Biobanks in Europe: Prospects for Harmonisation and Networking

Biobanks (i.e. the organised collections consisting of biological samples and associated data, have gained great significance for research and personalised medicine) are increasingly recognised as a crucial infrastructure for research. However, at the same time the widely varied practices in biobanking regarding for example collection, storage and consent procedures may also pose a barrier to cross-border research and collaboration by limiting access to samples and data. In this context, a recent study indicates that the limited sharing and linkage of samples is a key barrier for research, such as pharmacogenetics. Wide variation is observed in the implementation of relevant existing regulation, which may add further burden to harnessing the public health benefit of these collections. Therefore, it has been suggested that there is a strong need for a harmonised approach on biobanking practices and improved networking of existing and new collections. This Report shows information on the extent of biobanking in Europe, collected through a survey of existing European biobanks regarding both technical aspects (e.g. storage conditions) and aspects of governance and ethics (e.g. sample and data sharing, consent procedures, collaborations etc.). In total, 126 biobanks from 23 countries in Europe were surveyed. Significant lack of harmonisation has been found, especially in the legal aspects (e.g. data protection, consent). This may be partly attributed to the varied interpretation and implementation of EC directives covering aspects of biobanking by national authorities. One of the main complications is that, although the field of data protection is harmonised through the EC directive on data protection, the collection, storage, and sharing of samples is not. Furthermore, in countries that have introduced special biobanks acts it is not always clear where the borderline lies between the scope of these acts and that of the Directive. Indeed, according to the survey, biobanks within the same country reported different practices, suggesting that the problems of harmonization might be higher than expected and claimed. Not only are there different national laws, but apparently within EU member states biobanks do not implement homogenous practices on privacy and data protection issues. Desk research and expert interviews were done to complete the picture presented by the survey. Experts widely recognised the need to improve collaboration and networking among the numerous existing biobanks, as well as new initiatives in Europe (and world-wide). Efficient organisation of these resources through the development, for example, of an infrastructure would potentially facilitate financial sustainability and greatly contribute to the rapid progress of research and development of better diagnostic and therapeutic approaches. The most favoured model involved the development of a virtual biobank that would allow networking of biobanks across different countries and centralisation of data rather than samples. However, several organisational challenges (wide variation in biospecimen collection, storage techniques, data comparability, etc.) may hamper such an effort. The lack of uniform regulatory and ethical requirements and/or practices may pose an additional barrier. The European Commission has already recognised the importance of international biobank projects and many of them have been funded and established in the context of the EU Framework Programmes. To help promote networking of biobanks and thus maximise public health benefits, at least some degree of harmonisation must be achieved. Whether this should be achieved solely at the level of legal/regulatory requirements and practices and/or by technical standardisation requires further investigation. Experts suggested the establishment of an international (rathen than just a European) umbrella (or network) organization, which would establish common operating procedures.JRC.DDG.J.2-The economics of climate change, energy and transpor

A Generalized Equatorial Model for the Accelerating Solar Wind

A new theoretical model for the solar wind is developed that includes the wind’s acceleration, conservation of angular momentum, deviations from corotation, and nonradial velocity and magnetic field components from an inner boundary (corresponding to the onset of the solar wind) to beyond 1 AU. The model uses a solution of the time-steady isothermal equation of motion to describe the acceleration and analytically predicts the Alfvénic critical radius. We fit the model to near-Earth observations of the Wind spacecraft during the solar rotation period of 1–27 August 2010. The resulting data-driven model demonstrates the existence of noncorotating, nonradial flows and fields from the inner boundary (r = rs)outward and predicts the magnetic field B = (Br , B), velocity v = (vr , v), and density n(r , , t), which vary with heliocentric distance r, heliolatitude , and time t in a Sun-centered standard inertial plane. Thedescription applies formally only in the equatorial plane. In a frame corotating with the Sun, the transformed velocity v ′ and a field B′are not parallel, resulting in an electric field with a component E′z along the z axis.The resulting E ′ × B′ = E ′ × B drift lies in the equatorial plane, while the B and curvature drifts are out of the plane. Together these may lead to enhanced scattering/heating of sufficiently energetic particles. The model predicts that deviations v from corotation at the inner boundary are common, with v(rs , s , ts) comparable to the transverse velocities due to granulation and supergranulation motions. Abrupt changesin v(rs , s , ts) are interpreted in terms of converging and diverging flows at the cell boundaries and centers, respectively. Large-scale variations in the predicted angular momentum demonstrate that the solar wind can drive vorticity and turbulence from near the Sun to 1 AU and beyond

Quantifying the daily economic impact of extreme space weather due to failure in electricity transmission infrastructure

Extreme space weather due to coronal mass ejections has the potential to cause considerable disruption to the global economy by damaging the transformers required to operate electricity transmission infrastructure. However, expert opinion is split between the potential outcome being one of a temporary regional blackout and of a more prolonged event. The temporary blackout scenario proposed by some is expected to last the length of the disturbance, with normal operations resuming after a couple of days. On the other hand, others have predicted widespread equipment damage with blackout scenarios lasting months. In this paper we explore the potential costs associated with failure in the electricity transmission infrastructure in the U.S. due to extreme space weather, focusing on daily economic loss. This provides insight into the direct and indirect economic consequences of how an extreme space weather event may affect domestic production, as well as other nations, via supply chain linkages. By exploring the sensitivity of the blackout zone, we show that on average the direct economic cost incurred from disruption to electricity represents only 49% of the total potential macroeconomic cost. Therefore, if indirect supply chain costs are not considered when undertaking cost-benefit analysis of space weather forecasting and mitigation investment, the total potential macroeconomic cost is not correctly represented. The paper contributes to our understanding of the economic impact of space weather, as well as making a number of key methodological contributions relevant for future work. Further economic impact assessment of this threat must consider multiday, multiregional event

Public health and valorization of genome-based technologies: a new model

<p>Abstract</p> <p>Background</p> <p>The success rate of timely translation of genome-based technologies to commercially feasible products/services with applicability in health care systems is significantly low. We identified both industry and scientists neglect health policy aspects when commercializing their technology, more specifically, Public Health Assessment Tools (PHAT) and early on involvement of decision makers through which market authorization and reimbursements are dependent. While Technology Transfer (TT) aims to facilitate translation of ideas into products, Health Technology Assessment, one component of PHAT, for example, facilitates translation of products/processes into healthcare services and eventually comes up with recommendations for decision makers. We aim to propose a new model of valorization to optimize integration of genome-based technologies into the healthcare system.</p> <p>Methods</p> <p>The method used to develop our model is an adapted version of the Fish Trap Model and the Basic Design Cycle.</p> <p>Results</p> <p>We found although different, similarities exist between TT and PHAT. Realizing the potential of being mutually beneficial justified our proposal of their relative parallel initiation. We observed that the Public Health Genomics Wheel should be included in this relative parallel activity to ensure all societal/policy aspects are dealt with preemptively by both stakeholders. On further analysis, we found out this whole process is dependent on the Value of Information. As a result, we present our LAL (Learning Adapting Leveling) model which proposes, based on market demand; TT and PHAT by consultation/bi-lateral communication should advocate for relevant technologies. This can be achieved by public-private partnerships (PPPs). These widely defined PPPs create the innovation network which is a developing, consultative/collaborative-networking platform between TT and PHAT. This network has iterations and requires learning, assimilating and using knowledge developed and is called absorption capacity. We hypothesize that the higher absorption capacity, higher success possibility. Our model however does not address the phasing out of technology although we believe the same model can be used to simultaneously phase out a technology.</p> <p>Conclusions</p> <p>This model proposes to facilitate optimization/decrease the timeframe of integration in healthcare. It also helps industry and researchers to come to a strategic decision at an early stage, about technology being developed thus, saving on resources, hence minimizing failures.</p

Labour forced impacts and production losses due to the 2013 flood in Germany

During May and June 2013 heavy rains caused disastrous floods in several countries in Europe. In thisstudy we use a new high-resolution model of the German economy to simulate the post-disaster economicshock of the flood. Due to the heavy reliance of modern economies on inter regional supply chains,substantial economic impacts are felt in states and industries outside the flooded area. Cessation ofexport from one industry, for example in Bayern, in the wake of the flood affects many other industriesand regions. Trade links are broken immediately and cause shortages. Supply restrictions from thoseindustries spread further, reducing production possibilities in the national and global economy.Industry- and region specific direct impacts are estimated from time series data about compensationsof lost working hours from social insurance schemes in the case of external events such as business cyclesand natural disasters. We estimate the total indirect loss of production possibilities that affect in particularthe motor vehicle and food industries in Baden-Württemberg, Nordrhein-Westfalen andNiedersachsen, but also foreign production, to be €6.2 billion. Regions and industries outside the floodedarea experience around €400 million of the loss. We find the economic impact of the flood to be muchhigher as in previous studies and mitigation is more likely to be considered if this effect is taken intoaccount