Measuring Immune Responsiveness in Xenopus laevis Using Phytohaemagglutanin (PHA)

Phytohaemagglutanin (PHA) is a red kidney bean extract that has been used to stimulate an immunological T cell response in a variety of animals. This procedure has become very popular method to analyze an individual animal’s ability to trigger an immunological response.(Brown 2014) PHA skin testing has been used in a variety of avian, mice, lizard, and amphibian species where it is injected into the muscle, skin, or webbing of an animal and then recording the amount of swelling before and after the injection.(Smits 1999) We are using the amphibian Xenopus laevis to test 1) their immune reaction under normal conditions and 2) to test how stress effects their immune reaction. In our control non-stress experiment to discover if PHA actually causes swelling, we found that significant swelling occurs at all time points in comparison to the saline injected foot. In the stress versus non-stress PHA experiments, we found no significant variation between the stressed versus non-stress, but still a significant difference between PHA versus saline injection

Motivation of Shoulder Surgery Patients for Rehabilitation

International Journal of Exercise Science 10(2): 234-245, 2017 Motivation can be a valuable construct during physical rehabilitation. Rehabilitation can be uncomfortable and painful, testing patients’ rehabilitation motivation and continued participation. Maintaining motivation throughout rehabilitation is important for patients to return to optimal joint motion and daily functioning. The purpose of this research project was to examine rehabilitation motivation after shoulder surgery (rotator cuff repairs, slap repairs, biceps tenodesis, acromioplasty, distal clavicle excision or combination). Persons who underwent shoulder surgery (December 2014 – April 2015) voluntarily participated in the study. The Self Regulation Questionnaire was used to assess patients’ self-regulation and motivation. Surveys were administered to participants during rehabilitation at appointments with the physician. This study revealed significant changes to participants’ self-regulation throughout the 16-week post shoulder surgical rehabilitation process. Significant increases were discovered when looking at patients’ attention to goals and employing strategies to meet those goals. Other main areas of increase included problem solving, planning rehabilitation outside of therapy and coping with challenging times in rehabilitation. Data allows researchers and health care professionals to evaluate the dynamics of motivation fluctuation during rehabilitation. In addition, data will allow researchers to identify areas of motivational concern to implement motivation techniques in order to aid patients through rehabilitation

Failure to Preserve β-Cell Function With Mycophenolate Mofetil and Daclizumab Combined Therapy in Patients With New- Onset Type 1 Diabetes

OBJECTIVE This trial tested whether mycophenolate mofetil (MMF) alone or with daclizumab (DZB) could arrest the loss of insulin-producing β-cells in subjects with new-onset type 1 diabetes. RESEARCH DESIGN AND METHODS A multi-center, randomized, placebo-controlled, double-masked trial was initiated by Type 1 Diabetes TrialNet at 13 sites in North America and Europe. Subjects diagnosed with type 1 diabetes and with sufficient C-peptide within 3 months of diagnosis were randomized to either MMF alone, MMF plus DZB, or placebo, and then followed for 2 years. The primary outcome was the geometric mean area under the curve (AUC) C-peptide from the 2-h mixed meal tolerance test. RESULTS One hundred and twenty-six subjects were randomized and treated during the trial. The geometric mean C-peptide AUC at 2 years was unaffected by MMF alone or MMF plus DZB versus placebo. Adverse events were more frequent in the active therapy groups relative to the control group, but not significantly. CONCLUSIONS Neither MMF alone nor MMF in combination with DZB had an effect on the loss of C-peptide in subjects with new-onset type 1 diabetes. Higher doses or more targeted immunotherapies may be needed to affect the autoimmune process

Project Daedalus: An Additive Manufacturing Vending Machine

The project was a research endeavor focused on designing and building a vending machine for 3D-printed parts. It also had the secondary objective of catalyzing leadership qualities among its membership by emphasizing individual responsibility and forward thinking. The project began in the spring of 2015, when the topic of autonomous 3D-printing was chosen, funding was secured, and the majority of the leadership was brought on. Over the summer and into the fall semester the team developed project requirements and infrastructure, and gathered members from the parent organization. By December of 2015 most of the machine design had been completed, and the parts were en route so that building could be started in the spring semester. Due to a combination of time constraints, underestimated difficulty, and unforeseen logistical circumstances, the project was not able to achieve its primary goal of having a working prototype by May 2016. However, it is the belief of the project’s leadership and many of the members that it succeeded in its secondary goal of creating competent and confident leaders, several of whom went on to lead projects of their own

The Student Movement Volume 107 Issue 8: Cuffing Season, Co-Curriculars, and CTC Telehealth: The Student Movement Highlights Important Issues on Campus

HUMANS CTC Prevention Coordinator/Staff Counselor Interview: Nycole Goldberg, Interviewed by: Lauren Kim Meet Ellie Dovich: Cast/Cardinal Lead Editor, Interviewed by: Nora Martin Women in Stem: A Peek into Physics, Interviewed by: Caryn Cruz ARTS & ENTERTAINMENT Creatives on Campus: Art via Insta, Ceiry Flores Currently..., Solana Campbell Spotlight: The Parent Trap, Skyler Campbell NEWS AUSA Senate News Update, November 2022, Neesa Richards, AUSA Senate Public Relations Officer Governor Whitmer Takes A Stop In Benton Harbor, Nicholas C. Gunn Home Season Opener, Solana Campbell Hopes and Plans Behind the Seminary Center of Community Change, Interviewed by: Gloria Oh The Days Speak on Veterans Day, Andrew Francis IDEAS T Spills the Tea on Co-Curriculars, T Bruggemann To Bee or not to Bee: The Importance, Causes, and Impact of Bee Disappearance, Alexander Navarro Ye Being an Issue Once Again!, Jonathon Woolford-Hunt PULSE A Dive into Lamson Hall Maintenance, Scott Moncrieff Condemned: Horror Stories from Lamson Hall, Joseph Keough Marriage From Our Point of View, Gloria Oh Reflections on the Soccer Season, Brendan Syto LAST WORD Reflection on Writing Poetry, Alannah Tjhatrahttps://digitalcommons.andrews.edu/sm-107/1007/thumbnail.jp

Exercise therapy in Type 2 diabetes

Structured exercise is considered an important cornerstone to achieve good glycemic control and improve cardiovascular risk profile in Type 2 diabetes. Current clinical guidelines acknowledge the therapeutic strength of exercise intervention. This paper reviews the wide pathophysiological problems associated with Type 2 diabetes and discusses the benefits of exercise therapy on phenotype characteristics, glycemic control and cardiovascular risk profile in Type 2 diabetes patients. Based on the currently available literature, it is concluded that Type 2 diabetes patients should be stimulated to participate in specifically designed exercise intervention programs. More attention should be paid to cardiovascular and musculoskeletal deconditioning as well as motivational factors to improve long-term treatment adherence and clinical efficacy. More clinical research is warranted to establish the efficacy of exercise intervention in a more differentiated approach for Type 2 diabetes subpopulations within different stages of the disease and various levels of co-morbidity

Primary peritoneal clear cell carcinoma treated with IMRT and interstitial HDR brachytherapy: a case report

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135568/1/acm20202-sup-0018.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135568/2/acm20202.pd

Replication Data for: Navigating the Range of Statistical Tools for Inferential Network Analysis

The last decade has seen substantial advances in statistical techniques for the analysis of network data, and a major increase in the frequency with which these tools are used. These techniques are designed to accomplish the same broad goal, statistically valid inference in the presence of highly interdependent relationships, but important differences remain between them. We review three approaches commonly used for inferential network analysis---the Quadratic Assignment Procedure, Exponential Random Graph Model, and Latent Space Network Model---highlighting the strengths and weaknesses of the techniques relative to one another. An illustrative example using climate change policy network data shows that all three network models outperform standard logit estimates on multiple criteria. This paper introduces political scientists to a class of network techniques beyond simple descriptive measures of network structure, and helps researchers choose which model to use in their own research