Adjoint-based distributed multiple shooting for large-scale systems

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Does the intermediate-mass black hole in LEDA 87300 (RGG 118) follow the near-quadratic Mbh-Mspheroid relation?

The mass scaling relation between supermassive black holes and their host spheroids has previously been described by a quadratic or steeper relation at low masses (105 < Mbh/Mo ≲ 107). How this extends into the realm of intermediate-mass black holes (102 < Mbh/Mo < 105) is not yet clear, although for the barred Sm galaxy LEDA 87300, Baldassare et al. recently reported a nominal virial mass of Mbh = 5 104 Mo residing in a "spheroid" of stellar mass equal to 6.3 108 Mo. We point out, for the first time, that LEDA 87300 therefore appears to reside on the near-quadratic Mbh-Msph,∗ relation. However, Baldassare et al. modeled the bulge and bar as the single spheroidal component of this galaxy. Here we perform a 3-component bulge+bar+disk decomposition and find a bulge luminosity which is 7.7 times fainter than the published "bulge" luminosity. After correcting for dust, we find that Mbulge = 0.9 108 Mo and Mbulge/Mdisk = 0.04 - which is now in accord with ratios typically found in Scd-Sm galaxies. We go on to discuss slight revisions to the stellar velocity dispersion (40 11 km s-1) and black hole mass () and show that LEDA 87300 remains consistent with the Mbh-σ relation, and also the near-quadratic Mbh-Msph,∗ relation when using the reduced bulge mass. LEDA 87300 therefore offers the first support for the rapid but regulated (near-quadratic) growth of black holes, relative to their host bulge/spheroid, extending into the domain of intermediate-mass black holes

Galaxy bulges and their massive black holes: a review

With references to both key and oft-forgotten pioneering works, this article starts by presenting a review into how we came to believe in the existence of massive black holes at the centres of galaxies. It then presents the historical development of the near-linear (black hole)-(host spheroid) mass relation, before explaining why this has recently been dramatically revised. Past disagreement over the slope of the (black hole)-(velocity dispersion) relation is also explained, and the discovery of sub-structure within the (black hole)-(velocity dispersion) diagram is discussed. As the search for the fundamental connection between massive black holes and their host galaxies continues, the competing array of additional black hole mass scaling relations for samples of predominantly inactive galaxies are presented.Comment: Invited (15 Feb. 2014) review article (submitted 16 Nov. 2014). 590 references, 9 figures, 25 pages in emulateApJ format. To appear in "Galactic Bulges", E. Laurikainen, R.F. Peletier, and D.A. Gadotti (eds.), Springer Publishin

Chromodynamical analysis of lenticular galaxies using globular clusters and planetary nebulae

Recovering the origins of lenticular galaxies can shed light on the understanding of galaxy formation and evolution, since they present properties that can be found in both elliptical and spiral galaxies. In this work we study the kinematics of the globular cluster (GC) systems of three lenticular galaxies located in low density environments (NGC2768, NGC3115 and NGC7457), and compare them with the kinematics of planetary nebulae (PNe). The PNe and GC data come from the Planetary Nebulae Spectrograph and the SLUGGS Surveys. Through photometric spheroid-disc decomposition and PNe kinematics we find the probability for a given GC to belong to either the spheroid or the disc of its host galaxy or be rejected from the model. We find that there is no correlation between the components that the GCs are likely to belong to and their colours. Particularly, for NGC2768 we find that its red GCs display rotation preferentially at inner radii (Re < 1). In the case of the GC system of NGC3115 we find a group of GCs with similar kinematics that are not likely to belong to neither its spheroid nor disc. For NGC7457 we find that 70% of its GCs are likely to belong to the disc. Overall, our results suggest that these galaxies assembled into S0s through different evolutionary paths. Mergers seem to have been very important for NGC2768 and NGC3115 while NGC7457 is more likely to have experienced secular evolution

The SLUGGS Survey: stellar masses and effective radii of early-type galaxies from Spitzer Space Telescope 3.6 μm imaging

Galaxy starlight at 3.6 μm is an excellent tracer of stellar mass. Here we use the latest 3.6 μm imaging from the Spitzer Space Telescope to measure the total stellar mass and effective radii in a homogeneous way for a sample of galaxies from the SAGES Legacy Unifying Globulars and GalaxieS (SLUGGS) survey. These galaxies are representative of nearby early-type galaxies in the stellar mass range of 10 < log M*/M⊙ < 11.7 and our methodology can be applied to other samples of early-type galaxies. We model each galaxy in 2D and estimate its total asymptotic magnitude from a 1D curve-of-growth. Magnitudes are converted into stellar masses using a 3.6 μm mass-to-light ratio from the latest stellar population models of Röck et al., assuming a Kroupa initial mass function. We apply a ratio based on each galaxy's mean mass-weighted stellar age within one effective radius (the mass-to-light ratio is insensitive to galaxy metallicity for the generally old stellar ages and high metallicities found in massive early-type galaxies). Our 3.6 μm stellar masses agree well with masses derived from 2.2 μm data. From the 1D surface brightness profile, we fit a single Sérsic law, excluding the very central regions. We measure the effective radius, Sérsic n parameter and effective surface brightness for each galaxy. We find that galaxy sizes derived from shallow optical imaging and the 2MASS survey tend to underestimate the true size of the largest, most massive galaxies in our sample. We adopt the 3.6 μm stellar masses and effective radii for the SLUGGS survey galaxies

The acute influence of vasopressin on hemodynamic status and tissue oxygenation following the Norwood procedure

Objectives: Arginine vasopressin (AVP) is used to treat hypotension. Because AVP increases blood pressure by increasing systemic vascular resistance, it may have an adverse effect on tissue oxygenation following the Norwood procedure. Methods: Retrospective analysis of continuously captured hemodynamic data of neonates receiving AVP following the Norwood procedure. Results: We studied 64 neonates exposed to AVP within 7 days after the Norwood procedure. For the entire group, AVP significantly increased mean blood pressure (2.5 ± 6.3) and cerebral and renal oxygen extraction ratios (4.1% ± 9.6% and 2.0% ± 4.7%, respectively; P \u3c .001 for all values). In the right ventricle to pulmonary artery shunt cohort, AVP significantly increased blood pressure, arterial oxygen saturation (1.4% ± 3.8%; P = .011), pulmonary to systemic perfusion ratio (0.2 ± 0.4; P = .017), and cerebral and renal oxygen extraction ratios (4.6% ± 8.7%; P = .010% and 4.7% ± 9.4%; P = .014, respectively). The Blalock-Taussig shunt cohort experienced a less significant vasopressor response and no change in arterial oxygen saturation, pulmonary to systemic perfusion ratio, or cerebral and renal oxygen extraction ratios. Conclusions: The right ventricle to pulmonary artery shunt cohort experienced a significant vasopressor response to AVP that was associated with a significant increase in pulmonary perfusion and decrease in cerebral and renal perfusion, whereas the Blalock-Taussig shunt cohort experienced a less significant vasopressor response and no change in pulmonary or systemic perfusion. The influence of AVP on tissue oxygenation following the Norwood procedure may have clinical implications that require further study

Relationship Between Gestational Age and Outcomes After Congenital Heart Surgery

BackgroundPrevious studies suggest that birth before 39 weeks' gestational age (GA) is associated with higher perioperative mortality and morbidity after congenital heart surgery. The optimal approach to timing of cardiac operation in premature infants remains unclear. We investigated the impact of GA at birth and corrected GA at surgery on postoperative outcomes using the Pediatric Cardiac Critical Care Consortium (PC4) database.MethodsInfants undergoing selected index cardiac operations before the end of the neonatal period were included (n&nbsp;= 2298). GA at birth and corrected GA at the time of the index cardiac operation were used as categorical predictors and fitted as a cubic spline to assess nonlinear relationships. The primary outcome was hospital mortality. Multivariable logistic regression models assessed the association between predictors and outcomes while adjusting for confounders.ResultsLate-preterm (34-36 weeks) birth was associated with increased odds of mortality compared with full-term (39-40 weeks) birth, while early-term (37-38 weeks) birth was not associated with increased mortality. Corrected GA at surgery of 34 to 37 weeks compared with 40 to 44 weeks was associated with increased mortality. When analyzing corrected GA at surgery as a continuous predictor of outcome, odds of survival improve as patients approach 39 weeks corrected GA.ConclusionsContrary to previous literature, we did not find an association between early-term birth and hospital mortality at PC4 hospitals. Our analysis of the relationship between corrected GA and mortality suggests that operating closer to full-term corrected GA may improve survival

RBC transfusion induced ST segment variability following the Norwood procedure

The transfusion of stored RBCs decreases nitric oxide bioavailability, which may have an adverse effect on vascular function. We assessed the effects of RBC transfusion on coronary vascular function by evaluating the relationship between myocardial oxygen delivery and demand as evidenced by ST segment variability. Design: Retrospective case-control study. Setting: Nine-hundred seventy-three-bed pediatric hospital with a 54-bed cardiovascular ICU. Patients: Seventy-three neonates with hypoplastic left heart syndrome following the Norwood procedure, 38 with a Blalock-Taussig shunt and 35 with a right ventricle to pulmonary artery shunt. Interventions: RBC transfusion. Materials and Main Results: High-frequency physiologic data were captured 30 minutes prior to the initiation of (baseline) and during the 120 minutes of the transfusion. A rate pressure product was calculated for each subject and used as an indicator of myocardial oxygen demand. Electrocardiogram leads (aVL, V1, II) were used to construct a 3D ST segment vector to assess ST segment variability and functioned as a surrogate indicator of myocardial ischemia. One-hundred thirty-eight transfusions occurred in the Blalock-Taussig shunt group and 139 in the right ventricle to pulmonary artery shunt group. There was no significant change in the rate pressure product for either group; however, ST segment variability progressively increased for the entire cohort during the transfusion, becoming statistically significant by the end of the transfusion. Upon subgroup analysis, this finding was noted with statistical significance in the Blalock-Taussig shunt group and trending toward significance in the right ventricle to pulmonary artery shunt group. Conclusions: We found a significant increase in the ST segment variability and evidence of myocardial ischemia temporally associated with RBC transfusions in neonates following the Norwood procedure, specifically among those in the Blalock-Taussig shunt group, which may impact immediate and long-term outcomes