Modelling and characterization of Quantum Dots as QLED devices for automotive lighting systems

This work reports the design, manufacturing and numerical simulation approach of an electroluminescent quantum dot light emitting device (QLED) based on quantum dots as an active layer. In addition, the electrical I-V curve was measured, observing how the fabrication process and layer thickness have an influence in the shape of the plot. This experimental device enabled us to create a computational model for the QLED based on the Transfer Hamiltonian approach to calculate the current density J(mA/cm2), the band diagram of the system and the accumulated charge distribution. Thanks to the QLED simulator developed, it would be possible to model the device and anticipate the electrical performance in a theoretical design step before going to QLED manufacturing at the laboratory. Eventually, particular automotive lighting system demonstrators were designed to integrate the theoretical and experimental research carried out in an industrial automotive product.Tesis Univ. Granada

High-Luminance QD-LED Device With Digital and Dynamic Lighting Functions for Efficient Automotive Systems

The work of F. M. Gomez-Campos and S. Rodriguez-Bolivar was supported by the Spanish Junta de Andalucia under Project P18-RT-3303.Thiswork reports the design of a 60-segment photoluminescence quantum dot light emitting device (QD-LED) for automotive lighting systems. The QD-LED device was fabricated using a quantum dot film (QDF), incorporating two kinds of quantum dots (QDs) synthesized to emit at 531 nm (green) and 624 nm (red). When the QDF is excited with blue wavelength at 465 nm, a white color output is obtained. Likewise, by using different color filters, all the automotive lighting functions (interior and exterior) can be achieved. In addition, an electronic control module, based on the state-of-the-art multichannel automotive lighting emitting diode (LED) drivers, was specifically designed to control each segment individually to enable the possibility of external digital communication with the vehicle surroundings. That is key to develop the autonomous vehicle by incorporating what is known as car-to-X communication, used to transmit information to other vehicles and road users through light. Furthermore, this work is remarkable due to the low power consumption of the QD-LED device designed, which implies a high electrical efficiency, something critical for the electrical vehicle development. Besides, figures ofmerit and performance indicators are measured, offering promising values to use this nanotechnology in the next future of the vehicle transportation lighting systems.Junta de Andalucia P18-RT-330

IMPLEMENTATION OF THE ELECTRICAL-ELECTRONIC SYSTEM AND SOFTWARE SYSTEM OF A CNC MACHINE

This article presents the operation of a CNC router controlled by a free open source firmware (GRBL) that runs on the Arduino Uno R3 card, thus describing and justifying the components that are part of the electrical-electronic system and the computer programs that constitute the software system for the machining of printed circuit boards. The tests performed recorded an estimated time of 21: 86 in minutes: seconds divided into the three processes of engraving (paths 13:12, holes 6:48 and contour 2:26 given in minutes: seconds), these values can vary depending on the dimensions of the required PCB, even so it turns out to be more efficient in quality and time compared to the conventional method of chemical attack

ESTADO DEL ARTE DE LAS CELDAS DE COMBUSTIBLE

Las celdas de combustible han sido implementadas desde hace varias décadas, la NASA desde 1960 las ha usado en sus programas espaciales, sin embargo, no se le ha dado la importancia que esta tecnología debería tener al ser una opción ambientalista y eficiente en su conversión y aporte energético. Este trabajo presenta una conceptualización y revisión de la literatura de las pilas, células o celdas de combustible con el objetivo de comprender fácilmente su comportamiento para contribuir con su divulgación en Colombia. Los temas enunciados en este documento son la clasificación de estos dispositivos, permitiendo identificar las características y el principio de funcionamiento; también se realiza una revisión de diferentes proyectos y artículos que evidencian los avances y aplicaciones desde el área académica hasta la industria, los documentos examinados fueron 57, estas investigaciones realizadas cubren un periodo de tiempo desde el año 2004 hasta 2018

Sistema de supervisión y control para el Banco de Pruebas de Bombas Centrífugas

Centrifuges pumps are machines that absorb mechanical energy and in turn returned to the fluid hydraulic energy, this energy is represented in the flow and the head supplied by the pump; when a specific flow requirements in any industrial sector either pharmaceutical, food among others, it is necessary to apply a driver that is responsible for maintaining the variable of interest at the desired point. Therefore IDENT Matlab® tool offered by the software to perform the approximate plant model using the identification method, was used in this particular study and then with the help of PID TUNNING toolbox that allowed the PID controller was designed will correct errors stability, reduce oscillations and maintain the flow in the reference responding adequately to possible disturbances present in the test, finally implementing the controller and interface for monitoring it was conducted in the Labview® software using the DAQ 6009 for the acquisition and the data sent, in the analysis of the results it shows that the system is considerably improved by modifying the activation times of the coils of the stepper motor.Keywords: centrifuges pumps; controller PID; DAQ 6009; IDENT; Matlab®; Labview®Las bombas centrifugas son máquinas que absorben energía mecánica y a su vez devuelven al fluido energía hidráulica, esta energía se ve representada en el caudal y la altura suministrada por la bomba; cuando se requiere un caudal especifico en algún sector industrial ya sea farmacéutico, alimenticio, entre otros, se hace necesario aplicar un controlador que se encargue de mantener la variable de interés en el punto deseado. Por lo tanto, en este estudio en particular se utilizó la herramienta IDENT€¡ ofrecida por el software Matlab® para realizar el modelo aproximado de la planta utilizando el método de identificación, seguidamente y con la ayuda del toolbox PID TUNNING se diseñó el controlador PID, que permitió corregir errores de estabilidad, disminuir las oscilaciones y mantener el caudal en la referencia establecida, respondiendo de manera adecuada a posibles perturbaciones presentes en el banco de pruebas, por último la implementación del controlador y la interfaz para el monitoreo se realizó en el software Labview®, empleando la DAQ 6009 para la adquisición y envió de los datos, en el análisis de los resultados se observó que el sistema mejora considerablemente al modificar los tiempos de activación de las bobinas del motor paso a paso.Palabras clave: Bombas centrifugas; controlador PID; DAQ 6009; IDENT; Matlab®; Labview

Applications of serum albumins in delivery systems: Differences in interfacial behaviour and interacting abilities with polysaccharides

One of the major applications of SerumAlbumins is their use as delivery systems for lipophilic compounds in biomedicine. Their biomedical application is based on the similarity with Human Serum Albumin (HSA), as a fully biocompatible protein. In general, Bovine Serum Albumin (BSA) is treated as comparable to its human homologue and used as a model protein for fundamental studies since it is available in high amounts and well understood. This protein can act as a carrier for lipophilic compounds or as protective shell in an emulsion-based vehicle. Polysaccharides are generally included in these formulations in order to increase the stability and/or applicability of the carrier. In this review, themain biomedical applications of Albumins as drug delivery systems are first presented. Secondly, the differences between BSA andHSA are highlighted, exploring the similarities and differences between these proteins and their interaction with polysaccharides, both in solution and adsorbed at interfaces. Finally, the use of Albumins as emulsifiers for emulsion-based delivery systems, concretely as Liquid Lipid Nanocapsules (LLNs), is revised and discussed in terms of the differences encountered in the molecular structure and in the interfacial properties. The specific case of Hyaluronic Acid is considered as a promising additivewith important applications in biomedicine. The literatureworks are thoroughly discussed highlighting similarities and differences between BSA and HSA and their interaction with polysaccharides encountered at different structural levels, hence providing routes to control the optimal design of delivery systems.This work has been funded by the following projects, which are gratefully acknowledged: MAT2017-82182-R and RTI2018-101309-BC21 (Ministerio de Ciencia e Innovación). The authors also acknowledge “Mancomunidad de los Pueblos de la Alpujarra Granadina” for the funds raised and supplied for this research

Modelo matemático de una cámara de combustión de una caldera pirotubular utilizando la herramienta matlab-simulink

En este artículo se presenta la implementación del modelo matemático de la cámara de combustión de una caldera piro-tubular, por medio del planteamiento de los balances de masa, energía y estequiométrico. Estos balances fueron descritos por los componentes de entrada (aire y combustible) que se presentan en la zona de combustión, basados en el concepto de mantener la relación estequiométrica entre ellos, los cuales, fueron simulados a través de las herramientas computacionales como el ESS y Matlab®, con el fin de determinar el comportamiento de los gases de combustión dependiendo del tipo de reacción química presentada. Así mismo, fue determinado la cantidad de carbonos e hidrógenos que componen los combustibles de estudio (ACMP y Keroseno), igualmente los kmol/s que componen al aire, con el objetivo de analizar su oxidación y determinar la producción de y . Finalmente, se realizó la respectiva comparación analizando los valores de presión y temperatura en los tres tipos de combustión, estequiométrica, con presencia de inquemados y con exceso de aire. El planteamiento del modelo matemático fue aplicado para los dos tipos de combustibles de estudio.Palabras clave: modelo matemático, relación aire combustible, Simulink®. cámara de combustión, sistem

Effect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapy

The use of foams to deliver bioactive agents and drugs is increasing in pharmaceutics. One example is the use of foam as a delivery system for polidocanol (POL) in sclerotherapy, with the addition of bioactive compounds to improve the delivery system being a current subject of study. This work shows the influence of two bioactive additives on the structure and stability of POL foam: hyaluronic acid (HA) and Pluronic-F68 (F68). HA is a natural non-surface-active biopolymer present in the extracellular matrix while F68 is a surface-active poloxamer that is biocompatible with plasma-derived fluids. Both additives increase the bulk viscosity of the sample, improving foam stability. However, HA doubled and F68 quadruplicated the foam half lifetime of POL. HA reduced the size and polydispersity of the bubble size distribution and increased the surface elasticity with respect to POL. Both facts have a positive impact in terms of foam stability. F68 also altered bubble structure and increased surface elasticity, again contributing to the enhancement of foam stability. The surface characterization of these systems is important, as in foam sclerotherapy it is crucial to assure the presence of POL at the surface of the bubbles in order to deliver the sclerosant agent in the target vein.Junta de Andalucia NANOFOAM-PI12.2956Instituto de Salud Carlos III Spanish Government MAT2017-82182-R RTI2018-101309-B-C21Consejeria de Economia, Conocimiento, Empresas y UniversidadEuropean Union (EU) SOMM17/6109/UG

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe