36 research outputs found
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Ion kinetic effects on the tilt mode in FRCs
Theory and simulations have shown that field reversed configurations (FRG's) should be unstable magnetohydrodynamically to the tilting mode, yet tilting seldom is seen in the experiments. Profile effects (within MHD) and ion finite larmor radius (FLR) effects have been prosed to explain the observed stability of FRC's. The present work seeks to test both of these effects
ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders
Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMAâAnxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. This paper elaborates on the concepts and methods informing the work of the working group to date, and describes the initial approach of the four subgroups studying generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobia. At present, the ENIGMAâAnxiety database contains information about more than 100 unique samples, from 16 countries and 59 institutes. Future directions include examining additional imaging modalities, integrating imaging and genetic data, and collaborating with other ENIGMA working groups. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMAâAnxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders
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Theoretical studies of field-reversed configurations (FRCs) and experimental study of the FRC during translation
Theoretical studies of FRC stability and tranport are summarized. Finite Larmor radius theories are shown to be unreliable for explaining the experimentally observed stability to tilting. Control of the n=2 rotational instability has been demonstrated in 2-dimensional hybrid-code simulations, and the stability appears to be described within MHD if the nearly square equilibria that result from quadrupole fields are taken into account. Simulations of the lower-hybrid-drift instability in parameter regimes relevant to experiments show good agreement with a nonlocal theory of the instability. A 1.5-dimensional transport code shows agreement with the energy confinement time but disagreement with the flux loss time observed in FRX-C. The process of FRC translation in which the plasma is formed, translated into a dc solenoid, and trapped by magnetic mirrors has been studied in the FRX-C/T experiment
ENIGMA-anxiety working group : Rationale for and organization of large-scale neuroimaging studies of anxiety disorders
Altres ajuts: Anxiety Disorders Research Network European College of Neuropsychopharmacology; Claude Leon Postdoctoral Fellowship; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, 44541416-TRR58); EU7th Frame Work Marie Curie Actions International Staff Exchange Scheme grant 'European and South African Research Network in Anxiety Disorders' (EUSARNAD); Geestkracht programme of the Netherlands Organization for Health Research and Development (ZonMw, 10-000-1002); Intramural Research Training Award (IRTA) program within the National Institute of Mental Health under the Intramural Research Program (NIMH-IRP, MH002781); National Institute of Mental Health under the Intramural Research Program (NIMH-IRP, ZIA-MH-002782); SA Medical Research Council; U.S. National Institutes of Health grants (P01 AG026572, P01 AG055367, P41 EB015922, R01 AG060610, R56 AG058854, RF1 AG051710, U54 EB020403).Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA-Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. This paper elaborates on the concepts and methods informing the work of the working group to date, and describes the initial approach of the four subgroups studying generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobia. At present, the ENIGMA-Anxiety database contains information about more than 100 unique samples, from 16 countries and 59 institutes. Future directions include examining additional imaging modalities, integrating imaging and genetic data, and collaborating with other ENIGMA working groups. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMA-Anxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders
A randomized, open-label, multicentre, phase 2/3 study to evaluate the safety and efficacy of lumiliximab in combination with fludarabine, cyclophosphamide and rituximab versus fludarabine, cyclophosphamide and rituximab alone in subjects with relapsed chronic lymphocytic leukaemia
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Recent results of an internal tilt mode calculation in FRCs
Recent theoretical results on the stability of FRCs to the internal tilt mode are presented. An approximate treatment of collisions shows that collisions have a small effect on the growth rate of the mode until the plasma becomes very collisional (lambda/sub ii/ less than or equal to r/sub s/2). Finite Larmor radius theory predicts that the growth rate of the instability normalized to that of MHD depends only on the combination anti s/e, where e is the plasma elongation. However, a full Vlasov stability calculation does not appear to show such a scaling
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Tilting mode in field-reversed configurations
Field Reversed Configurations (FRCs) experimentally have exhibited remarkable stability on the magnetohydrodynamic (MHD) timescale, despite numerous MHD calculations showing FRCs to be unstable. It is easy to believe that local modes are stabilized by finite Larmor radius (FLR) effects, but more puzzling is the apparent stability of FRCs against global modes, where one would expect FLR effects to be less important. In this paper we study the tilting mode, which MHD has shown to be a rapidly growing global mode. The tilting mode in FRCs is driven by the pressure gradient, and magnetic compression and field line bending are the stabilizing forces. A schematic of the evolution of the tilting mode is shown. The tilting mode is considered dangerous, because it would lead to rapid tearing across the separatrix. Unlike spheromaks, the tilting mode in FRCs has a separatrix that is fixed in space, so that the mode is strictly internal
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Proposed FRX-D experiment
The field-reversed-configuration (FRC) research program is poised for a significant step forward. Resolution of the critical FRC physics issues, which must now be addressed in order to advance the development of this concept, requires experimental studies in a plasma regime closer to reactor relevance than is possible with existing devices. The purpose of FRX-D is to extrapolate the parameters of FRC's into the required regime of large plasma size relative to an ion gyroradius, i.e., large anti s. The critical issues that FRX-D will address are: (1) the FRC stability and confinement properties at large anti s; (2) the demonstration of adiabatic compression as an efficient, technologically attractive FRC heating method; (3) the identification of the dominant electron energy-loss mechanism; and (4) the determination of the dependence of poloidal flux loss on electron temperature. An additional, more technologically oriented purpose of FRX-D is to demonstrate the separation of FRC formation and heating functions using the reactor-like technique of sequential formation/translation/compression