Beziehung des halothan-genotyps zu den produktions- und reproduktionsmerkmalen der schweizerischen landrasse

International audienc

Dust coagulation in star formation with different metallicities

Dust grains coagulate into larger aggregates in dense gas. This changes their size distribution and possibly affects the thermal evolution of star-forming clouds. We here investigate dust coagulation in collapsing pre-stellar cores with different metallicities by considering the thermal motions of grains. We show that coagulation does occur even at low metallicity \sim 10^{-6} \Zsun. However, we also find (i) that the H$_2$ formation rate on dust grains is reduced only after the majority of H$_2$ is formed; and (ii) that the dust opacity is modified only after the core becomes optically thick. Therefore, we conclude that the effects of dust coagulation can safely be neglected in discussing the temperature evolution of the pre-stellar cores for any metallicity as long as the grain motions are thermal.Comment: 7 pages, 3 figures. Accepted for publication in MNRA

In vivo import of unspliced tRNATyr containing synthetic introns of variable length into mitochondria of Leishmania tarentolae

The mitochondrial genomes of trypanosomatids lack tRNA genes. Instead, mitochondrial tRNAs are encoded and synthesized in the nucleus and are then imported into mitochondria. This also applies for tRNATyr, which in trypanosomatids contains an 11 nt intron. Previous work has defined an exon mutation which leads to accumulation of unspliced precursor tRNATyr. In this study we have used the splicing-deficient tRNATyr as a vehicle to introduce foreign sequences into the mitochondrion of Leishmania tarentolae. The naturally occurring intron was replaced by synthetic sequences of increasing length and the resulting tRNATyr precursors were expressed in transgenic cell lines. Whereas stable expression of precursor tRNAsTyr was obtained for introns up to a length of 76 nt, only precursors having introns up to 38 nt were imported into mitochondria. These results demonstrate that splicing-deficient tRNATyr can be used to introduce short synthetic sequences into mitochondria in vivo. In addition, our results show that one factor which limits the efficiency of import is the length of the molecul

Complex Organic Materials in the HR 4796A Disk?

The red spectral shape of the visible to near infrared reflectance spectrum of the sharply-edged ring-like disk around the young main sequence star HR 4796A was recently interpreted as the presence of tholin-like complex organic materials which are seen in the atmosphere and surface of Titan and the surfaces of icy bodies in the solar system. However, we show in this Letter that porous grains comprised of common cosmic dust species (amorphous silicate, amorphous carbon, and water ice) also closely reproduce the observed reflectance spectrum, suggesting that the presence of complex organic materials in the HR 4796 disk is still not definitive.Comment: 6 pages, 3 figures; To be published in The Astrophysical Journal Letter

Visible-light photocatalytic intramolecular cyclopropane ring expansion

Described herein is a new visible-light photocatalytic strategy for the synthesis of enantioenriched dihydrofurans and cyclopentenes by an intramolecular nitro cyclopropane ring expansion reaction. Mechanistic studies and DFT calculations are used to elucidate the key factors in this new ring expansion reaction, and the need for the nitro group on the cyclopropaneThe Spanish Government (CTQ2015-64561-R, CTQ2014-59544-P) and the European Research Council (ERC-CG,contract number:647550) are acknowledge

CMR detects decreased myocardial deformation in asymptomatic patients at risk for heart failure

Aims: The main management strategy of heart failure with preserved ejection fraction (HFpEF) is prevention since HFpEF is associated with many cardiovascular (CV) risk factors, especially since HFpEF is linked to a high risk for both mortality and recurrent heart failure (HF) hospitalizations. Therefore, there is a need for new tools to identify patients with a high risk profile early. Regional strain assessment by CMR seems to be superior in describing deformation impairment in HF. The MyoHealth score is a promising tool to identify cardiac changes early. Methods and results: Heart failure patients irrespective of LVEF and asymptomatic controls were recruited, and CMR based measures were obtained. For this analysis the asymptomatic control group (n = 19) was divided into asymptomatic subjects without CV co-morbidities or evidence of cardiac abnormalities and (n = 12) and asymptomatic subjects with CV co-morbidities or evidence of cardiac abnormalities (n = 7) as well as patients with HFpEF (n = 19). We performed CMR scans at rest and during a stress test using isometric handgrip exercise (HG). Assessing the MyoHealth score at rest revealed preserved regional strain in 85 +/- 9% of LV segments in controls, 73 +/- 11% in at Risk subjects and 73 +/- 8% in HFpEF patients. During stress the MyoHealth score was 84 +/- 7% in controls, 83 +/- 7 in at risk subjects and 74 +/- 11 in HFpEF patients. Conclusion: In summary, we show for the first time that asymptomatic subjects with increased CV risk present with HFpEF like impaired myocardial deformation at rest, while they show results like controls under HG stress. The potential of preventive treatment in this group of patients merits further investigation in future