The importance of diffusion apparent diffusion coefficient values in the evaluation of soft tissue sarcomas after treatment

Purpose: In our study, we aimed to show the efficiency of diffusion-weighted images at different b-values and apparent diffusion coefficient (ADC) values in the differentiation of recurrent tumours from post-treatment tissue changes. Material and methods: The conventional and diffusion magnetic resonance images (MRIs) of 42 patients operated for soft tissue sarcomas between June 2012 and March 2015 followed up with MRIs that were evaluated by 2 radiologists retrospectively. Diffusion MRIs were acquired at 4 different b-values (50, 400, 800, 1000 s/mm2). The lesions were classified according to conventional MRI findings as post-treatment changes and recurrent tumours. Results: When the patient group with recurrent tumours was compared with the patient group with postoperative changes the ADC calculations were statistically significantly lower for the recurrent tumours at all b-levels (p < 0.001 for all b-levels). The sensitivity of b-50 values lower than 3.01 × 103 mm²/s in showing recurrent tumours was 100% and the specificity was 77.78%. The sensitivity of b-400 values lower than 2.1 × 103 mm²/s in showing recurrent tumours was 80% and the specificity was 96.3%. The sensitivity of b-800 values lower than 2.26 × 103 mm²/s in showing recurrent tumours was 100% and the specificity was 88.89%. The sensitivity of b-1000 values lower than 2 × 103 mm²/s in showing recurrent tumours was 93.3% and the specificity was 92.5%. Conclusions: The ADC values obtained from diffusion-weighted images have high sensitivity and specificity in differentiating recurring soft tissue sarcomas during monitoring after treatment from postoperative changes

Pseudoprogression; discussion of the concept of pseudoprogression on the characteristics of tomographic changes in liver metastases of colorectal cancer patients receiving bevacizumab therapy

In this study, we aimed to investigate the concept of pseudoprogression in colorectal cancer patients with liver metastases receiving bevacizumab treatment by considering the changes in the shape, size, and density of liver metastases by abdominal Computed Tomography (CT) scans taken before and after treatment. This study is a retrospective evaluation of 16 patients with metastatic colorectal cancer treated with 5-fluorouracil, leucovorin, irinotecan and bevacizumab and is based on computed tissue analysis of the dominant liver lesion at baseline and 2 months after chemotherapy. The borders of all metastatic lesions observed in the livers of patients treated with bevacizumab after adjuvant chemotherapy were sharpened, the size of some lesions remained the same while others increased, and the density of most metastatic lesions decreased. In our study, we concluded that the evaluation of response to treatment based only on size and number should be avoided by noting a pseudoprogression in liver metastases that shows an increase in size but no progression on clinical/laboratory and follow-up images. [Med-Science 2023; 12(3.000): 951-4

TÜRKIYE’DE YOĞUN BAKIM ÜNITELERINDE VENTILATÖR ILIŞKILI PNÖMONIYI ÖNLEMEK IÇIN ALINAN GÜNCEL ÖNLEMLER: TÜRK TORAKS DERNEĞI SOLUNUM YETMEZLIĞI VE YOĞUN BAKIM ÇALIŞMA GRUBU NOKTA PREVALANS ÇALIŞMASI

Objectives: The inadequate quality and nature of sleep is a commonly reported problem among hospitalized patients. The purpose of this study is to examine the effects of progressive muscle relaxation training program on sleep quality, sleep state, pain and life quality of patients who underwent pulmonary resection

Franchismo

We aimed to obtain information about the characteristics of the ICUs in our country via a point prevalence study