Pleistocene vertebrate faunas of the Süttő Travertine Complex (Hungary)

Numerous fossil remains (vertebrates, molluscs and plants) were found in more than twenty sites of the Süttő Travertine Complex during the last 150 years. The majority of these remains were recovered from fissures of the travertine, but also from the travertine and an overlying loess-paleosol sequence. The aims of this study were to review the fossil content, to determine the stratigraphical positions of the various vertebrate faunas of Süttő and provide paleoecological interpretation of the periods on the basis of their faunas and floras. In addition, this paper describes new faunas and floras from the sites Süttő 16–20 and provides 14C dates for Süttő 16. On the basis of the new uranium series isotope and optical dating (OSL), the age of the travertine complex is Middle Pleistocene (235±21–314±45 ka, MIS 7–9), while the age of the loess-paleosol sequence in superposition of the travertine is Middle-Late Pleistocene (MIS 2–MIS 6). In contrast, the fossils of the travertine indicated an older, Pliocene–Early Pleistocene age. A fissure (Süttő 17) and a red clay layer (Süttő 19) contained mammal faunas of Early–Middle Pleistocene age. These results indicated the existence of older travertine in certain quarries (Hegyháti quarry, Cukor quarry). Sedimentological and OSL data of well-dated layers of the loess-paleosol sequence (Süttő/LPS) at Süttő allowed a correlation with the layers of Süttő 6. The paleosol layer in the upper part of the sequence of Süttő 6, was correlated with a pedocomplex of the overlying loess-paleosol sequence, which was dated to MIS 5c (upper, dark soil) and MIS 5e (lower, reddish brown soil). The paleoecological analysis of the mammal and mollusc faunas supported the former interpretation of Novothny et al., inferring warm, dry climate during the sedimentation of the upper layers, and more humid climate for the lower layers). However, the fauna of the lower soil layer indicated cold climate, so an age of MIS 5d is suggested. Dating of the fissure faunas is based on similarity studies. For some faunas, this method cannot be used, because of the low number of species. On the basis of the species compositions and former interpretations, these faunas originated mainly from sediments that were deposited under cold climatic conditions. Other fissure faunas were dated by AMS 14C (Süttő 16), or by correlation with soil layers of Süttő 6. According to these results, most of the fissure faunas can be correlated with different phases of MIS 5. However, there are a younger (MIS 2) and an older (Early–Middle Pleistocene) fissure fauna.status: publishe

Stratigraphy, facies and geodynamic settings of Jurassic formations in the Bükk Mountains, North Hungary: its relations with the other areas of the Neotethyan realm.

Jurassic mélange complexes related to the subduction of the Neotethys Ocean occur in the Bükk Mountains, North Hungary. This paper characterizes the sedimentary sequence of basin and slope facies that occur in the southwestern part of the Bükk Mountains, placing special emphasis on the redeposited sedimentary rocks (olistostromes, olistoliths: Mónosbél Group) in order to obtain information on the provenance of the clasts, and the mode and time of their redeposition. The series of formations studied shows a general coarsening-upwards trend. Based on radiolarians and foraminifera, the Mónosbél Group formed in Early to Late Bathonian time. The lower part of the complex is typified by a predominance of pelagic carbonates, shale and radiolarite with andesitic volcaniclastic intercalations. The higher part of the succession is characterized by polymictic olistostromes. Large olistoliths that are predominantly blocks of Bathonian shallow marine limestone (Bükkzsérc Limestone) appear in the upper part of the sequence. Based on the biostratigraphic and sedimentological data, results of analyses of the redeposited clasts and taking into consideration the concepts of the development of the western Neotethys domain, the evolutionary stages of the sedimentary basins were defined. The onset of the compressional stage led to initiation of nappe stacking that led to the formation of polymict olistostromes and then to the redeposition of large blocks derived from out-of-sequence nappes of the former platform foreland

Global prevalence and genotype distribution of hepatitis C virus infection in 2015 : A modelling study

Publisher Copyright: © 2017 Elsevier LtdBackground The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030, which can become a reality with the recent launch of direct acting antiviral therapies. Reliable disease burden estimates are required for national strategies. This analysis estimates the global prevalence of viraemic HCV at the end of 2015, an update of—and expansion on—the 2014 analysis, which reported 80 million (95% CI 64–103) viraemic infections in 2013. Methods We developed country-level disease burden models following a systematic review of HCV prevalence (number of studies, n=6754) and genotype (n=11 342) studies published after 2013. A Delphi process was used to gain country expert consensus and validate inputs. Published estimates alone were used for countries where expert panel meetings could not be scheduled. Global prevalence was estimated using regional averages for countries without data. Findings Models were built for 100 countries, 59 of which were approved by country experts, with the remaining 41 estimated using published data alone. The remaining countries had insufficient data to create a model. The global prevalence of viraemic HCV is estimated to be 1·0% (95% uncertainty interval 0·8–1·1) in 2015, corresponding to 71·1 million (62·5–79·4) viraemic infections. Genotypes 1 and 3 were the most common cause of infections (44% and 25%, respectively). Interpretation The global estimate of viraemic infections is lower than previous estimates, largely due to more recent (lower) prevalence estimates in Africa. Additionally, increased mortality due to liver-related causes and an ageing population may have contributed to a reduction in infections. Funding John C Martin Foundation.publishersversionPeer reviewe

SIMULATION AS A MEANS OF ACTIVITY STREAMLINING OF CONTINUOUSLY AND DISCRETE PRODUCTION IN SPECIFIC ENTERPRISE

The advantage of simulation is that it works with a model of real system, so it do not influence the system straight. The provision of quality simulation is also quality model, which has almost the same parameters as the real system. The goal of the project is to create a model and to try its different states, real or hypothetic. A system analysis is used for analysing and to reach of modelled system specifications. The base of synthesis is to create the simulation model. Described simulation model is the result of these steps. Description consists of the functional principle, importance and item setup. The section of variation calculations consists of several measured states of the system. At the output of every calculation, there lies summary of defined differences, their influence of gravure printing process in the technological and the economic aspects

Noninvasive Assessment of Liver Fibrosis in Patients with Chronic Hepatitis B or C by Contrast-Enhanced Magnetic Resonance Imaging

Background and Aim. To develop a noninvasive magnetic resonance imaging (MRI) method for evaluation of liver fibrosis. We evaluate the utility of hepatocyte-phase Gadoxetate disodium–enhanced magnetic resonance (MR) imaging in staging hepatic fibrosis and compare it with histological analysis as the reference standard (liver biopsy). Methods. Prospective cohort of 78 patients, who received Gadoxetate disodium dynamic contrast-enhanced MRI (DCE-MRI), were divided into three groups. The first group (n=19) was a control group of healthy individuals without liver injury and remaining 59 subjects were chronic hepatitis B and C patients who underwent liver biopsy. These patients were divided into the mild fibrosis F1-F2 (n=32) and advanced fibrosis F3-F4 (n=27) groups. Patients were examined by generated DCE-MRI in 20th minute. Variables such as liver surface changes, homogeneities, and quantitative contrast liver/spleen ratio-Q-LSCR were evaluated and these results were consequently compared between the three groups. Results. Gd-EOB-DTPA contrast-enhanced dynamic liver MRI examination (DCE-MRI) can in the 20th minute differentiate mild stage of liver fibrosis (F1-F2) from severe stage of liver fibrosis (F3-F4) on the basis of liver surface changes, homogeneities, and quantitative contrast liver/spleen ratio-Q-LSCR. Diagnostic MRI criteria were created and named MRI Triple test. This test correctly identified 96% of patients with F3-F4 fibrosis and 91% of patients with the F1-F2 fibrosis in the liver biopsy. This test correctly identified 42,1% of patients in the control group (presumed F0 fibrosis without liver disease). Spearman's rank correlation coefficient (r = 0,86, P < .001) confirmed high agreement of biopsy and MR Triple test. MR Triple test’s sensitivity was 96.30% (95%CI 81.03% to 99.91%), specificity 90.62% (95%CI 74.98% to 98.02%), positive predictive value 89.66% (95%CI 74.64% to 96.23%), and negative predictive value 96.67% (95%CI 80.86% to 99.50%) for discrimination between F3-4 and F1-2 fibrosis on liver biopsy. Conclusions. Gd-EOB-DTPA contrast-enhanced MRI liver examination in 20th minute is able to reliably differentiate mild stage of liver fibrosis (F1-F2) from severe stage fibrosis (F3-F4) on the basis of Triple test (liver surface changes, homogeneities, and quantitative contrast liver/spleen ratio-Q-LSCR)