Extracting the multiscale backbone of complex weighted networks

A large number of complex systems find a natural abstraction in the form of weighted networks whose nodes represent the elements of the system and the weighted edges identify the presence of an interaction and its relative strength. In recent years, the study of an increasing number of large scale networks has highlighted the statistical heterogeneity of their interaction pattern, with degree and weight distributions which vary over many orders of magnitude. These features, along with the large number of elements and links, make the extraction of the truly relevant connections forming the network's backbone a very challenging problem. More specifically, coarse-graining approaches and filtering techniques are at struggle with the multiscale nature of large scale systems. Here we define a filtering method that offers a practical procedure to extract the relevant connection backbone in complex multiscale networks, preserving the edges that represent statistical significant deviations with respect to a null model for the local assignment of weights to edges. An important aspect of the method is that it does not belittle small-scale interactions and operates at all scales defined by the weight distribution. We apply our method to real world network instances and compare the obtained results with alternative backbone extraction techniques

On the Anticorrelation Between Galaxy Light Concentration and X-ray-to-Optical Flux Ratio

Active Galactic Nuclei (AGN) play an important role in many aspects of the modern cosmology, and of particular interest is the issue of the interplay between AGN and their host galaxy. Using X-ray and optical data sets, we have explored the properties of a large sample of AGNs in the Subaru/XMM-Newton Deep Survey (SXDS) field, and studied their evolution in relation with the evolution of their host galaxy. We present here an anticorrelation between X-ray-to-optical flux ratio (X/O) and galaxy light concentration (C), which has been found for the first time and might suggest that early type galaxies, having poor matter supply to feed the AGN activity, have lower Eddington rates than those of late type galaxies.Comment: 9 pages, 3 figures, accepted for publication in ApJ Letter

Mindcraft, a mobile mental health monitoring platform for children and young people: development and acceptability pilot study

BACKGROUND: Children and young people's mental health is a growing public health concern, which is further exacerbated by the COVID-19 pandemic. Mobile health apps, particularly those using passive smartphone sensor data, present an opportunity to address this issue and support mental well-being. OBJECTIVE: This study aimed to develop and evaluate a mobile mental health platform for children and young people, Mindcraft, which integrates passive sensor data monitoring with active self-reported updates through an engaging user interface to monitor their well-being. METHODS: A user-centered design approach was used to develop Mindcraft, incorporating feedback from potential users. User acceptance testing was conducted with a group of 8 young people aged 15-17 years, followed by a pilot test with 39 secondary school students aged 14-18 years, which was conducted for a 2-week period. RESULTS: Mindcraft showed encouraging user engagement and retention. Users reported that they found the app to be a friendly tool helping them to increase their emotional awareness and gain a better understanding of themselves. Over 90% of users (36/39, 92.5%) answered all active data questions on the days they used the app. Passive data collection facilitated the gathering of a broader range of well-being metrics over time, with minimal user intervention. CONCLUSIONS: The Mindcraft app has shown promising results in monitoring mental health symptoms and promoting user engagement among children and young people during its development and initial testing. The app's user-centered design, the focus on privacy and transparency, and a combination of active and passive data collection strategies have all contributed to its efficacy and receptiveness among the target demographic. By continuing to refine and expand the app, the Mindcraft platform has the potential to contribute meaningfully to the field of mental health care for young people

Black hole masses and starbursts in X-shaped radio sources

It has been suggested that the X-shaped morphology observed in some radio sources can reflect either a recent merger of two supermassive black holes (SMBHs) or the presence of a second active black hole in the galactic nucleus. These scenarios are tested by studying the relationship between the black hole mass, radio and optical luminosity, starburst history, and dynamic age of radio lobes in a sample of 29 X-shaped radio galaxies drawn from a list of 100 X-shaped radio source candidates identified from the FIRST survey. The same relationships are also studied in a control sample consisting of 36 radio-loud active nuclei with similar redshifts and optical and radio luminosities. The X-shaped objects are found to have statistically higher black hole masses and older starburst activity compared to the objects from the control sample. Implications of these findings are discussed for the black hole merger scenario and for the potential presence of active secondary black holes in post-merger galaxies.Comment: 11 pages, 8 figure

The Accelerating Growth of Online Tagging Systems

Research on the growth of online tagging systems not only is interesting in its own right, but also yields insights for website management and semantic web analysis. Traditional models that describing the growth of online systems can be divided between linear and nonlinear versions. Linear models, including the BA model (Brabasi and Albert, 1999), assume that the average activity of users is a constant independent of population. Hence the total activity is a linear function of population. On the contrary, nonlinear models suggest that the average activity is affected by the size of the population and the total activity is a nonlinear function of population. In the current study, supporting evidences for the nonlinear growth assumption are obtained from data on Internet users' tagging behavior. A power law relationship between the number of new tags (F) and the population (P), which can be expressed as F ~ P ^ gamma (gamma > 1), is found. I call this pattern accelerating growth and find it relates the to time-invariant heterogeneity in individual activities. I also show how a greater heterogeneity leads to a faster growth.Comment: 8 pages, 3 figure

Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents : an in vitro study

Adenosine acting in the basal forebrain is a key mediator of sleep homeostasis. Extracellular adenosine concentrations increase during wakefulness, especially during prolonged wakefulness and lead to increased sleep pressure and subsequent rebound sleep. The release of endogenous adenosine during the sleep-wake cycle has mainly been studied in vivo with microdialysis techniques. The biochemical changes that accompany sleep-wake status may be preserved in vitro. We have therefore used adenosine-sensitive biosensors in slices of the basal forebrain (BFB) to study both depolarization-evoked adenosine release and the steady state adenosine tone in rats, mice and hamsters. Adenosine release was evoked by high K+, AMPA, NMDA and mGlu receptor agonists, but not by other transmitters associated with wakefulness such as orexin, histamine or neurotensin. Evoked and basal adenosine release in the BFB in vitro exhibited three key features: the magnitude of each varied systematically with the diurnal time at which the animal was sacrificed; sleep deprivation prior to sacrifice greatly increased both evoked adenosine release and the basal tone; and the enhancement of evoked adenosine release and basal tone resulting from sleep deprivation was reversed by the inducible nitric oxide synthase (iNOS) inhibitor, 1400 W. These data indicate that characteristics of adenosine release recorded in the BFB in vitro reflect those that have been linked in vivo to the homeostatic control of sleep. Our results provide methodologically independent support for a key role for induction of iNOS as a trigger for enhanced adenosine release following sleep deprivation and suggest that this induction may constitute a biochemical memory of this state

Tuning degree distributions of scale-free networks

Scale-free networks are characterized by a degree distribution with power-law behavior and have been shown to arise in many areas, ranging from the World Wide Web to transportation or social networks. Degree distributions of observed networks, however, often differ from the power-law type and data based investigations require modifications of the typical scale-free network. We present an algorithm that generates networks in which the skewness of the degree distribution is tuneable by modifying the preferential attachment step of the Barabasi-Albert construction algorithm. Skewness is linearly correlated with the maximal degree of the network and, therefore, adequately represents the influence of superspreaders or hubs. By combining our algorithm with work of Holme and Kim, we show how to generate networks with skewness gamma and clustering coefficient kappa, over a wide range of values.Comment: 13 pages, 5 figures. Submitted to Physical Review E; references added, intro rewritte

Lysosome-mediated processing of chromatin in senescence

Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism, and a likely contributor to tissue aging. Cellular senescence involves extensive cellular remodeling, including of chromatin structure. Autophagy and lysosomes are important for recycling of cellular constituents and cell remodeling. Here we show that an autophagy/lysosomal pathway processes chromatin in senescent cells. In senescent cells, lamin A/C–negative, but strongly γ-H2AX–positive and H3K27me3-positive, cytoplasmic chromatin fragments (CCFs) budded off nuclei, and this was associated with lamin B1 down-regulation and the loss of nuclear envelope integrity. In the cytoplasm, CCFs were targeted by the autophagy machinery. Senescent cells exhibited markers of lysosomal-mediated proteolytic processing of histones and were progressively depleted of total histone content in a lysosome-dependent manner. In vivo, depletion of histones correlated with nevus maturation, an established histopathologic parameter associated with proliferation arrest and clinical benignancy. We conclude that senescent cells process their chromatin via an autophagy/lysosomal pathway and that this might contribute to stability of senescence and tumor suppression

Evidence for the η_b(1S) Meson in Radiative Υ(2S) Decay

We have performed a search for the η_b(1S) meson in the radiative decay of the Υ(2S) resonance using a sample of 91.6 × 10^6 Υ(2S) events recorded with the BABAR detector at the PEP-II B factory at the SLAC National Accelerator Laboratory. We observe a peak in the photon energy spectrum at E_γ = 609.3^(+4.6)_(-4.5)(stat)±1.9(syst) MeV, corresponding to an η_b(1S) mass of 9394.2^(+4.8)_(-4.9)(stat) ± 2.0(syst) MeV/c^2. The branching fraction for the decay Υ(2S) → γη_b(1S) is determined to be [3.9 ± 1.1(stat)^(+1.1)_(-0.9)(syst)] × 10^(-4). We find the ratio of branching fractions B[Υ(2S) → γη_b(1S)]/B[Υ(3S) → γη_b(1S)]= 0.82 ± 0.24(stat)^(+0.20)_(-0.19)(syst)