Патологии метаподий древних копытных

This report describes pathological changes of twelve metapodial bones of ancient large ungulates (Bison priscus, Cervus elaphus, Megaloceros giganteus, Equus ex gr. gallicus) from various sites in West Siberia. Two basic types of deteriorations were observed: proximal epiphyseal deformity resulting from arthrosis, and periosteal proliferations on diaphysis. All of these likely are related to trauma. The most probable causes of the injuries include unsuccessful hunting activity of cave lions and environment-associated sharp or blunt force

Preserving Genome Integrity: The DdrA Protein of Deinococcus radiodurans R1

The bacterium Deinococcus radiodurans can withstand extraordinary levels of ionizing radiation, reflecting an equally extraordinary capacity for DNA repair. The hypothetical gene product DR0423 has been implicated in the recovery of this organism from DNA damage, indicating that this protein is a novel component of the D. radiodurans DNA repair system. DR0423 is a homologue of the eukaryotic Rad52 protein. Following exposure to ionizing radiation, DR0423 expression is induced relative to an untreated control, and strains carrying a deletion of the DR0423 gene exhibit increased sensitivity to ionizing radiation. When recovering from ionizing-radiation-induced DNA damage in the absence of nutrients, wild-type D. radiodurans reassembles its genome while the mutant lacking DR0423 function does not. In vitro, the purified DR0423 protein binds to single-stranded DNA with an apparent affinity for 3′ ends, and protects those ends from nuclease degradation. We propose that DR0423 is part of a DNA end-protection system that helps to preserve genome integrity following exposure to ionizing radiation. We designate the DR0423 protein as DNA damage response A protein

Gravitational dressing of D-instantons

The non-perturbative corrections to the universal hypermultiplet moduli space metric in the type-IIA superstring compactification on a Calabi-Yau threefold are investigated in the presence of 4d, N=2 supergravity. These corrections come from multiple wrapping of the BPS (Euclidean) D2-branes around certain (BPS) Calabi-Yau 3-cycles, and they are known as the D-instantons. The exact universal hypermultiplet metric is governed by a quaternionic potential that satisfies the SU(\infty) Toda equation. The mechanism is proposed, which elevates any four-dimensional hyper-K"ahler metric with a rotational isometry to the quaternionic metric of the same dimension. A generic separable solution to the Toda equation appears to be related to the Eguchi-Hanson metric, whereas another solution originating from the Atiyah-Hitchin metric describes the gravitationally dressed (mixed) D-instantons.Comment: 10 pages, LaTeX; small text improvement

Superconformal hypermultiplets in superspace

We use the manifestly N=2 supersymmetric, off-shell, harmonic (or twistor) superspace approach to solve the constraints implied by four-dimensional N=2 superconformal symmetry on the N=2 non-linear sigma-model target space, known as the special hyper-K"ahler geometry. Our general solution is formulated in terms of a homogeneous (of degree two) function of unconstrained (analytic) Fayet-Sohnius hypermultiplet superfields. We also derive the improved (N=2 superconformal) actions for the off-shell (constrained) N=2 projective hypermultiplets, and relate them (via non-conformal deformations) to the asymptotically locally-flat (ALF) A_k and D_k series of the gravitational instantons. The same metrics describe Kaluza-Klein monopoles in M-theory, while they also arise in the quantum moduli spaces of N=4 supersymmetric gauge field theories with SU(2) gauge group and matter hypermultiplets in three spacetime dimensions. We comment on rotational isometries versus translational isometries in the context of N=2 NLSM in terms of projective hypermultiplets.Comment: 28 pages, LaTeX; minor improvements, to appear in Nucl. Phys.

Universal hypermultiplet metrics

Some instanton corrections to the universal hypermultiplet moduli space metric of the type-IIA string theory compactified on a Calabi-Yau threefold arise due to multiple wrapping of BPS membranes and fivebranes around certain cycles of Calabi-Yau. The classical universal hypermultipet metric is locally equivalent to the Bergmann metric of the symmetric quaternionic space SU(2,1)/U(2), whereas its generic quaternionic deformations are governed by the integrable SU(infinity) Toda equation. We calculate the exact (non-perturbative) UH metrics in the special cases of (i) the D-instantons (the wrapped D2-branes) in the absence of fivebranes, and (ii) the fivebrane instantons with vanishing charges, in the absence of D-instantons. The solutions of the first type preserve the U(1)xU(1) classical symmetry, while they can be interpreted as the gravitational dressing of the hyper-K"ahler D-instanton solutions. The second type solution preserves the non-abelian SU(2) classical symmetry, while it can be interpreted as a gradient flow in the universal hypermultiplet moduli space.Comment: 30 pages, LaTe

Aerodynamic investigations of ventilated brake discs.

The heat dissipation and performance of a ventilated brake disc strongly depends on the aerodynamic characteristics of the flow through the rotor passages. The aim of this investigation was to provide an improved understanding of ventilated brake rotor flow phenomena, with a view to improving heat dissipation, as well as providing a measurement data set for validation of computational fluid dynamics methods. The flow fields at the exit of four different brake rotor geometries, rotated in free air, were measured using a five-hole pressure probe and a hot-wire anemometry system. The principal measurements were taken using two-component hot-wire techniques and were used to determine mean and unsteady flow characteristics at the exit of the brake rotors. Using phase-locked data processing, it was possible to reveal the spatial and temporal flow variation within individual rotor passages. The effects of disc geometry and rotational speed on the mean flow, passage turbulence intensity, and mass flow were determined. The rotor exit jet and wake flow were clearly observed as characterized by the passage geometry as well as definite regions of high and low turbulence. The aerodynamic flow characteristics were found to be reasonably independent of rotational speed but highly dependent upon rotor geometry

Product analysis illuminates the final steps of IES deletion in Tetrahymena thermophila

DNA sequences (IES elements) eliminated from the developing macronucleus in the ciliate Tetrahymena thermophila are released as linear fragments, which have now been detected and isolated. A PCR-mediated examination of fragment end structures reveals three types of strand scission events, reflecting three steps in the deletion process. New evidence is provided for two steps proposed previously: an initiating double-stranded cleavage, and strand transfer to create a branched deletion intermediate. The fragment ends provide evidence for a previously uncharacterized third step: the branched DNA strand is cleaved at one of several defined sites located within 15–16 nucleotides of the IES boundary, liberating the deleted DNA in a linear form

A fossil brain from the Cretaceous of European Russia and avian sensory evolution

Fossils preserving traces of soft anatomy are rare in the fossil record; even rarer is evidence bearing on the size and shape of sense organs that provide us with insights into mode of life. Here, we describe unique fossil preservation of an avian brain from the Volgograd region of European Russia. The brain of this Melovatka bird is similar in shape and morphology to those of known fossil ornithurines (the lineage that includes living birds), such as the marine diving birds Hesperornis and Enaliornis, but documents a new stage in avian sensory evolution: acute nocturnal vision coupled with well-developed hearing and smell, developed by the Late Cretaceous (ca 90?Myr ago). This fossil also provides insights into previous ‘bird-like’ brain reconstructions for the most basal avian Archaeopteryx—reduction of olfactory lobes (sense of smell) and enlargement of the hindbrain (cerebellum) occurred subsequent to Archaeopteryx in avian evolution, closer to the ornithurine lineage that comprises living birds. The Melovatka bird also suggests that brain enlargement in early avians was not correlated with the evolution of powered fligh