9 research outputs found
Parents' nonstandard work schedules and parents' perception of adolescent social and emotional wellbeing
Objective: We investigated the association between joint parents' work schedules and parent-reported adolescent mental health and test parental time for adolescents and parenting style as mediators. Background: Increasing evidence shows that parents' evening/night/irregular work schedules have a negative impact on childrenâs physical and mental health. Few studies examine adolescents and joint parental work schedules. Method: We analysed one wave of the Australian Raine Study data, focusing on adolescents who were followed up at ages 16-17 and lived in dual earner-households (N=607). Adolescent mental health was measured in the Child Behavioural Checklist (morbidity, internalising behaviour, externalising behaviour, anxiety/depression). Parental work schedules were defined as: both parents work standard daytime schedules (reference), both parents work evening/night/irregular shifts; fathers work evening/night/irregular shifts - mothers day schedules, mothers work evening/night/irregular shifts - fathers daytime schedules. We estimated a linear regression model with robust standard errors and log transformation of the dependent variables. Results: Compared to the reference group, when one or both parents worked evening/night/irregular schedules, there was a significant increase in parent-reported total morbidity, externalizing behaviour and anxiety/depression in adolescents. Fathersâ only evening/night/irregular schedules was associated with a significant increase in parent-reported total morbidity and externalizing behaviour. Inconsistent parenting partially mediated this association. Mothersâ only evening/night/irregular schedules was not significantly associated with parent-reported adolescent mental health. Conclusion: Our findings underscore the importance of fathers' work-family balance with implications for adolescent mental health
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When Armâs Length Is Too Far. Relationship Banking over the Credit Cycle
We conduct face-to-face interviews with bank CEOs to classify 397 banks across 21 countries as either relationship or transaction lenders. We then use the geographic coordinates of these banksâ branches and of 14,100 businesses to analyze how the lending techniques of banks in the vicinity of firms are related to credit constraints at two contrasting points of the credit cycle. We find that while relationship lending is not associated with credit constraints during a credit boom, it alleviates such constraints during a downturn. This positive role of relationship lending is stronger for small and opaque firms and in regions with a more severe economic downturn. Moreover, our evidence suggests thatrelationship lending mitigates the impact of a downturn on firm growth and does not constitute evergreening of loans
Sulfur trioxide formation/emissions in coalâfired airâ and oxyâfuel combustion processes: a review
In oxyâfuel combustion, fuel is burned using oxygen together with recycled flue gas, which is needed to control the combustion temperature. This leads to higher concentrations of sulfur dioxide and sulfur trioxide in the recycled gas, which can result in the formation of sulfuric acid and enhanced corrosion. Current experimental data on SO3 formation, reaction mechanisms, and mathematical modelling have indicated significant differences in SO3 formation between airâ and oxyâfuel combustion for both the wet and dry flue gas recycle options. This paper provides an extensive review of sulfur trioxide formation in airâ and oxyâfuel combustion environments, with an emphasis on coalâfired systems. The first part summarizes recent findings on oxyâfuel combustion experiments, as they affect sulfur trioxide formation. In the second part, the review focuses on sulfur trioxide formation mechanisms, and the influence of catalysis on sulfur trioxide formation. Finally, the current methods for measuring sulfur trioxide concentration are also reviewed along with the major difficulties associated with those measurements using data available from both benchâ and pilotâscale units
Car travel demand: spillovers and asymmetric price effects in a spatial setting
A novel analysis framework for the spatial aspects of car travel, measured by vehicle miles traveled (VMT), is introduced in this paper. The specification of a dynamic spatial Durbin model enables the analysis of VMT spatial spillovers and diffusion between neighboring areas in the short and long run. The framework is further developed to capture and introduce to a spatial setting potential asymmetry and hysteresis that can reflect reference dependence and habits. A panel data set is compiled at the subregional level, based on official car mileage recordings in England and Wales. In addition to the inelastic long-run responses of VMT to fuel price (â0.124) and income (0.116) changes, the results illustrate asymmetries and hysteresis in price elasticities with a significant spatial component. The impact magnitude on VMT from a number of factors, such as alternative fuel use, fuel deserts in rural areas, and road network and car fleet characteristics, is also estimated. The results are consistent with the car use saturation hypothesis through the positive impact of motorization rate to VMT. The negative effect of public transport infrastructure on car travel is only significant in the spatial models. The paper demonstrates the applicability and importance of spatial econometrics in transport research
Current perspectives on targeting PIM kinases to overcome mechanisms of drug resistance and immune evasion in cancer
PIM kinases are a class of serine/threonine kinases that play a role in several of the hallmarks of cancer including cell cycle progression, metabolism, inflammation and immune evasion. Their constitutively active nature and unique catalytic structure has led them to be an attractive anticancer target through the use of small molecule inhibitors. This review highlights the enhanced activity of PIM kinases in cancer that can be driven by hypoxia in the tumour microenvironment and the important role that aberrant PIM kinase activity plays in resistance mechanisms to chemotherapy, radiotherapy, anti-angiogenic therapies and targeted therapies. We highlight an interaction of PIM kinases with numerous major oncogenic players, including but not limited to, stabilisation of p53, synergism with c-Myc, and notable parallel signalling with PI3K/Akt. We provide a comprehensive overview of PIM kinase's role as an escape mechanism to targeted therapies including PI3K/mTOR inhibitors, MET inhibitors, anti-HER2/EGFR treatments and the immunosuppressant rapamycin, providing a rationale for co-targeting treatment strategies for a more durable patient response. The current status of PIM kinase inhibitors and their use as a combination therapy with other targeted agents, in addition to the development of novel multi-molecularly targeted single therapeutic agents containing a PIM kinase targeting moiety are discussed