Heavy with the unspoken : the interplay of absence and presence in Margaret Atwood's Cat's eye

This study explores the philosophical, linguistic and textual interplay of absence and presence in Margaret Atwood's novel Cat's Eye. The premise of the thesis is that the novel posits language as a problematic communicative medium; as such, language conveys that meanings of words are flexible, mutable and transient. It is through frameworks which both establish states of absence and presence as well as destroy binary oppositions between the two that Cat's Eye conveys its positions about language. Thus, textual and extra-textual discourses about the natures of language and linguistic meaning are situated within recurrent thematic and formal attention to relationships between absence and presence. By exploring the roles of absence and presence in various phenomenological and linguistic contexts, this study concludes that absence/presence is a paradigm in Cat's Eye for the way in which words are (alternately as well as simultaneously) spoken and silent, understood and misunderstood, opposed and united

The Influence of Trauma, Life Events, and Social Relationships on Bipolar Depression

A growing body of research suggests that the social environment exerts a powerful influence on the course of bipolar depression. We review longitudinal research to suggest that trauma, negative life events, social support deficits, and family difficulties are common and predict a more severe course of depression when present among those diagnosed with bipolar disorder. The triggers of bipolar depression overlap with those documented for unipolar depression, suggesting that many of the treatment targets for unipolar depression may be applicable for bipolar depression

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas ( TCGA) pilot project aims to assess the value of large- scale multi- dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community. Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas - the most common type of primary adult brain cancer - and nucleotide sequence aberrations in 91 of the 206 glioblastomas. This analysis provides new insights into the roles of ERBB2, NF1 and TP53, uncovers frequent mutations of the phosphatidylinositol- 3- OH kinase regulatory subunit gene PIK3R1, and provides a network view of the pathways altered in the development of glioblastoma. Furthermore, integration of mutation, DNA methylation and clinical treatment data reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated glioblastomas, an observation with potential clinical implications. Together, these findings establish the feasibility and power of TCGA, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer

13Th International Conference On Conservative Management Of Spinal Deformities And First Joint Meeting Of The International Research Society On Spinal Deformities And The Society On Scoliosis Orthopaedic And Rehabilitation Treatment – Sosort-Irssd 2016 Meeting

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