Piman Song Syntax: Its Historical Significance

Proceedings of the Seventh Annual Meeting of the Berkeley Linguistics Society (1981), pp. 275-28

Esselen Structural Prehistory

Proceedings of the Eighth Annual Meeting of the Berkeley Linguistics Society (1982

Biological Survey Report for the Calypso Natural Gas Pipeline: Shore Approach Route North of Port Everglades Entrance Channel with Landing South of Port Everglades Entrance Channel

The Calypso Natural Gas Pipeline Project (project) will include a 24-inch pipeline which will extend from the Exclusive Economic Zone (EEZ) off the southeast Florida coastline to a shore approach at Port Everglades in Fort Lauderdale, Florida. This report, which was commissioned in May 2001 and completed in July, 2001, documents the results of a detailed biological survey of underwater marine habitats from 5 to 200 feet water depth for the pipeline route. The route, which was established based on the subsea survey that was completed in May 2001 by Williamson & Associates, Inc., includes a shore approach from the north of the Port Everglades entrance channel to a pipeline landing site south of the Port Everglades entrance channel. The purpose of this biological survey report was to identify benthic characteristics within the nearshore pipeline corridor and to identify and evaluate potential temporary impacts to the marine ecosystems. The pipeline corridor investigated was 300 feet wide and extended from the shoreline to the 200 foot water depth, a distance of approximately 14,000 feet. In addition, some video surveying was conducted to approximately the 250-foot depth contour (an additional distance of approximately 500 feet). Underwater survey methods included use of SCUBA diving to conduct underwater quantitative biological transects and integrated video mapping using a vessel towed system which provided a permanent record together with a DGPS location. Remote sensing information included use of aerial photographs and LIDAR bathymetry to guide habitat delineation. A total of eight (8) benthic habitats were defined within the pipeline corridor. These habitats included: 1. First Reef 2. Submerged Breakwater/Spoil 3. Second Reef 4. Second Reef-Sand Complex 5. Sand 6. Third Reef 7. Third Reef-Sand Complex, and 8. Third Reef Transitional. Density (number per m2) of hard corals, soft corals, and sponges was determined at several representative transects within certain habitats. Results of the study indicated that overall coverage by hard corals, soft corals, and sponges is very low in the proposed project area. Along the proposed pipeline route, percent hard coral coverage ranged from 0.16% in the Submerged Breakwater / Spoil Area to 1.34% in the Third Reef habitat. Soft coral density was lowest in Second Reef-Sand Complex (0.02 soft corals per m2) and highest at the Third Reef (11.85 soft corals per m2). Sponge density varied from 0.23 sponges per m2 in the Submerged Breakwater / Spoil Area to 19.48 sponges per m2in the Second Reef zone. Previous surveys in the general project vicinity indicate that no zooxanthellate reef-building hard corals occur in water depths greater than about 120 feet of seawater (FSW). Direct impacts of approximately 1.60 acres of hardbottom habitat characterized by very low coverage by hard corals, sponges and soft corals are expected. These impacts will occur at proposed horizontal directional drilling exit or entrance holes, laydown areas of pipeline, trenching, and blanketing to bury pipeline from the Port Everglades entrance channel from the shoreline to the 200-foot depth contour, as shown in Tables 5, 6, and 7. A further approximately 4.34 acres of area would be affected adversely by temporary indirect effects (i.e., sedimentation and turbidity) effects as shown in Tables 8, 9, and 10. Table 11 provides a summary total that 5.94 acres of hardbottom habitat would be directly or indirectly affected. In addition, approximately 0.008 acres of very sparse seagrass (Halophila decipiens) will be directly impacted. Finally, no threatened or endangered species (including the federally threatened seagrass Halophila johnsonii) were observed in the project area. Observations were conducted to the approximate 250-foot depth contour. Video surveys to that depth indicated benthic conditions consistent with those of the Third Reef Transitional complex and open sand. Project activities beyond 200 FSW will consist only of pipe placement directly on the sea bottom

17β-Estradiol dysregulates innate immune responses to Pseudomonas aeruginosa respiratory infection and is modulated by estrogen receptor antagonism

ABSTRACT Females have a more severe clinical course than males in terms of several inflammatory lung conditions. Notably, females with cystic fibrosis (CF) suffer worse outcomes, particularly in the setting of Pseudomonas aeruginosa infection. Sex hormones have been implicated in experimental and clinical studies; however, immune mechanisms responsible for this sex-based disparity are unknown and the specific sex hormone target for therapeutic manipulation has not been identified. The objective of this study was to assess mechanisms behind the impact of female sex hormones on host immune responses to P. aeruginosa . We used wild-type and CF mice, which we hormone manipulated, inoculated with P. aeruginosa , and then examined for outcomes and inflammatory responses. Neutrophils isolated from mice and human subjects were tested for responses to P. aeruginosa . We found that female mice inoculated with P. aeruginosa died earlier and showed slower bacterial clearance than males ( P &lt; 0.0001). Ovariectomized females supplemented with 17β-estradiol succumbed to P. aeruginosa challenge earlier than progesterone- or vehicle-supplemented mice ( P = 0.0003). 17β-Estradiol-treated ovariectomized female mice demonstrated increased lung levels of inflammatory cytokines, and when rendered neutropenic the mortality difference was abrogated. Neutrophils treated with 17β-estradiol demonstrated an enhanced oxidative burst but decreased P. aeruginosa killing and earlier cell necrosis. The estrogen receptor (ER) antagonist ICI 182,780 improved survival in female mice infected with P. aeruginosa and restored neutrophil function. We concluded that ER antagonism rescues estrogen-mediated neutrophil dysfunction and improves survival in response to P. aeruginosa . ER-mediated processes may explain the sex-based mortality gap in CF and other inflammatory lung illnesses, and the ER blockade represents a rational therapeutic strategy. </jats:p

New insights into the classification and nomenclature of cortical GABAergic interneurons.

A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria. Using Bayesian analysis and clustering algorithms on the resulting data, we investigated the suitability of several anatomical terms and neuron names for cortical GABAergic interneurons. Moreover, we show that supervised classification models could automatically categorize interneurons in agreement with experts' assignments. These results demonstrate a practical and objective approach to the naming, characterization and classification of neurons based on community consensus

Roadmap of ultrafast x-ray atomic and molecular physics

X-ray free-electron lasers (XFELs) and table-top sources of x-rays based upon high harmonic generation (HHG) have revolutionized the field of ultrafast x-ray atomic and molecular physics, largely due to an explosive growth in capabilities in the past decade. XFELs now provide unprecedented intensity (1020 W cm−2) of x-rays at wavelengths down to ~1 Angstrom, and HHG provides unprecedented time resolution (∼50 attoseconds) and a correspondingly large coherent bandwidth at longer wavelengths. For context, timescales can be referenced to the Bohr orbital period in hydrogen atom of 150 attoseconds and the hydrogen-molecule vibrational period of 8 femtoseconds; wavelength scales can be referenced to the chemically significant carbon K-edge at a photon energy of ∼280 eV (44 Angstroms) and the bond length in methane of ∼1 Ångstrom. With these modern x-ray sources one now has the ability to focus on individual atoms, even when embedded in a complex molecule, and view electronic and nuclear motion on their intrinsic scales (attoseconds and Ångstroms). These sources have enabled coherent diffractive imaging, where one can image non-crystalline objects in three dimensions on ultrafast timescales, potentially with atomic resolution. The unprecedented intensity available with XFELs has opened new fields of multiphoton and nonlinear x-ray physics where behavior of matter under extreme conditions can be explored. The unprecedented time resolution and pulse synchronization provided by HHG sources has kindled fundamental investigations of time delays in photoionization, charge migration in molecules, and dynamics near conical intersections that are foundational to AMO physics and chemistry. This roadmap coincides with the year when three new XFEL facilities, operating at Ångstrom wavelengths, opened for users (European XFEL, Swiss-FEL and PAL-FEL in Korea) almost doubling the present worldwide number of XFELs, and documents the remarkable progress in HHG capabilities since its discovery roughly 30 years ago, showcasing experiments in AMO physics and other applications. Here we capture the perspectives of 17 leading groups and organize the contributions into four categories: ultrafast molecular dynamics, multidimensional x-ray spectroscopies; high-intensity x-ray phenomena; attosecond x-ray science

Roadmap of ultrafast x-ray atomic and molecular physics

X-ray free-electron lasers (XFELs) and table-top sources of x-rays based upon high harmonic generation (HHG) have revolutionized the field of ultrafast x-ray atomic and molecular physics, largely due to an explosive growth in capabilities in the past decade. XFELs now provide unprecedented intensity (1020 W cm−2) of x-rays at wavelengths down to ~1 Angstrom, and HHG provides unprecedented time resolution (∼50 attoseconds) and a correspondingly large coherent bandwidth at longer wavelengths. For context, timescales can be referenced to the Bohr orbital period in hydrogen atom of 150 attoseconds and the hydrogen-molecule vibrational period of 8 femtoseconds; wavelength scales can be referenced to the chemically significant carbon K-edge at a photon energy of ∼280 eV (44 Angstroms) and the bond length in methane of ∼1 Ångstrom. With these modern x-ray sources one now has the ability to focus on individual atoms, even when embedded in a complex molecule, and view electronic and nuclear motion on their intrinsic scales (attoseconds and Ångstroms). These sources have enabled coherent diffractive imaging, where one can image non-crystalline objects in three dimensions on ultrafast timescales, potentially with atomic resolution. The unprecedented intensity available with XFELs has opened new fields of multiphoton and nonlinear x-ray physics where behavior of matter under extreme conditions can be explored. The unprecedented time resolution and pulse synchronization provided by HHG sources has kindled fundamental investigations of time delays in photoionization, charge migration in molecules, and dynamics near conical intersections that are foundational to AMO physics and chemistry. This roadmap coincides with the year when three new XFEL facilities, operating at Ångstrom wavelengths, opened for users (European XFEL, Swiss-FEL and PAL-FEL in Korea) almost doubling the present worldwide number of XFELs, and documents the remarkable progress in HHG capabilities since its discovery roughly 30 years ago, showcasing experiments in AMO physics and other applications. Here we capture the perspectives of 17 leading groups and organize the contributions into four categories: ultrafast molecular dynamics, multidimensional x-ray spectroscopies; high-intensity x-ray phenomena; attosecond x-ray science

Inflation and Dark Energy from spectroscopy at z > 2

The expansion of the Universe is understood to have accelerated during two epochs: in its very first moments during a period of Inflation and much more recently, at z < 1, when Dark Energy is hypothesized to drive cosmic acceleration. The undiscovered mechanisms behind these two epochs represent some of the most important open problems in fundamental physics. The large cosmological volume at 2 < z < 5, together with the ability to efficiently target high-$z$ galaxies with known techniques, enables large gains in the study of Inflation and Dark Energy. A future spectroscopic survey can test the Gaussianity of the initial conditions up to a factor of ~50 better than our current bounds, crossing the crucial theoretical threshold of $\sigma(f_{NL}^{\rm local})$ of order unity that separates single field and multi-field models. Simultaneously, it can measure the fraction of Dark Energy at the percent level up to $z = 5$, thus serving as an unprecedented test of the standard model and opening up a tremendous discovery space

HAWC+ Far-infrared Observations of the Magnetic Field Geometry in M51 and NGC 891

Abstract: Stratospheric Observatory for Infrared Astronomy High-resolution Airborne Wideband Camera Plus polarimetry at 154 μm is reported for the face-on galaxy M51 and the edge-on galaxy NGC 891. For M51, the polarization vectors generally follow the spiral pattern defined by the molecular gas distribution, the far-infrared (FIR) intensity contours, and other tracers of star formation. The fractional polarization is much lower in the FIR-bright central regions than in the outer regions, and we rule out loss of grain alignment and variations in magnetic field strength as causes. When compared with existing synchrotron observations, which sample different regions with different weighting, we find the net position angles are strongly correlated, the fractional polarizations are moderately correlated, but the polarized intensities are uncorrelated. We argue that the low fractional polarization in the central regions must be due to significant numbers of highly turbulent segments across the beam and along lines of sight in the beam in the central 3 kpc of M51. For NGC 891, the FIR polarization vectors within an intensity contour of 1500 are oriented very close to the plane of the galaxy. The FIR polarimetry is probably sampling the magnetic field geometry in NGC 891 much deeper into the disk than is possible with NIR polarimetry and radio synchrotron measurements. In some locations in NGC 891, the FIR polarization is very low, suggesting we are preferentially viewing the magnetic field mostly along the line of sight, down the length of embedded spiral arms. There is tentative evidence for a vertical field in the polarized emission off the plane of the disk