Disminución del dolor y mejoramiento de la funcionalidad de miembros afectados en pacientes diagnosticados de tendinopatía y dolor musculotendinoso refractarios a tratamientos convencionales, posterior al tratamiento con ondas de choque extracorpóreas, del centro “Traumatología & Ortopedia. Medicina del Deporte”, consulta privada del “Centro Médico Meditropoli”, Quito-Ecuador

“Tendinitis” es el término generalmente utilizado para describir el tendón doloroso, pero este concepto asume tácitamente que la lesión está acompañada obligatoriamente de una respuesta inflamatoria, hecho desmentido con reciente evidencia. Por ello, muchos autores prefieren utilizar el término “tendinopatía”, ya que no se puede excluir la posibilidad de que realmente exista inflamación

Metales tóxicos en polvos de una avenida de alto aforo vehicular de la Ciudad de México

En este estudio se determinó la concentración de metales totales de plomo, cadmio, hierro, zinc y cobre en muestras de polvo recolectadas de la avenida Paseo de la Reforma con diferente intensidad de tráfico. La extracción de metales en polvos se llevó a cabo mediante digestión ácida y los análisis se realizaron por espectroscopia de absorción atómica. Los niveles encontrados siguieron el orden Fe>Pb>Cu>Zn>Cd en todos los sitios de muestreo, los cuales oscilaron entre 64027 a 36734; 239 a 83; 128 a 67; 44 a 18 y 2 a 5 mg/kg respectivamente. Los sitios con mayor presencia de metales tóxicos son la glorieta de San Marín y Cuauhtémoc y la de menor concentración es la glorieta del Ángel de la Independencia. El coeficiente correlación de Spearman, demostró una fuerte asociación entre metales, flujo vehicular y sitios de muestreo, además confirmó la contribución de las fuentes antropogénicas como el flujo vehicular, fugas de aceite, desgaste de piezas metálicas, entre otrasIn this study the concentration of total metals lead, cadmium, iron, zinc and copper in dust samples collected from the Paseo de la Reforma Avenue with different traffic intensity was determined. The metal extraction of powders was carried out by acid digestion whereas analyzes were performed by atomic absorption spectroscopy. The levels found followed Fe> Pb> Cu> Zn> Cd order in all sampling sites, which ranged from 64,027 to 36,734; 239-83; 128-67; 44-18 and 2 to 5 mg/kg respectively. The sites with greater presence of toxic metals are the square of San Marin and Cuauhtémoc and the lowest concentration is the square of the Angel of Independence. The coefficient Spearman correlation showed a strong association between metals, traffic flow and sampling sites, also confirmed the contribution of anthropogenic sources such as traffic flow, oil leaks, wear of metal parts, among others

Group and call effect in achieving success in a subject: Analyses of the "Biology and Botany" whole life in the E.U.I.T.A. (University of Seville)

La Biología y la Botánica son dos materias fundamentales en la formación de un ingeniero técnico agrícola. Sus contenidos se han ofrecido a veces en asignaturas independientes y, en otras ocasiones como la que nos ocupa, en una sola asignatura. Por otra parte, siempre se ha mirado con interés, e incluso preocupación, el efecto de la variable grupo, de forma independiente o relacionándola con su distribución en turnos de mañana o tarde, así como la importancia de la convocatoria (en los distintos momentos a lo largo del curso académico) en la que el alumno consigue superar la asignatura. Aquí presentamos los resultados en la consecución de objetivos por parte de los alumnos y, por ende, de los profesores y de la Universidad de Sevilla a lo largo de la totalidad de la vida de la asignatura "Biología y Botánica" dentro del plan de estudios 2003/04 para tres titulaciones simultáneas, desde su comienzo en el curso 2003/04 hasta su extinción en el curso 2009/10, de la E.U.I.T.A. (Escuela Universitaria de Ingeniería Técnica Agrícola) de la Universidad de Sevilla. Además se consideran convocatorias pertenecientes al período de extinción añadido. Los análisis toman en cuenta además el éxito en la superación de la asignatura tanto de forma cualitativa (aprobado o suspenso de la evaluación a la que el alumno se ha sometido) como cuantitativa (nota conseguida). Las conclusiones obtenidas permiten mirar los resultados y la consecución de objetivos, así como una potencial toma de decisiones para el futuro, basándose en un marco temporal amplio y objetivo.Biology and Botany are two critical issues in the formation of a technical agricultural engineer. Their topics are sometimes offered in separate subjects and, at other times as here, within a single one. Besides, it has always been considered with interest, and even concern, the effect of the variable group, independently or in relation to their distribution in the morning or afternoon turns, and the importance of the call (at different times during the academic year) at which the student gets to pass the subject. Here we present the results in the achievement of objectives by students, and therefore teachers and the University of Seville, along the entire life of the subject "Biology and Botany" within the teaching 2003/04 plan for three simultaneous academic programs, from its start in the course 2003/04 to its extinction in the course 2009/10, in the E.U.I.T.A. (University School of Technical Agricultural Engineering) of the University of Seville. Calls belonging to the period of extinction are also considered. Analyses are both qualitative, based on having success in passing the subject or not, and quantitative (mark scored). Obtained conclusions let us see the results and the achievement of objectives, as well as a potential decision-making for the future, with a base on a comprehensive and objective frame

Relationships between body mass index, ultrasound measurements and, internal body fat depots in pelibuey sheep

The objective of this study was to evaluate the relationship between body mass index (BMI), ultrasound measurements (USM), and internal fat (IF) in hair sheep. The BMI and USM were determined 24 hours before laughter in 35 animals finished in intensive fattening. At slaughter, the IF (inner adipose tissue) was dissected, weighed, and grouped as mesenteric, omental, or perirenal fat; these three depots were summed to obtain their total weight. The relationship of the variables was evaluated through Pearson's correlation coefficient (r) using the CORR procedure and by regression models using the REG procedure of SAS ver. 9.3. The IF and BMI presented r= 0.75 (P 0.05). The regression equation between IF and BMI had a coefficient of determination (r2) of 0.67 (P <.0001). The inclusion of the subcutaneous fat thickness together with the BMI improved the r2 with a range of 0.77. The BMI and the subcutaneous fat thickness could be used to predict the weight of the internal fat in hair sheep

Cysteamine (Cystagon®) adherence in patients with cystinosis in Spain: successful in children and a challenge in adolescents and adults.

Journal Article; Research Support, Non-U.S. Gov't;BACKGROUND Cysteamine has improved survival and prognosis in cystinosis. Increasing numbers of patients reach adulthood and face new challenges such as compliance that wanes over time. The aim of this study was to evaluate adherence to cysteamine treatment in a group of cystinotic patients in Spain in an attempt to identify potential therapy pitfalls and improve the overall care of affected individuals. Despite the impact of cysteamine on prognosis, there is a paucity of data regarding adherence. METHOD Thirty-four cystinotic patients (21 male) 38% ≥18 years were enrolled in a voluntary, anonymous survey. Replies were obtained from patients (15/34), mothers (11/34), fathers (4/34) and both parents (4/34). RESULTS Patient age (median and interquartile range) at diagnosis was 1 year (0.57-1), and patient age at Cystagon® initiation was also 1 year (0.8-1.8). Sixteen (47%) were kidney transplant (KTx) recipients; six were retransplanted. Age at first KTx 10 years (8.7-13.7). Patient understanding of multiorgan involvement in cystinosis: 4.1 organs reported; eye 97% and kidney 91%. Cysteamine was given by mother (100%) and father (83%) in <11 year olds, or self-administered (94%) in ≥11 year olds. Four daily doses in 89% versus 56% in <11 year olds or ≥11 year olds, with fixed schedule in 94% versus 50% in <11 or ≥11 year olds and progressive loss of reminders over time. Furthermore, 44% complained of unpleasant smell. Motivation for treatment compliance was 100% versus 40% in <11 versus ≥11 year olds, respectively. Disease impact in patients <18 years is as follows: school (29%), social (14%), 'feeling different' (10%); in patients ≥18 years: 'feeling different' (62%), professional (39%) and job absenteeism (31%). Referring physician: paediatric nephrologist (94%) and nephrologist (63%) in <11 versus ≥11 year olds. Ophthalmological follow-up: 83% versus 38% in <11 versus ≥11 year olds. Patient opinion of physician expertise: paediatric nephrologist (94%) and nephrologist (44%). New treatment options (65%) and better information (42%) were demanded to improve adherence. CONCLUSION Treatment with Cystagon is effective in young patients. However, adherence diminishes over time in adolescents and adults despite disease impact. Strategies such as better information on the disease, patient self-care promotion and facilitated transition to adult healthcare services are required to improve compliance and the clinical management of cystinosis.This study has been supported by A.C. Nielsen Company S.L.and Orphan Europe S.L.UYe

La enseñanza del metabolismo: retos y oportunidades

En el marco del Proyecto de Innovación Educativa de la Universidad de Málaga PIE15-163, cuya descripción y resultados incluimos, decidimos que esta era una excelente oportunidad para reflexionar acerca de la enseñanza del metabolismo y de poner por escrito dichas reflexiones en un libro. Quisimos y pudimos contar con la colaboración de buena parte de los compañeros del Departamento de Biología Molecular y Bioquímica que apoyaron con su firma el proyecto PIE15-163 y extendimos nuestra invitaciones a otros compañeros de dentro y fuera de la Universidad de Málaga. Del Departamento de Biología Molecular y Bioquímica de la Universidad de Málaga hemos recibido aportaciones de los catedráticos Victoriano Valpuesta Fernández, Ana Rodríguez Quesada y Antonio Heredia Bayona, los profesores titulares María Josefa Pérez Rodríguez, José Luis Urdiales Ruiz e Ignacio Fajardo Paredes y la investigadora postdoctoral y profesora sustituta interina Beatriz Martínez Poveda. De otros departamentos de la Universidad de Málaga hemos contado con las aportaciones de la catedrática del Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología Pilar Morata Losa, del catedrático del Departamento de Lenguajes y Ciencias de la Computación José Francisco Aldana Montes y los componentes de su grupo de investigación Khaos Ismael Navas Delgado, María Jesús García Godoy, Esteban López Camacho y Maciej Rybinski, del catedrático Ángel Blanco López, del Área de Conocimiento de Didáctica de las Ciencias Experimentales y del Doctor en Ciencias Químicas y actual doctorando del Programa de Doctorado "Educación y Comunicación Social" Ángel Luis García Ponce. De fuera de la Universidad de Málaga, hemos contado con las aportaciones del catedrático de la Universidad de La Laguna Néstor V. Torres Darias, de la catedrática de la Universitat de les Illes Balears Pilar Roca Salom y de sus compañeros los profesores Jorge Sastre Serra y Jordi Oliver, de los catedráticos de la Universidad de Granada Rafael Salto González y María Dolores Girón González y su colaborador el Dr. José Dámaso Vílchez Rienda, del profesor titular de la Universidad de Alcalá Ángel Herráez, del investigador postdoctoral de la Universidad de Erlangen (Alemania) Guido Santos y del investigador postdoctoral de la empresa Brain Dynamics Carlos Rodríguez Caso.Hemos estructurado los contenidos del libro en diversas secciones. La primera presenta el Proyecto en cuyo marco se ha gestado la iniciativa que ha conducido a la edición del presente libro. La segunda sección la hemos titulado "¿Qué metabolismo?" e incluye diversas aportaciones personales que reflexionan acerca de qué metabolismo debe conocer un graduado en Bioquímica, en Biología, en Química, en Farmacia o en Medicina, así como una aportación acerca de qué bioquímica estructural y enzimología son útiles y necesarias para un estudiante que vaya a afrontar el estudio del metabolismo. La tercera sección, "Bases conceptuales", analiza las aportaciones del aprendizaje colaborativo, el contrato de aprendizaje y el aprendizaje basado en la resolución de casos prácticos a la mejora del proceso enseñanza-aprendizaje dentro del campo de la Bioquímica y Biología Molecular, más concretamente en el estudio del metabolismo. La cuarta sección se titula "Herramientas", es la más extensa e incluye las diversas aportaciones centradas en propuestas concretas de aplicación relevantes y útiles para la mejora de la docencia-aprendizaje del metabolismo. Sigue una sección dedicada a presentar de forma resumida los "Resultados" del proyecto PIE15-163. El libro concluye con una "coda final" en la que se reflexiona acerca del aprendizaje de la Química a la luz de la investigación didáctica.Patrocinado por el Proyecto de Innovación Educativa de la Universidad de Málaga PIE15-16

Faixas normais de nutrientes em cana-de-açúcar pelos métodos ChM, DRIS e CND e nível crítico pela distribuição normal reduzida

Existem diversos métodos para a interpretação da diagnose foliar; o nível crítico ou as faixas de suficiência descritas na literatura são os mais utilizados. Porém, o uso de métodos de determinação de faixas normais de nutrientes que contemplam regiões específicas (localidades) aumenta a eficiência da interpretação. O objetivo deste trabalho foi determinar as faixas normais de nutrientes para a cultura da cana-de-açúcar, mediante a utilização dos métodos Chance Matemática (ChM), Sistema Integrado de Diagnose e Recomendação (DRIS) e Diagnose da Composição Nutricional (CND), além do Nível Crítico determinado pelo método de distribuição normal reduzida. O trabalho foi realizado tomando-se como base dados relativos a teores de nutrientes em amostras foliares e de produtividade de lavouras comerciais de cana-de-açúcar, localizadas no município de Campos de Goytacazes, RJ. Com o método da ChM, foram obtidas faixas de suficiência semelhantes aos métodos DRIS e CND, para N, Ca, S e Mn, enquanto para P, K, Mg, Cu e Zn os valores obtidos pela ChM foram superiores. A utilização dos métodos ChM, DRIS e CND, em lavouras comerciais de cana-de-açúcar em geral, possibilitou a obtenção de menor amplitude da faixa normal dos nutrientes, em comparação com os valores alcançados pelos métodos nível crítico e faixa de suficiência

Lee, imagina y juega con la literatura infantil y juvenil

Memoria ID-0030. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015

Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019

Altres ajuts: Spanish AIDS Research Network; European Funding for Regional Development (FEDER).Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. Methods: The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. Results: The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). Conclusions: In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality