194 research outputs found
Experimental realization of a highly secure chaos communication under strong channel noise
A one-way coupled spatiotemporally chaotic map lattice is used to contruct
cryptosystem. With the combinatorial applications of both chaotic computations
and conventional algebraic operations, our system has optimal cryptographic
properties much better than the separative applications of known chaotic and
conventional methods. We have realized experiments to pratice duplex voice
secure communications in realistic Wired Public Switched Telephone Network by
applying our chaotic system and the system of Advanced Encryption Standard
(AES), respectively, for cryptography. Our system can work stably against
strong channel noise when AES fails to work.Comment: 15 pages, 5 figure
Entropy in general physical theories
Information plays an important role in our understanding of the physical
world. We hence propose an entropic measure of information for any physical
theory that admits systems, states and measurements. In the quantum and
classical world, our measure reduces to the von Neumann and Shannon entropy
respectively. It can even be used in a quantum or classical setting where we
are only allowed to perform a limited set of operations. In a world that admits
superstrong correlations in the form of non-local boxes, our measure can be
used to analyze protocols such as superstrong random access encodings and the
violation of `information causality'. However, we also show that in such a
world no entropic measure can exhibit all properties we commonly accept in a
quantum setting. For example, there exists no`reasonable' measure of
conditional entropy that is subadditive. Finally, we prove a coding theorem for
some theories that is analogous to the quantum and classical setting, providing
us with an appealing operational interpretation.Comment: 20 pages, revtex, 7 figures, v2: Coding theorem revised, published
versio
Crystal Structure of the Sodium Cobaltate Deuterate Superconductor NaxCoO2o4xD2O (x=1/3)
Neutron and x-ray powder diffraction have been used to investigate the
crystal structures of a sample of the newly-discovered superconducting sodium
cobaltate deuterate compound with composition Na0.31(3)CoO2o1.25(2)D2O and its
anhydrous parent compound Na0.61(1)CoO2. The deuterate superconducting compound
is formed by coordinating four D2O molecules (two above and two below) to each
Na ion in a way that gives Na-O distances nearly equal to those in the parent
compound. One deuteron of the D2O molecule is hydrogen bonded to an oxygen atom
in the CoO2 plane and the oxygen atom and the second deuteron of each D2O
molecule lie approximately in a plane between the Na layer and the CoO2 layers.
This coordination of Na by four D2O molecules leads to ordering of the Na ions
and D2O molecules. The sample studied here, which has Tc=4.5 K, has a refined
composition of Na0.31(3)CoO2o1.25(2)D2O, in agreement with the expected 1:4
ratio of Na to D2O. These results show that the optimal superconducting
composition should be viewed as a specific hydrated compound, not a solid
solution of Na and D2O (H2O) in NaxCoO2oyD2O. Studies of physical properties
vs. Na or D2O composition should be viewed with caution until it is verified
that the compound remains in the same phase over the composition range of the
study.Comment: 22 pages, 8 figure
Bound To Shock: Protection from Lethal Endotoxemic Shock by a Novel, Nontoxic, Alkylpolyamine Lipopolysaccharide Sequestrant
Lipopolysaccharide (LPS), or endotoxin, a structural component of gram-negative bacterial outer membranes, plays a key role in the pathogenesis of septic shock, a syndrome of severe systemic inflammation which leads to multiple-system organ failure. Despite advances in antimicrobial chemotherapy, sepsis continues to be the commonest cause of death in the critically ill patient. This is attributable to the lack of therapeutic options that aim at limiting the exposure to the toxin and the prevention of subsequent downstream inflammatory processes. Polymyxin B (PMB), a peptide antibiotic, is a prototype small molecule that binds and neutralizes LPS toxicity. However, the antibiotic is too toxic for systemic use as an LPS sequestrant. Based on a nuclear magnetic resonance-derived model of polymyxin B-LPS complex, we had earlier identified the pharmacophore necessary for optimal recognition and neutralization of the toxin. Iterative cycles of pharmacophore-based ligand design and evaluation have yielded a synthetically easily accessible N1,mono-alkyl-mono-homologated spermine derivative, DS-96. We have found that DS-96 binds LPS and neutralizes its toxicity with a potency indistinguishable from that of PMB in a wide range of in vitro assays, affords complete protection in a murine model of LPS-induced lethality, and is apparently nontoxic in vertebrate animal models.This work was supported by NIH grant 1R01 AI50107
Thermoelectric transport properties of an apparent Fermi liquid: Relation to an analytic anomaly in the density of states and application to hole-doped delafossites
Through the motivation of the recent discovery of dispersionless regions in
the band structure of the delafossites, a model density of states of free
fermions including a discontinuity as analytical anomaly is studied. The
resulting temperature dependence of the chemical potential is obtained both
exactly and by different approximation schemes which are then discussed
thoroughly. This includes the introduction of an approximation of the
polylogarithm difference which is capable of accessing a parameter range
neither covered by Sommerfeld expansion nor by Boltzmann approximation. It is
found that the Fermi temperature and several other temperature scales may be
very low, giving rise to experimentally observable behaviours differing from
the one described by Fermi liquid theory. In particular, two kinds of apparent
Fermi liquid behaviour emerge at intermediate temperatures. This behaviour is
related to recent transport data reported for CuCr(1-x)MgxO2 [A. Maignan et.
al, Solid State Commun. 149, 962 (2009)] and CuRh(1-x)MgxO2 [A. Maignan et. al,
Phys. Rev. B 80, 115103 (2009)] by means of the temperature independent
correlation functions ratio approximation. In this way an effective density of
states as well as the effective charge carrier density of these materials are
determined. Furthermore, conclusions about the specific heat of the latter
material are drawn which presents particular effects of the analytical anomaly.Comment: 14 pages, 8 figure
Towards programming immune tolerance through geometric manipulation of phosphatidylserine
The possibility of engineering the immune system in a targeted fashion using biomaterials such as nanoparticles has made considerable headway in recent years. However, little is known as to how modulating the spatial presentation of a ligand augments downstream immune responses. In this report we show that geometric manipulation of phosphatidylserine (PS) through fabrication on rod-shaped PLGA nanoparticles robustly dampens inflammatory responses from innate immune cells while promoting T regulatory cell abundance by impeding effector T cell expansion. This response depends on the geometry of PS presentation as both PS liposomes and 1 micron cylindrical PS-PLGA particles are less potent signal inducers than 80 Γ 320 nm rod-shaped PS-PLGA particles for an equivalent dose of PS. We show that this immune tolerizing effect can be co-opted for therapeutic benefit in a mouse model of multiple sclerosis and an assay of organ rejection using a mixed lymphocyte reaction with primary human immune cells. These data provide evidence that geometric manipulation of a ligand via biomaterials may enable more efficient and tunable programming of cellular signaling networks for therapeutic benefit in a variety of disease states, including autoimmunity and organ rejection, and thus should be an active area of further research
Origins of the Tumor Microenvironment: Quantitative Assessment of Adipose-Derived and Bone MarrowβDerived Stroma
To meet the requirements for rapid tumor growth, a complex array of non-neoplastic cells are recruited to the tumor microenvironment. These cells facilitate tumor development by providing matrices, cytokines, growth factors, as well as vascular networks for nutrient and waste exchange, however their precise origins remain unclear. Through multicolored tissue transplant procedures; we have quantitatively determined the contribution of bone marrow-derived and adipose-derived cells to stromal populations within syngeneic ovarian and breast murine tumors. Our results indicate that subpopulations of tumor-associated fibroblasts (TAFs) are recruited from two distinct sources. The majority of fibroblast specific protein (FSP) positive and fibroblast activation protein (FAP) positive TAFs originate from mesenchymal stem/stromal cells (MSC) located in bone marrow sources, whereas most vascular and fibrovascular stroma (pericytes, Ξ±-SMA+ myofibroblasts, and endothelial cells) originates from neighboring adipose tissue. These results highlight the capacity for tumors to utilize multiple sources of structural cells in a systematic and discriminative manner
JunD/AP-1-Mediated Gene Expression Promotes Lymphocyte Growth Dependent on Interleukin-7 Signal Transduction
Interleukin-7 (IL-7) is an essential cytokine for lymphocyte growth that has the potential for promoting immune reconstitution. This feature makes IL-7 an ideal candidate for therapeutic development. As with other cytokines, signaling through the IL-7 receptor induces the JAK/STAT pathway. However, the broad scope of IL-7 regulatory targets likely necessitates the use of other signaling components whose identities remain poorly defined. To this end, we used an IL-7 dependent T-cell line to examine how expression of the glycolytic enzyme, Hexokinase II (HXKII) was regulated by IL-7 in a STAT5-independent manner. Our studies revealed that IL-7 promoted the activity of JNK (Jun N-terminal Kinase), and that JNK, in turn, drove the expression of JunD, a component of the Activating Protein 1 (AP-1) transcription factors. Gel shifts showed that the AP-1 complex induced by IL-7 contained JunD but not c-Fos or c-Jun. Inhibition of JNK/JunD blocked glucose uptake and HXKII gene expression, indicating that this pathway was responsible for promoting HXKII expression. Because others had shown that JunD was a negative regulator of cell growth, we performed a bioinformatics analysis to uncover possible JunD-regulated gene targets. Our search revealed that JunD could control the expression of proteins involved in signal transduction, cell survival and metabolism. One of these growth promoters was the oncogene, Pim-1. Pim-1 is an IL-7-induced protein that was inhibited when the activities of JNK or JunD were blocked, showing that in IL-7 dependent T-cells JunD can promote positive signals transduced through Pim-1. This was confirmed when the IL-7-induced proliferation of CD8 T-cells was impaired upon JunD inhibition. These results show that engagement of the IL-7 receptor drives a signal that is more complex than the JAK/STAT pathway, activating JNK and JunD to induce rapid growth stimulation through the expression of metabolic and signaling factors like HXKII and Pim-1
Horizontal zonation patterns and feeding structure of marine nematode assemblages on a macrotidal, ultra-dissipative sandy beach (De Panne, Belgium)
Accomplishing a Continuing Relationship in Psychotherapy: Updates and the Role of Time References
- β¦