Solidarity Economy, Social Enterprise, and Innovation Discourses: Understanding Hybrid Forms in Postcolonial Colombia

Dominant conceptions of solidarity economy, social enterprise, and innovation (SSEI) remain poorly positioned for understanding the diverse models emerging across the global South. The purpose of this paper is to examine the power relations between the global North and South in the production and dissemination of SSEI knowledge, highlighting the importance of recognizing alternative discourses in the global South. This contextual analysis is developed through consideration of the construction of the hybrid SSEI model in Colombia, drawing upon postcolonial theory and using Nicholls’ framework on the legitimacy of SSEI discourses. This paper offers the first application of postcolonial theory to the analysis of SSEI in the global South. This research has demonstrated that the construction of the SSEI sector in Colombia is a reflection of the dynamic interplay of the hybrids, as it incorporates the hero entrepreneur and business-like discourses within the traditional community discourse, which indeed is a combination of domestic (indigenous collective practices) and colonizer influences (e.g., cooperatives, associations). This paper also identifies the current tensions that have emerged from such hybridity within the country

SBAR Method for Improving Well-Being in the Internal Medicine Unit: Quasi-Experimental Research

SBAR (Situation, Background, Assessment, Recommendation) is a tool for standardizing and improving interprofessional communication. This study aims to explore the impact of SBAR in healthcare professionals’ wellbeing, through concepts such as job satisfaction, engagement, resilience, and job performance, in the internal medicine unit of a university hospital in the province of León (Spain). This is an observational, descriptive, longitudinal case study with a pre- and post-intervention approach. Questionnaires were distributed to a group of doctors, nurses, and healthcare assistants before and after the implementation of the SBAR tool in the ward. The use of SBAR was monitored to ensure staff compliance. Data statistical analysis was performed using the SPSS program. Resilience levels increased significantly post-intervention. Job satisfaction and engagement levels remained neutral, slightly decreasing post-intervention. Besides’ being a useful tool to improve communication, SBAR was effective in improving resilience among staff. Several aspects related to hospital management may have had an impact on job satisfaction and engagement results.S

Nanostructured Lipid Carriers Made of Ω-3 Polyunsaturated Fatty Acids: In Vitro Evaluation of Emerging Nanocarriers to Treat Neurodegenerative Diseases

Neurodegenerative diseases (ND) are one of the main problems of public health systems in the 21st century. The rise of nanotechnology-based drug delivery systems (DDS) has become in an emerging approach to target and treat these disorders related to the central nervous system (CNS). Among others, the use of nanostructured lipid carriers (NLCs) has increased in the last few years. Up to today, most of the developed NLCs have been made of a mixture of solid and liquid lipids without any active role in preventing or treating diseases. In this study, we successfully developed NLCs made of a functional lipid, such as the hydroxylated derivate of docohexaenoic acid (DHAH), named DHAH-NLCs. The newly developed nanocarriers were around 100 nm in size, with a polydispersity index (PDI) value of <0.3, and they exhibited positive zeta potential due to the successful chitosan (CS) and TAT coating. DHAH-NLCs were shown to be safe in both dopaminergic and microglia primary cell cultures. Moreover, they exhibited neuroprotective effects in dopaminergic neuron cell cultures after exposition to 6-hydroxydopamine hydrochloride (6-OHDA) neurotoxin and decreased the proinflammatory cytokine levels in microglia primary cell cultures after lipopolysaccharide (LPS) stimuli. The levels of the three tested cytokines, IL-6, IL-1β and TNF-α were decreased almost to control levels after the treatment with DHAH-NLCs. Taken together, these data suggest the suitability of DHAH-NLCs to attaining enhanced and synergistic effects for the treatment of NDs.This project was partially supported by the Spanish Ministry of Economy and Competitiveness (RTC-2015-3542-1) and the Basque Government (Consolidated Groups, IT 907-16)

Exploring what motivates the development of upcycling practices.

Faced with an aggressive production model with the use of resources, initiatives such as upcycling arise that seek to extend the life of products. This paper analyzes the role of individuals’ principles and values as driving factors, something that has not been studied in depth to date. The study is based on a field work in which 830 subjects from 180 countries have participated in a survey, from September 2019 to September 2020. This large sample of participants at the international level is one of the key contributions of the work, since it allows us to contrast conclusions from the few previous works and issue new ones based on the sequence of analysis described below, which broadens the empirical base in this field of study. The data so collected was analysed using the statistical software Stata and estimating standard multiple linear regressions, ordered logit and logit regressions. The findings confirmed the chain of actions - doing, frequency, entrepreneurship - is decisively conditioned by personal values and principles. This sequence of analysis constitutes the main contribution of our work. With regards to entrepreneurship, this work provides evidence that having the intention to start up an upcycling business is more likely when individuals consider upcycling important for them and report themselves as having a high probability of upcycling; but it is less likely among women and the older age groups (more than 55 years old)

Assessing the nonlinear decay of community similarity: permutation and site-block resampling significance tests

Modelling how community similarity decays with spatial distance is a key tool for the study of the processes behind community variation (beta diversity). Distance-decay models are computed from pairwise metrics (i.e. community similarity and spatial distance between localities) and hence suffer from pairwise dependence in the data, precluding the use of standard significance tests. Besides, distance-decay patterns are inherently nonlinear because similarity is bounded between 1 and 0. However, the only standard method to assess model significance under pairwise dependency is the Mantel test, which considers a linear model. To allow the use of nonlinear models in the assessment of distance-decay patterns, we introduce here a nonlinear significance test combining a pseudo-R2 statistic with either permutations or block-site resampling with replacementWe thank Xavier Picó, Christine Meynard, Simone Fattorini and two anonymous reviewers for insightful comments and suggestions to earlier versions of the manuscript. This research was supported by the Spanish Ministry of Science and Innovation and the European Regional Development Fund (ERDF) through grants CGL2016-76637-P and PID2020-112935GB-I00, PID2020-116587GB-I00 and a FPI scholarship to S.M.-S (BES-2017-081643). R.M.D. was supported by the Spanish Ministry of Education through a FPU scholarship (Ref.: FPU17/03016; Ministry of Education)S

Qualitative analysis on the driving force behind upcycling practices associated with mobile applications: Circular economy perspective

Upcycling is a type of practice included within the circular economy. Although interest in this type of activity has grown in recent years, academic analysis of the drivers that impel these activities is poorly developed. This work focuses on upcycling activities developed in the context of rural tourism. Through field work based on structured interviews applied in the region of Andalusia (Spain), evidence was sought about the drivers that promote this type of practice. In particular, attention was paid to the role of mobile applications as facilitators of upcycling. The main finding was that technology helps in using upcycling practices when considering rural tourism, as demonstrated by the use of mobile applications and websites such as Wallapop. There was also evidence of the different factors that drive the development of upcycling practices: the existence of a traditional social network as a means of obtaining second-hand items, technology as an element that facilitates access to items owned by strangers, the need to offer the image sought by tourists, and a desire to maintain the cultural essence of the region

Maximize Resolution or Minimize Error? Using Genotyping-By-Sequencing to Investigate the Recent Diversification of Helianthemum (Cistaceae)

A robust phylogenetic framework, in terms of extensive geographical and taxonomic sampling, well-resolved species relationships and high certainty of tree topologies and branch length estimations, is critical in the study of macroevolutionary patterns. Whereas Sanger sequencing-based methods usually recover insufficient phylogenetic signal, especially in recently diversified lineages, reduced-representation sequencing methods tend to provide well-supported phylogenetic relationships, but usually entail remarkable bioinformatic challenges due to the inherent trade-off between the number of SNPs and the magnitude of associated error rates. The genus Helianthemum (Cistaceae) is a species-rich and taxonomically complex Palearctic group of plants that diversified mainly since the Upper Miocene. It is a challenging case study since previous attempts using Sanger sequencing were unable to resolve the intrageneric phylogenetic relationships. Aiming to obtain a robust phylogenetic reconstruction based on genotyping-by-sequencing (GBS), we established a rigorous methodological workflow in which we i) explored how variable settings during dataset assembly have an impact on error rates and on the degree of resolution under concatenation and coalescent approaches, ii) assessed the effect of two extreme parameter configurations (minimizing error rates vs. maximizing phylogenetic resolution) on tree topology and branch lengths, and iii) evaluated the effects of these two configurations on estimates of divergence times and diversification rates. Our analyses produced highly supported topologically congruent phylogenetic trees for both configurations. However, minimizing error rates did produce more reliable branch lengths, critically affecting the accuracy of downstream analyses (i.e. divergence times and diversification rates). In addition to recommending a revision of intrageneric systematics, our results enabled us to identify three highly diversified lineages in Helianthemum in contrasting geographical areas and ecological conditions, which started radiating in the Upper Miocene.España, MINECO grants CGL2014- 52459-P and CGL2017-82465-PEspaña, Ministerio de Economía, Industria y Competitividad, reference IJCI-2015-2345

Actividad cicatrizante in vivo del polvo carbonizado de Punica granatum Linn y Eichhornia crassipes

Introducción: Las especies vegetales constituyen el remedio primero a los problemas de salud que aquejan a las personas. La granada es rica en ácido ascórbico, mejora la barrera epidérmica y reduce la contracción de las heridas. La flor de agua posee actividad antibacteriana. Objetivo: Evaluar el efecto cicatrizante del polvo carbonizado de Punica granatum Linn (granada) y de Eichhornia crassipes (flor de agua), en un modelo experimental en ratas. Métodos: Estudio analítico experimental con el empleo 30 ratas macho distribuidas en 3 grupos (n= 10). Grupo I y II; tratadas con el polvo carbonizado de la granada y flor de agua respectivamente. Grupo III: Tratadas con cloruro de sodio al 0,9 %. Se realizó un modelo de herida por escisión en el dorso. La evolución de la cicatrización fue seguida por la velocidad de contracción de la herida en milímetros. Se realizó histología sobre biopsias de tejido cicatrizado. Para el análisis estadístico se empleó la prueba no paramétrica de Mann- Whitney. El nivel de significación se fijó en p < 0,05. Resultados: Se comprobó el efecto cicatrizante de los polvos carbonizados de la granada y flor de agua; disminuyó el área de las heridas de manera significativa respecto al grupo control. El estudio histológico mostró dermis madura grado III en los grupos I y II. Conclusiones: La aplicación tópica del polvo carbonizado de granada y de flor de agua influyó sobre el cierre de las heridas y en la maduración de la dermis, por lo cual favoreció la cicatrización

A proof-of-concept clinical trial using mesenchymal stem cells for the treatment of corneal epithelial stem cell deficiency

Producción CientíficaOcular stem cell transplantation derived from either autologous or allogeneic donor corneoscleral junction is a functional cell therapy to manage extensive and/or severe limbal stem cell deficiencies that lead to corneal epithelial failure. Mesenchymal stem cells have been properly tested in animal models of this ophthalmic pathology, but never in human eyes despite their potential advantages. We conducted a 6- to 12-month proof-of-concept, randomized, and double-masked pilot trial to test whether allogeneic bone marrow-derived mesenchymal stem cell transplantation (MSCT], n = 17) was as safe and as equally efficient as allogeneic cultivated limbal epithelial transplantation (CLET), (n = 11) to improve corneal epithelial damage due to limbal stem cell deficiency. Primary endpoints demanded combination of symptoms, signs, and the objective improvement of the epithelial phenotype in central cornea by in vivo confocal microscopy. This proof-of-concept trial showed that MSCT was as safe and efficacious as CLET. Global success at 6–12 months was 72.7%–77.8% for CLET cases and 76.5%–85.7% for MSCT cases (not significant differences). Central corneal epithelial phenotype improved in 71.4% and 66.7% of MSCT and CLET cases, respectively at 12 months (P = 1.000). There were no adverse events related to cell products. This trial suggests first evidence that MSCT facilitated improvement of a diseased corneal epithelium due to lack of its stem cells as efficiently as CLET. Consequently, not only CLET but also MSCT deserves more preclinical investigational resources before the favorable results of this proof-of-concept trial could be transformed into the larger numbers of the multicenter trials that would provide stronger evidence. (ClinicalTrials.gov number, NCT01562002.)Ministerio de Sanidad, Consumo y Bienestar Social (project SAS/2481/2009)Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León (grant SAN 1178/200)Red de Terapia Celular TerCel (project RD12/0019/0036