102 research outputs found
Fantasy Motif Metaphors: Magical Powers as Exceptionality in Disney’s The Incredibles and Zizou Corder’s Lion Boy trilogy
While works of the fantasy genre convey literal stories which make sense according to the laws of their fictional worlds, the very impossibilities of these narratives invite further readings of their ‘secondary or tertiary levels of meaning’ (Bleiler 1983, p.vii; also see McGillis 1996a, p.72; Walsh 1981, p.38). Such readings have been generated through the analytical lenses of allegory, parable, fable, symbol and metaphor. A specific focus upon the operation of metaphor in recurrent fantasy motifs enables a precise analysis of fantasy’s secondary levels of meaning. Such a methodology scrutinises fantasy’s engagement with cultural assumptions and ideas, highlighting the ideological implications of fantasy and thus verifying fantasy’s inherent relevance to reality. This article aims to illustrate the value of this methodology by analysing the motif of magical powers as exceptionality in Disney’s The Incredibles (2003) and Zizou Corder’s Lion Boy trilogy (2003-2005)
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A new source of suprathermal O+ions near the dayside polar cap boundary
A new dayside source of O+ ions for the polar magnetosphere is described, and a statistical survey presented of upward flows of O+ ions using 2 years of data from the retarding ion mass spectrometer (RIMS) experiment on board DE 1, at geocentric distances below 3 RE and invariant latitudes above 40°. The flows are classified according to their spin angle distributions. It is believed that the spacecraft potential near perigee is generally less than +2 V, in which case the entire O+ population at energies below about 60 eV is sampled. Examples are given of field-aligned flow and of transversely accelerated “core” O+ ions; in the latter events a large fraction of the total O+ ion population has been transversely accelerated, and in some extreme cases all the observed ions (of all ion species) have been accelerated, and no residual cold population is observed (“toroidal” distributions). However, by far the most common type of O+ upflow seen by DE RIMS lies near the dayside polar cap boundary (particularly in the prenoon sector) and displays an asymmetric spin angle distribution. In such events the ions carry an upward heat flux, and strong upflow of all species is present (H+, He+, O+, O++, and N+ have all been observed with energies up to about 30 eV, but with the majority of ions below about 2 eV); hence, these have been termed upwelling ion events. The upwelling ions are embedded in larger regions of classical light ion polar wind and are persistently found under the following conditions: at geocentric distances greater than 1.4 RE; at all Kp in summer, but only at high Kp in winter. Low-energy conical ions (<30 eV) are only found near the equatorial edge of the events, the latitude of which moves equatorward with increasing Kp and is highly correlated with the location of field-aligned currents. The RIMS data are fully consistent with a “mass spectrometer effect,” whereby light ions and the more energetic O+ ions flow into the lobes and mantle and hence the far-tail plasma sheet, but lower-energy O+ is swept across the polar cap by the convection electric field, potentially acting as a source for the nightside auroral acceleration regions. The occurrence probability of upwelling ion events, as compared to those of low-altitude transversely accelerated core ions and of field-aligned flow, suggests this could be the dominant mechanism for supplying the nightside auroral acceleration region, and subsequently the ring current and near-earth plasma sheet, with ionospheric O+ ions. It is shown that the total rate of O+ outflow in upwelling ion events (greater than 10^25 s^{−1}) is sufficient for the region near the dayside polar cap boundary to be an important ionospheric heavy ion source
Exploring sources of magnetospheric plasma using multispecies MHD
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94632/1/jgra20151.pd
The role of oxidative stress and antioxidant supplementation in pregnancy disorders
Oxidative stress is widely implicated in failed reproductive performance including infertility, miscarriage, diabetes-related congenital malformations and preeclampsia. Maternal obesity is a strong risk factor for preeclampsia, and recently, in an animal model of maternal obesity we have reported evidence of oxidative stress in the oocytes of obese animals prior to pregnancy as well as in early stage embryos. This adds to the growing evidence for a greater focus on the pre-conceptual period in prevention of pregnancy disorders including those related to oxidative stress. Our research has also focussed on the role of free radicals and antioxidant capacity in preeclampsia. Assessment by measurement of markers of lipid peroxidation or of antioxidant capacity has provided unequivocal evidence for oxidative stress in this disorder. Partial failure of the process of placentation has been implicated, with recent evidence proposing that ischaemia-reperfusion in the placenta may contribute to oxidative stress in trophoblast. Endoplasmic reticulum stress in the placenta may also play a role. We and others have performed randomised controlled trials to determine whether early supplementation with vitamins C and E in women at risk of preeclampsia may be beneficial but these studies have shown no evidence for prevention of preeclampsia. Whether this represents an inappropriate antioxidant strategy or whether supplementation has been too late in gestation to be beneficial is not known. Other potential approaches to prevention of preeclampsia through amelioration of oxidative stress include provision of supplements in the pre-conceptual period, selenium supplements, anti-peroxynitrite strategies and statins
Characterizing and Improving the Data Reduction Pipeline for the Keck OSIRIS Integral Field Spectrograph
OSIRIS is a near-infrared (1.0--2.4 m) integral field spectrograph
operating behind the adaptive optics system at Keck Observatory, and is one of
the first lenslet-based integral field spectrographs. Since its commissioning
in 2005, it has been a productive instrument, producing nearly half the laser
guide star adaptive optics (LGS AO) papers on Keck. The complexity of its raw
data format necessitated a custom data reduction pipeline (DRP) delivered with
the instrument in order to iteratively assign flux in overlapping spectra to
the proper spatial and spectral locations in a data cube. Other than bug fixes
and updates required for hardware upgrades, the bulk of the DRP has not been
updated since initial instrument commissioning. We report on the first major
comprehensive characterization of the DRP using on-sky and calibration data. We
also detail improvements to the DRP including characterization of the flux
assignment algorithm; exploration of spatial rippling in the reduced data
cubes; and improvements to several calibration files, including the
rectification matrix, the bad pixel mask, and the wavelength solution. We
present lessons learned from over a decade of OSIRIS data reduction that are
relevant to the next generation of integral field spectrograph hardware and
data reduction software design.Comment: 18 pages, 16 figures; accepted for publication in A
Geotail observations of plasma sheet ion composition over 16 years: On variations of average plasma ion mass and O +
Reproducibility of adipogenic responses to metabolism disrupting chemicals in the 3T3-L1 pre-adipocyte model system: An interlaboratory study
Plasma sheet and (nonstorm) ring current formation from solar and polar wind sources
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95352/1/jgra17511.pd
Multilaboratory Survey To Evaluate Salmonella Prevalence in Diarrheic and Nondiarrheic Dogs and Cats in the United States between 2012 and 2014
Eleven laboratories collaborated to determine the periodic prevalence of Salmonella in a population of dogs and cats in the United States visiting veterinary clinics. Fecal samples (2,965) solicited from 11 geographically dispersed veterinary testing laboratories were collected in 36 states between January 2012 and April 2014 and tested using a harmonized method. The overall study prevalence of Salmonella in cats (3 of 542) was <1%. The prevalence in dogs (60 of 2,422) was 2.5%. Diarrhea was present in only 55% of positive dogs; however, 3.8% of the all diarrheic dogs were positive, compared with 1.8% of the nondiarrheic dogs. Salmonella-positive dogs were significantly more likely to have consumed raw food (P = 0.01), to have consumed probiotics (P = 0.002), or to have been given antibiotics (P = 0.01). Rural dogs were also more likely to be Salmonella positive than urban (P = 0.002) or suburban (P = 0.001) dogs. In the 67 isolates, 27 unique serovars were identified, with three dogs having two serovars present. Antimicrobial susceptibility testing of 66 isolates revealed that only four of the isolates were resistant to one or more antibiotics. Additional characterization of the 66 isolates was done using pulsed-field gel electrophoresis and whole-genome sequencing (WGS). Sequence data compared well to resistance phenotypic data and were submitted to the National Center for Biotechnology Information (NCBI). This study suggests an overall decline in prevalence of Salmonella-positive dogs and cats over the last decades and identifies consumption of raw food as a major risk factor for Salmonella infection. Of note is that almost half of the Salmonella-positive animals were clinically nondiarrheic
A mixed methods study of hope, transitions, and quality of life in family caregivers of persons with Alzheimer's disease
<p>Abstract</p> <p>Background</p> <p>Several research studies have reported the poor quality of life of family caregivers of persons with Alzheimer's disease (AD). However, factors that influence their quality of life have not been clearly defined. The purpose of this study was to examine factors associated with the quality of life of these caregivers such as demographic variables, their transition experience, and hope. A secondary aim was to explore the transition experience of family caregivers of persons with AD.</p> <p>Methods</p> <p>A cross-sectional triangulation data transformation model mixed method design (Quant +Qual) was utilized to address the purpose of the study. Eighty family caregivers of persons with AD completed a survey with quantitative measures [demographic variables, Herth Hope Index (HHI-hope), World Health Organization Quality of Life -BREF (WHOQOL-BREF)] and a qualitative survey about their transitions experience. The qualitative data (transition open ended- survey) was converted to quantitative data using content analysis. Variables significant at the p < 0.10 level in the univariate analysis were entered in the multivariate generalized linear model used to determine significant factors associated with quality of life.</p> <p>Results</p> <p>Subjects with higher hope scores (p < 0.0001) (Factor 1: temporality and future-cognitive-temporary dimension of hope) and who dealt with their transitions by actively seeking out knowledge and assistance (p = 0.02) had higher overall quality of life scores. HHI scores were associated with overall quality of life and for each of the four quality of life domains (physical psychosocial, relationships, and environment).</p> <p>Conclusions</p> <p>Hope played a significant role in the subjects' perceptions of overall quality of life as well as the 4 quality of life domains. This underscores the need to develop ways to foster hope in family caregivers. Moreover, the active engagement of families in seeking information and help, as a way to deal with their transitions, suggests encouraging this engagement is important. The findings of this study also suggest many directions for future research, such as increasing our understanding of the processes of transitions for this population.</p
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