Investigations towards new multidentate ligands as potential multimodal imaging agents

A Coordination chemistry based historical perspective of contrast agents which are utilised in various imaging modalities, forms the basis of Chapter 1. Chapter 1 also highlights the various latest advancements and the challenges confronted therein. Chapter 1 culminates in highlighting the need for dual purpose contrast agents. Chapter 2 and Chapter 3 deals with rx)lyarnino poly carboxylate derivatives based on EDTA and DTPA respectively. Chapter 2 sheds light upon Teslascan and other related manganese based potential contrast agents. It also highlights the emergence of Mn (II) as the direct competitor for Gd (HI) in the face of Nephrogenic Systemic Fibrosis (NSF) reported for Gd based contrast agents. The chapter culminates in describing the synthesis of a library of EDTA bisamides, including four new EDTA bisamides. Chapter 3 in turn takes a detailed look at a series of DTPA analogues and DTPA bisamides synthesized by scientists all over the world. It also highlights the various synthetic methodologies undertaken by the able scientists. The chapter culminates in describing four new multidentate ligands synthesized in this project, namely two new DTPA analogues and two new DTPA Bisamides. It has been shown that the synthetic methodology utilised to synthesize symmetric naphtha derivative L5 is fairly unique. Chapter 4 and Chapter 5 report the investigations carried out on these new multidentate ligands in terms of relaxometry, potentiometry and luminescence. Interesting results were obtained from relaxometric and luminescence measurements. For instance, symmetric naphtha derivative, reported a relaxivity of 8.8 mM'V1, relaxivity obtained for Mn (II) complex of EDTA bisamide of 4-aniinomethylpyridine is also highly commendable. Investigations on the optical properties of the multidentate ligands require a separate chapter. Thus it is has been allotted Chapter 5. DTPA bisamide of N, N-Bis (tert- butoxycarrx)nyl)memyl-2-bromcmylamine was found to quench the fluorescence upon binding with Cu (II), indicating its application as luminescent sensor for Cu (II)

Dual modal imaging agents based on chromophore-bearing DTPA analogues

Two new DTPA analogues, centrally (L1) and terminally (L2) functionalised with a 1,8-naphthalimide chromophore, have been successfully prepared and fully characterized.</p

The importance of Vasanthan Kooththu (Art Form) songs in revealing the existence of human social and professional life

The culture of a community plays a major role in narrating the history and life of that particular community. This culture includes various aspects such as religion, ritual, faith, food, customs or practices as well as art and culture. Among these aspects, art is not only for entertainment; but it is also for exposing the social character and tradition of that particular community. The undeniable thing here is the factor that art forms in every country, and in every region are not only to create entertainment but also to preserve the antiquity of their existence up to now. In that respect, Vasanthan Kooththu, one of the Sri Lankan Tamil art forms, is a notable art form in that category. Even though this art form is found in Batticaloa and Jaffna areas, they have differences between each other. This study focuses on the songs of Vasanthan Kooththu performed in the Katuthavalai area of ​​Batticaloa. This type of Kooththu is an art form of tapping and dancing with two sticks in the hands; however, these sticks are also used to express the function of the meaning of the song with dance. Even though this type of Kooththu is a dance form, the greatness of the songs used in this Kooththu is significant. There are 62 types of Vasanthan poems have been in use in the Art Form performances. These have been compiled around the year 1940. These 62 genres of songs are divided into six genres and compiled, namely 'Kattiyam', 'Thoththiram', 'Sariththiram', 'Tholil', 'Vedikkai', 'Vilaiyaattu' and are still in the practice during Kooththu performance. As mentioned earlier, these Kooththu song systems emphasize the art expression of the culture of a community. The songs related to the professions or job involved in these Kooththu songs express the whole series of activities of the agricultural industry. The reason that these Kooththu songs to aim to explore only a specific industry is to be explored. It is vital to discover this factor; and this article explores about how these Kooththu songs are still in operation today as a popular form of folk music performance to describe a particular social professional life, beyond globalization trends, imposition and blends of colonization thinking. This article also explores the significance of these Kooththu songs hold, the importance they have gained in the life of people as well as the value that these Kooththu songs have even today