Creación de espacios escenográficos virtuales con motores de videojuegos. Estudio de caso en un escenario en Virtual production.

A lo largo de los últimos años, se ha comenzado a vislumbrar como los motores gráficos de videojuegos han empezado a formar parte en el mundo audiovisual hasta que actualmente se han convertido en un elemento innovador dentro de las producciones denominado Virtual Production como una nueva técnica para trabajar en la generación de contenidos audiovisuales que afectan a todo el proceso de producción. En la actualidad, se aplican estas técnicas en diferentes series, películas y publicidad entre otros, dando lugar a grandes series como “The Mandalorian”, uno de los ejemplos más famosos e innovadores de estos años. Una producción en la que se deja casi de lado los green screen o blue screen para dar paso a una nueva tecnología, la de los escenarios LEDs. Esta nueva tecnología consiste en el uso de grandes pantallas, en las que se proyectan los diferentes entornos que se mostraran durante el rodaje. Para entrar en contexto, el equipo de “The Mandalorian” rodó la serie en un plató con esta nueva tecnología donde se muestran los sets virtuales generados con motores gráficos de videojuegos que podían ser manipulados a tiempo real junto con otro tipo de escenografía física. Para esta serie se utilizó el motor de juego Unreal Engine, que ha sido el primero en usarse en la industria audiovisual. Actualmente, Weta Digital ha cedido un conjunto de herramientas utilizadas en el cine para todos los usuarios de Unity haciendo este último motor gráfico un buen competidor de Unreal Engine.pre-print4084 K

Achievable Rate-Power Tradeoff in THz SWIPT Systems with Resonant Tunnelling Diodes

In this paper, we study terahertz (THz) simultaneous wireless information and power transfer (SWIPT) systems. Since coherent information detection is challenging at THz frequencies and Schottky diodes are not usable for THz energy harvesting (EH), we employ unipolar amplitude shift keying (ASK) modulation at the transmitter (TX) and a resonant tunnelling diode (RTD)- based EH circuit at the receiver (RX) to extract both information and power from the received signal. However, the electrical properties of Schottky diodes and RTDs are different, and unlike EH receivers based on a single Schottky diode, an accurate closed-form EH model for RTD-based RXs is not available, yet. In this paper, we model the dependency of the instantaneous RX output power on the instantaneous received power by a non-linear piecewise function, whose parameters are adjusted to fit circuit simulation results. We formulate an optimization problem to maximize the mutual information between the TX and RX signals subject to constraints on the peak amplitude of the transmitted signal and the required average harvested power at the RX. Furthermore, we determine a feasibility condition for the formulated problem, and for high and low required average harvested powers, we derive the achievable information rate numerically and in closed form, respectively. Our simulation results highlight a tradeoff between the information rate and the average harvested power. Finally, we show that this tradeoff is determined by the peak amplitude of the transmitted signal and the maximum instantaneous harvested power for low and high received signal powers, respectively.Comment: 6 pages, 5 figures, submitted for possible conference publicatio

Joint Transmit Signal and Beamforming Design for Integrated Sensing and Power Transfer Systems

Integrating different functionalities, conventionally implemented as dedicated systems, into a single platform allows utilising the available resources more efficiently. We consider an integrated sensing and power transfer (ISAPT) system and propose the joint optimisation of the rectangular pulse-shaped transmit signal and the beamforming vector to combine sensing and wireless power transfer (WPT) functionalities efficiently. In contrast to prior works, we adopt an accurate non-linear circuit-based energy harvesting (EH) model. We formulate and solve a non-convex optimisation problem for a general number of EH receivers to maximise a weighted sum of the average harvested powers at the EH receivers while ensuring the received echo signal reflected by a sensing target (ST) has sufficient power for estimating the range to the ST with a prescribed accuracy within the considered coverage region. The average harvested power is shown to monotonically increase with the pulse duration when the average transmit power budget is sufficiently large. We discuss the trade-off between sensing performance and power transfer for the considered ISAPT system. The proposed approach significantly outperforms a heuristic baseline scheme based on a linear EH model, which linearly combines energy beamforming with the beamsteering vector in the direction to the ST as its transmit strategy.Comment: 7 pages, 2 figures, six page version of this paper has been submitted to IEEE ICC 202

Supporting Third Mission activities at Universities: Deans' opinions and recommendations

Universities are increasingly required to address societal challenges in teaching and research as their third mission (TM). We took an educational-psychological approach to assessing parameters which support university members in setting goals and taking action for TM activities. For that purpose, we conducted semi-structured qualitative interviews with the deans of all 19 faculties at the University of Vienna assessing opinions and recommendations related to the TM. In addition, we conducted interviews with 23 TM actors and a university-wide online survey to capture current TM activities. Key requirements for implementing the TM were improved visibility and explicit appreciation of related activities

Neutrophil microvesicles drive atherosclerosis by delivering <i>miR-155</i> to atheroprone endothelium

Neutrophils are implicated in the pathogenesis of atherosclerosis but are seldom detected in atherosclerotic plaques. We investigated whether neutrophil-derived microvesicles may influence arterial pathophysiology. Here we report that levels of circulating neutrophil microvesicles are enhanced by exposure to a high fat diet, a known risk factor for atherosclerosis. Neutrophil microvesicles accumulate at disease-prone regions of arteries exposed to disturbed flow patterns, and promote vascular inflammation and atherosclerosis in a murine model. Using cultured endothelial cells exposed to disturbed flow, we demonstrate that neutrophil microvesicles promote inflammatory gene expression by delivering miR-155, enhancing NF-κB activation. Similarly, neutrophil microvesicles increase miR-155 and enhance NF-κB at disease-prone sites of disturbed flow in vivo. Enhancement of atherosclerotic plaque formation and increase in macrophage content by neutrophil microvesicles is dependent on miR-155. We conclude that neutrophils contribute to vascular inflammation and atherogenesis through delivery of microvesicles carrying miR-155 to disease-prone regions

Mammalian end binding proteins control persistent microtubule growth

© 2009 Komarova et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0. The definitive version was published in Journal of Cell Biology 184 (2009): 691-706, doi:10.1083/jcb.200807179.End binding proteins (EBs) are highly conserved core components of microtubule plus-end tracking protein networks. Here we investigated the roles of the three mammalian EBs in controlling microtubule dynamics and analyzed the domains involved. Protein depletion and rescue experiments showed that EB1 and EB3, but not EB2, promote persistent microtubule growth by suppressing catastrophes. Furthermore, we demonstrated in vitro and in cells that the EB plus-end tracking behavior depends on the calponin homology domain but does not require dimer formation. In contrast, dimerization is necessary for the EB anti-catastrophe activity in cells; this explains why the EB1 dimerization domain, which disrupts native EB dimers, exhibits a dominant-negative effect. When microtubule dynamics is reconstituted with purified tubulin, EBs promote rather than inhibit catastrophes, suggesting that in cells EBs prevent catastrophes by counteracting other microtubule regulators. This probably occurs through their action on microtubule ends, because catastrophe suppression does not require the EB domains needed for binding to known EB partners.This work was supported by the Netherlands Organization for Scientifi c Research grants to A.A., by Funda ç ã o para a Ci ê ncia e a Tecnologia fellowship to S.M. Gouveia, by a FEBS fellowship to R.M. Buey, by the National Institutes of Health grant GM25062 to G.G. Borisy and by the Swiss National Science Foundation through grant 3100A0-109423 and by the National Center of Competence in Research Structural Biology program to M.O. Steinmetz

Sarcoma treatment in the era of molecular medicine

Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More than 100 histological subtypes have been characterized to date, and many more are being discovered due to molecular profiling. Owing to their mostly aggressive biological behavior, relative rarity, and occurrence at virtually every anatomical site, many sarcoma subtypes are in particular difficult-to-treat categories. Current multimodal treatment concepts combine surgery, polychemotherapy (with/without local hyperthermia), irradiation, immunotherapy, and/or targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the latest advances in the molecular biology of sarcomas and their effects on clinical oncology; it is meant for a broad readership ranging from novices to experts in the field of sarcoma.Peer reviewe