analysis of the shiitake genus Lentinula

Lentinula is a broadly distributed group of fungi that contains the cultivated shiitake mushroom, L. edodes. We sequenced 24 genomes representing eight described species and several unnamed lineages of Lentinula from 15 countries on four continents. Lentinula comprises four major clades that arose in the Oligocene, three in the Americas and one in Asia–Australasia. To expand sampling of shiitake mushrooms, we assembled 60 genomes of L. edodes from China that were previously published as raw Illumina reads and added them to our dataset. Lentinula edodes sensu lato (s. lat.) contains three lineages that may warrant recognition as species, one including a single isolate from Nepal that is the sister group to the rest of L. edodes s. lat., a second with 20 cultivars and 12 wild isolates from China, Japan, Korea, and the Russian Far East, and a third with 28 wild isolates from China, Thailand, and Vietnam. Two additional lineages in China have arisen by hybridization among the second and third groups. Genes encoding cysteine sulfoxide lyase (lecsl) and γ-glutamyl transpeptidase (leggt), which are implicated in biosynthesis of the organosulfur flavor compound lenthionine, have diversified in Lentinula. Paralogs of both genes that are unique to Lentinula (lecsl 3 and leggt 5b) are coordinately up-regulated in fruiting bodies of L. edodes. The pangenome of L. edodes s. lat. contains 20,308 groups of orthologous genes, but only 6,438 orthogroups (32%) are shared among all strains, whereas 3,444 orthogroups (17%) are found only in wild populations, which should be targeted for conservation

Observation of two new Ξb−\Xi_b^- baryon resonances

Two structures are observed close to the kinematic threshold in the $\Xi_b^0 \pi^-$ mass spectrum in a sample of proton-proton collision data, corresponding to an integrated luminosity of 3.0 fb$^{-1}$ recorded by the LHCb experiment. In the quark model, two baryonic resonances with quark content $bds$ are expected in this mass region: the spin-parity $J^P = \frac{1}{2}^+$ and $J^P=\frac{3}{2}^+$ states, denoted $\Xi_b^{\prime -}$ and $\Xi_b^{*-}$. Interpreting the structures as these resonances, we measure the mass differences and the width of the heavier state to be $m(\Xi_b^{\prime -}) - m(\Xi_b^0) - m(\pi^{-}) = 3.653 \pm 0.018 \pm 0.006$ MeV$/c^2$, $m(\Xi_b^{*-}) - m(\Xi_b^0) - m(\pi^{-}) = 23.96 \pm 0.12 \pm 0.06$ MeV$/c^2$, $\Gamma(\Xi_b^{*-}) = 1.65 \pm 0.31 \pm 0.10$ MeV, where the first and second uncertainties are statistical and systematic, respectively. The width of the lighter state is consistent with zero, and we place an upper limit of $\Gamma(\Xi_b^{\prime -}) < 0.08$ MeV at 95% confidence level. Relative production rates of these states are also reported.Comment: 17 pages, 2 figure