El concepto de transculturación : un recorrido en la obra de Fernando Ortiz

Sociólogo (a)Pregrad

Uso del modelo de doble diamante para la propuesta de diseño de un servicio digital para apoyar el acceso a la información en salud sobre cuidados al egreso

En el presente trabajo de grado se propone el diseño de un servicio de información digital a través de una herramienta tipo web como una forma de facilitar contenidos que permitan el apoyo del cuidador del paciente al egreso de las instalaciones hospitalarias. Lo anterior, parte del hecho que el usuario se da a la apertura de buscar información fuera del centro hospitalario o bajo la asesoría de un profesional en medicina; ante la diversidad de elecciones surge la problemática de las fuentes de información virtuales a las que el cuidador y el paciente tienen acceso. Se produce entonces una cadena de desinformación motivada por las falsas noticias en salud, mediada por fuentes que carecen de autenticidad en sus contenidos de consulta y porque no cuentan con la participación de los profesionales encargados en el área de especialidad. Por lo tanto, se presenta la propuesta de un servicio digital a través de una herramienta tipo web orientado en el usuario, proporcionando información de primera mano, apoyando así al área sobre los cuidados preventivos y correctivos para tener en cuenta al momento del egreso del paciente.The present work of degree proposes the design of a service of digital information through a tool type Web as a way to facilitate contents that allow the support of the patient’s caregiver to the discharge of the hospital facilities. The user is given to the opening to seek information outside the hospital center or under the advice of a medical professional; Facing with the diversity of elections arises the problem of the virtual sources of information to which the caregiver and the patient have access. The misinformation, motivated by fake news in health, mediated by sources that lack authenticity in their contents of consultation and also because they do not have the participation of the professionals in charge in the area of specialization. Therefore, the proposal of a digital service is presented through a user-oriented web-type tool, providing first-hand information, supporting the area on preventive and corrective care to take into account at the time of Patient's discharge.Profesional en Ciencia de la Información - Bibliotecólogo (a)Pregrad

La ciudad como experiencia de conocimiento: Nuevas metodologías de aprendizaje, iniciación de la investigación y extensión universitaria a partir de la historia urbana

Depto. de GeografíaDepto. de Historia Moderna y ContemporáneaDepto. de Historia del ArteFac. de Geografía e HistoriaFALSEsubmitte

La ciudad como experiencia de conocimiento: nuevas metodologías de aprendizaje, iniciación a la investigación y extensión universitaria a partir de la historia urbana

Memoria que recoge las actividades desarolladas en el proyecto de Innovación docente 327 de 2020 con título La ciudad como experiencia de conocimiento: nuevas metodologías de aprendizaje, iniciación a la investigación y extensión universitaria a partir de la historia urbana y dirigido por Rubén Pallol Trigueros

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Almendras milk

Almendras milk busca satisfacer la necesidad de encontrar un precio accesible al momento de comprar una bebida de almendras. Muchos consumidores potenciales dan un paso al costado o compran un producto sustituto a la bebida de almendras simplemente por su precio. Hoy en día, las marcas de bebidas de almendras que llegan a Colombia como Silk o Blue Diamond, son importadas por el grupo Éxito, que por razones económicas venden el litro de esta bebida a un rango entre $14,000 y$16,000 pesos. El litro de leche tradicional tiene un precio de alrededor de $3000 pesos, es decir, estamos hablando de un producto cinco veces más costoso y eso pesa mucho en el momento en que el consumidor toma su decisión de compra.Introducción. Modelo de negocio. Estructura organizacional y legal. Plan de mercadeo. Estudio técnico de la producción. Estudio viabilidad financiera. Bibliografía. Lista de gráficas. Lista de tablas.Administrador de EmpresasPregrad

Development of a CRISPRi Human Retinal Pigmented Epithelium Model for Functional Study of Age-Related Macular Degeneration Genes

Age-related macular degeneration (AMD) is a blinding disease characterised by dysfunction of the retinal pigmented epithelium (RPE) which culminates in disruption or loss of the neurosensory retina. Genome-wide association studies have identified >60 genetic risk factors for AMD; however, the expression profile and functional role of many of these genes remain elusive in human RPE. To facilitate functional studies of AMD-associated genes, we developed a human RPE model with integrated CRISPR interference (CRISPRi) for gene repression by generating a stable ARPE19 cell line expressing dCas9-KRAB. We performed transcriptomic analysis of the human retina to prioritise AMD-associated genes and selected TMEM97 as a candidate gene for knockdown study. Using specific sgRNAs, we showed that knockdown of TMEM97 in ARPE19 reduced reactive oxygen species (ROS) levels and exerted a protective effect against oxidative stress-induced cell death. This work provides the first functional study of TMEM97 in RPE and supports a potential role of TMEM97 in AMD pathobiology. Our study highlights the potential for using CRISPRi to study AMD genetics, and the CRISPRi RPE platform generated here provided a useful in vitro tool for functional studies of AMD-associated genes

Seven Epidemic Waves of COVID-19 in a Hospital in Madrid: Analysis of Severity and Associated Factors

(1) Background: COVID-19 has evolved during seven epidemic waves in Spain. Our objective was to describe changes in mortality and severity in our hospitalized patients. (2) Method: This study employed a descriptive, retrospective approach for COVID-19 patients admitted to the Hospital de Fuenlabrada (Madrid, Spain) until 31 December 2022. (3) Results: A total of 5510 admissions for COVID-19 were recorded. The first wave accounted for 1823 (33%) admissions and exhibited the highest proportion of severe patients: 65% with bilateral pneumonia and 83% with oxygen saturation under 94% during admission and elevated levels of CRP, IL-6, and D-dimer. In contrast, the seventh wave had the highest median age (79 years) and comorbidity (Charlson: 2.7), while only 3% of patients had bilateral pneumonia and 3% required intubation. The overall mortality rate was 10.3%. The first wave represented 39% of the total. The variables related to mortality were age (OR: 1.08, 1.07–1.09), cancer (OR: 1.99, 1.53–2.60), dementia (OR: 1.82, 1.20–2.75), the Charlson index (1.38, 1.31–1.47), the need for high-flow oxygen (OR: 6.10, 4.94–7.52), mechanical ventilation (OR: 11.554, 6.996–19.080), and CRP (OR: 1.04, 1.03–1.06). (4) Conclusions: The variables associated with mortality included age, comorbidity, respiratory failure, and inflammation. Differences in the baseline characteristics of admitted patients explained the differences in mortality in each wave. Differences observed between patients admitted in the latest wave and the earlier ones suggest that COVID-19 has evolved into a distinct disease, requiring a distinct approach