The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer.

Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress. Recent studies have characterized the oncogenic role of ATF5 in the development of several different types of cancer, notably glioblastoma. Preclinical assessment of a systemically deliverable dominant-negative ATF5 (dnATF5) biologic has found that targeting ATF5 results in tumor regression and tumor growth inhibition of glioblastoma xenografts in mouse models. In this review, we comprehensively and critically detail the current scientific literature on ATF5 in the context of cellular differentiation, survival, and response to stressors in normal tissues. Furthermore, we will discuss how the prosurvival role of ATF5 aides in cancer development, followed by current advances in targeting ATF5 using dominant-negative biologics, and perspectives on future research

A Quantitative Analysis of Inner Speech Between Monolingual and Bilingual Speakers

Inner speech is an individual’s silent, inner monologue; a growing amount of evidence indicates that inner speech is very common among both monolingual and multilingual speakers. Studies have shown that important cognitive functions are involved in inner speech pertaining to psychological development, however connections between inner speech and language acquisition/usage across speakers have been less of a focus. This study investigates the frequency and degree to which inner speech is used between monolingual English speakers and early-onset bilingual English/Spanish speakers by using a survey called the Revised-Varieties of Inner Speech Questionnaire (VISQ-R) by Alderson-Day et al. (2018). The aim of the study is to report general inner speech use, compare relative frequencies of inner speech, and determine whether and how the features examined within the VISQ-R differ between Spanish-speaking bilinguals and English-speaking monolinguals

Function Concept: Learning from History

The importance of functions in school mathematics has grown tremendously within the past century. Functions have progressed from being scantly represented in school mathematics to being a core mathematical topic. C.B. Boyer (1946) acknowledged “The development of the function concept has revolutionized mathematics in much the same way as did the nearly simultaneous rise of non-Euclidean geometry. It has transformed mathematics from a pure natural science- the queen of the sciences- into something vastly large. It has established mathematics as the basis of all rigorous thinking – the logic of all possible relations” (Markovits, Eylor, & Bruckheimer, 1986, p. 18). Historical speeches and documents, such as Klein’s 1893 Evanston Colloquium, Moore’s 1902 presidential address to the American Mathematical Society, The Reorganization of Mathematics in Secondary Education Report (1923), and The Report of Progressive Education and Joint Committee (1940), advocated that functions and “relational thinking” be a core concept in school mathematics. In fact, Felix Klein considered functions to be the “soul of mathematics”, and advocated that teachers teach functional concepts. Fortunately, the recommendations made decades ago pertaining to the importance of functions, and the needs to readily integrate the function concept into school mathematics by researchers were not ignored. The recommendations made regarding functions decades ago are evident in today’s curriculum standards. Standards for mathematics require students to be able to define functions, describe functions, identify functions, analyze functions, and recognize patterns in function (NCTM, 2000; Common Core State Standards 2010). Most notably, The Common Core State Standards (2010) has functions as one of five conceptual categories in high school mathematics. Considering the increased emphasis placed on functions in school mathematics within the past century, we sought to describe how the function concept was presented in secondary mathematics textbooks prior to the “New Math” era

The benefits and opportunities: Engaging patients in identifying and reporting patient safety incidents

There is growing recognition that patients can and should be engaged in the identification of patient safety incidents arising during their experiences across health systems. In this article, we describe the benefits that can be harnessed from engaging patients in reporting patient safety incidents; identify opportunities to support patient engagement in reporting and learning from patient safety incidents; and describe the potential role of health leaders in connecting patient experience and patient safety using patient-reported patient safety incident data

Thomas Worthington: father of Ohio statehood

(print) viii, 260 p. ; 23 cmi A Virginian Transplanted 3 -- ii Businessman and Citizen 23 -- iii Territorial Legislator and Politician 46 -- iv State-Maker 73 -- v Framer of the Constitution 94 -- vi United States Senator 115 -- vii Ohio Politician 137 -- viii Anti-war Senator 159 -- ix Wartime Service in Ohio 175 -- x Governor of Ohio 193 -- xi Business, Politics, and Internal Improvements 211 -- xii Last Years 231 -- BIBLIOGRAPHY 243 -- INDEX 25

Pellets recovered from stick nests and new diet items of Furnariidae (Aves: Passeriformes)

This is the first record showing eleven species in seven genera of Furnariidae (Aves: Passeriformes) from Argentina that regurgitate pellets. A total of 627 nests of Furnariidae was examined, and from 84 nests (13.3%), 1,329 pellets were recovered. These pellets were found in the closed, domed nests of many Furnariidae, because in comparison to other passerine birds, their nests were used for roosting, especially in the subfamily Synallaxinae. Anumbius annumbi had the highest percentage of nests containing pellets. Food items identified from the pellets provided important new data on the diets of several species of Furnariidae.Fil: Turienzo, Paola Noemí. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Di Iorio, Osvaldo Rubén. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentin